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1.
《Molecular & cellular proteomics : MCP》2019,18(12):2516-2523
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- •Open source software for comprehensive HDX-MS data analysis.
- •Automatic back-exchange correction options.
- •Rigorous statistical analysis of the significance of uptake differences.
- •High quality visualization tools.
2.
《Molecular & cellular proteomics : MCP》2019,18(5):936-953
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- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells
3.
《Molecular & cellular proteomics : MCP》2019,18(2):231-244
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- •OMICS distinguish cancer cells from resistant or cancer stem cells.
- •Bactericidal antibiotics and mitochondria.
- •Linezolid and anticancer therapy.
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5.
《Molecular & cellular proteomics : MCP》2019,18(10):2018-2028
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- •Shotgun identification of neopeptides released from osteoarthritic cartilage.
- •Specific endogenous peptides from the cartilage ECM are measured by MRM.
- •Identification of neopeptides differentially generated from diseased tissue.
- •The peptide DSNKIETIPN shows the best metrics as biomarker of OA cartilage.
6.
《Molecular & cellular proteomics : MCP》2019,18(10):2108-2120
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- •Bayesian Beta-Binomial model integrates ion statistics with peptide ratio agreement.
- •Model appropriately interprets information from low signal peptides.
- •Confidence can be assigned even without replicates.
- •Model adds sensitivity to detection of small changes.
7.
《Molecular & cellular proteomics : MCP》2019,18(10):2089-2098
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- •Cathepsin-L is introduced as a novel protease for HX-MS studies.
- •Cathepsin-L improves resolution of traditionally challenging histone tails.
- •Cathepsin-L can be readily combined with pepsin for improved protein coverage.
- •In-solution dynamics of the H3.1 and H4 monomers reveal extensive EX1 kinetics.
8.
《Molecular & cellular proteomics : MCP》2019,18(4):669-685
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- •quantitative phosphoproteome analysis of TDM-activated macrophages.
- •distinct Mincle-dependent and independent phosphorylation and gene regulations.
- •Mincle-dependent activation of PI3K/AKT signaling by TDM.
- •Mincle-independent macrophage response is linked to cell cycle regulation.
9.
《Molecular & cellular proteomics : MCP》2019,18(6):1183-1196
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- •Atlantic salmon O-glycome expanded to 169 structures in three epithelia.
- •Low interindividual variation amongst all populations and geographical regions.
- •Small variations in glycosylation between geographical locations and fish size.
- •Prominent fucosylation in gastrointestinal mucins from Tasmanian fish.
10.
《Molecular & cellular proteomics : MCP》2019,18(8):1526-1542
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- •Definition of early systemin-responsive phosphorylation time course.
- •Reconstruction of kinase-substrate relationships from phosphorylation time profiles.
- •Phosphatase PLL5 rapidly dephosphorylated H+-ATPase LHA1 inducing alkalinization of the medium.
- •MAP-Kinase MPK2 re-phosphorylated LHA1 after 15 minutes.
11.
《Molecular & cellular proteomics : MCP》2019,18(8):1556-1571
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- •Functional role of a yet uncharacterized receptor kinase QSK1.
- •Activation model for SIRK1 receptor kinase in a heteromer with QSK1.
- •Role of QSK1 in substrate recruitment and stabilization of the complex.
12.
《Molecular & cellular proteomics : MCP》2019,18(10):1939-1949
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- •Proteome profiling of tissue interstitial fluids (TIFs) of oral cancer.
- •Pathway of aminoacyl tRNA biosynthesis enriched in proteome of TIFs.
- •Verification of nidogen-1 as a salivary biomarker of oral cancer.
- •High correlation between elevated tissue level of nidogen-1 and poor survival.
13.
《Molecular & cellular proteomics : MCP》2019,18(5):876-891
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- •Three novel Conodipines P1-3 in the injected venom of Conus purpurascens.
- •Conodipines P1-3 have consensus catalytic characteristics of sPLA2.
- •We determined multiple modification sites in Conodipines P1-3.
- •Evaluated the activity of Conohyal-P1 by a MS-based method.
14.
《Molecular & cellular proteomics : MCP》2019,18(6):1157-1170
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- •Auxin responsive proteins in Arabidopsis roots were identified from 3,514 detected proteins.
- •All six auxin receptors are stable in response to hormone via novel MRM assays.
- •The >100 differentially expressed proteins exhibit dynamic and transient responses to auxin.
- •Phenotypic screening of the top responsive proteins uncovered several novel root mutants.
15.
《Molecular & cellular proteomics : MCP》2019,18(8):1683-1699
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- •High-quality LFQ is valuable technique yet remains extremely challenging.
- •Fluctuating precision, limited robustness, and compromised accuracy are known issues.
- •We proposed a strategy collectively improving LFQ precision, robustness, and accuracy.
- •An online tool incorporating this novel strategy was also developed.
16.
《Molecular & cellular proteomics : MCP》2019,18(7):1437-1453
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- •mRNA-seq, miRNA-seq, proteomes of P. fulvidraco, P. vachelli, hybrid Huangyou-1.
- •Predicted miRNA-mRNA-protein pairs were found and validated by qRT-PCR and PRM.
- •Immune, metabolism, digestion, absorption, proliferation, development generate heterosis.
- •High parental gene/protein with low parental miRNAs inherit from the mother or father.
17.
《Molecular & cellular proteomics : MCP》2019,18(2):391-405
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- •PTMiner software for intelligent post-processing of open-search results.
- •Unrestrictive modification site localization based on a Bayesian model.
- •Extended transfer FDR estimation for accurate grouped FDR estimation.
- •Comprehensive PTM characterization in a draft map of human proteome.
18.
《Molecular & cellular proteomics : MCP》2019,18(11):2138-2148
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- •Highly glycosylated matrisome proteins and their binding partners comprise extracellular networks that mediate tissue-specific cellular microenvironments.
- •Elucidation of roles of matrisome molecules in disease mechanisms requires detailed mapping of matrisome glycosylation and other post-translational modifications.
- •We review tissue workup methods for matrisome proteomics, glycomics and glycoproteomics.
- •The combination of proteomics, glycomics and glycoproteomics profiles matrisome protein modifications distinct from those studied by immunohistochemistry.
19.
《Molecular & cellular proteomics : MCP》2019,18(2):200-215
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- •A global lysine succinylome was investigated in A. hydrophila.
- •The lysine succinylation modifications play crucial role on various metabolic pathways.
- •Reversible succinylation on Lys23 and Lys30 regulates the activity of S-ribosylhomocysteine lyase LuxS.
- •Lysine succinylation modifications of LuxS affect quorum sensing and metabolism.
20.
《Molecular & cellular proteomics : MCP》2019,18(8):1669-1682
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- •Spatiotemporal microproteomics analysis of TBI.
- •Injury site microproteomics reveal distinct phases in 10-day frame post TBI.
- •Uninjured proteomic profile is restored in TBI at 10 days post injury.
- •Substantia nigra protein post 3 days suggest link to Parkinson's disease.