HEREDITAS(Beijing) Vol.2 3 ,2 0 0 1 CONTENTS

Ｎｏ .1ＲｅｓｅａｒｃｈＲｅｐｏｒｔｓＥｘｐｒｅｓｓｉｏｎｏｆＷｉｌｄ ｔｙｐｅＰ5 3ＧｅｎｅａｎｄＰ16ＧｅｎｅｉｎＬｕｎｇＡｄｅｎｏｃａｒｃｉｎｏｍａＣｅｌｌＬｉｎｅｓＹＡＮＣｈｅｎｇ ｈｕｉ,ＷＡＮＧＢａｉ ｑｉｕ ,ＷＵＹａｎ ,ｅｔａｌ.( 1)………………Ｓｔｕｄｙｏｆ2 0ＣａｓｅｓｉｎＦｉｖｅＧｅｎｅｒａｔｉｏｎｓｏｆａＦａｍｉｌｙｗｉｔｈＳｉｍｐｌｅＣｏｎｇｅｎｉｔａｌＰｔｏｓｉｓＳＵＡｎ Ｌｉ ( 5 )………………………………………………………………ＰａｒａｍｅｔｒｉｃＬｉｎｋａｇｅＡｎａｌｙｓｉｓ…     

Koppelungsdaten aus 159 Familien für AB0, Rh,Gm, Gc und Hp

Ohne ZusammenfassungDirektor: Prof. Dr. G. G. Wendt     

Variation of the electron population by four units in the cluster series [(η-Cp′)3Mo3S4Co(L)] (L = I, CO, PPh3, NO; n = 0, 1)

The versatility of cuboidal Mo₃S₄Co clusters for the preparation of complexes with different numbers of valence shell electrons (VSE) in the cluster is described. The reaction of the geometrically incomplete cuboidal cluster salt [(η⁵-Cp′)₃Mo₃S₄][pts] (pts = p-toluenesulfonate) with one molar equivalent of [Co₂(CO)₈] afforded almost quantitatively the electroneutral 60 VSE cluster [(η⁵-Cp′)₃Mo₃S₄Co(CO)] (1), which previously has been prepared in low yield by Curtis et al. in autoclave syntheses [M.D. Curtis, U. Riaz, O.J. Curnow, J.W. Kampf, Organometallics 14 (1995) 5337]. Cluster 1 was also obtained in high yield by reaction of [(η⁵-Cp′)₃Mo₃S₄][pts] with [(η⁵-Cp^∗)Co(CO)₂]. Reaction of [(η⁵-Cp′)₃Mo₃S₄][pts] with two molar equivalents of [Co(I)(CO)₃(PPh₃)] led to a complex mixture of products, of which the electron deficient 58 VSE cluster salt [(η⁵-Cp′)₃Mo₃S₄Co(I)][Co(I)₃(thf)] ([2][Co(I)₃(thf)]) was isolated as single crystals. In the crystal structures of 1 and [2][Co(I)₃(thf)], the Co-Mo bond lengths are almost identical, indicating a delocalization of the electron deficiency in [2]⁺. The reduced form of [2]⁺, [(η⁵-Cp′)₃Mo₃S₄Co(I)] (2), was prepared by oxidative substitution of the carbonyl ligand in 1 by I₂. Further reactions of 1 with PPh₃ and NO leading to the 60 and 61 VSE cluster complexes [(η⁵-Cp′)₃Mo₃S₄Co(PPh₃)] (3) and [(η⁵-Cp′)₃Mo₃S₄Co(NO)] (4), respectively, enabled the preparation of Mo₃S₄Co clusters in altogether four different oxidation states.     

曹天钦学术基金会评选出本刊 2 0 0 0年优秀论文

曹天钦学术基金会最近对本刊 2 0 0 0年发表的优秀论文进行了评选。根据基金会评选细则 (见本刊 1998年第 6期 6 17页 ) ,由《生物化学与生物物理学报》编辑部根据论文的质量 (至少有一位审稿专家评为甲级 ) ,从 2 0 0 0年已发表的 137篇论文中推荐 9篇参加优秀学术论文的评选 ,然后由基金会聘请专家对所推荐论文进行了评选 ,结果公布如下 :优秀论文奖 :杨运桂 ,徐京宁 ,胡泰山 ,钱友存 ,杨胜利 ,龚　毅。信号肽疏水性的提高促进青毒素Ｇ酰化酶分泌。生物化学与生物物理学报 ,2 0 0 0 ,32 (2 ) :16 3— 16 8(专家点评 :这是一篇有关人工信号…     

中国昆虫科学 2 0 0 0年第 8卷 总目次

第 1期南极三种弹尾目昆虫记述岳巧云　田村浩志 (1)……………………………中国福建省金小蜂科三新种 (膜翅目 )肖　晖　黄大卫 (8)…………………中国姬蜂茧蜂属 (膜翅目 :茧蜂科 )记述并附一新种描述陈学新　何俊华　马　云 (13)……………………………………………………………………中国泊卡小蜂属 (膜翅目 :小蜂科 )及一新种和一新纪录种记述刘长明 (19…中国姬蜂科 (膜翅目 )二新种盛茂领　潘宏阳 (2 5)……………………………家蝇抗性和敏感品系中的乙酰胆碱酯酶动力学研究施明安　袁建忠　吴　峻　庄佩君　唐振华 (30 )………………     

Phase studies of model biomembranes: Macroscopic coexistence of Lα + Lβ, with light-induced coexistence of Lα + Lo Phases

Phase diagrams of 3-component lipid bilayer mixtures containing cholesterol reveal major differences among the different types of lipids. Here we report that mixtures of cholesterol together with POPC and a high-melting temperature PC or sphingomyelin show different phase behavior from similar mixtures that contain DOPC or di-phytanoyl-PC instead of POPC. In particular, only one region of macroscopic phase coexistence occurs with POPC, a region of coexisting liquid disordered and solid phases, {Lα + Lβ}. Fluorescence microscopy imaging is useful for these studies, but is subject to artifactual light-induced domain formation, as reported by Ayuyan and Cohen [A.G. Ayuyan, F.S. Cohen, Lipid peroxides promote large rafts: Effects of excitation of probes in fluorescence microscopy and electrochemical reactions during vesicle formation, Biophys. J. 91 (2006) 2172-2183.]. This artifact can be attenuated by decreased illumination and low dye concentration. The use of the free radical scavenger n-propyl gallate can reduce the artifact, but this molecule enters the bilayer and itself perturbs the phase behavior. We suggest that the light-induced domain separation artifact might actually arise from pre-existing lipid clusters that are induced to coalesce, and therefore indicates highly nonrandom mixing of the lipid components.     

20 0 0年阿尔伯特·拉斯克医学研究奖揭晓

阿尔伯特·拉斯克 (Albert Lasker)医学研究奖分设基础医学奖、临床医学奖和特别医学成就奖三项 .本年度该奖颁奖仪式于 9月 2 2日在美国纽约举行 ,6位科学家因对人类战胜疾病及死亡作出重要的理论贡献和其实际意义而获此殊荣 .获得基础医学奖是两位以色列科学家 Aaron Ciechanover与 Avram Hershko和加州理工学院Alexander Varshavsky.Ciechanover和 Hershko用了二十多年的时间研究蛋白质的降解机制及其对机体功能的影响 . 1 978年 ,他们发现了一种降解蛋白质的物质—— ATP依赖的蛋白质分解因子 ,即泛素 . 1 985年 ,他们证明细胞抽…     

PPARβ mRNA expression,reduced by n − 3 PUFA diet in mammary tumor,controls breast cancer cell growth

The effect of numerous anticancer drugs on breast cancer cell lines and rodent mammary tumors can be enhanced by a treatment with long-chain n − 3 polyunsaturated fatty acids (n − 3 PUFA) such as docosahexaenoic acid (DHA, 22:6n − 3) which is a natural ligand of peroxisome proliferator-activated receptors (PPAR). In order to identify the PPAR regulating breast cancer cell growth, we tested the impact of siRNA, selected to suppress PPARα, PPARβ or PPARγ mRNA in MDA-MB-231 and MCF-7 breast cancer cell lines. The siPPARβ was the most effective to inhibit breast cancer cell growth in both cell lines. Using PPARα, PPARβ and PPARγ pharmacological antagonists, we showed that PPARβ regulated DHA-induced inhibition of growth in MDA-MB-231 and MCF-7 cells. In addition, the expressions of all 3 PPAR mRNA were co-regulated in both cell lines, upon treatments with siRNA or PPAR antagonists. PPAR mRNA expression was also examined in the NitrosoMethylUrea (NMU)-induced rat mammary tumor model. The expressions of PPARα and PPARβ mRNAs were correlated in the control group but not in the n − 3 PUFA group in which the expression of PPARβ mRNA was reduced. Although PPARα expression was also increased in the n − 3 PUFA-enriched diet group under docetaxel treatment, it is only the expression of PPARβ mRNA that correlated with the regression of mammary tumors: those that most regressed displayed the lowest PPARβ mRNA expression. Altogether, these data identify PPARβ as an important player capable of modulating other PPAR mRNA expressions, under DHA diet, for inhibiting breast cancer cell growth and mammary tumor growth.     

不同取代度N,0-羧甲基壳聚糖的抗氧化性能

低聚壳聚糖经醚化得到三种取代度不同的 N,O-羧甲基壳聚糖(NOA、NOB和NOC),本文对其结构进行表征,考察了其对超氧阴离子自由基O2、DPPH 自由基和过氧化氢(H2O2)的清除活性和还原能力.结果表明NOA、NOB 和 NOC 对O2和 DPPH 的清除活性随-OH 位置取代度的降低而升高;对H2O2的清除率随一NH2位置取代度的降低而升高;还原能力大小随其总取代度的升高而增强.