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1.
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Highlights
  • •OMICS distinguish cancer cells from resistant or cancer stem cells.
  • •Bactericidal antibiotics and mitochondria.
  • •Linezolid and anticancer therapy.
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2.
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Highlights
  • •In-depth proteome profiling of primary human myeloma cells
  • •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
  • •Myeloma cells show specific immune evasion strategies
  • •Metabolic adaptations involve tumor and stroma cells
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3.
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Highlights
  • •Chromobodies are stabilized by antigen binding in live cells.
  • •Monitoring changes of endogenous protein levels in living cells with chromobodies.
  • •Broadly applicable system to generate turnover-accelerated chromobodies.
  • •Quantification of time- and dose-dependent compound effects.
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4.
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Highlights
  • •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
  • •Label-free quantification determined 2843 phagosomal proteins.
  • •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
  • •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
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5.
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Highlights
  • •Open source software for comprehensive HDX-MS data analysis.
  • •Automatic back-exchange correction options.
  • •Rigorous statistical analysis of the significance of uptake differences.
  • •High quality visualization tools.
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6.
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Highlights
  • •Quantitative (phospho)proteome analysis of antibiotic treatment in E. coli.
  • •Largest bacterial phosphorylation catalogue.
  • •Specific phosphorylation motifs changes during resistance development.
  • •Phosphorylation mediated signaling could be a potential target for drug design.
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7.
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Highlights
  • •Rapamycin and zinc induce moderate but significant mitochondrial proteome changes.
  • •The mitochondrial proteins processing system is robust under subtoxic conditions.
  • •Rapamycin and zinc perturb the mitochondrial proteins processing system.
  • •Rapamycin and zinc perturb the mitochondrial proteins homeostasis.
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8.
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Highlights
  • •Interplay of epithelial cells and internalized S. aureus was dissected over 96 h.
  • •Surviving host cells contain nonreplicating bacteria that persists in the cytoplasm.
  • •Competition over resources triggers temporal metabolic changes.
  • •Metabolic adaptation of host and bacteria determines the outcome of infection.
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9.
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Highlights
  • •Profiling antibody responses of patients with naturally acquired malaria immunity.
  • •High-density peptide arrays featuring linear epitopes.
  • •Epitope mapping of known and potential novel vaccine candidates.
  • •Novel immunogenic epitopes discovered, and known antibody target motifs confirmed.
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10.
11.
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Highlights
  • •Developed a data processing pipeline to format phosphopeptide identifications.
  • •Identified the preferred substrate motif for FLT3 and mutant kinases.
  • •Designed and validated a panel of pan-FTL3 artificial substrates.
  • •Monitored FLT3 and mutant kinase activity through FAStide phosphorylation.
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12.
13.
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Highlights
  • •MHC-II-bound peptide repertoires from DO-sufficient and DO-deficient cells.
  • •Fewer unique peptides and core epitopes were presented in the absence of DO.
  • •Immunopeptidome differences appeared to result from reduced DM editing.
  • •DO-dependent self-epitopes elicited CD4 T cell responses in mice.
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14.
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Highlights
  • •quantitative phosphoproteome analysis of TDM-activated macrophages.
  • •distinct Mincle-dependent and independent phosphorylation and gene regulations.
  • •Mincle-dependent activation of PI3K/AKT signaling by TDM.
  • •Mincle-independent macrophage response is linked to cell cycle regulation.
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15.
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Highlights
  • •Single-pot workflow for manual or automated enrichment of N-terminal peptides.
  • •Sensitive enrichment of protein N termini from 10,000 cells or 2 μg crude proteome.
  • •Data independent acquisition improves precision of peptide level quantification.
  • •First degradomic analyses of sorted immune cells, single seedlings, and mitochondria from patient cells.
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16.
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Highlights
  • •Spatiotemporal microproteomics analysis of TBI.
  • •Injury site microproteomics reveal distinct phases in 10-day frame post TBI.
  • •Uninjured proteomic profile is restored in TBI at 10 days post injury.
  • Substantia nigra protein post 3 days suggest link to Parkinson's disease.
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17.
18.
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Highlights
  • •First global study on laryngeal cells cultured with cigarette smoke enriched medium.
  • •Vocal fold fibroblasts increased production of ECM component hyaluronan.
  • •Expression of several fibrillar collagens was reduced.
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19.
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Highlights
  • •First global study on metabolic regulation of Nt-acetylation.
  • •Yeast cells maintain global Nt-acetylation levels during prolonged starvation.
  • •Nt-acetylation can in some cases be either up- or downregulated by starvation.
  • •Naa10/NatA affects the steady-state protein levels of Rsa3 and Rpl7a.
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20.
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