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《Molecular & cellular proteomics : MCP》2019,18(10):1939-1949
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- •Proteome profiling of tissue interstitial fluids (TIFs) of oral cancer.
- •Pathway of aminoacyl tRNA biosynthesis enriched in proteome of TIFs.
- •Verification of nidogen-1 as a salivary biomarker of oral cancer.
- •High correlation between elevated tissue level of nidogen-1 and poor survival.
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《Molecular & cellular proteomics : MCP》2019,18(5):818-836
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- •Kallikrein-related peptidase 7 is over expressed in ovarian cancer.
- •Quantitative PROTOMAP and TAILS approaches identified putative substrates of KLK7.
- •Pro-MMP10 is activated by KLK7.
- •KLK7 cleaves thrombospondin 1 and IGFBP6 in vitro.
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《Molecular & cellular proteomics : MCP》2019,18(2):231-244
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- •OMICS distinguish cancer cells from resistant or cancer stem cells.
- •Bactericidal antibiotics and mitochondria.
- •Linezolid and anticancer therapy.
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《Molecular & cellular proteomics : MCP》2019,18(9):1796-1806
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- •iTRAQ-based analysis of saliva samples from oral cancer patients.
- •Proteome profiling of saliva samples from patients with oral premalignant lesions.
- •Verification of salivary biomarker candidates with MRM-MS and immunoassays.
- •Identification of salivary proteins as potential biomarkers of oral cancer.
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《Molecular & cellular proteomics : MCP》2019,18(12):2401-2417
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- •Quantitative proteomics reveals GBF1 to interact with Uukuniemi virus glycoproteins.
- •GBF1 is a proviral host factor for phleboviruses and other zoonotic RNA viruses.
- •GBF1 supports phlebovirus replication and assembly and release of particles.
- •The GBF1 inhibitor Golgicide A blocks infection with zoonotic RNA viruses.
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《Molecular & cellular proteomics : MCP》2019,18(12):2516-2523
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- •Open source software for comprehensive HDX-MS data analysis.
- •Automatic back-exchange correction options.
- •Rigorous statistical analysis of the significance of uptake differences.
- •High quality visualization tools.
10.
《Molecular & cellular proteomics : MCP》2019,18(4):735-743
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- •HPV is being introduced as the primary test in cervical cancer screening programs.
- •New biomarkers are needed for co-testing of women HPV positive in screening.
- •Analysis of plasma from women with invasive cervical cancer identified a 11-marker panel.
- •This signature shows high sensitivity and specificity to identify women with cancer.
11.
《Molecular & cellular proteomics : MCP》2019,18(7):1330-1344
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- •Cts L−/− cells proliferate faster than wild types and shift to aerobic glycolysis.
- •LDHA is a key glycolytic enzyme controlling Cts L−/− cell proliferation.
- •Cts L regulates LDHA expression and function.
12.
《Molecular & cellular proteomics : MCP》2019,18(5):936-953
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- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells
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《Molecular & cellular proteomics : MCP》2019,18(11):2178-2190
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- •Enough CD16a from NK cells can be isolated from a single donor following apheresis.
- •NK cell CD16a shows variability between different donors.
- •NK cells preferentially bind IgG1 that lacks core fucosylation.
14.
《Molecular & cellular proteomics : MCP》2019,18(4):669-685
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- •quantitative phosphoproteome analysis of TDM-activated macrophages.
- •distinct Mincle-dependent and independent phosphorylation and gene regulations.
- •Mincle-dependent activation of PI3K/AKT signaling by TDM.
- •Mincle-independent macrophage response is linked to cell cycle regulation.
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《Molecular & cellular proteomics : MCP》2019,18(8):1630-1650
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- •Our search identifies 2,134 kinase-substrate phosphosite pairs in breast cancer.
- •CDKs and MAPKs are dominant regulators of trans substrate-phosphorylation.
- •Druggability, outcomes, and immune signatures related to kinase-substrates.
- •Experimentally validated activated phosphosites of ERBB2, EIF4EBP1, and EGFR.
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《Molecular & cellular proteomics : MCP》2019,18(3):448-460
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- •Multiplexed PTM assays on HuProt array were developed using ovarian tumor lysates.
- •Proteome-wide Tyr phosphorylation with 102 ovarian tumors were performed and analyzed.
- •19 kinases were predicted to have elevated activities in ovarian tumor.
- •Elevated activities of PTK2 and PTK2B were confirmed in ovarian cancer cell lines.
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《Molecular & cellular proteomics : MCP》2019,18(4):622-641
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- •Serial biopsies and autopsy from a metastatic lung cancer patient over 7 years.
- •Tumor heterogeneity characterized by quantifying the proteome and phosphoproteome.
- •Patient-specific database built using whole genome sequencing data from tumors.
- •MRM assay and functional validation of a novel lung-specific CDK12-G879V mutant.
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《Molecular & cellular proteomics : MCP》2019,18(12):2348-2358
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- •Glycosylation is not currently considered in flu vaccine design.
- •Glycosylation influences on immunodominance are not well understood.
- •Identification of site-specific glycosylation using mass spectrometry has matured.
- •New methods are needed to quantify site-specific glycosylation for vaccine design.
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《Molecular & cellular proteomics : MCP》2018,17(12):2496-2507
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- •Quantitative (phospho)proteome analysis of antibiotic treatment in E. coli.
- •Largest bacterial phosphorylation catalogue.
- •Specific phosphorylation motifs changes during resistance development.
- •Phosphorylation mediated signaling could be a potential target for drug design.
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《Molecular & cellular proteomics : MCP》2019,18(5):982-994
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- •MaxQuant.Live controls Orbitrap mass analyzers in real-time.
- •Freely available apps enable advanced data acquisition strategies.
- •On-the-fly mass, retention time and intensity recalibration.
- •Global targeting unifies shotgun and targeted proteomics.