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1.
《Molecular & cellular proteomics : MCP》2019,18(12):2401-2417
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- •Quantitative proteomics reveals GBF1 to interact with Uukuniemi virus glycoproteins.
- •GBF1 is a proviral host factor for phleboviruses and other zoonotic RNA viruses.
- •GBF1 supports phlebovirus replication and assembly and release of particles.
- •The GBF1 inhibitor Golgicide A blocks infection with zoonotic RNA viruses.
2.
《Molecular & cellular proteomics : MCP》2019,18(5):854-864
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- •Zero-length chemical cross-linking of APOA1 peptides in HDL.
- •Cross-links match antiparallel isomers of APOA dimers in molecular modeling.
- •Identical MS/MS spectra of native and synthetic cross-linked peptides.
- •First biochemical evidence of LL5/5 and LL5/4 isomers in human HDL.
3.
《Molecular & cellular proteomics : MCP》2019,18(12):2516-2523
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- •Open source software for comprehensive HDX-MS data analysis.
- •Automatic back-exchange correction options.
- •Rigorous statistical analysis of the significance of uptake differences.
- •High quality visualization tools.
4.
《Molecular & cellular proteomics : MCP》2018,17(12):2324-2334
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- •C9, GSN, PON1, and PON3 validated as serum biomarker candidates of EAC.
- •Multimarker panel with AUROC of 0.93 to aid current endoscopy surveillance of BE.
- •Induction of tissue C9 in BE, dysplastic BE and EAC.
- •Alteration of complement pathway glycoproteins during BE-EAC pathogenesis.
5.
《Molecular & cellular proteomics : MCP》2019,18(5):936-953
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- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells
6.
《Molecular & cellular proteomics : MCP》2018,17(12):2518-2533
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- •Chromobodies are stabilized by antigen binding in live cells.
- •Monitoring changes of endogenous protein levels in living cells with chromobodies.
- •Broadly applicable system to generate turnover-accelerated chromobodies.
- •Quantification of time- and dose-dependent compound effects.
7.
《Molecular & cellular proteomics : MCP》2019,18(8):1700-1702
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- •Automated metadata extraction from potentially large sets of mass spectrometric raw data.
- •Reduction of extracted metadata into groups of shared parameter sets.
- •Tabular representation for quality control, reporting and publication.
8.
《Molecular & cellular proteomics : MCP》2019,18(8):1669-1682
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- •Spatiotemporal microproteomics analysis of TBI.
- •Injury site microproteomics reveal distinct phases in 10-day frame post TBI.
- •Uninjured proteomic profile is restored in TBI at 10 days post injury.
- •Substantia nigra protein post 3 days suggest link to Parkinson's disease.
9.
《Molecular & cellular proteomics : MCP》2019,18(7):1285-1306
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- •Identification of previously undetected chloroplast envelope proteins.
- •Up to date manual annotation of genuine (or shared) envelope components.
- •New hypotheses for localizations, functions, interactions among cell compartments.
- •A new resource of significant value to the broader plant science community.
10.
《Molecular & cellular proteomics : MCP》2018,17(12):2309-2323
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- •First global study on metabolic regulation of Nt-acetylation.
- •Yeast cells maintain global Nt-acetylation levels during prolonged starvation.
- •Nt-acetylation can in some cases be either up- or downregulated by starvation.
- •Naa10/NatA affects the steady-state protein levels of Rsa3 and Rpl7a.
11.
《Molecular & cellular proteomics : MCP》2019,18(5):818-836
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- •Kallikrein-related peptidase 7 is over expressed in ovarian cancer.
- •Quantitative PROTOMAP and TAILS approaches identified putative substrates of KLK7.
- •Pro-MMP10 is activated by KLK7.
- •KLK7 cleaves thrombospondin 1 and IGFBP6 in vitro.
12.
《Molecular & cellular proteomics : MCP》2019,18(4):669-685
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- •quantitative phosphoproteome analysis of TDM-activated macrophages.
- •distinct Mincle-dependent and independent phosphorylation and gene regulations.
- •Mincle-dependent activation of PI3K/AKT signaling by TDM.
- •Mincle-independent macrophage response is linked to cell cycle regulation.
13.
《Molecular & cellular proteomics : MCP》2019,18(12):2348-2358
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- •Glycosylation is not currently considered in flu vaccine design.
- •Glycosylation influences on immunodominance are not well understood.
- •Identification of site-specific glycosylation using mass spectrometry has matured.
- •New methods are needed to quantify site-specific glycosylation for vaccine design.
14.
《Molecular & cellular proteomics : MCP》2019,18(2):231-244
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- •OMICS distinguish cancer cells from resistant or cancer stem cells.
- •Bactericidal antibiotics and mitochondria.
- •Linezolid and anticancer therapy.
15.
《Molecular & cellular proteomics : MCP》2019,18(9):1899-1915
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- •Development of a method for low-abundance small protein analysis in human plasma.
- •Deep proteome profiling demonstrated unbiased identification of diverse factors.
- •Method enabled identification of a novel human plasma protein C5ORF46.
- •Analysis of intermittent fasting response showed changes in iron regulation.
16.
《Molecular & cellular proteomics : MCP》2019,18(5):982-994
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- •MaxQuant.Live controls Orbitrap mass analyzers in real-time.
- •Freely available apps enable advanced data acquisition strategies.
- •On-the-fly mass, retention time and intensity recalibration.
- •Global targeting unifies shotgun and targeted proteomics.
17.
《Molecular & cellular proteomics : MCP》2019,18(6):1227-1241
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- •Quantitative microproteomics to study the CNS and PNS of the Twitcher mouse.
- •10plex TMT experiments on corpus callosum, motor cortex and sciatic nerves extracts.
- •More than 400 proteins groups deregulated between Twitcher and wildtype mice.
- •New insights into the molecular mechanisms of Krabbe disease.
18.
《Molecular & cellular proteomics : MCP》2019,18(9):1796-1806
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- •iTRAQ-based analysis of saliva samples from oral cancer patients.
- •Proteome profiling of saliva samples from patients with oral premalignant lesions.
- •Verification of salivary biomarker candidates with MRM-MS and immunoassays.
- •Identification of salivary proteins as potential biomarkers of oral cancer.
19.
《Molecular & cellular proteomics : MCP》2019,18(9):1705-1720
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- •Quantitative changes in global proteome and ubiquitinome in Huntington's disease.
- •Differential ubiquitination of wild-type and mutant Htt in mice brain.
- •Enriched pathways include vesicle transport and mRNA processing.
- •Correlation between protein and diGly site fold changes.
20.
《Molecular & cellular proteomics : MCP》2018,17(12):2496-2507
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- •Quantitative (phospho)proteome analysis of antibiotic treatment in E. coli.
- •Largest bacterial phosphorylation catalogue.
- •Specific phosphorylation motifs changes during resistance development.
- •Phosphorylation mediated signaling could be a potential target for drug design.