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1.
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Highlights
  • •Quantitative global proteome, acetylome and succinylome of phytoplasma-infected Paulownia tomentosa seedlings.
  • •Acetylation may be more important than succinylation in response to phytoplasma infection.
  • •Acetylation modified the activities of POR and RuBisCO.
  • •Possible model to elucidate the molecular mechanism responses to PaWB from proteome and PTMs.
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2.
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Highlights
  • •Zero-length chemical cross-linking of APOA1 peptides in HDL.
  • •Cross-links match antiparallel isomers of APOA dimers in molecular modeling.
  • •Identical MS/MS spectra of native and synthetic cross-linked peptides.
  • •First biochemical evidence of LL5/5 and LL5/4 isomers in human HDL.
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3.
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Highlights
  • •Cathepsin-L is introduced as a novel protease for HX-MS studies.
  • •Cathepsin-L improves resolution of traditionally challenging histone tails.
  • •Cathepsin-L can be readily combined with pepsin for improved protein coverage.
  • •In-solution dynamics of the H3.1 and H4 monomers reveal extensive EX1 kinetics.
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4.
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Highlights
  • •In-depth proteome underpins the gland ontogeny and age-specific activity of the HGs.
  • •The well-developed acini in the HGs of NBs promote the RJ secretary activities.
  • •The enhanced protein and energy metabolism in the HGs boost the stronger RJ secretion of RJBs.
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5.
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Highlights
  • •Frequent genetic polymorphism affects the glycosylation pattern of fetuin.
  • •Personalized in-depth proteoform profiling of fetuin purified from 20 donors.
  • •Classification of serum donors into three different genotypes.
  • •Septic patients show increased level of fucosylation at N-glycolation site N176.
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6.
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Highlights
  • •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
  • •Label-free quantification determined 2843 phagosomal proteins.
  • •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
  • •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
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7.
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Highlights
  • •Functional role of a yet uncharacterized receptor kinase QSK1.
  • •Activation model for SIRK1 receptor kinase in a heteromer with QSK1.
  • •Role of QSK1 in substrate recruitment and stabilization of the complex.
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8.
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Highlights
  • •Comprehensive analysis of inter-individual variation of normal urinary proteome.
  • •Significant gender differences were observed.
  • •Proteins increased in female urine are enriched in immunological pathways.
  • •Estimated reference intervals of proteins as the baseline for biomarker discovery.
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9.
10.
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Highlights
  • •First report on the quantitative proteomic profiling of Drosophila lymph glands.
  • •Comparative proteomic analysis under conditions of perturbed blood cell homeostasis.
  • •Resource for identifying new regulators of insect and vertebrate hematopoiesis.
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11.
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Highlights
  • •Kallikrein-related peptidase 7 is over expressed in ovarian cancer.
  • •Quantitative PROTOMAP and TAILS approaches identified putative substrates of KLK7.
  • •Pro-MMP10 is activated by KLK7.
  • •KLK7 cleaves thrombospondin 1 and IGFBP6 in vitro.
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12.
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Highlights
  • •Two-step cross-linking coupled with affinity purification to facilitate structural analysis of protein complexes.
  • •Integrated QXL-MS workflow for studying condition-dependent structural changes of protein complexes.
  • •Mechanistic insights on in vivo H2O2-induced conformational dynamics of proteasome complexes.
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13.
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Highlights
  • •Protein interaction screen of SETD1A/COMPASS complex subunits.
  • •Unexpected interaction with DNA damage protein RAD18 was confirmed for SETD1A, but not for other subunits.
  • •SETD1A and/or RAD18 influence each other's mRNA and protein expression levels, and disruption of either gene elicits a similar DNA damage sensitivity phenotype.
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16.
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Highlights
  • •Our search identifies 2,134 kinase-substrate phosphosite pairs in breast cancer.
  • •CDKs and MAPKs are dominant regulators of trans substrate-phosphorylation.
  • •Druggability, outcomes, and immune signatures related to kinase-substrates.
  • •Experimentally validated activated phosphosites of ERBB2, EIF4EBP1, and EGFR.
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17.
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Highlights
  • •Multiplex epitope mapping/antigenic determinant identification in the gas phase.
  • •Intact transition and controlled dissociation of immune complexes by MS.
  • •Simultaneous identification and amino acid sequence determination of epitopes.
  • •Simplified in-solution sample handling because of ion manipulation and filtering by MS.
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18.
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Highlights
  • •Auxin responsive proteins in Arabidopsis roots were identified from 3,514 detected proteins.
  • •All six auxin receptors are stable in response to hormone via novel MRM assays.
  • •The >100 differentially expressed proteins exhibit dynamic and transient responses to auxin.
  • •Phenotypic screening of the top responsive proteins uncovered several novel root mutants.
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19.
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Highlights
  • •Production of sera with different levels of protection against rodent Plasmodium.
  • •Generation of immunomic and proteomic data sets enriched in protective antigens.
  • •Prediction of the most likely protective antigens using a weighted scoring system.
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20.
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Highlights
  • •nLC-MS/MS method to analyze immunoglobulin (Ig) N-glycopeptides from human serum.
  • •Multi-isotype, site-specific characterization of immunoglobulin N-glycosylation.
  • •IgA2 sequence and glycosylation-site variant analyses.
  • •Platform to define disease-specific N-glycan signatures for different Ig isotypes.
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