共查询到20条相似文献,搜索用时 31 毫秒
1.
Background
The increasing availability of full-text biomedical articles will allow more biomedical knowledge to be extracted automatically with greater reliability. However, most Information Retrieval (IR) and Extraction (IE) tools currently process only abstracts. The lack of corpora has limited the development of tools that are capable of exploiting the knowledge in full-text articles. As a result, there has been little investigation into the advantages of full-text document structure, and the challenges developers will face in processing full-text articles. 相似文献2.
Rainer König Gunnar Schramm Marcus Oswald Hanna Seitz Sebastian Sager Marc Zapatka Gerhard Reinelt Roland Eils 《BMC bioinformatics》2006,7(1):119-14
Background
Microarray technology produces gene expression data on a genomic scale for an endless variety of organisms and conditions. However, this vast amount of information needs to be extracted in a reasonable way and funneled into manageable and functionally meaningful patterns. Genes may be reasonably combined using knowledge about their interaction behaviour. On a proteomic level, biochemical research has elucidated an increasingly complete image of the metabolic architecture, especially for less complex organisms like the well studied bacterium Escherichia coli. 相似文献3.
Thibaut Pelat Michael Hust Martha Hale Marie-Paule Lefranc Stefan Dübel Philippe Thullier 《BMC biotechnology》2009,9(1):60
Background
Ricin is a lethal toxin that inhibits protein synthesis. It is easily extracted from a ubiquitously grown plant, Ricinus communis, and thus readily available for use as a bioweapon (BW). Anti-ricin antibodies provide the only known therapeutic against ricin intoxication. 相似文献4.
Background
Post-hybridization washing is an essential part of microarray experiments. Both the quality of the experimental washing protocol and adequate consideration of washing in intensity calibration ultimately affect the quality of the expression estimates extracted from the microarray intensities. 相似文献5.
Bob?JA?Schijvenaars Barend?Mons Marc?Weeber Martijn?J?Schuemie Erik?M?van Mulligen Hester?M?Wain Jan?A?Kors
Background
Massive text mining of the biological literature holds great promise of relating disparate information and discovering new knowledge. However, disambiguation of gene symbols is a major bottleneck. 相似文献6.
Background
In Sweden, knowledge about the role of enteropathogenic Escherichia coli in neonatal calf diarrhea and the occurrence of antimicrobial resistance in E. coli from young calves is largely unknown. This has therapeutic concern and such knowledge is also required for prudent use of antimicrobials. 相似文献7.
Identifying biological concepts from a protein-related corpus with a probabilistic topic model 总被引:1,自引:0,他引:1
Background
Biomedical literature, e.g., MEDLINE, contains a wealth of knowledge regarding functions of proteins. Major recurring biological concepts within such text corpora represent the domains of this body of knowledge. The goal of this research is to identify the major biological topics/concepts from a corpus of protein-related MEDLINE? titles and abstracts by applying a probabilistic topic model. 相似文献8.
Background
To effectively apply evolutionary concepts in genome-scale studies, large numbers of phylogenetic trees have to be automatically analysed, at a level approaching human expertise. Complex architectures must be recognized within the trees, so that associated information can be extracted. 相似文献9.
Background
Styrylpyrone derivative (SPD) is a plant-derived pharmacologically active compound extracted from Goniothalamus sp. Previously, we have reported that SPD inhibited the proliferation of MCF-7 human breast cancer cells by inducing apoptotic cell death, while having minimal effects on non-malignant cells. Here, we attempt to further elucidate the mode of action of SPD. 相似文献10.
Tine Alkjær Peter K Larsen Gitte Pedersen Linda H Nielsen Erik B Simonsen 《Biomedical engineering online》2006,5(1):2-7
Background
The rollator is a very popular walking aid. However, knowledge about how a rollator affects the walking patterns is limited. Thus, the purpose of the study was to investigate the biomechanical effects of walking with and without a rollator on the walking pattern in healthy subjects. 相似文献11.
Yongzhong Xing Uschi Frei Britt Schejbel Torben Asp Thomas Lübberstedt 《BMC plant biology》2007,7(1):43
Background
Association analysis is an alternative way for QTL mapping in ryegrass. So far, knowledge on nucleotide diversity and linkage disequilibrium in ryegrass is lacking, which is essential for the efficiency of association analyses. 相似文献12.
Background
The scope of this work is to show that the correct and complete definition of the system of muscle contraction requires the knowledge of both the mass and the acceleration of the load. 相似文献13.
Background
Oat is an important crop in North America and northern Europe. In Scandinavia, yields are limited by the fact that oat cannot be used as a winter crop. In order to develop such a crop, more knowledge about mechanisms of cold tolerance in oat is required. 相似文献14.
André Fischer Nils Enkler Gerd Neudert Marco Bocola Reinhard Sterner Rainer Merkl 《BMC bioinformatics》2009,10(1):54
Background
Computational enzyme design is far from being applicable for the general case. Due to computational complexity and limited knowledge of the structure-function interplay, heuristic methods have to be used. 相似文献15.
J Lynn Fink Pablo Fernicola Rahul Chandran Savas Parastatidis Alex Wade Oscar Naim Gregory B Quinn Philip E Bourne 《BMC bioinformatics》2010,11(1):103
Background
In the current era of scientific research, efficient communication of information is paramount. As such, the nature of scholarly and scientific communication is changing; cyberinfrastructure is now absolutely necessary and new media are allowing information and knowledge to be more interactive and immediate. One approach to making knowledge more accessible is the addition of machine-readable semantic data to scholarly articles. 相似文献16.
Tsz-Kwong Man Yiting Li Tu Anh Dang Jianhe Shen Laszlo Perlaky Ching C Lau 《Proteome science》2006,4(1):3
Background
Research with clinical specimens is always hampered by the limited availability of relevant samples, necessitating the use of a single sample for multiple assays. TRIzol is a common reagent for RNA extraction, but DNA and protein fractions can also be used for other studies. However, little is known about using TRIzol-extracted proteins in proteomic research, partly because proteins extracted from TRIzol are very resistant to solubilization. 相似文献17.
Alessio Valletta Livio Trainotti Anna Rita Santamaria Gabriella Pasqua 《BMC plant biology》2010,10(1):69
Background
Camptotheca acuminata is a major natural source of the terpenoid indole alkaloid camptothecin (CPT). At present, little is known about the cellular distribution of the biosynthesis of CPT, which would be useful knowledge for developing new strategies and technologies for improving alkaloid production. 相似文献18.
Background
Recent advances in molecular biology techniques provide an opportunity for developing detailed mathematical models of biological processes. An iterative scheme is introduced for model identification using available system knowledge and experimental measurements. 相似文献19.
Background
The suitability of the strain Rhodococcus erythropolis ATCC 25544 grown in a two-liter fermentor as a source of cholesterol oxidase has been investigated. The strain produces both cell-linked and extracellular cholesterol oxidase in a high amount, that can be extracted, purified and concentrated by using the detergent Triton X-114. 相似文献20.