共查询到20条相似文献,搜索用时 15 毫秒
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Eukaryotic RNA polymerases are multisubunit assemblies, whose enzymatic function in the nucleus is intensively studied. However, little is known about the biogenesis of the three RNA polymerases and coupling to nucleo-cytoplasmic transport. Here, we show that Rpc128, the second largest subunit of RNA polymerase III, was mislocalized to the cytoplasm, when a short sequence in the N-terminal domain was deleted. Importantly, nuclear import of other, but not all, RNA polymerase III subunits was impaired in this RPC128DeltaN mutant. These data suggest that RNA polymerase III subunits are not imported independently into the nucleus but may require preassembly into cytoplasmic subcomplexes for coordinated nuclear uptake. We expect these studies to be a starting point to dissect the complex biogenesis pathway of eukaryotic RNA polymerases. 相似文献
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Stress-induced transcription of satellite III repeats 总被引:1,自引:0,他引:1
Jolly C Metz A Govin J Vigneron M Turner BM Khochbin S Vourc'h C 《The Journal of cell biology》2004,164(1):25-33
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Regulation of herpes simplex virus gene transcription in vitro 总被引:2,自引:0,他引:2
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Nucleolar dominance and silencing of transcription 总被引:1,自引:0,他引:1
Pikaard CS 《Trends in plant science》1999,4(12):478-483
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