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1.
《Molecular & cellular proteomics : MCP》2019,18(11):2324-2334
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- •Automated analysis of protein complexes in proteomic experiments.
- •Quantitative measurement of the coordinated changes in protein complex components.
- •Interactive visualizations for exploratory analysis of proteomic results.
2.
《Molecular & cellular proteomics : MCP》2019,18(12):2516-2523
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- •Open source software for comprehensive HDX-MS data analysis.
- •Automatic back-exchange correction options.
- •Rigorous statistical analysis of the significance of uptake differences.
- •High quality visualization tools.
3.
《Molecular & cellular proteomics : MCP》2019,18(10):2058-2077
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- •Identification of the substrates profile of the endothelial phosphatase VE-PTP.
- •A large fraction of VE-PTP substrate candidates (29%) is cell junction related.
- •Tie-2 and EPHB are substrates which associate as ternary complex with VE-PTP.
4.
《Molecular & cellular proteomics : MCP》2019,18(4):669-685
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- •quantitative phosphoproteome analysis of TDM-activated macrophages.
- •distinct Mincle-dependent and independent phosphorylation and gene regulations.
- •Mincle-dependent activation of PI3K/AKT signaling by TDM.
- •Mincle-independent macrophage response is linked to cell cycle regulation.
5.
《Molecular & cellular proteomics : MCP》2019,18(11):2178-2190
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- •Enough CD16a from NK cells can be isolated from a single donor following apheresis.
- •NK cell CD16a shows variability between different donors.
- •NK cells preferentially bind IgG1 that lacks core fucosylation.
6.
《Molecular & cellular proteomics : MCP》2019,18(7):1396-1409
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- •A panel of HEK293 isogenic cell lines with knockout of GALNT genes.
- •Identification of nonredundant O-glycosylation sites regulated by specific GalNAc-T isoforms.
- •GalNAc-T7 and T10 contribute to follow-up activity in regions of high density O-glycosylation.
- •GalNAc-T11 specifically controls O-glycosylation of specific linker regions in the low-density lipoprotein receptor related proteins.
7.
《Molecular & cellular proteomics : MCP》2019,18(5):854-864
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- •Zero-length chemical cross-linking of APOA1 peptides in HDL.
- •Cross-links match antiparallel isomers of APOA dimers in molecular modeling.
- •Identical MS/MS spectra of native and synthetic cross-linked peptides.
- •First biochemical evidence of LL5/5 and LL5/4 isomers in human HDL.
8.
《Molecular & cellular proteomics : MCP》2019,18(8):1556-1571
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- •Functional role of a yet uncharacterized receptor kinase QSK1.
- •Activation model for SIRK1 receptor kinase in a heteromer with QSK1.
- •Role of QSK1 in substrate recruitment and stabilization of the complex.
9.
《Molecular & cellular proteomics : MCP》2019,18(6):1171-1182
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- •First report on the quantitative proteomic profiling of Drosophila lymph glands.
- •Comparative proteomic analysis under conditions of perturbed blood cell homeostasis.
- •Resource for identifying new regulators of insect and vertebrate hematopoiesis.
10.
《Molecular & cellular proteomics : MCP》2019,18(5):936-953
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- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells
11.
《Molecular & cellular proteomics : MCP》2018,17(11):2242-2255
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- •BioID and IP-MS were conducted to generate a global ZIKV-host protein interactome
- •Interactome consists of >3000 high confidence ZIKV-host protein interactions
- •Data mining indicates that ZIKV proteins interact with multiple host cell organelles
- •An important role for peroxisomes in ZIKV infection is uncovered
12.
《Molecular & cellular proteomics : MCP》2019,18(9):1796-1806
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- •iTRAQ-based analysis of saliva samples from oral cancer patients.
- •Proteome profiling of saliva samples from patients with oral premalignant lesions.
- •Verification of salivary biomarker candidates with MRM-MS and immunoassays.
- •Identification of salivary proteins as potential biomarkers of oral cancer.
13.
《Molecular & cellular proteomics : MCP》2019,18(3):571-575
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- •Incrementally build mzML 1.1, and mzIdentML 1.2 files in Python over a file stream.
- •Traverse controlled vocabularies using common mapping patterns.
- •Generate byte offset index as the document streams.
- •Manage referential integrity on-the-fly.
14.
《Molecular & cellular proteomics : MCP》2019,18(7):1285-1306
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- •Identification of previously undetected chloroplast envelope proteins.
- •Up to date manual annotation of genuine (or shared) envelope components.
- •New hypotheses for localizations, functions, interactions among cell compartments.
- •A new resource of significant value to the broader plant science community.
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16.
《Molecular & cellular proteomics : MCP》2018,17(11):2119-2131
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- •Temporal proteome profiling of lipotoxicity and glucolipotoxicity in β-cells
- •Palmitate induced cholesterol metabolism earlier than fatty acid metabolism
- •Setd8 promotes palmitate + glucose-stimulated INS-1 cell proliferation
- •PA induced apoptosis partially via upregulation of Rhob in INS-1 cells
17.
《Molecular & cellular proteomics : MCP》2019,18(10):2108-2120
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- •Bayesian Beta-Binomial model integrates ion statistics with peptide ratio agreement.
- •Model appropriately interprets information from low signal peptides.
- •Confidence can be assigned even without replicates.
- •Model adds sensitivity to detection of small changes.
18.
《Molecular & cellular proteomics : MCP》2019,18(3):561-570
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- •Unified identification and quantification error rates for protein quantification.
- •Error propagation using graphical models and Bayesian statistics.
- •Account for uncertainty of missing values instead of overconfident point estimates.
- •Control of differential expression false discovery rate at increased sensitivity.
19.
《Molecular & cellular proteomics : MCP》2019,18(3):490-503
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- •MHC-II-bound peptide repertoires from DO-sufficient and DO-deficient cells.
- •Fewer unique peptides and core epitopes were presented in the absence of DO.
- •Immunopeptidome differences appeared to result from reduced DM editing.
- •DO-dependent self-epitopes elicited CD4 T cell responses in mice.
20.
《Molecular & cellular proteomics : MCP》2019,18(11):2207-2224
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- •Quantitative proteomes and epigenetic regulation of T. gondii.
- •Protein crotonylation and 2-hydroxyisobutylation in phenotypically different T. gondii parasites.
- •Regulation of invasion regulation of T. gondii by protein modification.
- •Lysine crotonylation and 2-hydroxyisobutylation regulated in multiple biological processes in phenotypically different T. gondii parasites.