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Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions. 总被引:9,自引:2,他引:7
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We have investigated the interaction of the kappa immunoglobulin light chain intron and 3' enhancers with two different kappa promoters at distinct stages of B-cell development. We find that transiently transfected reporter gene constructs driven by either the kappa V-region promoter, or the kappa germline promoter, are controlled by the known enhancers of the locus in a developmentally regulated fashion. We have, however, observed differences in promoter activation by each enhancer. Moreover, constructs controlled by a combination of both enhancers are synergistically activated at the B-cell and plasma cell stages as compared with constructs containing either enhancer alone. This synergy is not observed early in development, at the pre-B cell stage. The pattern of enhancer and promoter interactions is discussed in the context of the known developmental regulation of the locus. 相似文献
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Epstein-Barr virus (EBV)-containing nasopharyngeal carcinoma cells express the B-cell activation antigen blast2/CD23 and low levels of the EBV receptor CR2. 总被引:4,自引:0,他引:4
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M Billaud P Busson D Huang N Mueller-Lantzch G Rousselet O Pavlish H Wakasugi J M Seigneurin T Tursz G M Lenoir 《Journal of virology》1989,63(10):4121-4128
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