膳食结构对供浆员血浆蛋白及血脂含量的影响研究

目的探讨不同的膳食结构对供浆员血浆蛋白及血脂含量的影响。方法测定400例以牛、羊肉和马铃薯为主要膳食结构的供血浆者和400例以猪肉和马铃薯为主要膳食结构的供血浆者的血浆蛋白和血脂水平;同时统计食用高脂肪膳食后血浆出现乳糜的情况。结果经测定以牛、羊肉和马铃薯为主要膳食结构的供血浆者和以猪肉和马铃薯为主要饮食结构的供血浆者的血浆蛋白和血脂水平相当,两者之间无显著性差异(P>0.05);献浆前1 2 h内食用高脂肪膳食后血浆出现乳糜的概率明显增高,与食用清淡膳食相比具有显著性差异(P<0.05)。结论这两种膳食结构的差异对供浆员血浆蛋白及血脂水平没有明显影响;献浆前12 h内应当避免食用高脂肪类膳食。     

北京市居民营养膳食结构研究

为了解并掌握北京市居民不同年龄段居民的饮食习惯及不同来源食物食用率,项目组以抽样入户访问的方式进行调查,结果显示：98.5%的居民日常主食以大米及制品为主,14岁以下青少年对各种主食的食用频率均高于平均水平;食用率较高的蔬菜为西红柿（92.4%）,茄子的进食频率在不同年龄段存在显著差异,其余26种蔬菜在各年龄段群组之间的进食频率均无显著差异;水果类食品中苹果食用率为92.0%,高于其他水果,其次西瓜和香蕉食用率分别为80.7%和77.1%,即说明这3种水果是居民日常食用的主要选择对象。     

我国不同区域膳食结构分析及膳食营养建议

结合地理区域与气候特征,综述了我国西北地区、北方地区、青藏地区和南方地区四大地理区域居民的膳食结构,对膳食结构中的植物蛋白和动物蛋白组成情况进行了剖析,对不同区域居民的膳食结构与居民区域性慢性疾病进行了关联分析,并对各区域居民的膳食营养提出了建议,旨为制定科学合理的区域性居民膳食营养指南提供理论基础,为中国“双蛋白工程”及“国民营养计划”的实施提供科学依据。     

老年2型糖尿病患者膳食结构及营养状况的影响分析

目的：探讨老年糖尿病（T2DM）患者营养状况及膳食结构的关系及营养状况的影响因素。方法：选取老年T2DM住院患者252例,年龄≥65岁,采用食物频率表（FFQ）、简易营养风险筛查量表（MNA-SF）、肌肉衰减风险表（SARC-F）现场调查;检测空腹血总蛋白（TP）、血清蛋白（ALB）、血红蛋白（Hb）、糖化血红蛋白（HbA1C%）、甘油三酯（TG）、胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、血糖（Glu）。结果：按MNA-SF结果分为3组：营养正常组109例（43.3%）、营养不良组18例（7.14%）、营养不良风险组125例（49.6%）;3组TC、TG、LDL-C、HDL、HbA1C%水平有差异性（P＜0.05）;3组患者膳食结构有统计学差异（P＜0.05）;膳食结构与HbA1C%水平相关联（P＜0.05）;Ｌogistic 回归分析结果示：年龄、BMI（体质指数）、HbA1C%、并发症、情绪、运动、肌肉衰减是老年T2DM患者营养不良风险的相关影响因素（P＜0.05）。结论：半数以上老年T2DM患者存在营养不良风险,需要制订综合干预手段,包括调整膳食结构,控制HbA1c水平,同时提供心理干预和运动指导,提高生存质量。     

上海市食管癌流行动态与居民膳食结构变化的调查研究

目的：调查上海市居民近10年食管癌的流行动态以及与膳食结构变化的关系。方法：对2006-2008年和2016-2018年近10年的两个时间段的上海市居民每日的各种食物摄入量进行统计,并分析其膳食结构变化,并对近10年上海食管癌的流行动态进行统计,分析膳食结构与食管癌动态变化的相关性。结果：近10年上海市食管癌的发病率呈现增加趋势,2016-2018年和2006-2008年相比较,上海市居民的膳食结构发生明显改变,近10年来居民对大米、杂粮、鱼类、有色蔬菜和动物油等摄入量明显减少（P＜0.05或P＜0.01）,而对小麦、玉米、牛羊肉、蛋类、植物油等摄入量明显增多（P＜0.05或P＜0.01）。结论：上海市居民食管癌的发病率有所增加,食管癌的发生与膳食结构具有密切关系,所以应采取积极干预措施,调整居民的膳食结构,以降低食管癌的发病率。     

黄山地区居民超重/肥胖与膳食结构的关系研究

目的：了解安徽黄山地区居民的超重/肥胖与膳食结构的关系,为当地居民超重/肥胖的膳食营养干预提供参考和建议。方法：利用方便抽样的方法,在黄山地区居住时间超过10年的家庭中选择200户,称重法记录包括1个休息日在内的连续3日膳食摄入情况,根据标准人日数求出平均每人每天膳食摄入量。从每个家庭中选1名40岁以上者,问卷调查人口学资料及健康状况,规范测量身高、体重、血压、腰围。采用二分类Logistic回归分析超重/肥胖与膳食因素的关系。结果:居民超重率为23.5%、肥胖率5.0%。Logistic回归分析表明：蛋白质供能比过低（OR=1.325,95%CI=1.011～2.948）、脂肪供能比过高（OR=1.749,95%CI=1.064～3.699）、碳水化合物供能比过高（OR=1.238,95%CI=1.057～2.853）以及食盐摄入量（OR=1.493,95%CI=1.270～1.755）具有统计学意义。脂肪供能比过高（OR=1.281,95%CI=1.110～2.716）可能是腹型肥胖的危险因素。结论：膳食因素对该地区居民超重/肥胖和腰围可能有影响。     

高半胱氨酸膳食对小鼠生长和免疫力的影响

探讨了高半胱氨酸膳食对小鼠生长及对外来抗原刺激产生抗体的免疫力的影响。实验取小白鼠32只,随机分为高半胱氨酸组(H)和对照组(C)各16只。H组每天给予含半咣氨酸质量分数为3％的饲料,分别在1、4、8周对其腹腔注射牛血清白蛋白,在第9周处死动物,取血测量血清抗体效价。结果显示实验组生长缓慢,血清抗体效价显著高于对照组,表明高半胱氨酸膳食可提高小鼠血清抗体效价,但高含量的半胱氨酸对小鼠生长有抑制作用。     

幽门螺杆菌感染患者的膳食营养状况分析

目的：探讨Hp感染患者的膳食营养状况及膳食模式特点,为合理膳食预防和控制幽门螺杆菌（Hp）感染提供参考。方法：采用病例对照研究,于2017年10月—2018年9月在山东某医院选取1 140名（≥18岁）完成13C 尿素呼气试验（13C UBT）的检查者,根据13C 尿素呼气试验结果（DOB）和标准,将研究对象分为感染组（DOB≥4）596名和非感染组（DOB＜4）544名。收集研究对象的基本信息、相关临床检查指标;采用3d连续24h膳食回顾法收集研究对象近期膳食情况,分析两组人群营养素摄入水平及供能来源。根据食物频率表收集研究对象过去约6个月内的食物种类及平均每天的食物消费水平,并累计每位研究对象1周内消费的食物种类来计算膳食多样化评分（DDS）,每消费1类食物计1分,两类食物计2分,最高为9分。结果：营养状况分析显示,感染组患者营养不良率达7.9%,显著高于非感染组的2.0%（P＜0.05）。膳食营养素摄入情况显示,感染组人群能量摄入水平为1 980kcal/d,显著高于非感染组的1 823kcal/d,碳水化合物摄入（287.51g/d）显著高于非感染组（253.81g/d）（P均＜0.05）。膳食种类分析,感染者DDS评分为6.65分,显著低于非感染组的7.58分（P＜0.05）。感染组蔬菜和水果的平均摄入量（291.39 g/d和92.46 g/d）显著低于非感染组（330.09 g/d和119.10 g/d）（P＜0.05）。经偏相关分析,校正经济水平、文化水平、饮酒史3项混杂因素,Hp感染与营养状况和膳食多样化均呈负相关。结论：Hp感染患者营养不良率较高,膳食结构不合理,每周食用的食物种类较少,碳水化合物摄入量较高,而蔬菜和水果摄入量明显不足;应加强Hp感染人群的营养不良风险监测,及时有效地改善其营养状况。     

膳食纤维对肥胖相关的肠道微生态的影响

研究发现,肠道微生态的改变与肥胖等代谢性疾病相关。膳食纤维作为饮食的一部分,通过在肠道的作用改变肠道菌群比例及丰度、改善炎症反应、调节肠道激素及脂质代谢来改善肥胖,但膳食纤维在防治肥胖方面的推荐摄入量、种类及与肠道菌群的作用机制还需进一步研究。本文对膳食纤维对肥胖相关的肠道微生态的影响的研究进展进行了综述。     

膳食因素对妊娠期缺铁性贫血的影响研究

目的：分析膳食因素对妊娠期缺铁性贫血（IDA）的影响。方法：选取2018年2月-2020年2月在我院门诊行产前检查的妊娠期IDA孕妇（病例组）102例和正常孕妇（对照组）102例为研究对象,采用半定量《食物频率调查表》对孕妇进行膳食调查,比较两组孕妇膳食种类的摄入频率,并分析影响妊娠期IDA发生的膳食因素。结果：两组孕妇妊娠期在水果类、油脂类、蔬菜类、谷薯类以及干果类的摄入频率比较无显著差异（P>0.05）,病例组孕妇在鱼肉禽类、血制品、动物内脏及钙补充剂、铁补充剂、维生素补充剂、蛋类的摄入频率明显低于对照组（P<0.01）,病例组在豆类、刺激性饮品和奶类及奶制品的摄入频率明显高于对照组（P<0.01）。经单因素及Logistic多因素回归分析显示,鱼肉禽类、血制品、动物内脏、铁补充剂、钙补充剂、维生素补充剂属于妊娠期IDA发生的保护因素,刺激性饮品及奶类及奶制品属于妊娠期IDA发生的危险因素。结论:膳食因素与妊娠期IDA关系密切,孕妇在妊娠期合理增加动物内脏、鱼肉禽类、血制品、铁补充剂、钙补充剂和维生素补充剂的摄入对预防和改善妊娠期IDA可起到保护作用,而摄入过多牛奶及奶制品和刺激性饮品会增加妊娠期IDA发生的风险。     

Leptin Expression in Hypothalamic PVN Reverses Dietary Obesity and Hyperinsulinemia but Stimulates Ghrelin*

Objective: In order to circumvent the multiple peripheral effects of hyperleptinemia and leptin resistance, the efficacy of leptin transgene expression in the hypothalamic paraventricular nucleus (PVN) to reinstate the central energy homeostasis in obesity was examined. Research Methods and Procedures: A recombinant adeno‐associated viral vector encoding either leptin (rAAV‐lep) or green fluorescent protein (rAAV‐GFP) was microinjected into the PVN of obesity‐prone rats consuming a high‐fat diet (HFD). Results: rAAV‐lep, and not rAAV‐GFP, microinjection significantly reduced energy intake and enhanced energy expenditure, thereby resulting in normalization of weight and blood levels of leptin, insulin, free fatty acids, and glucose concomitant with enhanced ghrelin secretion during the extended period of observation. Discussion: Thus, we show, for the first time, that amelioration of leptin insufficiency with enhanced localized leptin availability in the PVN alone can reverse dietary obesity and the attendant hyperinsulinemia and concurrently block the central stimulatory effects of elevated endogenous ghrelin on food intake and adiposity.     

Effect of Dietary Carbohydrate Source on the Development of Obesity in Agouti Transgenic Mice**

Objectives: Our objective was to evaluate the effects of a qualitative change in dietary carbohydrate source on body weight and adiposity in a rodent model of diet‐induced obesity. Research Methods and Procedures: We evaluated the effects of high‐fat diets (basal) varying in carbohydrate source in aP2‐agouti transgenic mice. In the ad libitum study, animals were given free access to the basal diet or one of four test diets for 6 weeks. In two of the diets, dietary carbohydrate was derived from a single source: mung bean noodles (MUNG) or rolled oats (ROLL). The remaining diets were designed to mimic commercially available instant oatmeal with added sugar (IO‐S) or flavored instant oatmeal (IO‐F). In the energy‐restricted study, animals were given ad libitum access to the basal diet for 6 weeks. Subsequently, animals were assigned to one of six treatment groups for 6 weeks. One group was continued on the basal diet ad libitum. The remaining groups were maintained with energy restriction (70% ad libitum) on either the basal, MUNG, ROLL, IO‐S, or IO‐F diet. Results: Subcutaneous fat pad mass was significantly higher (p < 0.05) in the energy‐restricted basal and IO‐S groups compared with the energy‐restricted ROLL diet. Similarly, visceral fat pad mass was significantly lower with ROLL and MUNG diets (p < 0.05 for both) compared with basal and IO‐S diets, and the insulin:glucose ratio was reduced (by 23% to 34%, p < 0.05) in these two diets compared with all others. In ad libitum‐fed animals, liver fatty acid synthase expression was 43% to 62% lower (p < 0.05) with ROLL and MUNG diets compared with all others. Discussion: These data suggest that a qualitative change in dietary carbohydrate source modulates body weight and adiposity.     

Neuropeptide Y Expression and Endogenous Leptin Concentrations in a Dietary Model of Obesity

LAUTERIO, THOMAS J., MICHAEL J. DAVIES, MARK DEANGELO, MICHAEL PEYSER, AND JAMES LEE. Neuropeptide Y expression and endogenous leptin concentrations in a dietary model of obesity. Obes Res. Objective: To determine how leptin concentrations and neuropeptide (NPY) are regulated in a model of dietary obesity in relation to relative growth (RG) and relative food consumption (RFC). Research Methods and Procedures: Sprague—Dawley rats were fed a moderately high-fat diet for 14 weeks over which time animals diverged into obesity-prone (OP) and obesity-resistant (OR) populations. RG rates and RFC were calculated weekly. Following the study, an adiposity index was calculated and arcuate nucleus (ARC) NPY expression was determined by in situ hybridization (ISH) or ribonuclease protection (RPA) assays. Results: Body weights were greater in OP rats after 2 weeks on the diet compared to OR rats and remained different throughout the study. RG and RFC were greater in OP rats compared to OR rats only during the first 2 weeks of the study. Leptin concentrations rose in both groups during the experiment, but the increase was greater in OP rats than in OR rats. Insulin changes paralleled those for leptin. ARC NPY mRNA expression was not different between OP and OR rats as measured by ISH and RPA. Discussion: Although NPY expression has been reported to be different initially in OP and OR rats, this difference dissipates following divergence of body weight. RFC and RG data suggest the initial NPY elevation may contribute to increased weight gain of OP rats during the first 2 weeks of the diet. Higher relative leptin concentrations in OP rats may be necessary to normalize differences in adiposity and apparent leptin and insulin resistance of OP rats.     

Dietary Patterns and Their Associations with Obesity in the Brazilian City of Rio de Janeiro

Objective: To evaluate the dietary patterns of adults living in the city of Rio de Janeiro, Brazil and their associations with body mass index (BMI). Research Methods and Procedures: A survey was conducted in 1996 in a probabilistic sample of 2040 households. Weight and height were measured and food intake was based on an 80-item semi-quantitative food frequency questionnaire. Dietary patterns were identified through factor analysis. Results: More than one-third of the adult population (20 to 60 years old) was overweight (BMI = 25 to 29.9 kg/m²), and 12% were obese (BMI ≥ 30 kg/m²). Three major dietary patterns were identified: mixed pattern when all food groups and items had about the same factor loading, except for rice and beans; one pattern that relies mainly on rice and beans, which was called a traditional diet; and a third pattern, termed a Western diet, where fat (butter and margarine) and added sugar (sodas) showed the highest positive loading and rice and beans were strong negative components. Among men, the Western diet also included deep-fried snacks and milk products with high positive values. The traditional diet was associated with lower risk of overweight/obesity in logistic models adjusted for dieting, age, leisure physical activity, and occupation (13% reduction in men and 14% reduction in women comparing the traditional and Western diets). Discussion: Factors contributing to the effects of the Brazilian traditional diet may include low-energy density, high-dietary fiber content, incorporation of low glycemic index foods such as beans, or a relatively low food variety.     

冬季上海市城区河道中原生动物群落的结构特征

于2007年11月至2008年1月,对上海市城区经过初步修复的四条河道(午潮港、横港、朝阳河和曹杨环浜)中原生动物的群落结构和多样性进行了调查.共鉴定出原生动物88种,其中鞭毛虫31种,肉足虫13种,纤毛虫44种.除曹杨环浜无优势种外,其他三条河道的种类均以耐污种类为优势种,如波豆虫 Bodo sp.、滴虫 Monas sp.、隐藻 Cryptomonas sp.等;四条河道均呈现纤毛虫和鞭毛虫种类较为丰富,肉足虫相对较少的现象.四条河道中原生动物多样性指数的平均值变动在1.14～2.87之间;密度变动在900.35～2837.89 ind/ml间.分析发现,前期生态治理较为成功的曹杨环浜具有多样性指数高、密度大、无明显优势种等特征,而其他三条河道中原生动物种类相对较单一,且分布不均匀,主要优势种为一些耐污种类.提示经过人工合理的修复,可以有效改善受污染河道的状况.因此对已经初步修复河道的生态系统进行评估,探索和制定出有针对性的修复方案,并对其加以合理的维护,对建立健康、稳态的河道生态系统是十分必要的.     

Stimulatory Effect of Leptin on Nitric Oxide Production Is Impaired in Dietary‐Induced Obesity

Objective: We investigated the effect of leptin on nitric oxide production in lean and rats made obese by a high‐calorie diet. Research Methods and Procedures: The animals were placed in metabolic cages, and urine was collected in 2‐hour periods after leptin (1 mg/kg intraperintoneally) or vehicle administration. Blood was obtained 0.5, 1, 2, 4, or 6 hours after injection. Results: Leptin had no effect on systolic blood pressure in either lean or obese animals. Plasma concentration of NO metabolites (nitrites + nitrates, NO_x) increased in lean rats by 31.5%, 58.0%, and 27.9% at 1, 2, and 4 hours after leptin injection, respectively. In the obese group, plasma NO_x increased only at 2 hours (+36.5%). Leptin increased urinary NO_x excretion by 31.8% in the first 2‐hour period after injection in lean but not in obese rats. In lean animals, leptin elevated plasma cyclic 3′, 5′‐guanosine monophosphate (cGMP) at 1, 2, and 4 hours by 35.3%, 96.3%, and 57.3%, respectively. In the obese group, plasma cGMP was higher only at 2 and 4 hours (+44.6% and +32.1%, respectively). Urinary excretion of cGMP increased in lean animals by 67.1% in the first period and by 50.4% in the second period. In the obese group, leptin induced a 53.9% increase in urinary cGMP excretion only in the first 2‐hour period. Discussion: The stimulatory effect of leptin on NO production is impaired in dietary‐induced obesity; however, leptin does not increase blood pressure in obese animals, suggesting that other NO—independent depressor mechanisms are stimulated.     

Effects of Weight Cycling Induced by Diet Cycling in Rats Differing in Susceptibility to Dietary Obesity

LAUER, JOAN B., GEORGE W. REED, AND JAMES O. HILL. Effects of weight cycling induced by diet cycling in rats differing in susceptibility to dietary obesity. Obes Res. Objective Although the majority of evidence in rodents does not support the view that weight cycling (consisting of bouts of food restriction and refeeding) promotes obesity, the effects of weight cycling on body weight regulation remain controversial. We have previously demonstrated that some rats within a strain are more susceptible to develop obesity than others when given free access to a high-fat diet. In this study, we tested the hypothesis that rats most susceptible to weight gain on a high-fat diet would also be most susceptible to weight gain as a consequence of weight cycling. Research Methods and Procedures Rats were provided a low-fat diet (12% corn oil) for 2 weeks, then given a high-fat diet (45% corn oil) for 2 weeks to identify those most (obesity prone) and least (obesity resistant) susceptible to weight gain. Half of each group was then subjected to three 30-day cycles of food restriction (10 days) and refeeding (20 days) [weight cycler (WC) rats]. The other half were allowed free access to the high-fat diet [control (CO) rats]. All rats were then followed for an additional 10 weeks, with free access to the high-fat diet. Results When considering the entire 160 days of the study, we found no evidence that WC rats relative to CO rats had increased body weight, increased body fat content, or elevated energy efficiency. We found no evidence that rats most prone to dietary obesity were also prone to weight gain after weight cycling. During the weight cycling phase (days 1 to 90), weight cycled groups consumed less energy and gained less weight than controls. During the follow-up phase, WC and CO rats did not differ significantly in weight gain or energy intake. Discussion In this study, weight cycling did not exacerbate the obesity produced by high-fat diet feeding.     

Prevalence of Pre‐obesity and Obesity in Urban Adult Mexicans in Comparison with Other Large Surveys

Objective: 1. To estimate the prevalence of pre‐obesity and obesity in a 1992 to 1993 national survey of the Mexican urban adult population. 2. To compare our findings with other national surveys and with data for Mexican Americans. Research Methods and Procedures: The national representative sample of the Mexican urban adult population included 8462 women and 5929 men aged 20 to 69 years from 417 towns of >2500 people. Body mass index (BMI), calculated from measured weight and height, was classified using the World Health Organization categories of underweight (BMI < 18.5 kg/m²), normal weight (BMI 18.5 to 24.9 kg/m²), pre‐obesity (PreOB = BMI 25 to 29.9 kg/m²) and obesity (OB = BMI 30+ kg/m²). Estimates for Mexican Americans were calculated from U.S. survey data. Results: Overall, 38% of the Mexican urban adult population were classified as pre‐obese and 21% as obese. Men had a higher prevalence of pre‐obesity than women did at all ages, but women had higher values of obesity. Both pre‐obesity and obesity increased with age up to the age range brackets of 40 to 49 or 50 to 59 years for both men and women. Both pre‐obesity and obesity prevalence estimates were remarkably similar to data for Mexican Americans from 1982 through 1984. Comparison with other large surveys showed that countries differed more in the prevalence of obesity than of pre‐obesity, leading to differences in the PreOB/OB ratio, and that countries also differed in the gender ratio (female/male) for both pre‐obesity and obesity. Discussion: Pre‐obesity and obesity were high in our population and increased with age. Our approach of characterizing large surveys by PreOB/OB and gender ratios appeared promising.     

The Prevalence of Obesity and Its Determinants in Urban and Rural Aging Mexican Populations

LERMAN-GARBER, ISRAEL, ANTONIO R. VILLA, CRISTINA LLACA MARTINEZ, LETICIA CERVANTES TURRUBIATEZ, CARLOS A. AGUILAR SALINAS, VILLAGRA LUCY, BELIA WONG, JUAN C. LÓPEZ ALVARENGA, FRANCISCO GÓMEZ PÉREZ, AND LUIS MIGUEL GUTIERREZ ROBLEDO. The prevalence of obesity and its determinants in urban and rural older mexican populations. Obes Res. Objective: To determine the prevalence of obesity and its association to different variables in urban and rural older Mexican populations. Methods and Procedures: A cross-sectional study of three different Mexican communities. A total of 121 men and 223 women 60 years and older and 93 men and 180 women aged 35 to 59 years old were selected randomly for inclusion in the survey. A personal interview assessed demographic information, personal medical history and functional status and a 24-hour diet recall was obtained. The physical examination included anthropometric and blood pressure measurements. A fasting blood sample was obtained for measurements of lipids, insulin and glucose. Results: Obesity was highly prevalent in women, in individuals from the urban communities and diminished with advancing age. A BMI ≥30 kg/m² was observed in 23. 6% younger vs. 15. 6% older adult men (p = 0. 21) and 28. 4% younger vs. 19. 7% older adult women (p = 0. 06). Conclusions: The present survey confirms the high prevalence of obesity in the Mexican urban population that declines with advanced age. Studies in elderly population must consider the bias produced by increased early mortality in those individuals with a more unfavorable risk profile. The association of obesity with other variables was estimated using a stepwise multivariate logistic regression, increased insulin levels [Odds Ratio (OR) 1. 68, p = 0. 006] and living in an urban area (OR 5. 90, p <0. 007) were variables independently associated to obesity in adult older individuals. In the younger adults, obesity was associated with hypertension (OR 2. 74, p<0. 0009), higher insulin levels (OR 1. 31, p<0. 03) and central adiposity (OR 2. 97, p = 0. 05), these relationship were not observed with gender, distribution of food or alcohol intake or other coronary risk factors.     

腹型肥胖对急性冠脉综合征患者冠状动脉病变严重程度的影响

目的:研究腹型肥胖对急性冠脉综合征(ACS)患者冠状动脉病变严重程度的影响。方法:选择2012年4月至2013年4月在我院接受治疗的ACS患者120例,根据腰围身高比(RWH)将患者分为无腹型肥胖者60例(对照组,RWH0.5)及腹型肥胖者60例(观察组,RWH0.5)。测量所有患者的基本参数,计算RWH,利用冠脉造影判断冠脉病变的支数和程度,根据Gensini评分法对冠脉造影结果进行评价,分析冠脉病变范围、Gensini积分和RWH的相关性。结果:观察组的收缩压(SBP)、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)及Gensini积分水平均显著高于对照组,差异均有统计学意义(均P0.05)。观察组的高密度脂蛋白(HDL-C)水平显著低于对照组,差异有统计学意义(P0.05)。双支病变的RWH及Gensini积分水平显著高于单支病变,三支病变的RWH及Gensini积分水平显著高于单支病变及双支病变,差异均有统计学意义(均P0.05)。根据Spearman法分析相关性可知,冠脉病变范围、Gensini积分和RWH均呈正相关(r=0.635,0.739;P=0.000,0.000)。结论:ACS患者RWH水平增高与冠脉病变的严重程度关系密切,有效控制腹型肥胖对于降低心血管类疾病发病率以及降低冠脉病变的程度具有重要意义。