THE MEANING OF DISEASE

A wider concept of disease is developing, which deals with the social environment, not only with the physical, chemical or ecological factors, as they affect the homeostasis of the internal environment of the organism. In such a concept it is the fitness of the whole personality which determines ease or dis-ease in adaptation. If the medical profession is to retain the strategic direction as well as the tactical command of the battle for health, it must widen the bases of its educational program so that every physician will understand and conform to the plan of battle even though his individual role is highly restricted; so that even in the office of a technical specialist the whole personality of the patient in relation to his whole environment is dealt with.     

The Problem of Generalization in the Works of L. S. Vygotsky

An aspect of Vygotsky's psychological theory which is still meaningful as a genuine scientific problem today is the treatment he gave to the structure, function, and formation of generalization as a special means of reflecting reality in human consciousness. Many of the central propositions of the theory — concerning such questions as the role of symbols in the establishment of higher mental functions, the hierarchical structure of consciousness, and the connection between instruction and development — were refined, concentrated, and cast in a new light by the concept of generalization which Lev Semyonovich worked on so intensively in the last years of his life. The problem of generalization is the knot that ties together the fundamental strands of the whole conception. By carefully untying it one can avoid misunderstandings in evaluating some of Vygotsky's propositions, and, even more important, one can then correctly understand his fundamental ideas, which he clearly formulated but was not able to develop fully. The significance of these ideas is such that they belong in the arsenal of modern psychology to resolve burning theoretical and practical problems of the day.     

L.S. Vygotsky and the Theater

The article presents the analysis of L.S. Vygotsky's works dedicated to the theater arts and is organized according Vygotsky's different life and work stages. Meanwhile special attention is paid to the Gomel period during which a large number of reviews were written by Vygotsky and published in “Nash ponedel'nik” and “Polesskaia pravda” newspapers. Biographical facts are widely used in this analysis and help to clarify Vygotsky's interest in art. It is shown that even at the beginning of his oeuvre, he was interested not only in a range of problems in art, but also psychological problems related to art perception and creativeness. Vygotsky's usage of structural concept ideas about the peculiar properties of literary text composition are also explored. Vygotsky analyzes the socio-psychological mechanisms of theatrical art effect. Furthermore, those areas which are widely used by Vygotsky in determining the characteristics of cast reincarnation are examined. Special emphasis is placed on the different elements of the actor techniques (speech, movement, emotional expression, acting personality and etc.). Materials are widely used in this study and help identify the socio-cultural context that defined Vygotsky's values at different stages of his work, related to his drama criticism and his formation as a professional psychologist.     

Photosynthetic electron transport: Emergence of a concept, 1949–59

Historically, two main concepts guided research into possible mechanisms of light-induced atomic rearrangements in oxygenic photosynthesis: Photodecomposition of CO₂ and photodecomposition of water. Both concepts envisioned photoinduced transfers of cumbersome whole atoms and not, as is currently held, photoinduced electron transfers. Early proposals for light-induced electron transfers were relegated to obscurity because they were speculative ideas, not supported by meaningful experimental findings and tied to hypothetical and ephemeral schemes. The concept of photoinduced rearrangements of whole atoms rather than electrons was so well entrenched that it was even invoked to explain their findings by the discoverers of the Hill reaction and cyclic photophosphorylation. The light-induced electron flow concept gained acceptance in photosynthesis research only with the discovery of non-cyclic photophosphorylation in which ATP formation is coupled with electron transport to ferredoxin/NADP⁺ or to artificial substitutes like ferricyanide.     

Kant's concept of natural purpose and the reflecting power of judgement

This paper examines how in the 'Critique of teleological judgment' Kant characterized the concept of natural purpose in relation to and in distinction from the concepts of nature and the concept of purpose he had developed in his other critical writings. Kant maintained that neither the principles of mechanical science nor the pure concepts of the understanding through which we determine experience in general provide adequate conceptualizations of the unique capacities of organisms. He also held that although the concept of natural purpose was derived through reflection upon an analogy to human purposive activity in artistic production and moral action, it articulates a unique notion of intrinsic purposiveness. Kant restricted his critical reflections on organisms to phenomena that can be given to us in experience, criticizing speculations on their first origins or final purpose. But I argue that he held that the concept of natural purpose is a product of the reflecting power of judgment, rather than an empirical concept, and represents only the relation of things to our power of judgment. Yet it is necessary for the identification of organisms as organized and self-organizing, and as subject to unique norms and causal relations between parts and whole.     

Human adaptation to levels of environmental stimulation

This paper examines the environment as a source of dimensions of stimulation that are directly related to the individual's affective response to his environment, and his behavioral adaptation to it. The concept of an optimal level of stimulation is introduced, along with a view of environmental stress as resulting from conditions of excessive deviation from such optimal levels, with particular reference to variations in intensity, diversity, and patterning of the stimulus input. This analysis provides the framework for a consideration of behavioral adaptation to the environment by reference to the concept of adaptation level. Levels of adaptation to particular environmental dimensions, established as a function of past exposure, are shown to act as potent determiners of the individual's evaluation of his environment, as well as representing a plausible basis for the optimal level of stimulation principle itself. The presentation proceeds to an examination of the process of adaptation to the environment as a multilayered process, and to a discussion of the concept of the cost of adaptation as it applies in the behavioral realm. Finally, adaptation is contrasted with an alternative mechanism, adjustment, involving active alteration of the environment by the individual, and the relative place to be accorded to these two processes in the individual's relation to the environment is considered.     

Decision Theory and the Concept of Threshold in Psychophysics

Psychophysics deals basically with how signals are perceived. It is assumed that a signal or stimulus is perceived after it reaches a certain threshold value, called the sensory threshold. Thus, there are two possible states: either a signal is perceived by the neuronal system, or it is not. Fechner deserves most of the credit for the concept of the sensory threshold and for detailing the various techniques for measuring it. A discussion of this cardinal concept may be found in his book Elemente der Psychophysik (1860), although the idea is actually of much earlier origins: Leibnitz and Herbart certainly spoke of it, and indeed it seems to have been considered even by ancient Greek philosophers. Methods for measuring the sensory threshold were known even before Fechner; his contribution was being the first to systematize and perfect them. It is for this reason that his book (Elemente) is considered basic.     

Whatever happened to the ‘microtrabecular concept’?

Keith Porter culminated his stellar career as the founding father of biological electron microscopy by acquiring, in the late 1970s, a high-voltage electron microscope (HVEM). With this magnificent instrument he examined whole-mounts of cultured cells, and perceived within them a structured cytoplasmic matrix he named the "microtrabecular lattice". Over the next decade Porter published a series of studies, together with a team of outstanding young colleagues, which elaborated his broader "microtrabecular concept." This concept posited that microtrabeculae were real physical entities that represented the fundamental organization the cytoplasm, and that they were the physical basis of cytoplasmic motility and of cell-shape determination. The present review presents Porter's original images of microtrabeculae, after conversion to a more interpretable "digital-anaglyph" form, and discusses the rise and fall of the microtrabecular concept. Further, it explains how the HVEM images of microtrabeculae finally came to be considered as an artifact of the preparative methods Porter used to prepare whole cells for HVEM. Still, Keith's "microtrabecular concept" foretold of our current appreciation of the complexity and pervasiveness of the cytoskeleton, which has now been found by more modern methods of EM to actually be the fundamental organizing principle of the cytoplasmic matrix. During the impending eclipse of Porter's microtrabecular concept in the late 1980s, many of Keith's colleagues fondly described the cell as being filled, not with protoplasm, but with "Porterplasm." Despite the fact that Keith's view was clouded by the methods of his time, it would be fitting and apt to retain this name, still today, for the ordered matrix of cytoskeletal macromolecules that exists in the living cell. In the end, the story of what happened to Porter's microtrabecular concept should be an object lesson in scientific hubris that should humble and inform all of us in cell biology, even today--particularly when we begin to think that our most recent methods and observations are achieving "the last word".     

Kant’s concept of natural purpose and the reflecting power of judgement

This paper examines how in the ‘Critique of teleological judgment’ Kant characterized the concept of natural purpose in relation to and in distinction from the concepts of nature and the concept of purpose he had developed in his other critical writings. Kant maintained that neither the principles of mechanical science nor the pure concepts of the understanding through which we determine experience in general provide adequate conceptualizations of the unique capacities of organisms. He also held that although the concept of natural purpose was derived through reflection upon an analogy to human purposive activity in artistic production and moral action, it articulates a unique notion of intrinsic purposiveness. Kant restricted his critical reflections on organisms to phenomena that can be given to us in experience, criticizing speculations on their first origins or final purpose. But I argue that he held that the concept of natural purpose is a product of the reflecting power of judgment, rather than an empirical concept, and represents only the relation of things to our power of judgment. Yet it is necessary for the identification of organisms as organized and self-organizing, and as subject to unique norms and causal relations between parts and whole.     

Social groups with diverse personalities mitigate physiological stress in a songbird

Social groups often consist of diverse phenotypes, including personality types, and this diversity is known to affect the functioning of the group as a whole. Social selection theory proposes that group composition (i.e. social environment) also influences the performance of individual group members. However, the effect of group behavioural composition on group members remains largely unexplored, and it is still contentious whether individuals benefit more in a social environment with homogeneous or diverse behavioural composition. We experimentally formed groups of house sparrows Passer domesticus with high and low diversity of personality (exploratory behaviour), and found that their physiological state (body condition, physiological stress and oxidative damage) improved with increasing group-level diversity of personality. These findings demonstrate that group personality composition affects the condition of group members and individuals benefit from social heterosis (i.e. associating with a diverse set of behavioural types). This aspect of the social life can play a key role in affiliation rules of social animals and might explain the evolutionary coexistence of different personalities in nature.     

Sensing pH?

Abstract. pH is an all-pervasive variable in the environment of phototrophs. Phototrophs as a whole, and even the single genus Dunaliella , can grow over essentially the whole range of pH values found in nature. Such a large range of pH values, combined with other chemical variations in the environment, impose a range of constraints on plant behaviour related to intracellular pH regulation, nutrient acquisition, and avoidance of toxic effects. No single genotype can grow well over the whole pH range compatible with growth of phototrophs as a whole, although some deliberately alter surface pH so as to create a 5–6 unit pH gradient over the surface related to nutrient acquisition and avoidance of toxic influences. The regulation of these various processes does not, on current evidence, involve pH-sensing by any extracellular sensor which is not part of the catalytic or regulatory mechanism of a membrane protein such as a porter.     

Reflections on the meanings of dreams prompted by reading Stekel.

What does it mean to interpret a dream? While reading Stekel, an underappreciated but fascinating author, I was struck both by his keen insights as well as his interpretive limitations. This led to broader questions concerning the polyvocal concept of “meaning” in the interpretation of dreams. This article suggests the meaning of dreams can include wish fulfillments, univocal translations, clarifying the life context, morphological equivalences, associations, and personal history. Stepping back, even the question of “interpretation” versus “appreciation” reminds us that the need, if any, for interpretation will vary depending on who is asking the question. Indeed, reflections on the “who” or ego in the dream leads beyond dreaming to ultimate questions concerning the reality of ego and meditative reflections on what it means to truly be awake and aware of life as it is. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The natural chlorine cycle – fitting the scattered pieces

Chlorine is one of the most abundant elements on the surface of the earth. Until recently, it was widely believed that all chlorinated organic compounds were xenobiotic, that chlorine does not participate in biological processes and that it is present in the environment only as chloride. However, over the years, research has revealed that chlorine takes part in a complex biogeochemical cycle, that it is one of the major elements of soil organic matter and that the amount of naturally formed organic chlorine present in the environment can be counted in tons per km(2). Interestingly enough, some of the pieces of the chlorine puzzle have actually been known for decades, but the information has been scattered among a number of different disciplines with little or no exchange of information. The lack of communication appears to be due to the fact that the points of departure in the various fields have not corresponded; a number of paradoxes are actually revealed when the known pieces of the chlorine puzzle are fit together. It appears as if a number of generally agreed statements or tacit understandings have guided perceptions, and that these have obstructed the understanding of the chlorine-cycle as a whole. The present review enlightens four paradoxes that spring up when some persistent tacit understandings are viewed in the light of recent work as well as earlier findings in other areas. The paradoxes illuminated in this paper are that it is generally agreed that: (1) chlorinated organic compounds are xenobiotic even though more than 1,000 naturally produced chlorinated compounds have been identified; (2) only a few, rather specialised, organisms are able to convert chloride to organic chlorine even though it appears as if the ability among organisms to transform chloride to organic chlorine is more the rule than the exception; (3) all chlorinated organic compounds are persistent and toxic even though the vast majority of naturally produced organic chlorine is neither persistent nor toxic; (4) chlorine is mainly found in its ionic form in the environment even though organic chlorine is as abundant or even more abundant than chloride in soil. Furthermore, the contours of the terrestrial chlorine cycle are outlined and put in a concrete form by constructing a rough chlorine budget over a small forested catchment. Finally, possible ecological roles of the turnover of chlorine are discussed.     

Préservation de la fertilité chez les enfants et les adolescents traités pour un cancer. Aspects relationnels et éthiques

Proposing fertility preservation to an adolescent before chemotherapy that may induce sterility raises numerous relational and ethical issues, as it concerns an adolescent, cancer, sexuality, and parenthood. The goal is to preserve fertility without exacerbating confusion and suffering, without triggering a senses of guilt or irretrievable loss in the event of failure, without hampering his relations with the oncologist caregiver, without transforming his self-esteem and existential dynamics, so that later the memory of the illness and its treatment will not be shameful or traumatic. In routine practice, it is importannt to be attentive to two problems: if semen collection is impossible or fails (how will the adolescent react?) and when parents are too reticent or too eager to do so in the adolescent's place. In these situations, and even more so when a rare, innovative procedure is proposed, it is important to take into account the main principles of clinical ethics: respect the patient's autonomy and dignity, the principles of causing no harm and justice. It is also important to determine the adolescent's objectives, expectations and motivations (whether he accepts or refuses the proposal) which are not necessarily the same as those of the clinicians or parents. Dialogue is not always easy because the diagnosis of cancer (and the resulting shock) is recent, the treatment must commence rapidly, and the doctor and patient do not know each other very well. Training in the use of dialogue and relational skills, in issues specific to adolescents and adolescent psychology, and in solving ethical problems in the medical field can be useful.     

生态意识及其主要特点

一、生态意识产生的时代背景生态意识作为人类思想的先进观念,产生于20世纪后半叶。产业革命以来二百多年,人类依据先进科学技术武装的强大生产力,无限制地向自然进     

Personality in the context of social networks

There is great interest in environmental effects on the development and evolution of animal personality traits. An important component of an individual's environment is its social environment. However, few studies look beyond dyadic relationships and try to place the personality of individuals in the context of a social network. Social network analysis provides us with many new metrics to characterize the social fine-structure of populations and, therefore, with an opportunity to gain an understanding of the role that different personalities play in groups, communities and populations regarding information or disease transmission or in terms of cooperation and policing of social conflicts. The network position of an individual is largely a consequence of its interactive strategies. However, the network position can also shape an individual's experiences (especially in the case of juveniles) and therefore can influence the way in which it interacts with others in future. Finally, over evolutionary time, the social fine-structure of animal populations (as quantified by social network analysis) can have important consequences for the evolution of personalities-an approach that goes beyond the conventional game-theoretic analyses that assumed random mixing of individuals in populations.     

Memories and traces. From Jewish exilists' authoritarian personality research via Cloninger's psychobiology of personality traits to a neurobiological approach to conflict management

Research on personality as a useful construct to understand people's behavior in conflict situations was traced over more than fifty years, and an attempt was made to add neurobiological parameters to psycho-socio-cultural approaches. As a starting point, scientists in exile have been called to mind who had been expelled from Nazi Germany for their Jewish origins. Among them were Adorno and Frenkel-Brunswik whose extensive studies on the authoritarian personality structure were quoted. In their work, personality was defined as a more or less enduring organisation of forces within the individual helping to determine responses in various situations, which is responsible for consistency in behavior. As a next step, Cloninger's psychobiology of personality traits was presented. In his personality concept, four temperamental traits (novelty seeking, harm avoidance, reward dependency and persistence) and three character dimensions are included. Temperamental traits are heritable, developmentally stable, emotionally based, uninfluenced by social learning, and linked to specific brain biological features. The temperaments have a certain neuroendocrinological feature which can be determined. Character dimensions develop in a stagelike process from infancy to adulthood and are influenced by temperament, social learning, genetic factors, and random life events. Personality is still considered a useful theoretical approach to conflict management research and practice. A neurobiological point of view seems to be a useful supplementation in addition to traditional psycho-socio-cultural approaches. Measuring biological compounds can supply the conflict manager with an additional tool of knowledge enhancing the ability to understand and anticipate conflict behavior.     

The confederation worm token.

To an increasing degree the psychiatrist is oriented to the community and general hospital either as consultant, therapist, or collaborator in overall patient management. In these new roles, he becomes a more comprehensive physician and also conveys psychiatric insights to his colleagues.Psychological factors and the patient''s personality “style” influence the development and course of every disease, complicating diagnosis and effective treatment. It is a basic requirement that a good working alliance be established between patient and physician. This is assisted by comprehensive history taking, which clarifies the lifesetting in which the illness began, the patient''s personality and his habitual reactions of emotional regression under stress. It will also point up errors introduced by the patient, omissions, and distortions in offering the subjective data which the physician must evaluate.Seven major personality types and appropriate physician responses are outlined: the dependent demanding oral patient, the orderly controlled obsessive, the dramatic seductive hysteric, the long-suffering masochist, the querulous paranoid, the overbearing narcissist and the aloof withdrawn schizoid.The non-psychiatrist can resolve complex and puzzling medical problems if he has an increased awareness of how emotional forces complicate illness and if he can exploit comprehensive history taking to the full.     

I. I. Shmal'gauzen's concept of the evolution of ontogeny

The concept of evolution of ontogenesis by I. I. Shmal'gauzen is presented as a result of reviewing some of his theoretical works. This concept appears to be the most consistent development of classical darwinism on the basis of a basically new (as compared with synthetic theory of evolution) evolutionary-synthetic approach. This latter has been based on the idea of the organism integrity in onto- and phylogenesis and the involvement of the organismic level (ontogenesis), together with the population and biocoenotic ones, in the evolutionary process as a whole.     

Q & A: Samir Khleif

In 1999, Hussein bin Talal, the king of Jordan, died after a long battle with non-Hodgkin's lymphoma. Since then, his eldest son and successor, King Abdullah II bin Al Hussein, has sought to improve cancer treatment in his country as part of an effort to boost healthcare and technological development. The country's capital, Amman, now boasts a world-class cancer treatment center, which draws patients from throughout the region. To lead that effort, the king tapped Samir Khleif, chief of the cancer vaccine section at the US National Cancer Institute in Bethesda, Maryland. Khleif, who received his medical degree in Jordan, now has an even bigger mandate from the king: to build an internationally renowned institute devoted to cancer research and biotechnology. Construction on The King Hussein Institute for Cancer and Biotechnology is scheduled to begin on the outskirts of Amman this month, with an expected completion in 2010.