共查询到20条相似文献,搜索用时 31 毫秒
1.
Brian Levy J. G. Sivak 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1980,137(3):267-272
Summary Keratoscopic study of corneal curvature before and after accommodation in two common bird species failed to provide evidence of a corneal accommodative mechanism. Accommodative changes in refractive state measured retinoscopically are presumably brought about by the effect of ciliary muscle contraction on lens curvature. However, retinoscopic and freeze-sectioning study of accommodation in diving ducks supports the long suspected existence of an iris accommodative mechanism capable of producing dramatic changes in lens curvature. This mechanism is believed to be a means of compensating for the refractive loss of the cornea in water.This research was supported in part by a grant from the Canadian National Sportsmen's Fund. The assistance of Dr. W.F. Long and Mr. R. Ortleib (Niska Wildlife Foundation) is gratefully acknowledged. 相似文献
2.
J. D. Pettigrew S. P. Collin K. Fritsches 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》2000,186(3):247-260
The eyes of the sandlance, Limnichthyes fasciatus (Creediidae, Teleostei) move independently and possess a refractive cornea, a convexiclivate fovea and a non-spherical lens
giving rise to a wide separation of the nodal point from the axis of rotation of the eye much like that of a chameleon. To
investigate this apparent convergence of the visual optics in these phylogenetically disparate species, we examine feeding
behaviour and accommodation in the sandlance with special reference to the possibility that sandlances use accommodation as
a depth cue to judge strike length. Frame-by-frame analysis of over 2000 strikes show a 100% success rate. Explosive strikes
are completed in 50 ms over prey distances of four body lengths. Close-up video confirms that successful strikes can be initiated
monocularly (both normally and after monocular occlusion) showing that binocular cues are not necessary to judge the length
of a strike. Additional means of judging prey distance may also be derived from parallax information generated by rotation
of the eye as suggested for chameleons. Using photorefraction on anaesthetised sandlances, accommodative changes were induced
with acetylcholine and found to range between 120 D and 180 D at a speed of 600–720 D s−1. The large range of accommodation (25% of the total power) is also thought to be mediated by corneal accommodation where
the contraction of a unique cornealis muscle acts to change the corneal curvatures.
Accepted: 8 December 1999 相似文献
3.
K. L. Schmid H. C. Howland M. Howland 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1992,170(3):263-266
Summary Photorefraction and photokeratometry were performed on two juvenile tuatara (Sphenodon punctatus, 7 years of age, total length approx. 27 cm). Sphenodon is the only surviving genus of the Rhynchocephalia, an order of reptiles. Both existing species are endangered and are found only in New Zealand. Even though Walls (1942) has stated that the ciliary muscle is relatively weak in tuataras, we observed 8 D of accommodation. The eyes were found to focus independently and we could induce an anisometropia of 6 D. The average corneal power of the tuatara was found to be 101 D. 相似文献
4.
L S Kwok 《Journal of theoretical biology》1984,108(2):295-313
The macroscopic anterior surface area was calculated for three models of the average human cornea. Two models, a general ellipsoid and a rotational ellipse (rotationally symmetric ellipsoid) gave a surface area of 132 mm2, while a spherical model gave 126 mm2. A general ellipsoidal model having the maximum radius horizontal (with-the-rule corneal astigmatism) has less surface area than a rotational ellipse with the same horizontal radius. For a corneal sagittal height of 2.59 mm, the surface area of an ellipsoidal cornea equals -19.2Q + 16.3R -0.476 which specifies a rotational ellipse (radius R, asphericity Q) of equal surface area. In a cornea with the maximum radius vertical (against-the-rule corneal astigmatism), the ellipsoid has slightly more surface area than a rotational ellipse with the same horizontal radius of curvature. For a given horizontal radius of curvature, the sphere has the lowest surface area. For a corneal sagittal height s of 2.59 mm, the sphere underestimates by 8% the surface area of a rotational ellipse with asphericity -0.5. The anterior corneal surface area of a rotational ellipse model, radius R, asphericity Q is given by 2 pi Rs- 19.2Q. In all three models, the surface area increases with horizontal radius of curvature. In the rotational ellipse model, the rate of increase (slope) is independent of asphericity, and the slope found in with-the-rule astigmatism is less than the slope found with against-the-rule astigmatism. The calculated surface area predicts a precorneal tear volume of 0.86 microliter for a 6.5 micron tear thickness. The apparent, or plane projected are of an epithelial lesion underestimates the curved surface area with a percentage error that increases rapidly with lesion diameter. For a 12 mm diameter lesion on a rotational ellipse model, the apparent area underestimates the surface area by 18%. The average posterior corneal surface in human is not spherical but imitates the anterior surface, and has an area of 137 mm2 or 3.8% greater than the anterior area. 相似文献
5.
Matthias Ott 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》2006,192(2):97-111
The mechanism and stimulation of the accommodative reflex in vertebrate eyes are reviewed. Except for lampreys, accommodation
is brought about by intraocular muscles that mediate either a displacement or deformation of the lens, a change of the corneal
radius of curvature or a combination of these mechanisms. Elasmobranchs have little accommodation and are emmetropic in water
rather than hyperopic as commonly stated. Accommodation in teleosts and amphibians is well understood and achieved by lens
displacement. The accommodative mechanism of amniotes is of considerable diversity and reflects different lifestyles rather
than phylogenetical relationships. In all amniotes, the ciliary muscle never has a direct impact on the lens. It relaxes the
tension applied to the lens by zonular fibers and/or ligaments. In birds and reptiles the ciliary muscle is usually split
into two parts, of which the anterior portion changes the corneal radius of curvature. The deformation of the lens is generally
achieved either by its own elasticity (humans, probably other mammals and sauropsids) or by the force of circular muscle fibers
in the iris (reptiles, birds, aquatic mammals). In the second part of the paper, some of the current hypotheses about the
accommodative stimulus are reviewed together with physiological response characteristics. 相似文献
6.
OCT layered tomography of the cornea provides new insights on remodeling after photorefractive keratectomy
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Rachana S. Chandapura Rohit Shetty Rushad Shroff Neha Shilpy Mathew Francis Abhijit Sinha Roy 《Journal of biophotonics》2018,11(2)
OCT (optical coherence tomography) of corneal layers was generated to analyze the remodeling of the epithelium and stroma after photorefractive keratectomy (PRK). Myopic PRK was performed in 15 patients. One eye underwent manual scraping of epithelium while the other was treated with Epi clear. Epi clear allowed a gentler removal of the epithelium compared to manual scraping. Scheimpflug (Pentacam, OCULUS Optikgerate Gmbh, Wetzlar, Germany) and OCT (RTVue, Optovue Inc., Fremont, California, USA) scans of the cornea were performed before and after PRK (3 months). The OCT scanner and Pentacam acquired 8 and 25 radial 2‐D scans of the cornea, respectively. The results showed similar topographic changes on the anterior corneal surface between Scheimpflug and OCT imaging. The curvature of the underlying anterior surface of the stroma after PRK was similar to the anterior corneal surface (air‐epithelium interface), when measured with OCT. Aberrometric changes were mostly similar between Scheimpflug and OCT. However, Scheimpflug imaging reported greater changes in spherical aberration and corneal higher order aberrations than OCT after PRK. This is the first study to quantify the curvatures of the stromal layers with OCT after PRK. New insights were gained, which could be useful for refinement of surgical ablation algorithms, refractive procedures and detection of ectasia. 相似文献
7.
Boote C Hayes S Jones S Quantock AJ Hocking PM Inglehearn CF Ali M Meek KM 《Journal of structural biology》2008,161(1):1-8
An investigation into the collagenous structure of the mature avian cornea is presented. Wide-angle X-ray diffraction is employed to assess collagen organization in 9-month-old chicken corneas. The central 2-4mm corneal region features a preponderance of fibrils directed along the superior-inferior and nasal-temporal orthogonal meridians. More peripherally the orientation of fibrils alters in favor of a predominantly tangential arrangement. The chicken cornea appears to be circumscribed by an annulus of fibrils that extends into the limbus. The natural arrangement of collagen in the chicken cornea is discussed in relation to corneal shape and the mechanical requirements of avian corneal accommodation. Equivalent data are also presented from age-matched blind chickens affected with the retinopathy, globe enlarged (rge) mutation, characterized by an abnormally thick and flat cornea. The data indicate considerable realignment and redistribution of collagen lamellae in the peripheral rge cornea. In contrast to normal chickens, no obvious tangential collagen alignment was evident in the periphery of rge corneas. In mammals, the presence of a limbal fibril annulus is believed to be important in corneal shape preservation. We postulate that corneal flattening in rge chickens may be related to biomechanical changes brought about by an alteration in collagen arrangement at the corneal periphery. 相似文献
8.
J Sivak H C Howland P McGill-Harelstad 《Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain)》1987,229(1257):467-472
Refractive states measured by retinoscopy and photorefraction indicate that the eyes of the Humboldt penguin, Spheniscus humboldti, are approximately emmetropic in air and water. Extensive myopia in air, as predicted by earlier authors and by a recent anatomical study, is non-existent. Photorefractive measurements of the refractive state, in water, of the Humboldt penguin indicate that it can accommodate sufficiently to make up the loss of the refractive power of the cornea. The cornea of the Humboldt penguin is flattened relative to the overall size of the eye. In all these respects (corneal flattening, and accommodation in air and water) the eyes of Humboldt penguins are like those of gentoo, (Pygoscelis papua), rockhopper (Eudyptes crestatus), Magellanic (Spheniscus magellanicus), and king penguins (Aptenodytes patagonica). 相似文献
9.
Intraocular pressure (IOP) in the human eye as measured by a Goldmann applanation tonometer (GAT) is known to be affected by individual differences in central corneal thickness (CCT). However, data from clinical studies also show considerable scatter in the correlation between measured IOP and CCT. One possible implication of the large observed scatter is that the true IOP (IOPT) also depends significantly on individual variations in the material stiffness properties of the cornea. This hypothesis is explored and evaluated herein using computational simulation of applanation tonometry. A simplified 2D finite element model of the eye, which employs a calibrated nonlinear transversely isotropic material model for the cornea, is developed, and a series of GAT simulations is carried out to study the effect of geometry and material properties of the cornea on the IOP readings obtained via GAT. The results of this parametric study provide a simple correction equation, which quantifies the effect on measured IOP of variations in CCT and corneal material stiffness. In addition, several previously proposed IOP correction equations are compared with the one proposed here. 相似文献
10.
H. C. Howland M. Howland K. L. Schmid 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1992,170(6):687-689
Summary Brown kiwis are an endangered species of nocturnal, flightless birds which are native to New Zealand. The resting focus of two specimens has previously been studied by retinoscopy in a zoo while the birds were restrained by their keeper (Sivak and Howland 1987). Those birds appeared to be hyperopic (farsighted) by 2–7 D. In this study, examination with infrared photorefraction of the focusing of two unrestrained, feeding birds showed that they could focus objects at infinity and objects in their immediate environment and that they had modest powers of accommodation. Measurements on two 6 month old kiwi chicks showed their corneal radius of curvature to be between 2.90 and 3.00 mm (117 D and 101 D in power). 相似文献
11.
An X-Ray Scattering Study into the Structural Basis of Corneal Refractive Function in an Avian Model
Sian?R. Morgan Erin?P. Dooley Paul?M. Hocking Chris?F. Inglehearn Manir Ali Thomas L.-M. Sorensen Keith?M. Meek Craig Boote 《Biophysical journal》2013,104(12):2586-2594
Avian vision diseases in which eye growth is compromised are helping to define what governs corneal shape and ultrastructural organization. The highly specific collagen architecture of the main corneal layer, the stroma, is believed to be important for the maintenance of corneal curvature and hence visual quality. Blindness enlarged globe (beg) is a recessively inherited condition of chickens characterized by retinal dystrophy and blindness at hatch, with secondary globe enlargement and loss of corneal curvature by 3–4 months. Here we define corneal ultrastructural changes as the beg eye develops posthatch, using wide-angle x-ray scattering to map collagen fibril orientation across affected corneas at three posthatch time points. The results disclosed alterations in the bulk alignment of corneal collagen in beg chicks compared with age-matched controls. These changes accompanied the eye globe enlargement and corneal flattening observed in affected birds, and were manifested as a progressive loss of circumferential collagen alignment in the peripheral cornea and limbus in birds older than 1 month. Progressive remodeling of peripheral stromal collagen in beg birds posthatch may relate to the morphometric changes exhibited by the disease, likely as an extension of myopia-like scleral remodeling triggered by deprivation of a retinal image. 相似文献
12.
An X-Ray Scattering Study into the Structural Basis of Corneal Refractive Function in an Avian Model
Siân R. Morgan Erin P. Dooley Paul M. Hocking Chris F. Inglehearn Manir Ali Thomas L.-M. Sorensen Keith M. Meek Craig Boote 《Biophysical journal》2013
Avian vision diseases in which eye growth is compromised are helping to define what governs corneal shape and ultrastructural organization. The highly specific collagen architecture of the main corneal layer, the stroma, is believed to be important for the maintenance of corneal curvature and hence visual quality. Blindness enlarged globe (beg) is a recessively inherited condition of chickens characterized by retinal dystrophy and blindness at hatch, with secondary globe enlargement and loss of corneal curvature by 3–4 months. Here we define corneal ultrastructural changes as the beg eye develops posthatch, using wide-angle x-ray scattering to map collagen fibril orientation across affected corneas at three posthatch time points. The results disclosed alterations in the bulk alignment of corneal collagen in beg chicks compared with age-matched controls. These changes accompanied the eye globe enlargement and corneal flattening observed in affected birds, and were manifested as a progressive loss of circumferential collagen alignment in the peripheral cornea and limbus in birds older than 1 month. Progressive remodeling of peripheral stromal collagen in beg birds posthatch may relate to the morphometric changes exhibited by the disease, likely as an extension of myopia-like scleral remodeling triggered by deprivation of a retinal image. 相似文献
13.
Liu CY Birk DE Hassell JR Kane B Kao WW 《The Journal of biological chemistry》2003,278(24):21672-21677
Keratocan (Kera) is a cornea-specific keratan sulfate proteoglycan (KSPG) in the adult vertebrate eye. It belongs to the small leucine-rich proteoglycan (SLRP) gene family and is one of the major components of extracellular KSPG in the vertebrate corneal stroma. The Kera gene is expressed in ocular surface tissues including cornea and eyelids during morphogenesis. Corneal KSPGs play a pivotal role in matrix assembly, which is accountable for corneal transparency. In humans, mutations of the KERA gene are associated with cornea plana (CNA2) that manifests decreases in vision acuity due to the flattened forward convex curvature of cornea. To investigate the biological role of the Kera gene and to establish an animal model for corneal plana, we generated Kera knockout mice via gene targeting. Northern and Western blotting and immunohistochemical analysis showed that no Kera mRNA or keratocan protein was detected in the Kera-/- cornea. The expression levels of other SLRP members including lumican, decorin, and fibromodulin were not altered in the Kera-/- cornea as compared with that of the wild-type littermates. Mice lacking keratocan have normal corneal transparency at the age of 12 months. However, they have a thinner corneal stroma and a narrower cornea-iris angle of the anterior segment in comparison to the wild-type littermates. As demonstrated by transmission electron microscopy, Kera-/- mice have larger stromal fibril diameters and less organized packing of collagen fibrils in stroma than those of wild type. Taken together, our results showed that ablation of the Kera gene resulted in subtle structural alterations of collagenous matrix and did not perturb the expression of other SLRPs in cornea. Keratocan thus plays a unique role in maintaining the appropriate corneal shape to ensure normal vision. 相似文献
14.
Ulfah Rimayanti Yoshiaki Kiuchi Shohei Uemura Joji Takenaka Hideki Mochizuki Makoto Kaneko 《PloS one》2014,9(4)
Purpose
To evaluate the displacement of the central ocular surface during non-contact tonometry with and without soft contact lenses and determine the factors associated with the displacement of the central ocular surface and intraocular pressure (IOP) reading changes caused by wearing soft contact lenses (CLs).Methods
One eye each in 21 subjects was studied. The cornea was photographed using a high-speed camera at 5,000 frames/sec during non-contact tonometry without contact lenses (NCL), with -5.0 diopters (D), -0.5 D and +5.0 D CL. The displacement of the ocular surface and the factors affecting displacement at the IOP reading and maximum displacement time were investigated.Results
The IOP readings while wearing +5 D CL were significantly higher than those obtained while wearing -5 D CL. The ocular surface displacement between +5 D CL and other groups were significantly different. A significant positive correlation was found between the ocular surface displacement of subjects at the IOP reading time and the IOP obtained with the non-contact tonometer. A significant negative correlation was found between the ocular surface curvature and the IOP obtained using the non-contact tonometer. The radius of curvature of the ocular surface affected the displacement during the IOP reading and maximum displacement time.Conclusions
Our results indicate that soft contact lens use changes the ocular surface behavior and IOP readings during non-contact tonometry. The radius of curvature of the eye affects the ocular surface displacement and IOP readings in this situation. 相似文献15.
A two-component model of the eyeball that represents the cornea as a momentless, linearly elastic deformable surface and the scleral region, as an elastic element that responds to intraocular pressure changes by volume changes, has been used to analyze the effect of spatial inhomogeneity in the distribution of effective corneal stiffness on the mechanical properties of the eye. The effective stiffness of the cornea characterized both the elastic properties and the thickness of the cornea within the framework of the model. Various axisymmetric forms of the effective stiffness distribution characterized by monotonic increase along the arc between a point on the corneal surface and the apex of the cornea were studied. The considered distributions simulated both natural inhomogeneity and apical region weakening due to surgical interventions. Numerical simulation yielded the dependences of deformation parameters on intraocular pressure changes. These parameters characterized the deformation properties of both the cornea (apex displacement) and the eyeball as a whole (intraocular volume change). In the case of moderate inhomogeneity, the dependences were only slightly different from those for a homogeneous cornea with an effective stiffness equal to the mean value for the corresponding inhomogeneous distribution. A noticeable increase in the integral response of the cornea and the eyeball as a whole to changes in pressure was observed if the effective stiffness amplitude was very high (two or more times higher than the mean value). The effect of inhomogeneity on the results of tonometric measurements with a Maklakoff tonometer (flat stamp) was studied. The tonometric difference, that is, the difference between the tonometric pressure (in the loaded eye) and the true pressure (before loading), mainly depended on the average stiffness of the cornea in this case as well, with a substantial increase observed at very high stiffness amplitudes only. Apical weakening of the cornea led to an increase (although not very pronounced) of the tonometric difference. 相似文献
16.
Ping Xie Zizhong Hu Xiaojun Zhang Xinhua Li Zhishan Gao Dongqing Yuan Qinghuai Liu 《PloS one》2014,9(11)
Objective
To construct a life-sized eye model using the three-dimensional (3D) printing technology for fundus viewing study of the viewing system.Methods
We devised our schematic model eye based on Navarro''s eye and redesigned some parameters because of the change of the corneal material and the implantation of intraocular lenses (IOLs). Optical performance of our schematic model eye was compared with Navarro''s schematic eye and other two reported physical model eyes using the ZEMAX optical design software. With computer aided design (CAD) software, we designed the 3D digital model of the main structure of the physical model eye, which was used for three-dimensional (3D) printing. Together with the main printed structure, polymethyl methacrylate(PMMA) aspherical cornea, variable iris, and IOLs were assembled to a physical eye model. Angle scale bars were glued from posterior to periphery of the retina. Then we fabricated other three physical models with different states of ammetropia. Optical parameters of these physical eye models were measured to verify the 3D printing accuracy.Results
In on-axis calculations, our schematic model eye possessed similar size of spot diagram compared with Navarro''s and Bakaraju''s model eye, much smaller than Arianpour''s model eye. Moreover, the spherical aberration of our schematic eye was much less than other three model eyes. While in off- axis simulation, it possessed a bit higher coma and similar astigmatism, field curvature and distortion. The MTF curves showed that all the model eyes diminished in resolution with increasing field of view, and the diminished tendency of resolution of our physical eye model was similar to the Navarro''s eye. The measured parameters of our eye models with different status of ametropia were in line with the theoretical value.Conclusions
The schematic eye model we designed can well simulate the optical performance of the human eye, and the fabricated physical one can be used as a tool in fundus range viewing research. 相似文献17.
Corneal thickness (CT) maps of the central (2-mm diameter), para-central (2 to 5-mm diameter), peripheral (5 to 6-mm diameter), and minimum (5-mm diameter) cornea were measured in normal Chinese school children aged 7 to 15 years old using Fourier-domain optical coherence tomography. Multiple regression analyses were performed to explore the effect of associated factors [age, gender, refraction, axial length and corneal curvature radius (CCR)] on CT and the relationship between central corneal thickness (CCT) and intraocular pressure (IOP). A total of 1228 eyes from 614 children were analyzed. The average CCT was 532.96 ± 28.33 μm for right eyes and 532.70 ±28.45 μm for left eyes. With a 10 μm increase in CCT, the IOP was elevated by 0.37 mm Hg, as measured by noncontact tonometry. The CT increased gradually from the center to the periphery. The superior and superior nasal regions had the thickest CTs, while the thinnest points were primarily located in the inferior temporal cornea. The CCT was associated with CCR (p = 0.008) but not with gender (p = 0.075), age (p = 0.286), axial length (p = 0.405), or refraction (p = 0.985). In the para-central region and the peripheral cornea, increased CT was associated with younger age, male gender, and a flatter cornea. 相似文献
18.
Ute Mathis Frank Schaeffel Howard C. Howland 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1988,163(2):201-213
Aspects of visual optics were investigated in the American toad (Bufo americanus). The development of the refractive state of the eye during metamorphosis was followed with IR photoretinoscopy. Frozen sections documented the changes in optical parameters before and after metamorphosis. There is a difference in light sensitivity between juvenile and adult toads. Binocular accommodation in adult toads was observed. 1. IR photoretinoscopic measurements showed that the refractive state of the eye changed very rapidly during metamorphosis, about 10 D/h while the animal entered the terrestrial habitat. 2. Frozen sections showed that the almost spherical lens in a tadpole eye had flattened in a just metamorphosed toad's eye while at the same time the distance of the lens to the retina had decreased. However, the morphological measurements were not sufficiently sensitive to record the relatively small changes in ocular dimensions that were responsible for the rapid changes in refractive state during metamorphosis. 3. Schematic eyes, with homogeneous and non homogeneous lenses, were constructed for tadpoles, juvenile toads, and adult toads. 4. Nonparaxial raytracing studies in schematic eyes suggested that the lenses of animals of the three developmental stages tadpole, juvenile toad, and adult are not homogeneous but have a refractive index gradient. The raytracing studies indicated that the refractive index gradient is different for the different developmental stages, being highest in the tadpole lens. 5. The observations of toads during feeding behavior at different light levels showed an increased light sensitivity in the adult nocturnal toads in contrast to the juvenile animals, which are diurnal. The increased light sensitivity could partly be explained with an increase in aperture and an increase in red rod outer segments. To fully explain the higher light sensitivity in adult toads, changes in neuronal parameters had to be assumed. 6. Retinoscopic measurements of the resting refractive state in the adult toad showed a hyperopic defocus of about +8 D. By subtracting the measurement artefact for retinoscopy, the true resting focus was found to be nearly emmetropic. 7. The amount of natural accommodation in adult toads during normal feeding behavior was investigated with IR photoretinoscopy. Binocular accommodation of about 8 D was observed. 相似文献
19.
Dorit R. Hochbaum Samuel E. Moskowitz Jonathan D. Wirtschafter 《Journal of biomechanics》1977,10(11-12)
An analytical model has been developed for the localized corneal deformation produced in the region of the head of a pterygia. Astigmatism results when this localized deformation enters the central region or optical zone of the cornea. The amount and direction of the pterygia-induced astigmatism may be predicted from the values of the corneal curvature within the optical zone. The analytical solution of Lur'e based on the Papkovich-Neuber theory was applied to the anatomical and mechanical conditions affecting the cornea and conjunctiva. The force exerted by the head of a pterygia was measured experimentally for the first time. This force is of the order of that produced by the extraocular muscles in primary gaze. Using this model it is possible to predict that 2.35 diopters of the pterygia-induced astigmatism would result from a pterygia exerting 5 g of force along a meridian passing through the center of the cornea, and whose head is located 2.38 millimeters from the optical center of the cornea of an eye having a 4 mm pupillary diameter. 相似文献
20.