共查询到20条相似文献,搜索用时 31 毫秒
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AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity 总被引:3,自引:0,他引:3
Ferguson BJ Alexander C Rossi SW Liiv I Rebane A Worth CL Wong J Laan M Peterson P Jenkinson EJ Anderson G Scott HS Cooke A Rich T 《The Journal of biological chemistry》2008,283(3):1723-1731
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The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein 总被引:11,自引:0,他引:11
Pitkänen J Doucas V Sternsdorf T Nakajima T Aratani S Jensen K Will H Vähämurto P Ollila J Vihinen M Scott HS Antonarakis SE Kudoh J Shimizu N Krohn K Peterson P 《The Journal of biological chemistry》2000,275(22):16802-16809
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Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla 总被引:14,自引:0,他引:14
Heino M Peterson P Kudoh J Nagamine K Lagerstedt A Ovod V Ranki A Rantala I Nieminen M Tuukkanen J Scott HS Antonarakis SE Shimizu N Krohn K 《Biochemical and biophysical research communications》1999,257(3):821-825
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The autoimmune regulator (AIRE) is a DNA-binding protein 总被引:9,自引:0,他引:9
Kumar PG Laloraya M Wang CY Ruan QG Davoodi-Semiromi A Kao KJ She JX 《The Journal of biological chemistry》2001,276(44):41357-41364
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盛德乔 《国外医学:分子生物学分册》2011,(5):433-436
目的分析转录因子Deafl的功能结构域并预测其功能。方法利用现有的数据库和软件对Deafl的转录因子结构域,核定位信号及和输出信号进行分析和预测。结果Deafl含有一个保守的SAND结构域及一个能介导蛋白质一蛋白质相互作用的MYND结构域;有核定位信号和核输出信号;在其N端还有一个富含丙氨酸结构域。结论Deafl除有典型转录因子必需的功能结构域之外,可能还有不止一个结构域能介导与其它蛋白质因子的相互作用,这对Deafl调控外周组织抗原表达至关重要。 相似文献
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Purohit S Kumar PG Laloraya M She JX 《Biochemical and biophysical research communications》2005,327(3):939-944
The human autoimmune regulator (AIRE) gene encodes a putative DNA-binding protein, which is mutated in patients affected by the autoimmune polyglandular syndrome type 1 or autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. We have recently reported that AIRE can bind to two different DNA sequence motifs, suggesting the existence of at least two DNA-binding domains in the AIRE protein. By expressing a series of recombinant AIRE protein fragments, we demonstrate here that the two well-known plant homeodomains (PHD) domains in AIRE can bind to the ATTGGTTA sequence motif. The first ATTGGTTA-binding domain is mapped to amino acids 299-355 and the second ATTGGTTA-binding domain to amino acids 434-475. Furthermore, the SAND domain of AIRE is shown to bind to TTATTA motif. Results presented herein show that the residues at position 189-196 of AIRE (QRAVAMSS) are required for its binding to the TTATTA motif. The required sequence for DNA binding in the SAND domain of AIRE is remarkably different from other SAND-containing proteins such as Sp-100b and NUDR. Data presented in this paper indicate that the two PHD domains contained in AIRE, in addition to the SAND domain, can bind to specific DNA sequence motifs. 相似文献
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