共查询到20条相似文献,搜索用时 31 毫秒
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Megan K Townsend Nathan J Carr Jyoti G Iyer Shelley M Horne Penelope S Gibbs Birgit M Prüß 《BMC microbiology》2008,8(1):12
Background
The Yersinia enterocolitica flagellar master regulator FlhD/FlhC affects the expression levels of non-flagellar genes, including 21 genes that are involved in central metabolism. The sigma factor of the flagellar system, FliA, has a negative effect on the expression levels of seven plasmid-encoded virulence genes in addition to its positive effect on the expression levels of eight of the flagellar operons. This study investigates the phenotypes of flhD and fliA mutants that result from the complex gene regulation. 相似文献12.
The ClpXP ATP-Dependent Protease Regulates Flagellum Synthesis in Salmonella enterica Serovar Typhimurium 总被引:6,自引:0,他引:6
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Toshifumi Tomoyasu Tomiko Ohkishi Yoshifumi Ukyo Akane Tokumitsu Akiko Takaya Masato Suzuki Kachiko Sekiya Hidenori Matsui Kazuhiro Kutsukake Tomoko Yamamoto 《Journal of bacteriology》2002,184(3):645-653
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The oxygen sensor Aer of Escherichia coli affects the expression level of genes that are involved in sugar acid degradation. Phenotypes of Aer mediated gene regulation,
namely growth on sugar acids was tested ‘in vitro’ with Phenotype MicroArrays and colonization of the mouse large intestine
was tested ‘in vivo’. The aer mutant did not grow on the sugar acids d-gluconate, d-glucuronate, d-galacturonate, as well as the sugar alcohol d-mannitol. Since sugar acids are the predominant carbon source for E. coli in the intestinal mucosa, the ability of the aer mutant to colonize the streptomycin-treated mouse large intestine was tested. The mutant exhibited a decreased ability to
colonize the intestine when compared to wild-type cells. This effect was more pronounced under competitive conditions. The
colonization phenotype of the aer mutant was complemented with either of two plasmids. One of them expressed the Aer protein, whereas the other one expressed
the sugar acid degradation enzymes that are encoded by edd and eda. The data support the interpretation that decreased expression of edd and eda along with the decreased ability to grow on sugar acids may contribute to the reduced capacity of the aer mutant to colonize the mouse intestine. While Aer seems to be important during the initiation phase of colonization, FlhD/FlhC
appears to be of disadvantage during maintenance phase. FlhD/FlhC is the master regulator of all flagellar genes and required
for Aer expression. Mutants in flhD exhibited an initial competitive disadvantage during the first 3 days of colonization, but recovered lateron. 相似文献
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