共查询到20条相似文献,搜索用时 21 毫秒
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Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis 总被引:11,自引:0,他引:11
Aberg T Wang XP Kim JH Yamashiro T Bei M Rice R Ryoo HM Thesleff I 《Developmental biology》2004,270(1):76-93
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MamoruIshii KeikoMitsunaga-Nakatsubo TakashiKitajima ShinichiroKusunoki HirakuShimada KojiAkasaka 《Development, growth & differentiation》1999,41(3):241-252
In spite of their potential importance in evolution, there is little information about Hox genes in animal groups that are related to ancestors of deuterostome. It has been reported that only two Hox genes (Hbox1 and Hbox7) are expressed significantly in sea urchin embryos. Expression of Hbox1 protein is restricted to the aboral ectoderm, and Hbox7 expression is restricted to oral ectoderm, endoderm and secondary mesenchyme cells in sea urchin embryos after the gastrula stage. With the aim of gaining insight into the role of Hbox1 and Hbox7 in sea urchin development, Hbox1 and Hbox7 overexpression experiments were performed. Overexpression of Hbox1 repressed the development of oral ectoderm, endoderm and mesenchyme cells. On the contrary, overexpression of Hbox7 repressed the development of aboral ectoderm and primary mesenchyme cells. The data suggest that Hbox1 and Hbox7 are expressed in distinct non-overlapping territories, and overexpression of either one inhibits territory-specific gene expression in the domain of the other. It is proposed that an important function of both Hbox1 and Hbox7 genes is to maintain specific territorial gene expression by each one, in its domain of expression, while repressing the expression of the other in this same domain. 相似文献
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Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis 总被引:11,自引:0,他引:11
Kalev-Zylinska ML Horsfield JA Flores MV Postlethwait JH Vitas MR Baas AM Crosier PS Crosier KE 《Development (Cambridge, England)》2002,129(8):2015-2030
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Cohesin-dependent regulation of Runx genes 总被引:5,自引:0,他引:5
Horsfield JA Anagnostou SH Hu JK Cho KH Geisler R Lieschke G Crosier KE Crosier PS 《Development (Cambridge, England)》2007,134(14):2639-2649
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Di Bernardo M Castagnetti S Bellomonte D Oliveri P Melfi R Palla F Spinelli G 《Development (Cambridge, England)》1999,126(10):2171-2179