共查询到20条相似文献,搜索用时 15 毫秒
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细胞信号转导途径JAK-STAT通路是细胞因子由细胞膜外向细胞核内传递信号的主要途径,参与了介导细胞生长,增殖分化,炎症反应,细胞凋亡等多种病理生理过程。STAT蛋白是JAK-STAT通路的核心分子,且所有的STAT蛋白在心脏中均有表达,改变其分子结构能调节STAT蛋白的生物学活性。目前,已有大量文献报道了STAT1、STAT3在心脏疾病中的作用,缺血性心脏疾病、缺血再灌注引起心肌损伤、心肌肥大、心肌梗塞后的心脏衰竭以及缺血预/后处理介导的心脏保护作用等均与STAT蛋白密切相关。本文主要就近年来STAT蛋白在心脏疾病中作用的研究进展进行了综述。 相似文献
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M F Brizzi P Dentelli A Rosso Y Yarden L Pegoraro 《The Journal of biological chemistry》1999,274(24):16965-16972
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STAT signalling in cell proliferation and in development 总被引:6,自引:0,他引:6
Williams JG 《Current opinion in genetics & development》2000,10(5):503-507
Recent advances in STAT signalling research include a better understanding of the roles of mammalian STAT proteins in cell proliferation and apoptosis, and of non-mammalian STAT proteins in morphogenesis. Two different ways in which STAT signalling pathways can interface with Smad signalling pathways significantly increasing combinatorial signalling possibilities, have also been described. 相似文献
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Regulation of STAT signalling by proteolytic processing. 总被引:3,自引:0,他引:3
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Integrin-mediated Adhesion of Endothelial Cells Induces JAK2 and STAT5A Activation: Role in the Control of c-fos Gene Expression 总被引:4,自引:0,他引:4
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Maria Felice Brizzi Paola Defilippi Arturo Rosso Mascia Venturino Giovanni Garbarino Atsushi Miyajima Lorenzo Silengo Guido Tarone Luigi Pegoraro 《Molecular biology of the cell》1999,10(10):3463-3471