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1.
《Molecular & cellular proteomics : MCP》2018,17(12):2480-2495
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- •Quantitative co-IP-MS approach to discover the human TEX101 interactome.
- •Validation of the human testis-specific protein complex TEX101-DPEP3.
- •Development of a hybrid immunoassay to screen for disruptors of TEX101-DPEP3 complex.
2.
《Molecular & cellular proteomics : MCP》2019,18(6):1054-1069
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- •Intensive investigation of dynamic interactions in MyD88, TRAF6, and NEMO complexes.
- •Mechanistic insights into IRAKs proteins' assembly.
- •A signal amplification mechanism for MyD99-denpendent TLR signaling disclosed by stoichiometry of complexes.
- •Quantitative measurement of multiple phosphorylation sites on the key components in TLR signaling pathway.
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4.
《Molecular & cellular proteomics : MCP》2019,18(2):277-293
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- •This study reports the first proteomic characterization of a type II hemidesmosomal complex.
- •This study characterizes the interactome of β4-integrin in the presence and absence of α6-integrin in a simple epithelial cell model.
- •The assembly of the β4-integrin interacting complex was largely independent of α6-integrin expression.
5.
《Molecular & cellular proteomics : MCP》2019,18(7):1410-1427
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- •Quantitative (phoshpo)proteome of primary cell cultures of patient-matched prostate CAF and NPF.
- •Key CAF-associated proteins validated using orthogonal methodologies.
- •LOXL2 inhibitors D-penicillamine and PXS-S2A impaired CAF migration and ECM alignment.
- •Pre-treatment with LOXL2 inhibitors impaired migratory capacity of RWPE-2 cells in co-culture.
6.
《Molecular & cellular proteomics : MCP》2019,18(3):504-519
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- •Dimethyl fumarate covalently modifies cysteine residues in neurons and astrocytes.
- •Cofilin-1, tubulin and collapsin response mediator protein 2 (CRMP2) are targets.
- •DMF-modified cofilin-1 reduces actin-severing ability, preserving filamentous actin.
7.
《Molecular & cellular proteomics : MCP》2019,18(2):169-181
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- •Quantitative proteomics of mitotic chromosome scaffold isolated from chicken DT40 cells.
- •BAZ1B identified in the isolated mitotic chromosome scaffold localizes to mitotic chromosome axes.
- •BAZ1B knockout caused prophase delay because of altered chromosome condensation timing and impaired mitosis progression.
- •BAZ1B knockout did not affect prometaphase chromosome structure.
8.
《Molecular & cellular proteomics : MCP》2019,18(10):2003-2017
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- •Identification of the first evolutionary divergent sirtuin ScCobB2 in bacteria.
- •Implementing a global quantitative succinylome between ΔScCobB2 and WT cells.
- •ScCobB2 regulates S. coelicolor protein biosynthesis and carbon metabolism pathways.
- •The divergent sirtuin enzymes are prevalent in other groups of Actinobacteria.
9.
《Molecular & cellular proteomics : MCP》2019,18(6):1085-1095
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- •Rapamycin and zinc induce moderate but significant mitochondrial proteome changes.
- •The mitochondrial proteins processing system is robust under subtoxic conditions.
- •Rapamycin and zinc perturb the mitochondrial proteins processing system.
- •Rapamycin and zinc perturb the mitochondrial proteins homeostasis.
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Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*
《Molecular & cellular proteomics : MCP》2019,18(5):909-922
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- •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
- •Label-free quantification determined 2843 phagosomal proteins.
- •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
- •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
11.
《Molecular & cellular proteomics : MCP》2019,18(10):2058-2077
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- •Identification of the substrates profile of the endothelial phosphatase VE-PTP.
- •A large fraction of VE-PTP substrate candidates (29%) is cell junction related.
- •Tie-2 and EPHB are substrates which associate as ternary complex with VE-PTP.
12.
《Molecular & cellular proteomics : MCP》2019,18(3):490-503
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- •MHC-II-bound peptide repertoires from DO-sufficient and DO-deficient cells.
- •Fewer unique peptides and core epitopes were presented in the absence of DO.
- •Immunopeptidome differences appeared to result from reduced DM editing.
- •DO-dependent self-epitopes elicited CD4 T cell responses in mice.
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《Molecular & cellular proteomics : MCP》2019,18(6):1110-1122
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- •Comprehensive analysis of inter-individual variation of normal urinary proteome.
- •Significant gender differences were observed.
- •Proteins increased in female urine are enriched in immunological pathways.
- •Estimated reference intervals of proteins as the baseline for biomarker discovery.
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《Molecular & cellular proteomics : MCP》2019,18(6):1123-1137
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- •Changes to the proteome of skin fibroblasts subjected to reductive stress have been quantitated.
- •Only a small set of proteins is selectively diminished upon exposure to reductants.
- •Collagens (COL1A2 and COL6A2) emerge as sentinels of reductive stress.
- •Reductive stress triggers receptor-independent Akt phosphorylation at Ser473.
15.
《Molecular & cellular proteomics : MCP》2019,18(3):571-575
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- •Incrementally build mzML 1.1, and mzIdentML 1.2 files in Python over a file stream.
- •Traverse controlled vocabularies using common mapping patterns.
- •Generate byte offset index as the document streams.
- •Manage referential integrity on-the-fly.
16.
《Molecular & cellular proteomics : MCP》2019,18(6):1210-1226
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- •Quantitative global proteome, acetylome and succinylome of phytoplasma-infected Paulownia tomentosa seedlings.
- •Acetylation may be more important than succinylation in response to phytoplasma infection.
- •Acetylation modified the activities of POR and RuBisCO.
- •Possible model to elucidate the molecular mechanism responses to PaWB from proteome and PTMs.
17.
《Molecular & cellular proteomics : MCP》2019,18(3):477-489
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- •Developed a data processing pipeline to format phosphopeptide identifications.
- •Identified the preferred substrate motif for FLT3 and mutant kinases.
- •Designed and validated a panel of pan-FTL3 artificial substrates.
- •Monitored FLT3 and mutant kinase activity through FAStide phosphorylation.
18.
《Molecular & cellular proteomics : MCP》2019,18(12):2524-2531
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- •Efficient sample preparation workflow for deep N-glycomics analysis from serum.
- •Temperature gradient denaturing protocol to prevent protein precipitation.
- •Decrease of free sugar content in serum enhanced PNGase F digestion efficiency.
- •Modified evaporative labeling method increased fluorophore labeling yield.
19.
《Molecular & cellular proteomics : MCP》2019,18(7):1363-1381
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- •Insulin Affects the Phosphorylation of G2L1, MARK2, CLIP2, EB1, AGAP3, and CKAP5.
- •Insulin Increases CLASP2 +TIP Density and Decreases CLASP2 +TIP Velocity.
- •Insulin Stimulates CLASP2 and G2L1 Trailing Along Microtubules.
- •Insulin Stimulates α-Tubulin Acetylation at Lysine 40 and Microtubule Stabilization.
20.
《Molecular & cellular proteomics : MCP》2019,18(10):1950-1966
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- •Integrative multi-omics study characterizing the differentiation from hESCs into hMSCs.
- •Set of high confidence genes important in hESC to hMSC differentiation defined.
- •Two distinct expression waves of HOX genes and a AGO2-to-AGO3 switch in gene silencing identified.
- •AHNAK hypothesized as a defining factor in MSC biology.