首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 390 毫秒
1.
2.
3.
  1. Download : Download high-res image (128KB)
  2. Download : Download full-size image
Highlights
  • •Open source software for comprehensive HDX-MS data analysis.
  • •Automatic back-exchange correction options.
  • •Rigorous statistical analysis of the significance of uptake differences.
  • •High quality visualization tools.
  相似文献   

4.
  1. Download : Download high-res image (116KB)
  2. Download : Download full-size image
Highlights
  • •In-depth proteome profiling of primary human myeloma cells
  • •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
  • •Myeloma cells show specific immune evasion strategies
  • •Metabolic adaptations involve tumor and stroma cells
  相似文献   

5.
  1. Download : Download high-res image (102KB)
  2. Download : Download full-size image
Highlights
  • •quantitative phosphoproteome analysis of TDM-activated macrophages.
  • •distinct Mincle-dependent and independent phosphorylation and gene regulations.
  • •Mincle-dependent activation of PI3K/AKT signaling by TDM.
  • •Mincle-independent macrophage response is linked to cell cycle regulation.
  相似文献   

6.
  1. Download : Download high-res image (59KB)
  2. Download : Download full-size image
Highlights
  • •Glycosylation is not currently considered in flu vaccine design.
  • •Glycosylation influences on immunodominance are not well understood.
  • •Identification of site-specific glycosylation using mass spectrometry has matured.
  • •New methods are needed to quantify site-specific glycosylation for vaccine design.
  相似文献   

7.
  1. Download : Download high-res image (130KB)
  2. Download : Download full-size image
Highlights
  • •OMICS distinguish cancer cells from resistant or cancer stem cells.
  • •Bactericidal antibiotics and mitochondria.
  • •Linezolid and anticancer therapy.
  相似文献   

8.
  1. Download : Download high-res image (92KB)
  2. Download : Download full-size image
Highlights
  • •MaxQuant.Live controls Orbitrap mass analyzers in real-time.
  • •Freely available apps enable advanced data acquisition strategies.
  • •On-the-fly mass, retention time and intensity recalibration.
  • •Global targeting unifies shotgun and targeted proteomics.
  相似文献   

9.
  1. Download : Download high-res image (173KB)
  2. Download : Download full-size image
Highlights
  • •iTRAQ-based analysis of saliva samples from oral cancer patients.
  • •Proteome profiling of saliva samples from patients with oral premalignant lesions.
  • •Verification of salivary biomarker candidates with MRM-MS and immunoassays.
  • •Identification of salivary proteins as potential biomarkers of oral cancer.
  相似文献   

10.
  1. Download : Download high-res image (74KB)
  2. Download : Download full-size image
Highlights
  • •Quantitative changes in global proteome and ubiquitinome in Huntington's disease.
  • •Differential ubiquitination of wild-type and mutant Htt in mice brain.
  • •Enriched pathways include vesicle transport and mRNA processing.
  • •Correlation between protein and diGly site fold changes.
  相似文献   

11.
  1. Download : Download high-res image (61KB)
  2. Download : Download full-size image
Highlights
  • •BioID with Golgi fractions identified C10orf76 as proximal to GBF1.
  • •Tagged C10orf76 overlaps with Golgi markers.
  • •C10orf76 binds GBF1 and exchanges rapidly between free and bound forms.
  • •C10orf76 is essential for maintenance of the Golgi and for secretion.
  相似文献   

12.
  1. Download : Download high-res image (86KB)
  2. Download : Download full-size image
Highlights
  • •Quantitative (phospho)proteome analysis of antibiotic treatment in E. coli.
  • •Largest bacterial phosphorylation catalogue.
  • •Specific phosphorylation motifs changes during resistance development.
  • •Phosphorylation mediated signaling could be a potential target for drug design.
  相似文献   

13.
  1. Download : Download high-res image (90KB)
  2. Download : Download full-size image
Highlights
  • •Chromobodies are stabilized by antigen binding in live cells.
  • •Monitoring changes of endogenous protein levels in living cells with chromobodies.
  • •Broadly applicable system to generate turnover-accelerated chromobodies.
  • •Quantification of time- and dose-dependent compound effects.
  相似文献   

14.
  1. Download : Download high-res image (93KB)
  2. Download : Download full-size image
Highlights
  • •microRNA-222 attenuates TGEV-induced mitochondrial dysfunction.
  • •microRNA-222 downregulates THBS1 and CD47.
  • •THBS1 is the target of microRNA-222 during TGEV infection.
  • •THBS1 and CD47 increase mitochondrial Ca2+ level and reduced mitochondrial membrane potential (MMP).
  相似文献   

15.
  1. Download : Download high-res image (115KB)
  2. Download : Download full-size image
Highlights
  • •HLA-B*40:02 and ERAP2 are risk factors for ankylosing spondylitis.
  • •The effects of ERAP2 on the B*40:02 peptidome are defined.
  • •ERAP2 has a major influence mainly due to alterations of N-terminal residues.
  • •These effects provide a basis for the association of ERAP2 with disease.
  相似文献   

16.
  1. Download : Download high-res image (115KB)
  2. Download : Download full-size image
Highlights
  • •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
  • •Label-free quantification determined 2843 phagosomal proteins.
  • •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
  • •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
  相似文献   

17.
  1. Download : Download high-res image (74KB)
  2. Download : Download full-size image
Highlights
  • •Bayesian Beta-Binomial model integrates ion statistics with peptide ratio agreement.
  • •Model appropriately interprets information from low signal peptides.
  • •Confidence can be assigned even without replicates.
  • •Model adds sensitivity to detection of small changes.
  相似文献   

18.
  1. Download : Download high-res image (114KB)
  2. Download : Download full-size image
Highlights
  • •Developed a data processing pipeline to format phosphopeptide identifications.
  • •Identified the preferred substrate motif for FLT3 and mutant kinases.
  • •Designed and validated a panel of pan-FTL3 artificial substrates.
  • •Monitored FLT3 and mutant kinase activity through FAStide phosphorylation.
  相似文献   

19.
  1. Download : Download high-res image (84KB)
  2. Download : Download full-size image
Highlights
  • •Efficient sample preparation workflow for deep N-glycomics analysis from serum.
  • •Temperature gradient denaturing protocol to prevent protein precipitation.
  • •Decrease of free sugar content in serum enhanced PNGase F digestion efficiency.
  • •Modified evaporative labeling method increased fluorophore labeling yield.
  相似文献   

20.
  1. Download : Download high-res image (87KB)
  2. Download : Download full-size image
Highlights
  • •Enrichment of methyl peptides using two orthogonal techniques.
  • •Knockdown of PRMT1 leads to substantial changes in protein arginine “methylome”.
  • •Discrimination of ADMA and SDMA using characteristic neutral losses.
  • •Identification of PRMT1 targets and substrate scavenged by other PRMTs in the absence of PRMT1 activity.
  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号