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《Comparative biochemistry and physiology. A, Comparative physiology》1992,101(1):189-197
- 1.1. Short-chain fatty acid concentration was 180mmol/l in the proximal colon and decreased to 108 mmol/l in the rectum.
- 2.2. Fermentation in chymus from different regions of the colon, showed the pattern of end products to reflect the substrate and not the site of the colon.
- 3.3. Isolated mucosa from proximal and distal colon had electroneutral sodium absorption of 4.8 ± 0.2 and 2.9 ± 0.8 μeq/cm2 hr in bicarbonate free media, which was abolished in the absence of chloride.
- 4.4. Electroneutral sodium absorption was enhanced by short-chain fatty acids in the proximal colon and could be described by Michaelis-Menten kinetics with Km 2.0–11 mmol/l and Jm 1.6–3.6μeq/cm2 hr. In the distal colon the stimulation was smaller and propionate even inhibited sodium absorption.
- 5.5. Butyrate was absorbed in the proximal colon, whereas acetate and propionate, and butyrate in the distal colon had a flux ratio of one.
- 6.6. Amiloride (5 mmol/l) inhibited sodium absorption and net butyrate absorption.
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