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Characterization and structural analysis of novel mutations in human immunodeficiency virus type 1 reverse transcriptase involved in the regulation of resistance to nonnucleoside inhibitors 
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下载免费PDF全文 Ceccherini-Silberstein F Svicher V Sing T Artese A Santoro MM Forbici F Bertoli A Alcaro S Palamara G d'Arminio Monforte A Balzarini J Antinori A Lengauer T Perno CF 《Journal of virology》2007,81(20):11507-11519
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Bal TR Anand B Yogeeswari P Sriram D 《Bioorganic & medicinal chemistry letters》2005,15(20):4451-4455
On the basis of pharmacophoric modelling studies of existing NNRTIs, a series of isatin beta-thiosemicarbazone derivatives was synthesized and evaluated for their anti-HIV activity in HTLV-III(B) strain in the CEM cell line. Three compounds showed significant anti-HIV activity, whereupon compound 6 was found to be the most active compound with an EC(50) value of 2.62 microM and a selectivity index of 17.41, while not being cytotoxic to the cell line at a CC(50) value of 44.90 microM. Other tested compounds exhibited marked activity below their toxicity threshold. 相似文献
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Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains 总被引：1，自引：0，他引：1
Barreca ML Rao A De Luca L Iraci N Monforte AM Maga G De Clercq E Pannecouque C Balzarini J Chimirri A 《Bioorganic & medicinal chemistry letters》2007,17(7):1956-1960
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Ambrose Z Boltz V Palmer S Coffin JM Hughes SH Kewalramani VN 《Journal of virology》2004,78(24):13553-13561