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《Molecular & cellular proteomics : MCP》2019,18(7):1428-1436
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- •Protein interaction screen of SETD1A/COMPASS complex subunits.
- •Unexpected interaction with DNA damage protein RAD18 was confirmed for SETD1A, but not for other subunits.
- •SETD1A and/or RAD18 influence each other's mRNA and protein expression levels, and disruption of either gene elicits a similar DNA damage sensitivity phenotype.
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《Molecular & cellular proteomics : MCP》2019,18(6):1210-1226
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- •Quantitative global proteome, acetylome and succinylome of phytoplasma-infected Paulownia tomentosa seedlings.
- •Acetylation may be more important than succinylation in response to phytoplasma infection.
- •Acetylation modified the activities of POR and RuBisCO.
- •Possible model to elucidate the molecular mechanism responses to PaWB from proteome and PTMs.
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《Molecular & cellular proteomics : MCP》2019,18(6):1085-1095
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- •Rapamycin and zinc induce moderate but significant mitochondrial proteome changes.
- •The mitochondrial proteins processing system is robust under subtoxic conditions.
- •Rapamycin and zinc perturb the mitochondrial proteins processing system.
- •Rapamycin and zinc perturb the mitochondrial proteins homeostasis.
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Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*
《Molecular & cellular proteomics : MCP》2019,18(5):909-922
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- •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
- •Label-free quantification determined 2843 phagosomal proteins.
- •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
- •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
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《Molecular & cellular proteomics : MCP》2019,18(8):1479-1490
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- •Frequent genetic polymorphism affects the glycosylation pattern of fetuin.
- •Personalized in-depth proteoform profiling of fetuin purified from 20 donors.
- •Classification of serum donors into three different genotypes.
- •Septic patients show increased level of fucosylation at N-glycolation site N176.
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《Molecular & cellular proteomics : MCP》2019,18(6):1123-1137
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- •Changes to the proteome of skin fibroblasts subjected to reductive stress have been quantitated.
- •Only a small set of proteins is selectively diminished upon exposure to reductants.
- •Collagens (COL1A2 and COL6A2) emerge as sentinels of reductive stress.
- •Reductive stress triggers receptor-independent Akt phosphorylation at Ser473.
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《Molecular & cellular proteomics : MCP》2019,18(8):1630-1650
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- •Our search identifies 2,134 kinase-substrate phosphosite pairs in breast cancer.
- •CDKs and MAPKs are dominant regulators of trans substrate-phosphorylation.
- •Druggability, outcomes, and immune signatures related to kinase-substrates.
- •Experimentally validated activated phosphosites of ERBB2, EIF4EBP1, and EGFR.
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《Molecular & cellular proteomics : MCP》2019,18(6):1110-1122
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- •Comprehensive analysis of inter-individual variation of normal urinary proteome.
- •Significant gender differences were observed.
- •Proteins increased in female urine are enriched in immunological pathways.
- •Estimated reference intervals of proteins as the baseline for biomarker discovery.
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Posttranslational Modifications Drive Protein Stability to Control the Dynamic Beer Brewing Proteome
《Molecular & cellular proteomics : MCP》2019,18(9):1721-1731
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- •SWATH-MS profiles protein abundance and modification during mashing in beer brewing.
- •Proteolysis due to barley proteases leads to extreme proteoform diversity.
- •Sequence-specific proteolytic clipping of proteins controls their stability.
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《Molecular & cellular proteomics : MCP》2019,18(4):606-621
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- •In-depth proteome underpins the gland ontogeny and age-specific activity of the HGs.
- •The well-developed acini in the HGs of NBs promote the RJ secretary activities.
- •The enhanced protein and energy metabolism in the HGs boost the stronger RJ secretion of RJBs.
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Intact Transition Epitope Mapping – Targeted High-Energy Rupture of Extracted Epitopes (ITEM-THREE),
《Molecular & cellular proteomics : MCP》2019,18(8):1543-1555
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- •Multiplex epitope mapping/antigenic determinant identification in the gas phase.
- •Intact transition and controlled dissociation of immune complexes by MS.
- •Simultaneous identification and amino acid sequence determination of epitopes.
- •Simplified in-solution sample handling because of ion manipulation and filtering by MS.
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《Molecular & cellular proteomics : MCP》2019,18(3):504-519
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- •Dimethyl fumarate covalently modifies cysteine residues in neurons and astrocytes.
- •Cofilin-1, tubulin and collapsin response mediator protein 2 (CRMP2) are targets.
- •DMF-modified cofilin-1 reduces actin-severing ability, preserving filamentous actin.
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《Molecular & cellular proteomics : MCP》2019,18(7):1363-1381
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- •Insulin Affects the Phosphorylation of G2L1, MARK2, CLIP2, EB1, AGAP3, and CKAP5.
- •Insulin Increases CLASP2 +TIP Density and Decreases CLASP2 +TIP Velocity.
- •Insulin Stimulates CLASP2 and G2L1 Trailing Along Microtubules.
- •Insulin Stimulates α-Tubulin Acetylation at Lysine 40 and Microtubule Stabilization.
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《Molecular & cellular proteomics : MCP》2019,18(6):1227-1241
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- •Quantitative microproteomics to study the CNS and PNS of the Twitcher mouse.
- •10plex TMT experiments on corpus callosum, motor cortex and sciatic nerves extracts.
- •More than 400 proteins groups deregulated between Twitcher and wildtype mice.
- •New insights into the molecular mechanisms of Krabbe disease.
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《Molecular & cellular proteomics : MCP》2019,18(5):968-981
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- •Quantitative substrate profiling method for characterizing peptidase specificity.
- •Applicable to both purified peptidases and peptidases in complex biological samples.
- •TMT labeling improves throughput, accuracy and reproducibility of the assay.
- •Design of fluorescent probes to monitor peptidase activity based on substrate data.
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《Molecular & cellular proteomics : MCP》2019,18(9):1899-1915
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- •Development of a method for low-abundance small protein analysis in human plasma.
- •Deep proteome profiling demonstrated unbiased identification of diverse factors.
- •Method enabled identification of a novel human plasma protein C5ORF46.
- •Analysis of intermittent fasting response showed changes in iron regulation.
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《Molecular & cellular proteomics : MCP》2019,18(3):408-422
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- •Quantitative phosphoproteomics of cells treated with sphingolipid analogs or PP2A inhibitor identify novel protein targets of PP2A.
- •PP2A substrates include several nutrient transporter proteins, GTPase regulators and proteins associated with actin cytoskeletal remodeling.
- •Differential regulation of Akt and Gsk3b account for the difference in vacuolating phenotype observed between SH-BC-893 and C2-ceramide.
- •Dynamic phosphoproteomics enabled the correlation of cell signaling with phenotypes to rationalize their mode of action.