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1.
《Molecular & cellular proteomics : MCP》2019,18(12):2516-2523
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- •Open source software for comprehensive HDX-MS data analysis.
- •Automatic back-exchange correction options.
- •Rigorous statistical analysis of the significance of uptake differences.
- •High quality visualization tools.
2.
《Molecular & cellular proteomics : MCP》2019,18(5):936-953
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- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells
3.
《Molecular & cellular proteomics : MCP》2019,18(4):669-685
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- •quantitative phosphoproteome analysis of TDM-activated macrophages.
- •distinct Mincle-dependent and independent phosphorylation and gene regulations.
- •Mincle-dependent activation of PI3K/AKT signaling by TDM.
- •Mincle-independent macrophage response is linked to cell cycle regulation.
4.
《Molecular & cellular proteomics : MCP》2019,18(5):982-994
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- •MaxQuant.Live controls Orbitrap mass analyzers in real-time.
- •Freely available apps enable advanced data acquisition strategies.
- •On-the-fly mass, retention time and intensity recalibration.
- •Global targeting unifies shotgun and targeted proteomics.
5.
《Molecular & cellular proteomics : MCP》2019,18(12):2348-2358
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- •Glycosylation is not currently considered in flu vaccine design.
- •Glycosylation influences on immunodominance are not well understood.
- •Identification of site-specific glycosylation using mass spectrometry has matured.
- •New methods are needed to quantify site-specific glycosylation for vaccine design.
6.
《Molecular & cellular proteomics : MCP》2019,18(9):1796-1806
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- •iTRAQ-based analysis of saliva samples from oral cancer patients.
- •Proteome profiling of saliva samples from patients with oral premalignant lesions.
- •Verification of salivary biomarker candidates with MRM-MS and immunoassays.
- •Identification of salivary proteins as potential biomarkers of oral cancer.
7.
《Molecular & cellular proteomics : MCP》2019,18(9):1705-1720
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- •Quantitative changes in global proteome and ubiquitinome in Huntington's disease.
- •Differential ubiquitination of wild-type and mutant Htt in mice brain.
- •Enriched pathways include vesicle transport and mRNA processing.
- •Correlation between protein and diGly site fold changes.
8.
《Molecular & cellular proteomics : MCP》2019,18(2):231-244
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- •OMICS distinguish cancer cells from resistant or cancer stem cells.
- •Bactericidal antibiotics and mitochondria.
- •Linezolid and anticancer therapy.
9.
《Molecular & cellular proteomics : MCP》2018,17(12):2518-2533
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- •Chromobodies are stabilized by antigen binding in live cells.
- •Monitoring changes of endogenous protein levels in living cells with chromobodies.
- •Broadly applicable system to generate turnover-accelerated chromobodies.
- •Quantification of time- and dose-dependent compound effects.
10.
《Molecular & cellular proteomics : MCP》2019,18(3):477-489
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- •Developed a data processing pipeline to format phosphopeptide identifications.
- •Identified the preferred substrate motif for FLT3 and mutant kinases.
- •Designed and validated a panel of pan-FTL3 artificial substrates.
- •Monitored FLT3 and mutant kinase activity through FAStide phosphorylation.
11.
《Molecular & cellular proteomics : MCP》2019,18(12):2524-2531
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- •Efficient sample preparation workflow for deep N-glycomics analysis from serum.
- •Temperature gradient denaturing protocol to prevent protein precipitation.
- •Decrease of free sugar content in serum enhanced PNGase F digestion efficiency.
- •Modified evaporative labeling method increased fluorophore labeling yield.
12.
《Molecular & cellular proteomics : MCP》2019,18(11):2298-2309
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- •HLA-B*40:02 and ERAP2 are risk factors for ankylosing spondylitis.
- •The effects of ERAP2 on the B*40:02 peptidome are defined.
- •ERAP2 has a major influence mainly due to alterations of N-terminal residues.
- •These effects provide a basis for the association of ERAP2 with disease.
13.
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*
《Molecular & cellular proteomics : MCP》2019,18(5):909-922
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- •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
- •Label-free quantification determined 2843 phagosomal proteins.
- •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
- •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
14.
《Molecular & cellular proteomics : MCP》2019,18(7):1285-1306
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- •Identification of previously undetected chloroplast envelope proteins.
- •Up to date manual annotation of genuine (or shared) envelope components.
- •New hypotheses for localizations, functions, interactions among cell compartments.
- •A new resource of significant value to the broader plant science community.
15.
《Molecular & cellular proteomics : MCP》2019,18(11):2285-2297
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- •BioID with Golgi fractions identified C10orf76 as proximal to GBF1.
- •Tagged C10orf76 overlaps with Golgi markers.
- •C10orf76 binds GBF1 and exchanges rapidly between free and bound forms.
- •C10orf76 is essential for maintenance of the Golgi and for secretion.
16.
《Molecular & cellular proteomics : MCP》2018,17(12):2496-2507
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- •Quantitative (phospho)proteome analysis of antibiotic treatment in E. coli.
- •Largest bacterial phosphorylation catalogue.
- •Specific phosphorylation motifs changes during resistance development.
- •Phosphorylation mediated signaling could be a potential target for drug design.
17.
《Molecular & cellular proteomics : MCP》2019,18(10):1939-1949
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- •Proteome profiling of tissue interstitial fluids (TIFs) of oral cancer.
- •Pathway of aminoacyl tRNA biosynthesis enriched in proteome of TIFs.
- •Verification of nidogen-1 as a salivary biomarker of oral cancer.
- •High correlation between elevated tissue level of nidogen-1 and poor survival.
18.
《Molecular & cellular proteomics : MCP》2019,18(6):1085-1095
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- •Rapamycin and zinc induce moderate but significant mitochondrial proteome changes.
- •The mitochondrial proteins processing system is robust under subtoxic conditions.
- •Rapamycin and zinc perturb the mitochondrial proteins processing system.
- •Rapamycin and zinc perturb the mitochondrial proteins homeostasis.
19.
《Molecular & cellular proteomics : MCP》2019,18(8):1526-1542
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- •Definition of early systemin-responsive phosphorylation time course.
- •Reconstruction of kinase-substrate relationships from phosphorylation time profiles.
- •Phosphatase PLL5 rapidly dephosphorylated H+-ATPase LHA1 inducing alkalinization of the medium.
- •MAP-Kinase MPK2 re-phosphorylated LHA1 after 15 minutes.
20.
《Molecular & cellular proteomics : MCP》2019,18(1):51-64
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- •microRNA-222 attenuates TGEV-induced mitochondrial dysfunction.
- •microRNA-222 downregulates THBS1 and CD47.
- •THBS1 is the target of microRNA-222 during TGEV infection.
- •THBS1 and CD47 increase mitochondrial Ca2+ level and reduced mitochondrial membrane potential (MMP).