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Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. 总被引：11，自引：0，他引：11 
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下载免费PDF全文 Carina I. Holmberg Ville Hietakangas Andrey Mikhailov Jouni O. Rantanen Marko Kallio Annika Meinander Jukka Hellman Nick Morrice Carol MacKintosh Richard I. Morimoto John E. Eriksson Lea Sistonen 《The EMBO journal》2001,20(14):3800-3810
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Rapid assay of HSF1 and HSF2 gene expression by RT-PCR 总被引：1，自引：0，他引：1
Xuan Z. Ding Robert C. Smallridge Richard J. Galloway Juliann G. Kiang 《Molecular and cellular biochemistry》1996,158(2):189-192
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Interaction of the DNA-binding domain of Drosophila heat shock factor with its cognate DNA site: a thermodynamic analysis using analytical ultracentrifugation. 总被引：3，自引：0，他引：3 下载免费PDF全文
下载免费PDF全文 S. J. Kim T. Tsukiyama M. S. Lewis C. Wu 《Protein science : a publication of the Protein Society》1994,3(7):1040-1051
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Ming Lu Si-Won Kim Suhkmann Kim Jang-Su Park 《Biochemical and biophysical research communications》2009,385(4):612-617
Heat shock factor 1 (HSF1) primarily regulates various cellular stress responses. The role of α-helix1 (H1) in its DNA-binding domain (DBD) during HSF1 activation remains unknown. Here, HSF1 lacking H1 loses its heat-induced activity, suggesting the importance of the latter. Furthermore, the CD spectra and AMBER prediction show that this H1 deficiency does not change the structure of HSF1 monomer, but does impact its heat-induced trimerization. Point mutation showed that Phe18 in H1 interacts with Tyr60, and that Trp23 interacts with Phe104 by an aromatic-aromatic interaction. Thus, the presence of H1 stabilizes the DBD structure, which facilitates the heat-induced trimerization and DNA-binding of HSF1. 相似文献