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1.
《Molecular & cellular proteomics : MCP》2019,18(2):231-244
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- •OMICS distinguish cancer cells from resistant or cancer stem cells.
- •Bactericidal antibiotics and mitochondria.
- •Linezolid and anticancer therapy.
2.
《Molecular & cellular proteomics : MCP》2019,18(5):936-953
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- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells
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《Molecular & cellular proteomics : MCP》2018,17(12):2518-2533
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- •Chromobodies are stabilized by antigen binding in live cells.
- •Monitoring changes of endogenous protein levels in living cells with chromobodies.
- •Broadly applicable system to generate turnover-accelerated chromobodies.
- •Quantification of time- and dose-dependent compound effects.
4.
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*
《Molecular & cellular proteomics : MCP》2019,18(5):909-922
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- •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
- •Label-free quantification determined 2843 phagosomal proteins.
- •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
- •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
5.
《Molecular & cellular proteomics : MCP》2019,18(12):2516-2523
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- •Open source software for comprehensive HDX-MS data analysis.
- •Automatic back-exchange correction options.
- •Rigorous statistical analysis of the significance of uptake differences.
- •High quality visualization tools.
6.
《Molecular & cellular proteomics : MCP》2018,17(12):2496-2507
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- •Quantitative (phospho)proteome analysis of antibiotic treatment in E. coli.
- •Largest bacterial phosphorylation catalogue.
- •Specific phosphorylation motifs changes during resistance development.
- •Phosphorylation mediated signaling could be a potential target for drug design.
7.
《Molecular & cellular proteomics : MCP》2019,18(6):1085-1095
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- •Rapamycin and zinc induce moderate but significant mitochondrial proteome changes.
- •The mitochondrial proteins processing system is robust under subtoxic conditions.
- •Rapamycin and zinc perturb the mitochondrial proteins processing system.
- •Rapamycin and zinc perturb the mitochondrial proteins homeostasis.
8.
《Molecular & cellular proteomics : MCP》2019,18(5):892-908
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- •Interplay of epithelial cells and internalized S. aureus was dissected over 96 h.
- •Surviving host cells contain nonreplicating bacteria that persists in the cytoplasm.
- •Competition over resources triggers temporal metabolic changes.
- •Metabolic adaptation of host and bacteria determines the outcome of infection.
9.
《Molecular & cellular proteomics : MCP》2019,18(4):642-656
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- •Profiling antibody responses of patients with naturally acquired malaria immunity.
- •High-density peptide arrays featuring linear epitopes.
- •Epitope mapping of known and potential novel vaccine candidates.
- •Novel immunogenic epitopes discovered, and known antibody target motifs confirmed.
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《Molecular & cellular proteomics : MCP》2019,18(3):477-489
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- •Developed a data processing pipeline to format phosphopeptide identifications.
- •Identified the preferred substrate motif for FLT3 and mutant kinases.
- •Designed and validated a panel of pan-FTL3 artificial substrates.
- •Monitored FLT3 and mutant kinase activity through FAStide phosphorylation.
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13.
《Molecular & cellular proteomics : MCP》2019,18(3):490-503
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- •MHC-II-bound peptide repertoires from DO-sufficient and DO-deficient cells.
- •Fewer unique peptides and core epitopes were presented in the absence of DO.
- •Immunopeptidome differences appeared to result from reduced DM editing.
- •DO-dependent self-epitopes elicited CD4 T cell responses in mice.
14.
《Molecular & cellular proteomics : MCP》2019,18(4):669-685
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- •quantitative phosphoproteome analysis of TDM-activated macrophages.
- •distinct Mincle-dependent and independent phosphorylation and gene regulations.
- •Mincle-dependent activation of PI3K/AKT signaling by TDM.
- •Mincle-independent macrophage response is linked to cell cycle regulation.
15.
《Molecular & cellular proteomics : MCP》2019,18(11):2335-2347
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- •Single-pot workflow for manual or automated enrichment of N-terminal peptides.
- •Sensitive enrichment of protein N termini from 10,000 cells or 2 μg crude proteome.
- •Data independent acquisition improves precision of peptide level quantification.
- •First degradomic analyses of sorted immune cells, single seedlings, and mitochondria from patient cells.
16.
《Molecular & cellular proteomics : MCP》2019,18(8):1669-1682
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- •Spatiotemporal microproteomics analysis of TBI.
- •Injury site microproteomics reveal distinct phases in 10-day frame post TBI.
- •Uninjured proteomic profile is restored in TBI at 10 days post injury.
- •Substantia nigra protein post 3 days suggest link to Parkinson's disease.
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18.
《Molecular & cellular proteomics : MCP》2019,18(8):1511-1525
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- •First global study on laryngeal cells cultured with cigarette smoke enriched medium.
- •Vocal fold fibroblasts increased production of ECM component hyaluronan.
- •Expression of several fibrillar collagens was reduced.
19.
《Molecular & cellular proteomics : MCP》2018,17(12):2309-2323
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- •First global study on metabolic regulation of Nt-acetylation.
- •Yeast cells maintain global Nt-acetylation levels during prolonged starvation.
- •Nt-acetylation can in some cases be either up- or downregulated by starvation.
- •Naa10/NatA affects the steady-state protein levels of Rsa3 and Rpl7a.