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1.
《Molecular & cellular proteomics : MCP》2018,17(12):2434-2447
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- •Anticancer activity of midostaurin but not other PKC inhibitors in NSCLC cells.
- •Mechanism of action by network-based integration of chemo- and phosphoproteomics.
- •Midostaurin polypharmacology by simultaneous inhibition of TBK1, PDPK1 and AURKA.
- •Design of synergistic drug combination with PLK1 inhibitor by pathway validation.
2.
《Molecular & cellular proteomics : MCP》2019,18(6):1085-1095
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- •Rapamycin and zinc induce moderate but significant mitochondrial proteome changes.
- •The mitochondrial proteins processing system is robust under subtoxic conditions.
- •Rapamycin and zinc perturb the mitochondrial proteins processing system.
- •Rapamycin and zinc perturb the mitochondrial proteins homeostasis.
3.
《Molecular & cellular proteomics : MCP》2019,18(9):1732-1744
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- •An innovative co-IP crosslinking proteomics study was designed for the TLR2 interactome.
- •Proteomic profiling revealed combinatorial effects of simvastatin and Pam3CSK4 on the TLR2 interactome.
- •ACTR1A and MARCKSL1 proteins were identified as potential interactors of TLR2 during the immune response.
- •ACTR1A has important modulatory actions on the TLR2 pro-inflammatory signaling cascade.
4.
《Molecular & cellular proteomics : MCP》2019,18(6):1123-1137
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- •Changes to the proteome of skin fibroblasts subjected to reductive stress have been quantitated.
- •Only a small set of proteins is selectively diminished upon exposure to reductants.
- •Collagens (COL1A2 and COL6A2) emerge as sentinels of reductive stress.
- •Reductive stress triggers receptor-independent Akt phosphorylation at Ser473.
5.
《Molecular & cellular proteomics : MCP》2019,18(2):245-262
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- •AP-DIA/SWATH analysis to identify TCTP-interacting proteins in NF1 tumor cells.
- •A highly specific TCTP–EF1A2 interaction but rather than TCTP–EF1A1 interaction.
- •TCTP–EF1A2 interaction mediating formation of EF1A2-elogation factor complex.
- •TCTP–EF1A2 dependent translation machinery regulating NF1 tumor cell growth.
6.
《Molecular & cellular proteomics : MCP》2018,17(11):2146-2163
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- •Construction of threespine stickleback gill assay library using DDA proteomics
- •Population-specific gill proteome signatures of four ecotypes identified by DIA
- •HSP47 and extracellular matrix proteins highly elevated in warm-adapted sticklebacks
- •Inflammasome and proteolytic proteins highly elevated in freshwater sticklebacks
7.
《Molecular & cellular proteomics : MCP》2019,18(7):1410-1427
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- •Quantitative (phoshpo)proteome of primary cell cultures of patient-matched prostate CAF and NPF.
- •Key CAF-associated proteins validated using orthogonal methodologies.
- •LOXL2 inhibitors D-penicillamine and PXS-S2A impaired CAF migration and ECM alignment.
- •Pre-treatment with LOXL2 inhibitors impaired migratory capacity of RWPE-2 cells in co-culture.
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《Molecular & cellular proteomics : MCP》2019,18(12):2359-2372
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- •Nonenzymatically Ksu proteins shown different pattern from native cell Ksu proteins.
- •Motif preference of Ksu proteins was associated with different biological processes.
- •Up to 67 developing rice seeds proteins contain PTMs of Kac, Ksu, Kcr, Kmal, and Khib.
- •Some lysine residues of the key pathway enzymes are modified by succinylation.
10.
《Molecular & cellular proteomics : MCP》2019,18(9):1880-1892
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- •New software to determine differentially expressed proteins in quantitative MS experiments.
- •Applicable to any modern quantitative MS setup and study type, including clinical setups.
- •Ultra-sensitive at strict FDR control, up to 1000 additional proteins in a single comparison.
- •Easy to use, fast processing and readily available package, including user friendly manual.
11.
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*
《Molecular & cellular proteomics : MCP》2019,18(5):909-922
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- •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
- •Label-free quantification determined 2843 phagosomal proteins.
- •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
- •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
12.
《Molecular & cellular proteomics : MCP》2019,18(11):2310-2323
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- •New platform for high throughput detection of transient interactions between membrane proteins.
- •IL20RA is a receptor for the orphan checkpoint inhibitor B7-H3.
- •The natural killer cell protein KIR2DL5A binds the immune receptor PVR.
- •KIR2DL5 binding to PVR regulates natural killer cell cytotoxicity and inhibits tumor cell killing.
- •Elucidation of receptor interactomes to gain insights into extracellular protein biology.
13.
《Molecular & cellular proteomics : MCP》2018,17(11):2242-2255
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- •BioID and IP-MS were conducted to generate a global ZIKV-host protein interactome
- •Interactome consists of >3000 high confidence ZIKV-host protein interactions
- •Data mining indicates that ZIKV proteins interact with multiple host cell organelles
- •An important role for peroxisomes in ZIKV infection is uncovered
14.
《Molecular & cellular proteomics : MCP》2019,18(6):1110-1122
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- •Comprehensive analysis of inter-individual variation of normal urinary proteome.
- •Significant gender differences were observed.
- •Proteins increased in female urine are enriched in immunological pathways.
- •Estimated reference intervals of proteins as the baseline for biomarker discovery.
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16.
《Molecular & cellular proteomics : MCP》2018,17(12):2534-2545
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- •Online PASEF achieves greater than 100 MS/MS per second at full sensitivity.
- •Accurate label-free quantification of over 6000 proteins in 2 h.
- •High throughput demonstrated on 50 ng digests measured in 5 min.
- •High-precision determination of 100,000 peptide collisional cross sections.
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18.
《Molecular & cellular proteomics : MCP》2019,18(1):28-40
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- •Method to probe the isomeric variants of the glycans attached to purified proteins.
- •Uses multiple rounds of glycosidase cleavage and lectin profiling.
- •Computation integration of lectin-binding, glycan-array, and mass spectrometry data.
- •Applied to microspots for compatibility with analyzing low-abundance proteins.
19.
《Molecular & cellular proteomics : MCP》2019,18(2):308-319
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- •Over 1700 Arabidopsis proteins with thermal models in multiple replicates.
- •Melting temperature correlates with 1°, 2°, and 3° protein characteristics.
- •Ligand-induced thermal shifts are evident in complex protein extracts.