共查询到20条相似文献,搜索用时 18 毫秒
1.
Xue CB He X Roderick J Corbett RL Duan JJ Liu RQ Covington MB Qian M Ribadeneira MD Vaddi K Christ DD Newton RC Trzaskos JM Magolda RL Wexler RR Decicco CP 《Bioorganic & medicinal chemistry letters》2003,13(24):4299-4304
Modifications of the lead TACE inhibitor 1 (N-hydroxy-trans-2-[[4-(4-quinolinyloxymethyl)anilinyl]carbonyl]-1-cyclohexanecarboxamide) at the cyclohexyl ring and the quinoline moiety led to the identification of a series of piperidine containing TACE inhibitors with potent activity in the inhibition of TNF-alpha release in the whole blood assay (WBA). The most potent analogue IM491 [N-hydroxy-(5S,6S)-1-methyl-6-[[4-(2-methyl-4-quinolinylmethoxy)anilinyl]carbonyl]-5-piperidinecarboxamide] exhibited an IC(50) value of 20 nM in WBA with excellent selectivity over MMP-1, -2 and -9 and is orally bioavailable with an F value of 43% in beagle dogs. 相似文献
2.
Gilmore JL King BW Asakawa N Harrison K Tebben A Sheppeck JE Liu RQ Covington M Duan JJ 《Bioorganic & medicinal chemistry letters》2007,17(16):4678-4682
A novel series of TNF-alpha converting enzyme (TACE) inhibitors which are non-hydroxamate have been discovered. These compounds use a triazolethione moiety as the zinc binding ligand and exhibit IC50 values from 1.5 to 100 nM in a porcine TACE assay. They also have excellent selectivities over other MMPs. 相似文献
3.
Gilmore JL King BW Harris C Maduskuie T Mercer SE Liu RQ Covington MB Qian M Ribadeneria MD Vaddi K Trzaskos JM Newton RC Decicco CP Duan JJ 《Bioorganic & medicinal chemistry letters》2006,16(10):2699-2704
A novel series of achiral TNF-alpha converting enzyme (TACE) inhibitors has been discovered. These compounds exhibited activities from 0.35 to 11nM in a porcine TACE assay and inhibited TNF-alpha production in an LPS-stimulated whole blood assay with an IC(50) value of 23nM for the most potent one. They also have excellent selectivities over related metalloproteases including aggrecanases. 相似文献
4.
Xue CB Chen XT He X Roderick J Corbett RL Ghavimi B Liu RQ Covington MB Qian M Ribadeneira MD Vaddi K Trzaskos J Newton RC Duan JJ Decicco CP 《Bioorganic & medicinal chemistry letters》2004,14(17):4453-4459
Replacement of the amide functionality in IM491 (N-hydroxy-(5S,6S)-1-methyl-6-[[4-(2-methyl-4-quinolinylmethoxy)anilinyl]carbonyl]5-piperidinecarboxamide) with a sulfonyl group led to a new series of alpha,beta-cyclic and beta,beta-cyclic gamma-sulfonyl hydroxamic acids, which were potent TNF-alpha converting enzyme (TACE) inhibitors. Among them, inhibitor 4b (N-hydroxy-(4S,5S)-1-methyl-5-[[4-(2-methyl-4-quinolinylmethoxy)phenyl]sulfonylmethyl]-4-pyrrolidinecarboxamide) exhibited IC50 values of < 1 nM and 180 nM in porcine TACE (pTACE) and cell assays, respectively, with excellent selectivity over MMP-1, -2, -9 and -13 and was orally bioavailable with an F value of 46% in mice. 相似文献
5.
Chun K Park SK Kim HM Choi Y Kim MH Park CH Joe BY Chun TG Choi HM Lee HY Hong SH Kim MS Nam KY Han G 《Bioorganic & medicinal chemistry》2008,16(1):530-535
A series of coumarin types MMP inhibitors were designed based on gelastatin hydroxamates (1) and evaluated for TACE, cellular TNF-alpha, and NO inhibitory activities. Among them, compounds 9b had potent inhibitory activities in enzymatic and cellular assays and good selectivity to MMP-2 and MMP-9. Further investigation of 9b will be carried out for its efficacy in RA animal model system. 相似文献
6.
Kaku T Matsunaga N Ojida A Tanaka T Hara T Yamaoka M Kusaka M Tasaka A 《Bioorganic & medicinal chemistry》2011,19(5):1751-1770
A novel series of naphthylmethylimidazole derivatives and related compounds have been investigated as selective 17,20-lyase inhibitors. Optimization of the substituent at the 6-position on the naphthalene ring was performed to yield a methylcarbamoyl derivative, which exhibited potent inhibitory activity against human 17,20-lyase and promising selectivity (>200-fold) for 17,20-lyase over CYP3A4. Further modifications of the methylcarbamoyl derivative led to the discovery of the corresponding tricyclic compound, which showed highly potent activity against human 17,20-lyase (IC(50) 19 nM) and good selectivity (>1000-fold) for inhibition of 17,20-lyase over CYP3A4. Additional biological evaluation revealed that the tricyclic compound had potent in vivo efficacy in monkeys and favorable pharmacokinetic profiles when administered in rats. Asymmetric synthesis of the selective tricyclic inhibitor was also achieved using a chiral α-hydroxy ketone. 相似文献
7.
Masakitsushima Iwamatsu K Umemura E Kudo T Sato Y Shiokawa S Takizawa H Kano Y Kobayashi K Ida T Tamura A Atsumi K 《Bioorganic & medicinal chemistry》2000,8(12):283-2789
A series of cephalosporins bearing a 5,5-fused ring system, an (imidazo[5,1-b]thiazolium-6-yl)methyl group, at the C-3 position were synthesized and evaluated for in vitro antibacterial activities. CP6679 (1s) and its analogues showed potent antibacterial activities against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa. They were also highly active against methicillin-resistant Staphylococcus aureus (MRSA). CP6679 (1s) showed more potent antibacterial activity than ceftazidime (CAZ) or cefpirome (CPR) against Pseudomonas aeruginosa and MRSA. 相似文献
8.
Aihara K Kano Y Shiokawa S Sasaki T Setsu F Sambongi Y Ishii M Tohyama K Ida T Tamura A Atsumi K Iwamatsu K 《Bioorganic & medicinal chemistry》2003,11(16):3475-3485
A series of 1beta-methylcarbapenems bearing an (imidazo[5,1-b]thiazolium-6-yl)methyl moiety, a 5,5-fused heterobicycle, at the C-2 position was synthesized and evaluated for in vitro antibacterial activities. CP0569 (1r) and its analogues showed potent antibacterial activities against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Gram-negative bacteria, including Pseudomonas aeruginosa. Moreover, CP0569 (1r) exhibited stronger antibacterial activity against MRSA and higher resistance to renal dehydropeptidase-1 (DHP-1) than any currently marketed carbapenems, that is, imipenem (IPM), panipenem (PAPM), and meropenem (MEPM). 相似文献
9.
Yoshiizumi K Nakajima F Dobashi R Nishimura N Ikeda S 《Bioorganic & medicinal chemistry》2002,10(8):2445-2460
Scavenger receptors have been proven to be implicated in the formation of atherosclerotic lesions. A series of novel derivatives of sulfatides were synthesized, and their inhibitory activities against incorporation of DiI-acetyl-LDL into macrophages were evaluated in order to clarify the structure-activity relationships of sulfatides as a scavenger receptor inhibitor and find out novel inhibitors with synthetic easiness. The chemical modification of the substructures of sulfatides led to the establishment of the following structure-activity relationships; (1) the ceramide moiety can be replaced with another structure bearing two long chains, (2) the galactose moiety can be replaced with another structure or be deleted without a large decrease in the inhibitory activity, (3) the sulfate moiety was crucial, and it was the most preferable functional group for a potent inhibitory activity. The inhibitory activity of (S)-2-octadecanoylamino-2-tetradecylcarbamoyl)ethyl sulfate sodium salt (3a) against incorporation of DiI-acetyl-LDL into macrophages was proven to be based on the inhibition against the binding of acetyl-LDL to the surface of macrophages. We discovered novel scavenger receptor inhibitors with synthetic easiness, such as (S)-2-octadecanoylamino-2-(tetradecylcarbamoyl)ethyl sulfate sodium salt (3a) and 2-octadecanoylamino-1-(octadecanoylaminomethyl)ethyl sulfate sodium salt (13q). 相似文献
10.
Yoon T De Lombaert S Brodbeck R Gulianello M Chandrasekhar J Horvath RF Ge P Kershaw MT Krause JE Kehne J Hoffman D Doller D Hodgetts KJ 《Bioorganic & medicinal chemistry letters》2008,18(3):891-896
The design, synthesis and structure-activity relationships of a novel series of CRF-1 receptor antagonist, the 1-aryl-4-alkylaminoisoquinolines, is described. The effects of substitution on the aromatic ring, the amino group and the isoquinoline core on CRF-1 receptor binding were investigated. 相似文献
11.
Shultz M Fan J Chen C Cho YS Davis N Bickford S Buteau K Cao X Holmqvist M Hsu M Jiang L Liu G Lu Q Patel C Suresh JR Selvaraj M Urban L Wang P Yan-Neale Y Whitehead L Zhang H Zhou L Atadja P 《Bioorganic & medicinal chemistry letters》2011,21(16):4909-4912
The design, synthesis and biological evaluation of a novel series of isoindoline-based hydroxamates is described. Several analogs were shown to inhibit HDAC1 with IC50 values in the low nanomolar range and inhibit cellular proliferation of HCT116 human colon cancer cells in the sub-micromolar range. The cellular potency of compound 17e was found to have greater in vitro anti-proliferative activity than several compounds in late stage clinical trials for the treatment of cancer. The in vitro safety profiles of selected compounds were assessed and shown to be suitable for further lead optimization. 相似文献
12.
Mewshaw RE Bowen SM Harris HA Xu ZB Manas ES Cohn ST 《Bioorganic & medicinal chemistry letters》2007,17(4):902-906
A series of 4'-hydroxyphenyl-aryl-carbaldehyde oximes (5b) was prepared and found to have high affinity (4nM) and modest selectivity (39-fold) for estrogen receptor-beta (ERbeta). Substitution of one of the core rings of the scaffold based around these novel ligands further expanded our knowledge in the quest toward achieving high affinity and selectivity for ERbeta. An X-ray co-crystal of structure 11 revealed that the oxime moiety was mimicking the C-ring of genistein, as previously predicted by SAR and docking studies. 相似文献
13.
Matsui T Kondo T Nishita Y Itadani S Nakatani S Omawari N Sakai M Nakazawa S Ogata A Mori H Terai K Kamoshima W Ohno H Obata T Nakai H Toda M 《Bioorganic & medicinal chemistry》2002,10(12):3757-3786
Discovery of new chemical leads of inhibitors for TNF-alpha production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-alpha expression in the liver and spleen of mice. Structure-activity relationships (SARs) are also discussed and full details including the chemistry are reported. 相似文献
14.
Aarajana Shrestha Seojeong Park Hae Jin Jang Pramila Katila Ritina Shrestha Youngjoo Kwon Eung-Seok Lee 《Bioorganic & medicinal chemistry》2018,26(18):5212-5223
DNA Topoisomerase IIα (topo IIα) is one of the most effective therapeutic targets to control cancer. In an effort to develop novel and effective topo IIα targeting anti-proliferative agent, a phenolic series of indenopyridinone and indenopyridinol were designed and prepared using efficient multi-component one pot synthetic method. Total twenty-two synthesized compounds were assessed for topo I and IIα inhibition, and anti-proliferation in three different human cancer cell lines. Overall structure-activity relationship study explored the significance of meta-phenolic group at 4-position and para-phenolic group at 2- and/or 4-position of indenopyridinone skeleton for strong topo IIα-selective inhibition and anti-proliferative activity against human cervix (HeLa) and colorectal (HCT15) cell lines. Compound 12 with excellent topo IIα inhibition (93.7%) was confirmed as a DNA intercalator that could be a new promising lead to develop effective topo IIα-targeted anticancer agents. 相似文献
15.
Allcock RW Blakli H Jiang Z Johnston KA Morgan KM Rosair GM Iwase K Kohno Y Adams DR 《Bioorganic & medicinal chemistry letters》2011,21(11):3307-3312
Ibudilast [1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one] is a nonselective phosphodiesterase inhibitor used clinically to treat asthma. Efforts to selectively develop the PDE3- and PDE4-inhibitory activity of ibudilast led to replacement of the isopropyl ketone by a pyridazinone heterocycle. Structure-activity relationship exploration in the resulting 6-(pyrazolo[1,5-a]pyridin-3-yl)pyridazin-3(2H)-ones revealed that the pyridazinone lactam functionality is a critical determinant for PDE3-inhibitory activity, with the nitrogen preferably unsubstituted. PDE4 inhibition is strongly promoted by introduction of a hydrophobic substituent at the pyridazinone N(2) centre and a methoxy group at C-7′ in the pyrazolopyridine. Migration of the pyridazinone ring connection from the pyrazolopyridine 3′-centre to C-4′ strongly enhances PDE4 inhibition. These studies establish a basis for development of potent PDE4-selective and dual PDE3/4-selective inhibitors derived from ibudilast. 相似文献
16.
Kaku T Tsujimoto S Matsunaga N Tanaka T Hara T Yamaoka M Kusaka M Tasaka A 《Bioorganic & medicinal chemistry》2011,19(7):2428-2442
A novel series of biphenylylmethylimidazole derivatives and related compounds were synthesized as inhibitors of 17,20-lyase, a key enzyme in the production of steroid hormones, and their biological activities were evaluated. In an attempt to identify potent and selective inhibitors of 17,20-lyase over the related CYP3A4 enzyme, a homology model for human 17,20-lyase was developed using the X-ray crystallographic structure of the mammalian CYP2C5 enzyme. With the aid of molecular modeling, optimization of the biphenyl moiety was performed to give an acetamide derivative, which was resolved by HPLC to give the active (-)-enantiomer. The obtained active enantiomer showed not only potent inhibition of both rat and human 17,20-lyase,with IC(50) values of 14 and 26 nM, respectively, but also excellent selectivity (>300-fold) for inhibition of 17,20-lyase over CYP3A4. Moreover, the active enantiomer significantly reduced both serum testosterone and DHEA concentrations in a monkey model after single oral administration. Asymmetric synthesis of the active enantiomer was also developed via a chiral intermediate using a diastereoselective Grignard reaction. 相似文献
17.
Bauer SM Goldman EA Huang W Su T Wang L Woolfrey J Wu Y Zuckett JF Arfsten A Huang B Kothule J Lin J May B Sinha U Wong PW Hutchaleelaha A Scarborough RM Zhu BY 《Bioorganic & medicinal chemistry letters》2004,14(15):4045-4050
Parallel synthesis and iterative optimization led to the discovery of a series of potent and specific factor Xa inhibitors demonstrating excellent in vitro activity with promising pharmacokinetics. 相似文献
18.
Ott GR Asakawa N Lu Z Liu RQ Covington MB Vaddi K Qian M Newton RC Christ DD Traskos JM Decicco CP Duan JJ 《Bioorganic & medicinal chemistry letters》2008,18(2):694-699
Selective inhibitors of TNF-alpha Converting Enzyme (TACE) based on (1R,2S)-cyclopentyl, (3S,4S)-pyrrolidinyl, and (3R,4S)-tetrahydrofuranyl beta-benzamido hydroxamic acids have been synthesized and evaluated. This study has led to the discovery of novel inhibitors whose profiles include activity against TACE in an enzyme assay, potency in the suppression of LPS-stimulated TNF-alpha in human whole blood, selectivity against a panel of MMPs and oral bioavailability. 相似文献
19.
Guillou C Mary A Renko DZ Gras E Thal C 《Bioorganic & medicinal chemistry letters》2000,10(7):637-639
The syntheses, the anticholinesterase activities and structure-activity relationships of homodimeric (3a-c) and heterodimeric (6a-c) alkylene linked bis-galanthamine are reported. Compounds 6b-c were found to be more potent than galanthamine and tacrine in inhibiting AChE. 相似文献
20.
Wenglowsky S Ahrendt KA Buckmelter AJ Feng B Gloor SL Gradl S Grina J Hansen JD Laird ER Lunghofer P Mathieu S Moreno D Newhouse B Ren L Risom T Rudolph J Seo J Sturgis HL Voegtli WC Wen Z 《Bioorganic & medicinal chemistry letters》2011,21(18):5533-5537
Structure-activity relationships around a novel series of B-Raf(V600E) inhibitors are reported. The enzymatic and cellular potencies of inhibitors derived from two related hinge-binding groups were compared and3-methoxypyrazolopyridine proved to be superior. The 3-alkoxy group of lead B-Raf(V600E) inhibitor 1 was extended and minimally affected potency. The propyl sulfonamide tail of compound 1, which occupies the small lipophilic pocket formed by an outward shift of the αC-helix, was expanded to a series of arylsulfonamides. X-ray crystallography revealed that this lipophilic pocket unexpectedly enlarges to accommodate the bulkier aryl group. 相似文献