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Myc: a weapon of mass destruction 总被引:11,自引:0,他引:11
Growth and proliferation potentiated by deregulated myc oncogene expression is balanced by myc-induced apoptosis. Abrogation of this apoptotic pathway in Myc overexpressing cells leads to cancer progression. Recent work has shown that cell clones in the Drosophila wing disc with higher dMyc expression levels act as supercompetitors to potentiate the programmed death of surrounding normal cells. Yet another paper identifies dE2F1 as a critical component of pathways that normally restrict the ability of growth perturbing genes like dMyc to cause organ overgrowth. 相似文献
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Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain 总被引:5,自引:0,他引:5
Du W 《Development (Cambridge, England)》2000,127(2):367-379
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dE2F2-independent rescue of proliferation in cells lacking an activator dE2F1 总被引:1,自引:0,他引:1 下载免费PDF全文
Ambrus AM Nicolay BN Rasheva VI Suckling RJ Frolov MV 《Molecular and cellular biology》2007,27(24):8561-8570
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