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1.
Atomic absorption spectrophotometric method was used to determine the serum selenium levels of 86 healthy individuals. Variations
in age, sex, and geographically different urban regions of Yugoslavia were investigated.
A group of 63 healthy children, ages 8–15 yr, were examined. Mean±standard deviation of the serum selenium concentration was
57±9 μg/L; age and geographic area had no effect on the Se status of children, but the difference between boys and girls was
significant (P<0.05).
A group of 23 men from Zagreb, ages 22–37 yr, were examined. The group was divided into three age subgroups and no difference
was found among these groups. The mean Se concentration was 69±18 μg/L, and a statistically significant difference was found
only between the group of adults and the group of children (P<0.05). 相似文献
2.
Selenium is an essential trace element and its isufficient status may cause serious health complications for both individuals
and the whole populations. To investigate the selenium status of the subpop-ulation in northeastern Bohemia represented by
the region ústí nad Orlicí, 253 serum, 469 urine, and 31 hair samples from 470 randomly selected volunteers between 6 and
65 yr of age have been analyzed for selenium concentration. Serum and hair Se were detected by instrumental neutron activation
analysis (means: 55 ±11 Μg Se/L sera, 0.268 ±0.040 Μg Se/g hair). Urine Se was measured by fluorimetry (12 ±5 Μg Se/L urine)
with coanalyses of Lyphocheck urine, SRM Urine 2670, and Seronorm urine for quality control of the method. Results proved
significant age-dependent differences, but gender differences were not significant. The frequency plot of serum Se proved
maximal frequencies in adults between 55 and 70 Μg Se/L and in children in the range 45–55 Μg Se/L. The same plots of urine
Se for both age groups showed maximal frequency in the limits 8–15 Μg Se/L. All indices used (Se in serum, urine, and hair)
confirmed mild to severe selenium deficiency in the population of the region. 相似文献
3.
There is no data or literature on the effects of supplementing infants with yeast selenium, although its intestinal absorption
and bioavailability are higher in adults compared with other selenium compounds.
The aim of the present investigation was to study the impact of selenium enriched yeast on the serum selenium concentration
of preterm infants living in a low selenium area (Hungary).
Twenty-eight preterm infants with mean ± SD birth weight of 962 ± 129 g and gestational age 27 ± 1 wk were randomized into
two groups at birth with respect to selenium supplementation. In the supplemented group (n = 14) infants received 4.8 mg yeast selenium containing 5 μg selenium daily via nasogastric drip during the first 14 postnatal
days. The nonsupplemented infants were used as a reference group.
In the supplemented group, the serum selenium concentration increased from 32.1 ± 8.5 μg/L to 41.5 ± 6.5 μg/L and in the nonsupplemented
group it decreased from 25.9 ± 6.8 μg/L to 18.2 ± 6.4 μg/L from birth in two weeks time. Compared with previous studies, our
results suggest that the bioavailability of selenium in the form of yeast selenium is higher than that of other selenium compounds
used for preterm infants. We did not observe any complications or side-effects owing to enterai yeast selenium supplementation.
We conclude that selenium enriched yeast is a safe and an effective form of short-term enterai selenium supplementation for
infants. 相似文献
4.
The serum selenium (Se) concentrations were determined to be 105.6±15.6 μg/L (
) and 116.7±18.4 μg/L (
) for the ovarian cancer patients and the control subjects in Singapore, respectively (p<0.0065). When we separated the patients into three age groups, namely <30, 30–50, and >50 yr, the ovarian cancer patients
showed significantly lower mean serum Se levels than the control subjects for the 30–50-yr age group only. However, when the
analysis of variance was used to evaluate the data, the values indicated that the age of the subject did not significantly
affect the serum Se level. Our findings suggest that there is an inverse relationship between serum Se concentration and the
incidence of human ovarian cancer.
A modified simple fluorimetric method for the determination of serum Se concentration is described. The procedure, with a
sensitivity limit of 5 μg/L and percentage recoveries of 96.2–100.7%, requires only 0.2 mL of serum sample. 相似文献
5.
Helle M. Meltzer Karen Bibow Irene T. Paulsen Håvard H. Mundal Gunnar Norheim Halvor Holm 《Biological trace element research》1993,36(3):229-241
The bioavailabilities of selenium (Se) from Se-rich fish species and Se-rich wheat were compared in a study involving 32 healthy
volunteers. Initial serum Se values were 109±16 μg/L (mean±SD). For 6 wk, one group (n=11) included Se-rich bread in their diet, bringing daily average intake of Se up to 135±25 μg/d. Another group (n=11) consumed Se-rich fish daily (average Se intake: 115±31 μg/d), whereas the control group (n=10) ate their normal diet, providing 77±25 μg Se/d. Serum Se increased by 17% (P<0.01), and platelet Se increased by 30% (P<0.01) in the wheat group. Although platelet Se decreased by 11% in the fish group, no changes in serum and platelet Se in
the fish or control group reached statistical significance. Glutathione peroxidase (EC 1.11.1.9; GSH-Px) activity in serum
and platelets did not change during the study, nor did platelet mercury (Hg) content. Since the dietary intake of Hg, arsenium
(As), and fatty acids could not satisfactorily explain the lack of response in the fish group, the results are indicative
of low bioavailability of fish Se in humans. At present, wheat Se seems to be the most important factor contributing to the
body stores of Se in this study population.
Dr. Norheim died on January 9, 1991. 相似文献
6.
Plasma molybdenum concentrations were determined in children, ages two to 12 yr, with and without phenylketonuria (PKU). Mean
plasma molybdenum concentrations did not differ significantly between the children with PKU (1.33±0.5 μg/L) and without PKU
(1.75±0.8 μg/L). Plasma molybdenum concentrations in both groups of children ranged from <1 to 3 μg/L.
When data from all children were combined and then separated based on gender, mean plasma molybdenum levels did not differ
significantly between 9 females (1.56±0.68 μg/L) and 12 males (1.58±0.76 μg/L). Data were also combined and mean (±SD) plasma
molybdenum concentrations calculated for age groups. Two children aged 1 to <4 yr had plasma molybdenum concentrations of
1.0 μg/L, and six children aged 4 to <7 yr had mean (±SD) plasma molybdenum concentrations of 1.5±0.8 μg/L. Eleven children
aged 7 to <11 yr had a mean plasma molybdenum concentration of 1.7±0.7 μg/L, and two children 11 to <14 yr had plasma molybdenum
concentrations of 1 μg/L and 2 μg/L. Plasma molybdenum concentrations did not differ significantly among children in the age
groups. 相似文献
7.
Selenium deficiency in yugoslavia 总被引:1,自引:0,他引:1
Zoran J. Maksimović Ivana Djujić Vidojko Jović Mihailo Ršumović 《Biological trace element research》1992,33(1-3):187-196
Data on selenium (Se) deficiency in Yugoslavia are presented. The results include Se content of soil, cereal crops, and garlic
grown in these soils, and human serum and scalp hair from several towns and regions. All data indicate a serious Se deficiency:
soil (n=140), the mean value of 200±69.6 μg/kg Se; wheat, (58)
= 20.5 ± 12.4 μg/kg; corn, (79)
= 13.7 ± 13.6 μg/kg; and garlic, (66)
= 13.7 ± 17.1 μg/kg Se. Analyses of human tissue show a very low Se status of the Yugoslav population: serum, (n=875)
= 50.0 ± 18.0 μg/L and scalp hair, (388)
= 94 ± 16 μg/kg Se. In some regions, Se contents of grain, garlic, and human serum and hair are approaching those in the
low-Se belt in China. It is assumed that very low Se status of a human population could be a risk factor in the development
of Balkan Endemic Nephropathy (BEN) and in a high incidence of urinary tract tumors (UTT) in endemic areas.
A portion of these results were presented at the International Symposium on Selenium, Belgrade, May 12–15, 1991, Abstracts
p.1, Serbian Academy of Sciences and Arts. 相似文献
8.
Marie J. Richard Veronique Ducros Michel Rorêt Josiane Arnaud Charles Coudray Michèle Fusselier Alain Favier 《Biological trace element research》1993,39(2-3):149-159
In six chronic dialyzed uremic patients, an intravenous sodium selenite (Se 50 μg during 5 wk and then 100 μg) and zinc gluconate
(Zn 5 mg) supplementation was performed during 20 wk at each dialysis session three times weekly. Before supplementation,
plasma Se and Zn, plasma and erythrocytes (RBC) antioxidant metalloenzymes glutathione peroxidase (GPX), and superoxide dismutase
(SOD) were significantly decreased, whereas lipid peroxidation (as thiobarbituric acid reactants TBARs) was increased. To
obtain a significative change in plasma selenium, we had to use an Se dose of 100 μg/dialysis session. Then, treatment-increased
plasma Se (from 0.58 ±0.09 to 0.89±0.16 μmol/L) led to a repletion of RBC-GPX (from 29.6±6 to 43±5.8 U/g Hb) and increased
plasma GPX levels (from 62±13 to 151±43 U/L). Plasma Zn and RBC-SOD did not vary significantly. The change of TBARs was not
observed between wk 1 and 4. They decreased significantly between wk 4 (4.80±0.21μmol/L) and wk 20 (4.16±0.26 μmol/L). We
noted a low correlation between TBARs and plasma GPX. A strong correlation was observed between Se and plasma GPX. The reversal
of Se deficiencies should reduce oxidative damage observed in these patients. 相似文献
9.
Vlasta Korunová Zdenka Škodová Jiří Dědina Zdeněk Valenta Jiří Pařizek Zbyněk Píša Miroslav Stýblo 《Biological trace element research》1993,37(2-3):91-99
The serum selenium levels in 367 healthy adult (25–64 yr) Central Bohemia residents, 176 men and 191 women, were determined
using atomic absorption spectrometry. An extremely wide range of values was found in the whole population sample (<20–296
μg/L) as well as in each sex or age category studied. The mean selenium concentration and 95% confidence interval calculated
after logarithmic transformation of the data were 74 μg/L (71–77) for the whole population sample, 72 μg/L (67–76) for men,
and 76 μg/L (72–81) for women. About 10% of the residents exhibited serum selenium level below 45 μg/L. There was no significant
correlation between serum selenium and sex, age, or smoking status of participants. However, the lowest average level was
found in the group of heavy smoking women: 66 μg/L. The selenium status of the Central Bohemia population seems to be below
European average. Groups of residents having a very low nutritional selenium intake may be expected to occur in this population.
Dedicated to the memory of Jiří Pařízek, former head of environmental physiology research group of the Institute of Nuclear
Biology and Radiochemistry. 相似文献
10.
Characteristics of Se-Enriched Mycelia by Stropharia rugoso-annulata and its Antioxidant Activities in vivo 总被引:1,自引:0,他引:1
Zhen Song Le Jia Feng Xu Fanyun Meng Peng Deng Keming Fan Xiaonan Liu 《Biological trace element research》2009,131(1):81-89
Selenium (Se) is an essential trace element for humans and animals. Stropharia rugoso-annulata is a nutritional and functional mushroom containing many kinds of bioactive ingredients. The aims of this study were to investigate
the Se-enrichment characteristics of S. rugoso-annulata in submerged culture and evaluate the antioxidant activities of Se-enriched mycelia in vivo in terms of the values of glutathione
peroxidase (GSH-Px), superoxide dismutase (SOD), and malondialdehyde (MDA). The optimum parameters of Se-enrichment under
the optimal Se concentration (150 μg/mL) in media were as follows: biomass 8.11 ± 0.25 g/L, Se content in mycelia 4,727.68 ± 13 μg/g,
Se-accumulated rate 24.68 ± 1.67%, and percentage of organic Se 96.27 ± 3.26%. The mainly subsistent forms of selenium in
Se-enriched mycelia were selenoprotein and selenium-polysaccharide. The contents of total amino acids (TAA) and essential
amino acids (EAA) in Se-enriched mycelia were increased by 13.5 ± 1.09% and 12.8 ± 0.89%, respectively. It was efficient for
Se-enriched mycelia to elevate GSH-Px and SOD activities and decrease MDA content. These results indicated that Se-enriched
mycelia of S. rugoso-annulata represent a novel dietary source of bioavailable supplemental selenium. 相似文献
11.
Gurkan F Atamer Y Ece A Kocyigit Y Tuzun H Mete M 《Biological trace element research》2004,100(2):97-104
Thirty-four infants with acute bronchiolitis and 25 age-matched healthy controls were enrolled to investigate the possible
relationship between serum malondialdehyde (MDA) and selenium (Se) levels and the occurrence and severity of acute bronchiolitis
in children. Serum samples were taken for serum Se and MDA measurements, and the clinical score was assessed at admission.
Blood was taken again from the children with bronchiolitis at 2 mo after discharge from the hospital. Mean serum MDA levels
were significantly higher in patients with acute bronchiolitis than at the postbronchiolitis stage and the controls (4.2±2.5nmol./L,
1.4±0.8 nmol/L, and 0.7±0.2 nmol/L, respectively [p<0.001]). Infants with bronchiolitis had lower mean serum Se levels at the acute stage than after 2 mo (31.7±28.9μg/L versus
68.4±26.4 μg/L, p<0.05, respectively); both of which were significantly lower than the control group measurements (145.0±21.9 μg/L) (p<0.001). There was a negative correlation between serum MDA and Se levels in the patient group (=−0.85, p<0.001). The age of the patient, child's immunization status, parental smoking habit, and family crowding index were not correlated
with serum Se, MDA levels, or clinical score at admission.
In conclusion, increased MDA levels and impaired Se status demonstrate the presence of possible relationship of these parameters
with pathogenesis of acute bronchiolitis, and antioxidant supplementation with Se might be thought to supply a beneficial
effect against bronchiolitis. 相似文献
12.
Abdellatif Chakar Ridha Mokni Philippe Chappuis Jean-Louis Mahu Philip A. Walravens Fanny Bleiberg-Daniel Patrice Therond Jean Navarro Daniel Lemonnier 《Biological trace element research》1993,36(1):25-33
Plasma selenium (Se) concentration and erythrocyte glutathione peroxidase activity (GPx) were assessed in a population of
healthy preschool children two to five years old, residing in the city of Paris. In the 118 subjects, mean (±SD) plasma Se
concentration was 62.10 ±13.96 μg/L, and mean GPx activity was 23.58±8.52 U/g Hb. Mean plasma Se of male children was significantly
(p=0.001) higher (12%) than levels of girls. Plasma selenium levels were not correlated with erythrocyte GPx activity. Children
from Mediterranean origin had a slightly lower erythrocyte GPx activity (p<0.05) than children from other regions. Mean plasma Se concentration of this group corresponded to the lower limit of intervals,
which characterizes geographical regions of intermediate selenium concentrations. 相似文献
13.
Markus P. Look Jürgen K. Rockstroh Govind S. Rao Karl A. Kreuzer Ulrich Spengler Tilman Sauerbruch 《Biological trace element research》1997,56(1):31-41
Serum selenium levels were determined cross-sectionally in 57 HIV-infected patients who were classified according to the Centers
for Disease Control (CDC) 1993 classification system. Mean serum selenium levels were lower in CDC stage II (58.7±12.2 μg/L;p<0.01;n=18) and stage III (47.6±11.3 μg/L;p<0.01;n=19) HIV-infected patients, than in healthy subjects (80.6±9.6 μg/L;n=48) and stage I patients (73.6±16.5 μg/L;n=20). Serum selenium levels were positively correlated with CD4 count, CD4/8 ratio, hematocrit, and serum albumin (r=0.42;r=0.39;r=0.48; andr=0.45;p<0.01, respectively) and inversely with serum levels of thymidine kinase (r=−0.49;p<0.01;n=49) and β2-microglobulin (r=−0.46;p<0.001;n=49). In addition, serum selenium levels in 20 randomly selected AIDS-free individuals (CDC I:n=10; CDC II:n=10) were inversely correlated with serum concentrations of interleukin-8 (IL-8) and soluble tumor necrosis factor receptors
(sTNFR) types I and II. There was no correlation with serum immuneglobulin A and total serum protein levels. The results show
that the progressive deprivation of serum selenium in HIV-infection is associated with loss of CD4+-cells and with increased levels of markers of disease progression and inflammatory response. 相似文献
14.
Deficiencies in Cu, Se, and Zn impair one or more biochemical functions, and excess are associated with toxicity. Baseline
studies on the Ghanaian population are scanty. The study was undertaken to determine whether significant rural/urban differences
in the serum levels of Cu, Se, and Zn did exist. Forty males/60 females from rural and 50 males/50 females from urban Ghanaian
communities were sampled. Serum Cu, Se, and Zn were determined using flame atomic absorption spectrometry. Cu level for rural
and urban subjects was 997 ± 333 and 979 ± 290 μg/L, respectively (p = 0.68). However, Cu levels were significantly higher in the rural females (1,063 ± 367 μg/L) than the rural males (898 ± 249 μg/L;
p = 0.0085). Se levels for rural/urban subjects were 97 ± 36 and 87 ± 31 μg/L, respectively (p = 0.03). Zn levels in the rural/urban subjects were 312 ± 218 and 150 ± 102 μg/L, respectively (p = 0.002). Additionally, Zn was significantly higher in rural females (428 ± 204 μg/L) than the urban females (166 ± 103 μg/L;
p = 0.0002). Finally, Zn was significantly higher in rural females (428 ± 204 μg/L) than males (172 ± 116 μg/L; p = 0.0028). In conclusion, Cu, Se, and Zn were higher in the rural group compared to the urban group, and the generally low
Zn levels were confirmed in another cohort follow-up study. 相似文献
15.
A. B. Serra S. D. Serra K. Nakamura E. A. Orden L. C. Cruz T. Fujihara 《Biological trace element research》1996,55(1-2):207-212
Soluble glass bolus (SGB) with selenium (Se) was administered intraruminally to Se-deficient Philippine does to determine
its effect on milk Se and to correlate the Se contents of does' milk and blood of does and kids. Five months after the Se
administration, the does in the treated group (n=14) had higher (p<0.01) Se content in their blood (62.2 vs 25.7 μg/L) and milk (5.1 vs 2.5 μg/L) than does in control group (n=13). Consequently, the blood Se of the kids (n=14) from the treated does was higher (p<0.05) than those kids (n=13) in the control group (28.0 vs 5.1 μg/L). Blood and milk Se of does and blood Se of their kids correlated (p<0.01) with each other. The increased Se level of does' milk because of Se supplementation was not regarded as a health hazard
to humans. 相似文献
16.
Maryam Pakfetrat Leila Malekmakan Mahshid Hasheminasab 《Biological trace element research》2010,137(3):335-339
In this cross-sectional study, selenium (Se) levels in the sera of 35 hemodialysis (HD) patients and 34 patients undergoing
continuous ambulatory peritoneal dialysis (CAPD) for more than 3 months were compared with the serum Se levels of 34 healthy
volunteers. The observed Se levels of 100.8 ± 51.9 μg/L in the sera of the HD patients and of 65.5 ± 32.1 μg/L in the sera
of the CAPD patients were significantly lower than the 134.9 ± 81.2 μg/L of the controls, with p = 0.002 and 0.02, respectively. Furthermore, the Se levels were significantly higher in the HD rather than the CAPD patients
(p = 0.01). In the spent dialysate effluent fluid of 32 of the CAPD patients Se was undetectable, in the remaining two CAPD
patients the Se levels were 1.9 and 4.6μg/l, respectively. The low Se levels of HD and CAPD patients as compared to healthy
persons are attributed to diminished Se retention due to chronic oxidative stress. 相似文献
17.
Matti Tolonen Seppo Sarna Markku Halme Seppo E. J. Tuominen Tuomas Westermarck Ulla-Riitta Nordberg Mirja Keinonen Jaap Schrijver 《Biological trace element research》1988,17(1):221-228
An “anti-oxidant cocktail” consisting of betacarotene, vitamins B6, C, E, zinc, and selenium or corresponding placebos were given for one y as daily dietary supplements to 45 elderly residents
of a nursing home. Initially, the serum TBA reactant levels were higher (2.7±0.7 μmol/L) than those of an ad hoc control group
of healthy younger adults (2.3±0.6 μmol/L),p<0.01. After three mo supplementation, the levels among the verum elderly had decreased to 2.2±0.6 μmol/L, and they remained
at this lower level until the end of the study period, whereas the placebo group showed no change.
A significant inverse correlation (r=−0.428,p<0.01) existed between the concentrations of serum TBA reactants and whole blood selenium (B-Se), but only B-Se levels above
200 μg/L were associated with a decrease in serum lipid peroxides. Serum alpha-tocopherol concentration also correlated inversely
with serum TBA reactants but this correlation (r=−0.273,p<0.76) was not as strong as that of B-Se.
Deficient vitamin B6 status, in biochemical terms, was observed in 25% of the elderly; a daily supplement of 2 mg B6 fully cured all cases of deficiency. The verum group improved slightly in several psychological tests, whereas subjects on
placebo remained unchanged or deteriorated during the follow-up period. Clinical amelioration among the verum subjects was
reported by the nurses; no toxic side effects were reported. In conclusion, the elderly benefited biochemically and clinically
of dietary antioxidant supplements. 相似文献
18.
A procedure using open digestion followed by flame atomic absorption spectrometry is described for measuring the total selenium
content of Se-enriched yeast. The limits of detection and quantitation were 2.5 mg/L and 5 mg/L Se, respectively. The signal
response was linear over the range of 5–50 mg/L Se, and the average recovery from spiked samples was 98.9%. The validated
method was used to measure the Se content of Se-enriched yeast reference material and produced a result of 2145±38 mg/kg (n=3), which is in good agreement with the certified level of 2125 ±65 mg/kg. 相似文献
19.
20.
Marques RC de Sousa AF do Monte SJ Oliveira FE do Nascimento Nogueira N Marreiro DN 《Biological trace element research》2007,120(1-3):11-18
Studies have evidenced that zinc metabolism is altered in presence of Down syndrome, and zinc seems to have a relationship
with the metabolic alterations usually present in this syndrome. In this work, the Zn-related nutritional status of adolescents
with Down syndrome was evaluated by means of biochemical parameters and diet. A case–control study was performed in a group
of adolescents with Down syndrome (n = 30) and a control group (n = 32), of both sexes, aged 10 to 19 years. Diet evaluation was accomplished by using a 3-day dietary record, and the analysis
was performed by the NutWin program, version 1.5. Antropometric measurements were performed for evaluation of body composition.
The Zn-related nutritional status of the groups was evaluated by means of zinc concentration determinations in plasma and
erythrocytes, and 24-h urinary zinc excretion, by using the method of atomic absorption spectroscopy. The diet of both groups
presented adequate concentrations of lipids, proteins, carbohydrates, and zinc. The mean values found for zinc concentration
in erythrocytes were 49.2 ± 8.5 μg Zn/g Hb for the Down syndrome group and 35.9 ± 6.1 μg Zn/g Hb for the control group (p = 0.001). The average values found for zinc concentration in plasma were 67.6 ± 25.6 μg/dL for the Down syndrome group and
68.9 ± 22.3 μg/dL for the control group. The mean values found for zinc concentration in urine were 244.3 ± 194.9 μg Zn/24 h
for the Down syndrome group and 200.3 ± 236.4 μg Zn/24 h for the control group. Assessment of body composition revealed overweight
(26.7%) and obesity (6.6%) in the Down syndrome group. In this study, patients with Down syndrome presented altered zinc levels
for some cellular compartments, and the average zinc concentrations were low in plasma and urine and elevated in erythrocytes. 相似文献