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Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta 总被引:2,自引:0,他引:2
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Joo M Hahn YS Kwon M Sadikot RT Blackwell TS Christman JW 《Journal of virology》2005,79(12):7648-7657
In addition to hepatocytes, hepatitis C virus (HCV) infects immune cells, including macrophages. However, little is known concerning the impact of HCV infection on cellular functions of these immune effector cells. Lipopolysaccharide (LPS) activates IkappaB kinase (IKK) signalsome and NF-kappaB, which leads to the expression of cyclooxygenase-2 (COX-2), which catalyzes production of prostaglandins, potent effectors on inflammation and possibly hepatitis. Here, we examined whether expression of HCV core interferes with IKK signalsome activity and COX-2 expression in activated macrophages. In reporter assays, HCV core inhibited NF-kappaB activation in RAW 264.7 and MH-S murine macrophage cell lines treated with bacterial LPS. HCV core inhibited IKK signalsome and IKKbeta kinase activities induced by tumor necrosis factor alpha in HeLa cells and coexpressed IKKgamma in 293 cells, respectively. HCV core was coprecipitated with IKappaKappabeta and prevented nuclear translocation of IKKbeta. NF-kappaB activation by either LPS or overexpression of IKKbeta was sufficient to induce robust expression of COX-2, which was markedly suppressed by ectopic expression of HCV core. Together, these data indicate that HCV core suppresses IKK signalsome activity, which blunts COX-2 expression in macrophages. Additional studies are necessary to determine whether interrupted COX-2 expression by HCV core contributes to HCV pathogenesis. 相似文献
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Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli 总被引:5,自引:0,他引:5
Pei L Castrillo A Chen M Hoffmann A Tontonoz P 《The Journal of biological chemistry》2005,280(32):29256-29262
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Multiple cis Regulatory Elements Control RANTES Promoter Activity in Alveolar Epithelial Cells Infected with Respiratory Syncytial Virus
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Antonella Casola Roberto P. Garofalo Helene Haeberle Todd F. Elliott Rongtuan Lin Mohammad Jamaluddin Allan R. Brasier 《Journal of virology》2001,75(14):6428-6439
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The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. 总被引:22,自引:0,他引:22
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Ju-Ming Wang Jyh-Rong Chao Wannhsin Chen Min-Liang Kuo Jeffrey J.-Y. Yen Hsin-Fang Yang-Yen 《Molecular and cellular biology》1999,19(9):6195-6206
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