共查询到20条相似文献,搜索用时 109 毫秒
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Burgess SC Leone TC Wende AR Croce MA Chen Z Sherry AD Malloy CR Finck BN 《The Journal of biological chemistry》2006,281(28):19000-19008
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PGC-1beta in the regulation of hepatic glucose and energy metabolism 总被引:14,自引:0,他引:14
Lin J Tarr PT Yang R Rhee J Puigserver P Newgard CB Spiegelman BM 《The Journal of biological chemistry》2003,278(33):30843-30848
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Herzog B Hall RK Wang XL Waltner-Law M Granner DK 《Molecular endocrinology (Baltimore, Md.)》2004,18(4):807-819
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SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes 总被引:12,自引:0,他引:12
Yamamoto T Shimano H Nakagawa Y Ide T Yahagi N Matsuzaka T Nakakuki M Takahashi A Suzuki H Sone H Toyoshima H Sato R Yamada N 《The Journal of biological chemistry》2004,279(13):12027-12035
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Novel concepts in insulin regulation of hepatic gluconeogenesis 总被引:1,自引:0,他引:1
Barthel A Schmoll D 《American journal of physiology. Endocrinology and metabolism》2003,285(4):E685-E692
The regulation of hepatic gluconeogenesis is an important process in the adjustment of the blood glucose level, and pathological changes in the glucose production of the liver are a central characteristic in type 2 diabetes. The pharmacological intervention in signaling events that regulate the expression of the key gluconeogenic enzymes phosphoenolpyruvate carboxykinase (PEPCK) and the catalytic subunit glucose-6-phosphatase (G-6-Pase) is regarded as a potential strategy for the treatment of metabolic aberrations associated with this disease. However, such intervention requires a detailed understanding of the molecular mechanisms involved in the regulation of this process. Glucagon and glucocorticoids are known to increase hepatic gluconeogenesis by inducing the expression of PEPCK and G-6-Pase. The coactivator protein PGC-1 has been identified as an important mediator of this regulation. In contrast, insulin is known to suppress both PEPCK and G-6-Pase gene expression by the activation of PI 3-kinase. However, PI 3-kinase-independent pathways can also lead to the inhibition of gluconeogenic enzymes. This review focuses on signaling mechanisms and nuclear events that transduce the regulation of gluconeogenic enzymes. 相似文献
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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice 总被引:26,自引:0,他引:26
Lin J Wu PH Tarr PT Lindenberg KS St-Pierre J Zhang CY Mootha VK Jäger S Vianna CR Reznick RM Cui L Manieri M Donovan MX Wu Z Cooper MP Fan MC Rohas LM Zavacki AM Cinti S Shulman GI Lowell BB Krainc D Spiegelman BM 《Cell》2004,119(1):121-135
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Laganière J Tremblay GB Dufour CR Giroux S Rousseau F Giguère V 《The Journal of biological chemistry》2004,279(18):18504-18510
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