The psychologic effects of spontaneous abortion.

Although 14% to 18% of pregnancies end in spontaneous abortion, miscarriage is often not recognized as a significant occurrence. Women may experience grief reactions similar to those after the loss of a neonate. If the woman is not given an opportunity to deal with her grief, there may be continuing feelings of sadness, inadequacy and fearfulness as well as impairment in the relationships with her spouse and children. Methods of helping the couple during this time include acknowledging the significance of the loss, providing information, permitting the couple to see the fetus, if desired, and suggesting a memorial service. Some women may require individual or group therapy to deal with their feelings.     

The breakdown of Tetrahymena ribosomes in vivo. The effects of inhibitors.

1. When Tetrahymena were deprived of nutrients 50% of the polysomes disaggregated within 20 min and 20% of the total RNA broke down in 2 h. Ribosomal RNA accounted for 75% of the RNA breakdown. 2. RNA labelled by a long incubation with [14C]uridine was stable in growing cells and in the presence of actinomycin D, but broke down at the same rate as bulk RNA in starved cells. 3. The following substances inhibited the loss of RNA during starvation: cycloheximide (which inhibited both polysome disaggregation and protein synthesis), inhibitors of energy metabolism and puromycin (all of which caused polysome disaggregation and inhibited protein synthesis), and chloroquine and 7-amino-1-chloro-3-L-tosylamidoheptan-2-one ('TLCK') (neither of which affected polysomes or protein synthesis). 4. Starvation appears to activate a ribosome degradation mechanism that may involve lysosomal and non-lysosomal enzymes.     

The effects of diseases on competing species.

In this paper we study the dynamics of two competing species when one of them is subject to a disease. In order to keep the model simple, we present it under the strong assumption that the disease cannot cross the species barrier. We answer several important questions about the long term behavior of the environment. In this situation, no population is necessarily wiped out. Also, not every individual of the infected species is bound to contract the disease. Finally, disease-induced persistent cycles for the populations are admissible.     

The effects of mefloquine on Escherichia coli.

Mefloquine, a quinoline-4-methanol antimalarial drug, also possesses bactericidal activity. Mefloquine causes rapid loss of bacterial viability, cell and spheroplast lysis, cessation of macromolecular synthesis, release of macromolecular constituents, and inhibition of the oxidation of NADH by isolated $\text{E. coli}$ membranes. Results are consistent with the hypothesis that mefloquine is a membrane-active drug.     

The effects of x-radiation on Taenia pisiformis.

Following the exposure of eggs of T. pisiformis to X-radiation at doses of 10,000, 20,000 and 30,000 rads, hatching and activation in vitro were unaffected. Growth of larvae both in vitro and in vivo was reduced and many irradiated larvae were overcome by the host inflammatory reaction during intra-hepatic development. A negative correlation was established between the log₁₀ number of cysticerci in the abdominal cavities of rabbits 42 days after infection and the radiation dose. Significant abnormalities were induced in the morphology of rostellar hooks of cysticerci following irradiation of eggs although adult cestodes which developed from cysticerci derived from irradiated eggs were normal. Cysticerci exposed to 5000 and 10,000 rads of X-radiation developed to adult worms when fed to dogs but abnormalities were found, principally in the testes, ovaries and vitellaria; segmentation and the genital ducts were affected to a lesser extent.     

The effects of luteinizing hormone releasing hormone (LH-RH) in pregnant rats. I. Postnidatory effects.

The effects of LH-RH on pregnancy in rats were investigated. A single 500 mcg injection of LH-RH on Days 9, 10, or 11 of pregnancy terminated pregnancy, whereas injection on Days 6-8 or 13-16 had little or no effect. The ED 50 on Day 10 for b.i.d. administration was 150 mcg and 550 mcg for a single injection. Administration on Day 9 was followed by a decrease in circulating progesterone levels on Days 10 and 11. The administration of large doses of progesterone reversed the effects of LH-RH administration on Days 7-12. Treatment with estradiol-17beta did not potentiate the effect of progesterone, but appeared to slightly retard fetal resorption when administered alone. The results suggest that the antifertility effect of LH-RH is mediated via functional luteolysis.