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1.
《Molecular & cellular proteomics : MCP》2019,18(10):2044-2057
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- •Loss of bisecting GlcNAc in N-glycan increases various terminal glycan modifications.
- •Glycosyltransferases commonly do not act well on glycans with bisecting GlcNAc.
- •Presence of bisecting GlcNAc alters overall conformation of N-glycan.
- •Bisecting GlcNAc serves as a general suppressor for terminal modification.
2.
《Molecular & cellular proteomics : MCP》2019,18(9):1796-1806
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- •iTRAQ-based analysis of saliva samples from oral cancer patients.
- •Proteome profiling of saliva samples from patients with oral premalignant lesions.
- •Verification of salivary biomarker candidates with MRM-MS and immunoassays.
- •Identification of salivary proteins as potential biomarkers of oral cancer.
3.
《Molecular & cellular proteomics : MCP》2019,18(4):686-703
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- •nLC-MS/MS method to analyze immunoglobulin (Ig) N-glycopeptides from human serum.
- •Multi-isotype, site-specific characterization of immunoglobulin N-glycosylation.
- •IgA2 sequence and glycosylation-site variant analyses.
- •Platform to define disease-specific N-glycan signatures for different Ig isotypes.
4.
《Molecular & cellular proteomics : MCP》2019,18(9):1899-1915
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- •Development of a method for low-abundance small protein analysis in human plasma.
- •Deep proteome profiling demonstrated unbiased identification of diverse factors.
- •Method enabled identification of a novel human plasma protein C5ORF46.
- •Analysis of intermittent fasting response showed changes in iron regulation.
5.
《Molecular & cellular proteomics : MCP》2019,18(12):2516-2523
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- •Open source software for comprehensive HDX-MS data analysis.
- •Automatic back-exchange correction options.
- •Rigorous statistical analysis of the significance of uptake differences.
- •High quality visualization tools.
6.
《Molecular & cellular proteomics : MCP》2019,18(5):936-953
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- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells
7.
《Molecular & cellular proteomics : MCP》2019,18(6):1183-1196
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- •Atlantic salmon O-glycome expanded to 169 structures in three epithelia.
- •Low interindividual variation amongst all populations and geographical regions.
- •Small variations in glycosylation between geographical locations and fish size.
- •Prominent fucosylation in gastrointestinal mucins from Tasmanian fish.
8.
《Molecular & cellular proteomics : MCP》2019,18(8):1630-1650
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- •Our search identifies 2,134 kinase-substrate phosphosite pairs in breast cancer.
- •CDKs and MAPKs are dominant regulators of trans substrate-phosphorylation.
- •Druggability, outcomes, and immune signatures related to kinase-substrates.
- •Experimentally validated activated phosphosites of ERBB2, EIF4EBP1, and EGFR.
9.
《Molecular & cellular proteomics : MCP》2019,18(10):2121-2137
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- •Endogenous plasma/serum QC marker that quantifies cumulative sample thawed time.
- •Mechanism of marker change known, and rate law established.
- •Data interpretation based on documented population averages and rate law.
- •Blind-challenge verified; utility proven via exposure of undisclosed freezer outage.
10.
《Molecular & cellular proteomics : MCP》2019,18(4):669-685
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- •quantitative phosphoproteome analysis of TDM-activated macrophages.
- •distinct Mincle-dependent and independent phosphorylation and gene regulations.
- •Mincle-dependent activation of PI3K/AKT signaling by TDM.
- •Mincle-independent macrophage response is linked to cell cycle regulation.
11.
《Molecular & cellular proteomics : MCP》2019,18(4):735-743
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- •HPV is being introduced as the primary test in cervical cancer screening programs.
- •New biomarkers are needed for co-testing of women HPV positive in screening.
- •Analysis of plasma from women with invasive cervical cancer identified a 11-marker panel.
- •This signature shows high sensitivity and specificity to identify women with cancer.
12.
13.
《Molecular & cellular proteomics : MCP》2019,18(11):2191-2206
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- •Quantitative high-throughput glycoanalytical technology as a diagnostic tool for ovarian cancer detection.
- •Multiplexed approach harnessing N-glycan data for six glycoproteins from a single biological sample.
- •Detailed characterization of human serum N-glycans from antibodies IgG, IgM and IgA and acute phase proteins transferrin, haptoglobin and alpha-1-antitrypsin.
- •Structural differences in antibody and acute phase protein glycosylation for mechanistic insights.
14.
《Molecular & cellular proteomics : MCP》2018,17(12):2496-2507
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- •Quantitative (phospho)proteome analysis of antibiotic treatment in E. coli.
- •Largest bacterial phosphorylation catalogue.
- •Specific phosphorylation motifs changes during resistance development.
- •Phosphorylation mediated signaling could be a potential target for drug design.
15.
《Molecular & cellular proteomics : MCP》2019,18(5):982-994
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- •MaxQuant.Live controls Orbitrap mass analyzers in real-time.
- •Freely available apps enable advanced data acquisition strategies.
- •On-the-fly mass, retention time and intensity recalibration.
- •Global targeting unifies shotgun and targeted proteomics.
16.
《Molecular & cellular proteomics : MCP》2018,17(12):2518-2533
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- •Chromobodies are stabilized by antigen binding in live cells.
- •Monitoring changes of endogenous protein levels in living cells with chromobodies.
- •Broadly applicable system to generate turnover-accelerated chromobodies.
- •Quantification of time- and dose-dependent compound effects.
17.
《Molecular & cellular proteomics : MCP》2019,18(12):2348-2358
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- •Glycosylation is not currently considered in flu vaccine design.
- •Glycosylation influences on immunodominance are not well understood.
- •Identification of site-specific glycosylation using mass spectrometry has matured.
- •New methods are needed to quantify site-specific glycosylation for vaccine design.
18.
《Molecular & cellular proteomics : MCP》2019,18(2):231-244
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- •OMICS distinguish cancer cells from resistant or cancer stem cells.
- •Bactericidal antibiotics and mitochondria.
- •Linezolid and anticancer therapy.
19.
《Molecular & cellular proteomics : MCP》2019,18(9):1705-1720
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- •Quantitative changes in global proteome and ubiquitinome in Huntington's disease.
- •Differential ubiquitination of wild-type and mutant Htt in mice brain.
- •Enriched pathways include vesicle transport and mRNA processing.
- •Correlation between protein and diGly site fold changes.
20.
《Molecular & cellular proteomics : MCP》2019,18(11):2298-2309
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- •HLA-B*40:02 and ERAP2 are risk factors for ankylosing spondylitis.
- •The effects of ERAP2 on the B*40:02 peptidome are defined.
- •ERAP2 has a major influence mainly due to alterations of N-terminal residues.
- •These effects provide a basis for the association of ERAP2 with disease.