共查询到20条相似文献,搜索用时 0 毫秒
1.
Trussell LO 《Current opinion in neurobiology》2002,12(4):400-404
The relay nuclei of the auditory brainstem contain some of the largest nerve terminals in the mammalian brain. Endbulb and calyceal synapses convey signals with a high degree of precision and reliability. However, recent studies reveal that these synapses possess numerous and remarkably diverse mechanisms for the modulation of transmitter release. The implication is that successful relay of signals in vivo may require the ability to fine-tune synaptic transmission. 相似文献
2.
Control of nerve-cell excitability is crucial for normal brain function. Two main groups of inhibitory neurotransmitter receptors--GABA(A) and glycine receptors--fulfil a significant part of this role. To mediate fast synaptic inhibition effectively, these receptors need to be localized and affixed opposite nerve terminals that release the appropriate neurotransmitter at multiple sites on postsynaptic neurons. But for this to occur, neurons require intracellular anchoring molecules, as well as mechanisms that ensure the efficient turnover and transport of mature, functional inhibitory synaptic receptor proteins. This review describes the dynamic regulation of synaptic GABA(A) and glycine receptors and discusses recent advances in this rapidly evolving field. 相似文献
3.
最近的研究发现,哺乳动物听觉系统中抑制性神经回路的成熟和优化依赖于自发性和经验性的神经活动,神经活动对于抑制性突触的亚细胞定位、抑制性神经回路的拓扑组构,以及耳优势带的形成均至关重要。这些研究可能揭示了脑发育过程中抑制性神经回路构建的一般规律和细胞机制。 相似文献
4.
Spike-timing-dependent synaptic plasticity has recently provided an account of both the acuity of sound localization and the development of temporal-feature maps in the avian auditory system. The dynamics of the resulting learning equation, which describes the evolution of the synaptic weights, is governed by an unstable fixed point. We outline the derivation of the learning equation for both the Poisson neuron model and the leaky integrate-and-fire neuron with conductance synapses. The asymptotic solutions of the learning equation can be described by a spectral representation based on a biorthogonal expansion. 相似文献
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Kandler K 《Current opinion in neurobiology》2004,14(1):96-104
In contrast to our detailed knowledge about the development and plasticity of excitatory neuronal circuits, little is known about the development of inhibitory circuits. Recent studies from the developing mammalian auditory system have revealed the presence of substantial activity-dependent synaptic reorganization in several inhibitory pathways. These studies importantly shed some new light on the general rules and cellular mechanisms that manage the organization of precise inhibitory circuits in the developing brain. 相似文献
7.
S I Frankshte?n T I Sergeeva Z N Sergeeva 《Biulleten' eksperimental'no? biologii i meditsiny》1979,87(6):521-522
Injection of subconvulsive doses of strychnine blocking the inhibitory synapses significantly increases the reflex activity of the respiratory muscle evoked by stimulation of the sciatic nerve as well as by inhalation of hypercapnic gas mixture. Thus the inhibitory synapses prevent the extreme hypocapnia evoked by hyperventilation. 相似文献
8.
Experience-dependent modifications of neural circuits and function are believed to heavily depend on changes in synaptic efficacy such as LTP/LTD. Hence, much effort has been devoted to elucidating the mechanisms underlying these forms of synaptic plasticity. Although most of this work has focused on excitatory synapses, it is now clear that diverse mechanisms of long-term inhibitory plasticity have evolved to provide additional flexibility to neural circuits. By changing the excitatory/inhibitory balance, GABAergic plasticity can regulate excitability, neural circuit function and ultimately, contribute to learning and memory, and neural circuit refinement. Here we discuss recent advancements in our understanding of the mechanisms and functional relevance of GABAergic inhibitory synaptic plasticity. 相似文献
9.
The cytoskeleton of afferent chemical synapses, with various ultrastructure of contact zones, was examined in the Mauthner cells of the goldfish. The synapses with combined active zones and desmosome-like specialized contacts possessed a well developed cytoskeleton consisting of filaments and microtubules oriented towards the synaptic apposition. Regular arrays of synaptic vesicles oriented in the same direction were observed beyond and near the active zones. The cytoskeleton of the synapses lacking desmosome-like formations was diffusely organized throughout the boutons. The distribution of vesicles in the vicinity of active zones was also not ordered. The role of cytoskeleton in organization of the two morphologically distinct synapses is discussed. A special function of cytoskeleton as an intermediary between synaptoplasm and membrane is regarded as a necessary basis for plasticity of excitatory rather than inhibitory synapses. 相似文献
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EA Heller W Zhang F Selimi JC Earnheart MA Ślimak J Santos-Torres I Ibañez-Tallon C Aoki BT Chait N Heintz 《PloS one》2012,7(6):e39572
Classical electron microscopic studies of the mammalian brain revealed two major classes of synapses, distinguished by the presence of a large postsynaptic density (PSD) exclusively at type 1, excitatory synapses. Biochemical studies of the PSD have established the paradigm of the synapse as a complex signal-processing machine that controls synaptic plasticity. We report here the results of a proteomic analysis of type 2, inhibitory synaptic complexes isolated by affinity purification from the cerebral cortex. We show that these synaptic complexes contain a variety of neurotransmitter receptors, neural cell-scaffolding and adhesion molecules, but that they are entirely lacking in cell signaling proteins. This fundamental distinction between the functions of type 1 and type 2 synapses in the nervous system has far reaching implications for models of synaptic plasticity, rapid adaptations in neural circuits, and homeostatic mechanisms controlling the balance of excitation and inhibition in the mature brain. 相似文献
13.
We study the dynamics and bifurcations of noise-free neurons coupled by gap junctions and inhibitory synapses, using both
delayed delta functions and alpha functions to model the latter. We focus on the case of two cells, as in the studies of Chow
and Kopell (2000) and Lewis and Rinzel (2003), but also show that stable asynchronous splay states exist for globally coupled
networks of N cells dominated by subthreshold electrical coupling. Our results agree with those of Lewis and Rinzel (2003) in the weak
coupling range, but our Poincaré map analysis yields more information about global behavior and domains of attraction, and
we show that the explicit discontinuous maps derived using delayed delta functions compare well with the continuous history-dependent,
implicitly-defined maps derived from alpha functions. We find that increased bias currents, super-threshold electrical coupling
and synaptic delays promote synchrony, while sub-threshold electrical coupling and fast synapses promote asynchrony. We compare
our analytical results with simulations of an ionic current model of spiking cells, and briefly discuss implications for stimulus
response modes of locus coeruleus and for central pattern generators.
Action Editor: F. Skinner 相似文献
14.
We construct a model of activity-dependent, anatomical inhibitory plasticity. We apply the model to the mammalian auditory
system. Specifically, we model the activity-dependent topographic refinement of inhibitory projections in the auditory brain
stem, and we construct an anatomically abstract model of binaural band formation in the primary auditory cortex involving
the segregation of different populations of inhibitory and excitatory afferents. Issues raised and predictions made include
the nature of interactions between excitatory and inhibitory afferents innervating the same population of target cells, and
the possibility that pharmacological manipulations of the developing primary auditory cortex might induce a shift in the periodicity
of binaural bands. Any model of inhibitory plasticity must confront the issue of postulating mechanisms underlying such plasticity.
In order to attempt to understand, at least theoretically, what the mechanisms underlying inhibitory plasticity might be,
we propose the existence of a new class of neurotrophic factors that promote neurite outgrowth from and mediate competitive
interactions between inhibitory afferents. We suppose that such factors are up-regulated by hyperpolarisation and down-regulated
by depolarisation. Furthermore, we suppose that their activity-dependent release from target cells depends on Cl− influx. Such factors are therefore assumed to be the physiological inverse of such factors as nerve growth factor and brain-derived
neurotrophic factor, which are up-regulated by depolarisation and down-regulated by hyperpolarisation, with their activity-dependent
release depending on Na+, and not Ca2+, influx.
Received: 16 December 1997 / Accepted in revised form: 3 April 1998 相似文献
15.
Proper developmental, neural cell-type-specific, and activity-dependent regulation of GABAergic transmission is essential for virtually all aspects of CNS function. The number of GABA(A) receptors in the postsynaptic membrane directly controls the efficacy of GABAergic synaptic transmission. Thus, regulated trafficking of GABA(A) receptors is essential for understanding brain function in both health and disease. Here we summarize recent progress in the understanding of mechanisms that allow dynamic adaptation of cell surface expression and postsynaptic accumulation and function of GABA(A) receptors. This includes activity-dependent and cell-type-specific changes in subunit gene expression, assembly of subunits into receptors, as well as exocytosis, endocytic recycling, diffusion dynamics, and degradation of GABA(A) receptors. In particular, we focus on the roles of receptor-interacting proteins, scaffold proteins, synaptic adhesion proteins, and enzymes that regulate the trafficking and function of receptors and associated proteins. In addition, we review neuropeptide signaling pathways that affect neural excitability through changes in GABA(A)R trafficking. 相似文献
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Receptors for γ-aminobutyric acid (GABA) and its agonists display a considerable tolerance to the size of the agonist molecule. By considering the potencies of four rigid GABA analogues, it is possible to construct a model for the elasticity of the receptor. Using this model in conjunction with the probability distributions of the charge separations of 12 GABA agonists, based on classical potential energy calculations, interaction probabilities are calculated which enable the molecular structure of the agonists to be correlated with their pharmacological activity. 相似文献
18.
Alessandro Ingrosso 《PLoS computational biology》2020,16(12)
Characterizing the relation between weight structure and input/output statistics is fundamental for understanding the computational capabilities of neural circuits. In this work, I study the problem of storing associations between analog signals in the presence of correlations, using methods from statistical mechanics. I characterize the typical learning performance in terms of the power spectrum of random input and output processes. I show that optimal synaptic weight configurations reach a capacity of 0.5 for any fraction of excitatory to inhibitory weights and have a peculiar synaptic distribution with a finite fraction of silent synapses. I further provide a link between typical learning performance and principal components analysis in single cases. These results may shed light on the synaptic profile of brain circuits, such as cerebellar structures, that are thought to engage in processing time-dependent signals and performing on-line prediction. 相似文献
19.
A key feature of the mammalian brain is its capacity to adapt in response to experience, in part by remodeling of synaptic connections between neurons. Excitatory synapse rearrangements have been monitored in vivo by observation of dendritic spine dynamics, but lack of a vital marker for inhibitory synapses has precluded their observation. Here, we simultaneously monitor in vivo inhibitory synapse and dendritic spine dynamics across the entire dendritic arbor of pyramidal neurons in the adult mammalian cortex using large-volume, high-resolution dual-color two-photon microscopy. We find that inhibitory synapses on dendritic shafts and spines differ in their distribution across the arbor and in their remodeling kinetics during normal and altered sensory experience. Further, we find inhibitory synapse and dendritic spine remodeling to be spatially clustered and that clustering is influenced by sensory input. Our findings provide in vivo evidence for local coordination of inhibitory and excitatory synaptic rearrangements. 相似文献