A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality

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Combining Transient Expression and Cryo-EM to Obtain High-Resolution Structures of Luteovirid Particles

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Integrative Protein Modeling in RosettaNMR from Sparse Paramagnetic Restraints

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Coupling Molecular Dynamics and Deep Learning to Mine Protein Conformational Space

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Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche

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High-Affinity Bent β2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis

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Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

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Sampling Native-like Structures of RNA-Protein Complexes through Rosetta Folding and Docking

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Segmentation and Comparative Modeling in an 8.6-Å Cryo-EM Map of the Singapore Grouper Iridovirus

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Completion of the Vimentin Rod Domain Structure Using Experimental Restraints: A New Tool for Exploring Intermediate Filament Assembly and Mutations

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Quantitative Operating Principles of Yeast Metabolism during Adaptation to Heat Stress

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Data-Driven Modeling of Intracellular Auxin Fluxes Indicates a Dominant Role of the ER in Controlling Nuclear Auxin Uptake

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Hybridization Kinetics Explains CRISPR-Cas Off-Targeting Rules

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DECA,A Comprehensive,Automatic Post-processing Program for HDX-MS Data*

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Highlights

• •Open source software for comprehensive HDX-MS data analysis.
• •Automatic back-exchange correction options.
• •Rigorous statistical analysis of the significance of uptake differences.
• •High quality visualization tools.

     

Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome

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FMR1 Reactivating Treatments in Fragile X iPSC-Derived Neural Progenitors In Vitro and In Vivo

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Integrating Structural Information to Study the Dynamics of Protein-Protein Interactions in Cells

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Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling

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Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus

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Nonparametric Analysis of Thermal Proteome Profiles Reveals Novel Drug-binding Proteins*

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Highlights

• •Method for the analysis of response curves from thermal proteome profiling (TPP).
• •NPARC uses nonparametric statistics and provides false discovery-rate (FDR) control.
• •Increased proteome coverage and sensitivity to identify drug-binding proteins.