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1.
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Highlights
  • •Quantitative co-IP-MS approach to discover the human TEX101 interactome.
  • •Validation of the human testis-specific protein complex TEX101-DPEP3.
  • •Development of a hybrid immunoassay to screen for disruptors of TEX101-DPEP3 complex.
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2.
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Highlights
  • •Intensive investigation of dynamic interactions in MyD88, TRAF6, and NEMO complexes.
  • •Mechanistic insights into IRAKs proteins' assembly.
  • •A signal amplification mechanism for MyD99-denpendent TLR signaling disclosed by stoichiometry of complexes.
  • •Quantitative measurement of multiple phosphorylation sites on the key components in TLR signaling pathway.
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3.
4.
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Highlights
  • •This study reports the first proteomic characterization of a type II hemidesmosomal complex.
  • •This study characterizes the interactome of β4-integrin in the presence and absence of α6-integrin in a simple epithelial cell model.
  • •The assembly of the β4-integrin interacting complex was largely independent of α6-integrin expression.
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5.
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Highlights
  • •Quantitative (phoshpo)proteome of primary cell cultures of patient-matched prostate CAF and NPF.
  • •Key CAF-associated proteins validated using orthogonal methodologies.
  • •LOXL2 inhibitors D-penicillamine and PXS-S2A impaired CAF migration and ECM alignment.
  • •Pre-treatment with LOXL2 inhibitors impaired migratory capacity of RWPE-2 cells in co-culture.
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6.
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Highlights
  • •Dimethyl fumarate covalently modifies cysteine residues in neurons and astrocytes.
  • •Cofilin-1, tubulin and collapsin response mediator protein 2 (CRMP2) are targets.
  • •DMF-modified cofilin-1 reduces actin-severing ability, preserving filamentous actin.
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7.
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Highlights
  • •Quantitative proteomics of mitotic chromosome scaffold isolated from chicken DT40 cells.
  • •BAZ1B identified in the isolated mitotic chromosome scaffold localizes to mitotic chromosome axes.
  • •BAZ1B knockout caused prophase delay because of altered chromosome condensation timing and impaired mitosis progression.
  • •BAZ1B knockout did not affect prometaphase chromosome structure.
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8.
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Highlights
  • •Identification of the first evolutionary divergent sirtuin ScCobB2 in bacteria.
  • •Implementing a global quantitative succinylome between ΔScCobB2 and WT cells.
  • •ScCobB2 regulates S. coelicolor protein biosynthesis and carbon metabolism pathways.
  • •The divergent sirtuin enzymes are prevalent in other groups of Actinobacteria.
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9.
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Highlights
  • •Rapamycin and zinc induce moderate but significant mitochondrial proteome changes.
  • •The mitochondrial proteins processing system is robust under subtoxic conditions.
  • •Rapamycin and zinc perturb the mitochondrial proteins processing system.
  • •Rapamycin and zinc perturb the mitochondrial proteins homeostasis.
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10.
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Highlights
  • •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
  • •Label-free quantification determined 2843 phagosomal proteins.
  • •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
  • •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
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11.
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Highlights
  • •Identification of the substrates profile of the endothelial phosphatase VE-PTP.
  • •A large fraction of VE-PTP substrate candidates (29%) is cell junction related.
  • •Tie-2 and EPHB are substrates which associate as ternary complex with VE-PTP.
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12.
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Highlights
  • •MHC-II-bound peptide repertoires from DO-sufficient and DO-deficient cells.
  • •Fewer unique peptides and core epitopes were presented in the absence of DO.
  • •Immunopeptidome differences appeared to result from reduced DM editing.
  • •DO-dependent self-epitopes elicited CD4 T cell responses in mice.
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13.
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Highlights
  • •Comprehensive analysis of inter-individual variation of normal urinary proteome.
  • •Significant gender differences were observed.
  • •Proteins increased in female urine are enriched in immunological pathways.
  • •Estimated reference intervals of proteins as the baseline for biomarker discovery.
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14.
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Highlights
  • •Changes to the proteome of skin fibroblasts subjected to reductive stress have been quantitated.
  • •Only a small set of proteins is selectively diminished upon exposure to reductants.
  • •Collagens (COL1A2 and COL6A2) emerge as sentinels of reductive stress.
  • •Reductive stress triggers receptor-independent Akt phosphorylation at Ser473.
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15.
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Highlights
  • •Incrementally build mzML 1.1, and mzIdentML 1.2 files in Python over a file stream.
  • •Traverse controlled vocabularies using common mapping patterns.
  • •Generate byte offset index as the document streams.
  • •Manage referential integrity on-the-fly.
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16.
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Highlights
  • •Quantitative global proteome, acetylome and succinylome of phytoplasma-infected Paulownia tomentosa seedlings.
  • •Acetylation may be more important than succinylation in response to phytoplasma infection.
  • •Acetylation modified the activities of POR and RuBisCO.
  • •Possible model to elucidate the molecular mechanism responses to PaWB from proteome and PTMs.
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17.
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Highlights
  • •Developed a data processing pipeline to format phosphopeptide identifications.
  • •Identified the preferred substrate motif for FLT3 and mutant kinases.
  • •Designed and validated a panel of pan-FTL3 artificial substrates.
  • •Monitored FLT3 and mutant kinase activity through FAStide phosphorylation.
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18.
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Highlights
  • •Efficient sample preparation workflow for deep N-glycomics analysis from serum.
  • •Temperature gradient denaturing protocol to prevent protein precipitation.
  • •Decrease of free sugar content in serum enhanced PNGase F digestion efficiency.
  • •Modified evaporative labeling method increased fluorophore labeling yield.
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19.
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Highlights
  • •Insulin Affects the Phosphorylation of G2L1, MARK2, CLIP2, EB1, AGAP3, and CKAP5.
  • •Insulin Increases CLASP2 +TIP Density and Decreases CLASP2 +TIP Velocity.
  • •Insulin Stimulates CLASP2 and G2L1 Trailing Along Microtubules.
  • •Insulin Stimulates α-Tubulin Acetylation at Lysine 40 and Microtubule Stabilization.
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20.
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Highlights
  • •Integrative multi-omics study characterizing the differentiation from hESCs into hMSCs.
  • •Set of high confidence genes important in hESC to hMSC differentiation defined.
  • •Two distinct expression waves of HOX genes and a AGO2-to-AGO3 switch in gene silencing identified.
  • •AHNAK hypothesized as a defining factor in MSC biology.
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