共查询到20条相似文献,搜索用时 15 毫秒
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G T Griffing M M Holbrook F A Bencsath J C Melby 《Journal of steroid biochemistry》1989,33(5):895-898
19-Nor-deoxycorticosterone (19-nor-DOC) is a mineralocorticoid present in both rat and human urine, and it is elevated in some forms of experimental and human hypertension. Although the exact steps in the biosynthesis of 19-nor-DOC are uncertain, it is probably produced from a 19-oxygenated derivative of DOC, which undergoes 19-desmolation in the kidney. Since DOC biosynthesis is partly due to renal 21-hydroxylation of progesterone (Prog), we sought to determine whether a parallel pathway could exist for the biosynthesis of 19-hydroxy-DOC, a precursor to 19-nor-DOC. In order to test this hypothesis, authentic 19-hydroxy-progesterone was incubated with homogenized renal tissues from either rat or human sources. Formation of 19-hydroxy-DOC was found to be the major metabolite in both rat and human incubations, as demonstrated by an HPLC retention time identical to authentic 19-hydroxy-DOC. 19-Hydroxy-DOC formation was further verified by GC/MS analysis with highly sensitive selected ion recording. Since it has been demonstrated that the placenta can convert progesterone to 19-hydroxy-progesterone, the renal 21-hydroxylation of 19-hydroxy-progesterone to 19-hydroxy-DOC could be an alternate pathway of 19-nor-DOC production especially during pregnancy. 相似文献
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Chair of Committee for Mouse Chromosome 19 相似文献
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Chair of Committee for Mouse Chromosome 19 相似文献
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During the separation of an extract from Tabernaemontana glandulosa, small amounts of a new alkaloid were obtained for which the structure 19-hydroxycoronaridine was deduced. This new alkaloid and 19-hydroxyibogamine, which can be obtained from it, show marked antibiotic activity in the agar plate diffusion test. 相似文献
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John C. Sih 《Prostaglandins & other lipid mediators》1977,13(5):831-835
We wish to report here the total synthesis of the naturally occurring (19R)-19-hydroxy-prostaglandins of the PGE and PGF series. 相似文献
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Digoxin-like immunoreactivity of 19-OH-androst-4-ene-3,17-dione and 19-NOR-androst-4-ene-3,17-dione estimated by radioimmunoassay was by about four orders of magnitude lower than that of digoxin. 相似文献
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