共查询到20条相似文献,搜索用时 109 毫秒
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对天然产物树豆内酯A进行皂化反应以期获得具有降血糖、降血脂活性的天然药物先导物树豆酮酸A。利用含有树豆内酯A和球松素各约50%的粗品,经0.65%KOH含水乙醇回流3.5 h皂化,产物经柱层析分离纯化获得皂化产物;通过理化和波谱学分析鉴定产物的化学结构。分离并鉴定了全部5个皂化产物,除了预期产物树豆酮酸A以外,其余4个低得率的副产物结构分别为1-(2,6-二羟基-4-甲氧基苯基)乙酮(2)、球松素查尔酮(3)、cajanotone(4)和1个新化合物(1),化合物1鉴定为CAA的异构体,命名为树豆酮酸B(Cajanonic acid B)。这为进一步研究开发树豆(Cajanus cajan)叶生物活性成分提供了新的实验依据。 相似文献
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天然产物是创新药物、食品、香料和日化产品等的重要来源,和人民的健康生活息息相关。近年来,随着现代生物学技术和天然产物化学技术的发展和融合,天然产物生物合成研究得到了迅猛的发展。一批天然产物的生物合成途径被解析,许多天然产物生物合成相关的途径酶与后修饰酶被挖掘和功能表征。进一步,这些参与天然产物生物合成的途径酶编码基因被组装到不同的底盘细胞中,利用合成生物学技术构建细胞工厂,用于天然产物的生物合成。此外,包括基因组编辑等新技术在内的生物技术也被用于天然产物的生物合成。为了进一步促进天然产物生物合成研究的发展,《生物工程学报》特组织出版"天然产物的生物合成"专刊,重点阐述了在天然产物生物合成途径的解析,工具酶的挖掘和功能表征以及生物合成技术制备天然产物三方面所取得的研究进展,并展望未来的发展趋势,为天然产物生物合成的进一步发展提供借鉴和指导。 相似文献
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后基因组时代的真菌天然产物发现 总被引:1,自引:0,他引:1
真菌产生的次级代谢产物是新药发现的重要来源之一,然而近年来传统的真菌天然产物发现方法在大量真菌基因组测序完成的时代遇到了很大的挑战。如何利用这些基因组数据来发现真菌中新的天然产物已成为后基因组时代天然产物发现的研究重点和热点。本综述先后介绍了真菌天然产物的类型及其相应基因簇和骨架酶的特征,基于基因组挖掘技术发展而来的天然产物发现新策略,以及利用合成生物学理念和技术在真菌天然产物发现中的应用现状,最后展望了后基因组时代中的天然产物发现研究前沿及基因组数据在后基因组时代对真菌天然产物发现的应用前景。 相似文献
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微生物天然产物是天然药物的重要组成部分,而天然产物的良好生物活性很大程度上取决于发挥药效的结构基团。这些特殊药效基团的生物合成,通常是利用小分子羧酸、氨基酸等结构简单的初级代谢产物,经过复杂的生物化学过程,最终合成结构复杂活性多样的天然产物。戊二酰亚胺类天然产物是一类重要的细菌来源天然产物,它们具有良好的生物活性,是潜在的先导化合物,部分化合物已被开发成分子探针。本文综述了近年来微生物来源的戊二酰亚胺类天然产物及其生物合成研究,包括Iso-Migrastatin、Lactimidomyin、Cycloheximide、Streptimidone、Gladiostatin、Sesbanimide等,对戊二酰亚胺类天然产物的生物合成研究,将有效促进通过基因组挖掘策略寻找新型戊二酰亚胺类天然产物。 相似文献
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覃舒然刘海翠李大山王文静 《天然产物研究与开发》2022,(11):1978-1987
质谱分子网络(molecular networking)常用于新颖天然产物发现及鉴定、药物代谢及药物研发等研究。目前,分子网络能够将具有相似二级质谱的化合物连接成簇,在天然产物分析中得到了广泛的应用。本综述将简单介绍分子网络的基本概念和构建分子网络的步骤,以及从化合物的鉴定及发现;鉴定天然产物的代谢产物;天然产物化学成分的定性及定量;天然产物活性成分筛选、分离与制备;天然产物的生物合成途径五个方面对分子网络的应用进行阐述。 相似文献
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Diels-Alder反应是著名的有机化学反应,其在天然产物的全合成中占有非常重要的地位。本文综述近年来从天然产物中发现的并且通过Diels-Alder反应形成的天然加合物,同时为复杂天然产物的仿生全合成提供一些思路。 相似文献
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Hong-Yan Guo Zheng-Ai Chen Qing-Kun Shen Zhe-Shan Quan 《Journal of enzyme inhibition and medicinal chemistry》2021,36(1):1115
Nature products have been extensively used in the discovery and development of new drugs, as the most important source of drugs. The triazole ring is one of main pharmacophore of the nitrogen-containing heterocycles. Thus, a new class of triazole-containing natural product conjugates has been synthesised. These compounds reportedly exert anticancer, anti-inflammatory, antimicrobial, antiparasitic, antiviral, antioxidant, anti-Alzheimer, and enzyme inhibitory effects. This review summarises the research progress of triazole-containing natural product derivatives involved in medicinal chemistry in the past six years. This review provides insights and perspectives that will help scientists in the fields of organic synthesis, medicinal chemistry, phytochemistry, and pharmacology. 相似文献
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Waldmann H 《Bioorganic & medicinal chemistry》2003,11(14):3045-3051
The life sciences are molecular and the harnessing of information gleaned from genomics and proteomics will require interdisciplinary research integrating chemistry and biology. This approach is illustrated by the synthesis and biological evaluation of lipidated peptides and proteins and the delineation of a concept arguing for natural product guided combinatorial chemistry. 相似文献
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The introduction of high-throughput synthesis and combinatorial chemistry has precipitated a global decline in the screening of natural products by the pharmaceutical industry. Some companies terminated their natural products program, despite the unproven success of the new technologies. This was a premature decision, as natural products have a long history of providing important medicinal agents. Furthermore, they occupy a complementary region of chemical space compared with the typical synthetic compound library. For these reasons, the interest in natural products has been rekindled. Various approaches have evolved that combine the power of natural products and organic chemistry, ranging from the combinatorial total synthesis of analogues to the exploration of natural product scaffolds and the design of completely unnatural molecules that resemble natural products in their molecular characteristics. 相似文献
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Natural products have served as an important source of medicinal compounds and pharmaceutical leads over the last century. Within the last 10 years, significant interest has developed in applying combinatorial chemistry techniques to the study of natural products and their biological activities. In this review, we examine several representative efforts wherein natural product skeletons have been constructed or immobilized on solid support and subsequently derivatized, giving rise to analog libraries useful in understanding the structure-activity relationships of the parent natural product. Issues such as target selection, library design, linker development, automation, and library characterization are addressed. 相似文献
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本文回顾了八十年代初期以来天然有机合成化学取得的主要进展,并着重从仿生育机合成、生理活性物质的有机合成和立体选择有机合成等方面取得的进展,展望了天然有机合成化学的发展趋势. 相似文献
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Yao C Jiang B Li T Qin B Feng X Zhang H Wang C Tu S 《Bioorganic & medicinal chemistry letters》2011,21(1):599-601
A series of 4-aryl-cyclopenta[b]pyran derivatives, designed based on natural product scaffold, were synthesized efficiently via multi-component reaction under solvent-free and catalyst-free conditions. This chemistry provides a new compound library with potential activity for biomedical screening. 相似文献
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我国资源植物化学与天然产物化学基础研究的现状与发展 总被引:8,自引:0,他引:8
本文从生物活性成分的筛选与分离、植物次生代谢产物生物合成及其分子调控、环境因子对植物次生代谢产物合成和积累的影响、植物体内生菌与植物次生代谢产物的关系等方面介绍了我国资源植物化学与天然产物化学领域基础研究的现状与发展。 相似文献
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Volgraf M Lumb JP Brastianos HC Carr G Chung MK Münzel M Mauk AG Andersen RJ Trauner D 《Nature chemical biology》2008,4(9):535-537
Biomimetic synthesis is an attempt to assemble natural products along biosynthetic lines without recourse to the full enzymatic machinery of nature. We exemplify this with a total synthesis of exiguamine A and the newly isolated natural product exiguamine B. The most noteworthy feature of this work is an oxidative endgame drawing from the complex chemistry of catecholamines, which allows for ready access to a new class of nanomolar indoleamine-2,3-dioxygenase inhibitors. 相似文献