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1.
Methods for Life Cycle Impact Assessment have to cope with two critical aspects, the uncertainty in values and the (unknown) system behaviour. LCA methodology should cope explicitly with these subjective elements. A structured aggregation procedure is proposed that differentiates between the technosphere and the ecosphere and embeds them in the valuesphere. LCA thus becomes a decision support system that models and combines these three spheres. We introduce three structurally identical types of LCA, each based on one coherent but different set of values. These sets of values can be derived from the Cultural Theory and are labeled as ‘egalitarian’, ‘individualistic’, and ‘hierarchic’. Within Life Cycle Impact Assessment, a damage oriented assessment model is complemented with both a newly developed precautionary indicator designed to address unknown damage and an indicator for the manageability of environmental damages. The indicators for unknown damage and for manageability complete the set of indicators judged to be relevant by decision makers. The weights given to these indicators are also value-dependent. The framework proposed here answers the criticisms that present LCA methodology does not strictly enough separate subjective from objective elements and that it fails to accurately model environmental impacts.  相似文献   

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Acknowledgement  Thanks are due to Drs. Paul Johnston (P.Johnston@ exeter.ac.uk) and E. William Beese (ebeese@t-online.de) for kindly providing dictionary definitions and for sharing their thoughts about the correct use of ‘data’.  相似文献   

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Background, aim and scope  

‘Streamlined’ life cycle assessment (LCA) tools hold out the possibility of providing LCA information quickly and easily in order to support a variety of decision-making environments and situations. The utility of such tools is closely related to the accuracy needs and possibilities, and the particular decisions to be supported. In order to facilitate the provision and application of LCA information in decision making during packaging design, development and utilisation, there is a prima facia case for a ‘streamlined’ LCA tool, provided it meets a set of requirements, including functionality, accuracy, validity, reliability and usability.  相似文献   

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We critically review the use of the term “life history theory” in recent publications on evolutionary psychology, focusing on how the idea of a fast-slow continuum is deployed in that literature. We raise four issues:First, concerning plasticity, should we expect the effects of plasticity on the developmental response of a trait to mirror the effects of selection on the mean of that trait? We conclude that we should not. Do only plastic responses to harsh or unpredictable environments accelerate maturation, or are there plausible alternatives, such as nutrition? In many situations better nutrition is a plausible alternative.Second, how should we conceive of the harshness of an environment? It has several important dimensions. It could mean an increase in the mean mortality rate, a decrease in the mean growth rate or fertility rate, or increases in the variances of any of those rates. Our judgement of harshness will also be affected by the distribution of such effects across patches in space and through generations in time. The combination and distribution of effects make important differences to predictions.Third, where did the fast-slow idea come from, and how much does it explain? It was initially detected in comparisons across higher taxonomic levels, whose relevance to variation among individuals is unclear and where it fails to explain much of the variation.Fourth, what sorts of processes could generate the fast-slow pattern? Here we expand on insights mentioned earlier in passing to make clear how spatial population structure and class effects generate alternative predictions.We conclude with some thoughts on the nature of theories and research strategies and on how one might respond to empirical puzzles.  相似文献   

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The 62nd life cycle assessment (LCA) forum was held on 9 September 2016 to discuss the state of research and application with regard to consequential life cycle assessment. This conference report presents the highlights of the LCA forum. The state of the art of consequential LCA was presented from different viewpoints. It was pointed out that consequential LCA is more than marginal mixes and avoided burdens and involves causal modelling. It was also said that social responsibility calls for consequential LCA. Currently, different models are used to support decision making. It was suggested to make use of the variety of models to check the conclusiveness of their results and thus the reliability of the LCAs. Current and future implementations of consequential LCI models in background databases and linking algorithms were presented. Several speakers presented consequential LCA case studies covering the sectors energy, transport, housing and mining. Some of the LCA models used in the case studies are complemented with general and partial computable equilibrium models and agent-based models and use environmentally extended input-output data or process-based LCA data. Some of the presentations focused on elements such as constrained production, marginal market mixes and technologies or recycling and system expansion. In three parallel workshops, the needs, contents and methodology, and implementation of consequential LCA approaches were discussed. The participants seemed to generally agree on the basic goal that LCA should be able to reflect the consequences of decisions. The inquiry among the participants showed that the demand for consequential LCA studies is hardly existent. The appropriate implementation of consequential modelling in LCA databases and on the appropriate model to be used in consequential LCA case studies was debated. It revealed a need for further and extensive discussions to be able to reach (minimum) consensus.  相似文献   

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Summary Studies of four combinations of Nicotiana involving four species, N. langsdorffii (N. l.), N. alata (N. a.), N. glutinosa (N. g.) and N. tabacum (N. t.), have shown that parthenogenetic haploid and diploid maternal individuals may arise with the use of male gametes (pollen) treated with high doses of ionising radiation in plants, similar to that found in animals (Hertwig Effect). At lower doses (10–20 Kr) rapidly diminishing numbers of seedlings were produced and many of these died soon after germination or before reaching maturity. In the intraspecific combination N. l. × N. l., viable seeds were produced only at the lower doses of 10 and 15 Kr. In the interspecific combination N. l. × N. a., at lower doses, all plants that came to bloom showed variable hybrid morphology. There were no plants resembling the female parent. In the combination N.t. × N.a., at lower doses there were rare surviving plants which were maternal dihaploid (1 plant out of 4 at 15 Kr) or tetraploid N. tabacum (all 5 plants at 20 Kr). All surviving plants at higher doses (50 and 100 Kr) were maternal tetraploids. In the combination N.t.×N.g., plants produced at lower than 20 Kr were almost all either aneuploid or triploid hybrids. Dihaploid, maternal N. tabacum plants appeared at 20 Kr and higher doses. After 50 Kr the large proportion of plants produced were maternal dihaploid or tetraploid N. tabacum.  相似文献   

9.
The amplification mechanism of short interfering RNAs (siRNAs) along the transgene sequence exists in RNA interference (RNAi). The RNA-dependent RNA polymerase synthesizes complementary RNAs by using the transgene mRNA as a template, and the secondary siRNAs are generated from the outside of primary RNAi target. Four independent RNAi vectors which produced primary siRNAs against distinct regions of the tobacco endoplasmic reticulum ω-3 fatty acid desaturase gene (NtFAD3) were transiently expressed in leaves of theNtF4D3-overexpressed transgenic plants. Regardless of the RNAi vector used, the secondaryNtFAD3 siRNAs were generated preferentially from the 3’ downstream region of the transgene. Secondary siRNAs from the 5’ upstream region adjacent to the annealing site of primary siRNAs accumulated under the detection level. Our results suggest that different regulatory mechanisms are involved in the spreading of RNA silencing into 5’ upstream and 3’ downstream regions of the target sequence, respectively.  相似文献   

10.
There continues to be a critical need for developing data-informed computational modeling techniques that enable systematic evaluations of mitral valve (MV) function. This is important for a better understanding of MV organ-level biomechanical performance, in vivo functional tissue stresses, and the biosynthetic responses of MV interstitial cells (MVICs) in the normal, pathophysiological, and surgically repaired states. In the present study, we utilized extant ovine MV population-averaged 3D fiducial marker data to quantify the MV anterior leaflet (MVAL) deformations in various kinematic states. This approach allowed us to make the critical connection between the in vivo functional and the in vitro experimental configurations. Moreover, we incorporated the in vivo MVAL deformations and pre-strains into an enhanced inverse finite element modeling framework (Path 1) to estimate the resulting in vivo tissue prestresses \((\sigma _\mathrm{CC}\cong \sigma _\mathrm{RR}\cong \, 30\,\hbox {kPa})\) and the in vivo peak functional tissue stresses \((\sigma _\mathrm{CC}\cong 510\, \hbox {kPa}, \sigma _\mathrm{RR}\cong 740\, \hbox {kPa})\). These in vivo stress estimates were then cross-verified with the results obtained from an alternative forward modeling method (Path 2), by taking account of the changes in the in vitro and in vivo reference configurations. Moreover, by integrating the tissue-level kinematic results into a downscale MVIC microenvironment FE model, we were able to estimate, for the first time, the in vivo layer-specific MVIC deformations and deformation rates of the normal and surgically repaired MVALs. From these simulations, we determined that the placement of annuloplasty ring greatly reduces the peak MVIC deformation levels in a layer-specific manner. This suggests that the associated reductions in MVIC deformation may down-regulate MV extracellular matrix maintenance, ultimately leading to reduction in tissue mechanical integrity. These simulations provide valuable insight into MV cellular mechanobiology in response to organ- and tissue-level alternations induced by MV disease or surgical repair. They will also assist in the future development of computer simulation tools for guiding MV surgery procedure with enhanced durability and improved long-term surgical outcomes.  相似文献   

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X-ray fluorescence microscopy was applied for two-dimensional elemental analysis of substantia nigra (SN) tissue. The samples representing Parkinson’s disease (PD) and control cases were examined at HASYLAB beamline L and at ESRF beamline ID22. Two-dimensional mapping of P, S, Cl, K, Ca, Fe, Cu, Zn, Se and Br was done with the spatial resolution of 15 and 5 μm. The masses per unit area of elements in neuromelanin reach nerve cells of SN were determined.The elemental data were processed using two multivariate techniques, namely cluster and discriminant analysis. The statistical methods were used for data reduction, both unsupervised and supervised classification as well as for the creation of a model that would simplify case identification based on the elemental analysis of SN tissue. The results of cluster analysis confirmed the statistical significance of the differences in elemental composition of PD and control SN nerve cells. Based on the results of discriminant analysis, the elements (P, Cl, Fe, Cu and Zn) that played the greatest role in the process of differentiation between neurons from examined groups were determined.  相似文献   

15.
Alzheimer’s disease (AD) is the leading cause of dementia. The two histopathological markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and neurofibrillary tangles of aggregated, abnormally hyperphosphorylated tau protein. The majority of AD cases are late-onset, after the age of 65, where a clear cause is still unknown. However, there are likely different multifactorial contributors including age, enviornment, biology and genetics which can increase risk for the disease. Genetic predisposition is considerable, with heritability estimates of 60–80%. Genetic factors such as rare variants of TREM2 (triggering receptor expressed on myeloid cells-2) strongly increase the risk of developing AD, confirming the role of microglia in AD pathogenesis. In the last 5 years, several studies have dissected the mechanisms by which TREM2, as well as its rare variants affect amyloid and tau pathologies and their consequences in both animal models and in human studies. In this review, we summarize increases in our understanding of the involvement of TREM2 and microglia in AD development that may open new therapeutic strategies targeting the immune system to influence AD pathogenesis.  相似文献   

16.
This research explores the role of opinion-based groups in understanding responses to racist violence such as the 2005 Cronulla riots in Australia. Traditionally, explanations of collective action in social psychology and sociology focus on conflict between broad social categories. We propose that the responses to the riots can be understood not only as inter-group conflict between Muslims and non-Muslims, or an in-group argument amongst non-Muslims, but as a bona fide inter-group conflict between supporters and opponents of the riots. We argue that these groups use rhetoric in attempts to claim dominant status within society by aligning their identities with positively valued social categories such as ethnicities and national identities. The analysis of rhetoric from the groups supporting and opposing the riots demonstrates consistent, albeit contested, attempts to align support for the riot with the Australian national category in conflict with countervailing attempts to align opposition to the riot with the same national category.  相似文献   

17.
Controlled fermentation of maize was carried out using six strains of Lactobacillus fermentum and one strain of yeast, Saccharomyces cerevisiae, isolated from traditionally fermented maize dough as starter cultures for inoculum enrichement. The fermentations were monitored by pH, acidity, microbiological analysis and taste panel evaluation of two products, kenkey and koko, prepared from the fermented doughs. The strains of L. fermentum used as starter culture dominated the microflora during fermentation and in most inoculated doughs the required pH was attained by 24 h instead of 48 h of dough fermentation. Higher contents of lactic acid bacteria and yeasts were observed in inoculated doughs at the initial stages of fermentation but the spontaneously fermented doughs attained similar lactic acid bacteria and yeasts counts by 24 h of dough fermentation. The organoleptic quality of kenkey and koko prepared from doughs fermented with starter culture for 48 h was not significantly different from the traditional products. Kenkey prepared from doughs fermented for 24 h with starter culture were found to be unacceptable by the taste panel although similarly produced koko was acceptable.The authors are with the Food Research Institute, Council for Scientific and Industrial Research, P.O Box M 20. Accra, Ghana.  相似文献   

18.
Species distribution models (SDMs) in river ecosystems can incorporate climate information by using air temperature and precipitation as surrogate measures of instream conditions or by using independent models of water temperature and hydrology to link climate to instream habitat. The latter approach is preferable but constrained by the logistical burden of developing water temperature and hydrology models. We therefore assessed whether regional scale, freshwater SDM predictions are fundamentally different when climate data versus instream temperature and hydrology are used as covariates. Maximum entropy (MaxEnt) SDMs were built for 15 freshwater fishes using one of two covariate sets: 1) air temperature and precipitation (climate variables) in combination with physical habitat variables; or 2) water temperature, hydrology (instream variables) and physical habitat. Three procedures were then used to compare results from climate vs instream models. First, equivalence tests assessed average pairwise differences (site‐specific comparisons throughout each species’ range) among climate and instream models. Second, ‘congruence’ tests determined how often the same stream segments were assigned high habitat suitability by climate and instream models. Third, Schoener's D and Warren's I niche overlap statistics quantified range‐wide similarity in predicted habitat suitability from climate vs instream models. Equivalence tests revealed small, pairwise differences in habitat suitability between climate and instream models (mean pairwise differences in MaxEnt raw scores for all species < 3 × 10–4). Congruence tests showed a strong tendency for climate and instream models to predict high habitat suitability at the same stream segments (median congruence = 68%). D and I statistics reflected a high margin of overlap among climate and instream models (median D = 0.78, median I = 0.96). Overall, we found little support for the hypothesis that SDM predictions are fundamentally different when climate versus instream covariates are used to model fish species’ distributions at the scale of the Columbia Basin.  相似文献   

19.
Plant Use by the Q’eqchi’ Maya of Belize in Ethnopsychiatry and Neurological Pathology. Economic Botany 59(4):326–336, 2005. Neurological and mental health disorders are extremely debilitating, and sufferers in developing countries often rely on traditional practitioners for these medical needs. Few studies have focused on botanical remedies used in this context, although these offer interesting treatment alternatives. The present study investigated plant use for the treatment of neurological and mental health disorders by Q'eqchi' Maya healers of southern Belize. We found that these healers generally recognize and treat epilepsy/seizures, headache, madness, fright (susto), depression, numbness, insomnia, and stress with herbal remedies. Quantitative analyses showed that there is selection for the use of certain species and botanical families, namely for species of the Pteridophyta division and for plants from the Piperaceae family. This study denotes the importance and selectivity of plant use by Q'eqchi' healers of southern Belize for the treatment of neurological and mental conditions and points to a possible underrepresentation of these disorders in the ethnobotanical literature.  相似文献   

20.

Purpose

In this study, life cycle assessment (LCA) is applied to a sample of 40 low-energy individual houses for the French context in order to identify guidance values for different environmental priorities (energy and water consumption, greenhouse gases emissions, waste generation etc.).

Methods

Calculation rules for the LCA derived from EeBGuide guidance and HQE Performance specific rules for the French context. Data are based on Environmental Product Declaration (EPD for the impacts related to products and technical equipment while generic data are used for energy and water processes. The LCA is defined for the entire life cycle of a building from cradle-to-grave according to NF EN 15978 standard. It includes the products and equipment implemented in the building, the different uses of energy for heating, domestic hot water, lighting, ventilation and auxiliaries, and the different uses of water consumption.

Results and discussion

Results for the 40 houses showed that the average life cycle non-renewable primary energy consumption is about 37 kWh/(m2*year) while the life cycle greenhouse gases emissions are of 8.4 kg CO2-eq/(m2*year). The embodied impacts represent between 40% and 72% for the following indicators: acidification, global warming, non-renewable primary energy, and radioactive waste. The net fresh water use is mostly determined by the direct use of the water in use, and the non-hazardous waste indicator is only linked to the materials and equipment. When integrating the variability of the different houses design, energy performance, climate requirements, it was found that those values can vary of an order of two between the 10 and 90% percentiles’ values. It was found that the results are also sensitive to the enlargement of the system boundaries (e.g. inclusion of the other uses of energy such as building appliances) and the modification of the reference study period.

Conclusions and recommendations

This study provided a first set of LCA guidance values describing a range of environmental impacts for new low-energy individual houses in France. Results were also reported for different design parameters, system boundaries and reference study period. The outcomes of this study can now serve as a basis to guide and support new LCA-based labelling systems developed by public authorities and labelling schemes (e.g. the HQE Association).
  相似文献   

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