共查询到20条相似文献,搜索用时 15 毫秒
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Ligoxygakis P Bray SJ Apidianakis Y Delidakis C 《Development (Cambridge, England)》1999,126(10):2205-2214
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Two modes of recruitment of E(spl) repressors onto target genes 总被引:9,自引:0,他引:9
Giagtzoglou N Alifragis P Koumbanakis KA Delidakis C 《Development (Cambridge, England)》2003,130(2):259-270
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F. Gigliani F. Longo L. Gaddini P. A. Battaglia 《Molecular & general genetics : MGG》1996,251(6):628-634
TheEnhancer of split andachaete-scute gene complexes [E(spl)-C and AS-C] encode helix-loop-helix proteins required for neurogenesis inDrosophila. Using a heterologous bacterial system, we show that (i) the bHLH domains of the proteins encoded by the two gene complexes differ in their ability to form homo- and/or heterodimers; (ii) the bHLH domains of the E(spl)-C proteins m5, m7 and m8 interact with the bHLH domains of the Ac and Sc proteins. These bHLH domains form an interaction network which may represent the molecular mechanism whereby the competent state of the proneural cells is maintained until the terminal determination to neuroblast occurs. Also, the pattern of interactions of the bHLH domains of certain proteins encoded by the two gene complexes may explain their functional redundancy. 相似文献
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F. Gigliani F. Longo L. Gaddini P. A. Battaglia 《Molecular genetics and genomics : MGG》1996,251(6):628-634
TheEnhancer of split andachaete-scute gene complexes [E(spl)-C and AS-C] encode helix-loop-helix proteins required for neurogenesis inDrosophila. Using a heterologous bacterial system, we show that (i) the bHLH domains of the proteins encoded by the two gene complexes differ in their ability to form homo- and/or heterodimers; (ii) the bHLH domains of the E(spl)-C proteins m5, m7 and m8 interact with the bHLH domains of the Ac and Sc proteins. These bHLH domains form an interaction network which may represent the molecular mechanism whereby the competent state of the proneural cells is maintained until the terminal determination to neuroblast occurs. Also, the pattern of interactions of the bHLH domains of certain proteins encoded by the two gene complexes may explain their functional redundancy. 相似文献
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HES and HERP families: multiple effectors of the Notch signaling pathway 总被引:38,自引:0,他引:38
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Nagel AC Apidianakis Y Wech I Maier D Delidakis C Preiss A 《Mechanisms of development》2000,98(1-2):19-28
The E(spl) complex (E(spl)-C) contains three different classes of genes that are downstream of Notch signaling. The bHLH genes mediate the Notch signal by repressing proneural gene activity, for example during the singularization of mechanosensory organ precursor cells (SOPs). Genes of the second class, the E(spl) m4/malpha family, antagonize this process if overexpressed. Here we show that this is based on dominant-negative effects since RNA interference gives neurogenic phenotypes indistinguishable from E(spl)-C mutations. Furthermore, a third member of the m4/malpha gene family, named bbu/tom, behaves differently with respect to RNA expression patterns, its regulation by Notch signaling and loss of function phenotypes. 相似文献
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