共查询到20条相似文献,搜索用时 15 毫秒
1.
Background
An appropriate choice of the modeling formalism from the broad range of existing ones may be crucial for efficiently describing and analyzing biological systems. 相似文献2.
Luke C Henry Sébastien Tremblay Suzanne Leclerc Abdesselam Khiat Yvan Boulanger Dave Ellemberg Maryse Lassonde 《BMC neurology》2011,11(1):105
Background
Despite negative neuroimaging findings many athletes display neurophysiological alterations and post-concussion symptoms that may be attributable to neurometabolic alterations. 相似文献3.
Nich C Langlois J Marchadier A Vidal C Cohen-Solal M Petite H Hamadouche M 《Arthritis research & therapy》2011,13(3):R100
Introduction
Postmenopausal osteoporosis may modulate bone response to wear debris. In this article, we evaluate the influence of oestrogen deficiency on experimental particle-induced osteolysis. 相似文献4.
Background
Understanding the constituent domains of oncogenes, their origins and their fusions may shed new light about the initiation and the development of cancers. 相似文献5.
Background
Application of phenetic methods to gene expression analysis proved to be a successful approach. Visualizing the results in a 3-dimentional space may further enhance these techniques. 相似文献6.
Gabor Er?s Saleh Ibrahim Nikolai Siebert Mihály Boros Brigitte Vollmar 《Arthritis research & therapy》2009,11(2):R43
Introduction
Phosphatidylcholine and phosphatidylcholine-derived metabolites exhibit anti-inflammatory properties in various stress conditions. We hypothesized that dietary phosphatidylcholine may potentially function as an anti-inflammatory substance and may decrease inflammatory activation in a chronic murine model of rheumatoid arthritis (collagen-induced arthritis). 相似文献7.
Background
Recent research shows that polycystic ovary syndrome (PCOS) may have an association with low-grade chronic inflammation, and that PCOS may induce an increase in serum interleukin-18 (IL-18) levels. 相似文献8.
Background
Perineuriomas have been defined as tumorous lesions of the peripheral nerves which derive from perineurial cell proliferation and may be associated with abnormalities on chromosome 22. 相似文献9.
Telomere length determined by the fluorescence in situ hybridisation distinguishes malignant and benign cells in cytological specimens 下载免费PDF全文
Y. Matsuda A. Suzuki S. Esaka Y. Hamashima M. Imaizumi M. Kinoshita H. Shirahata Y. Kiso H. Kojima M. Matsukawa Y. Fujii N. Ishikawa J. Aida K. Takubo T. Ishiwata M. Nishimura T. Arai 《Cytopathology》2018,29(3):262-266
Background
Telomeres are tandem repeats of TTAGGG at the end of eukaryotic chromosomes that play a key role in preventing chromosomal instability. The aim of the present study is to determine telomere length using fluorescence in situ hybridisation (FISH) on cytological specimens.Methods
Aspiration samples (n = 41) were smeared on glass slides and used for FISH.Results
Telomere signal intensity was significantly lower in positive cases (cases with malignancy, n = 25) as compared to negative cases (cases without malignancy, n = 16), and the same was observed for centromere intensity. The difference in DAPI intensity was not statistically significant. The ratio of telomere to centromere intensity did not show a significant difference between positive and negative cases. There was no statistical difference in the signal intensities of aspiration samples from ascites or pleural effusion (n = 23) and endoscopic ultrasound‐guided FNA samples from the pancreas (n = 18).Conclusions
The present study revealed that telomere length can be used as an indicator to distinguish malignant and benign cells in cytological specimens. This novel approach may help improve diagnosis for cancer patients. 相似文献10.
Background
Allogeneic and autologous haematopoietic stem cell transplantation are established treatment options for haematological malignancies and may possibly be employed to treat a range of genetic and autoimmune diseases. 相似文献11.
Henning A Haga Bjørnar Ytrehus Inger J Rudshaug Nina Ottesen 《Acta veterinaria Scandinavica》2008,50(1):9
Background
Neoplasia may cause hypoglycemia in different species including the horse, but hypoglycemia has not previously been reported in the horse associated with gastrointestinal stromal tumours. 相似文献12.
Dan Wang Jing Mao Bin Zhou Xiao-Fu Liao Shi-Qiang Gong Yan Liu Jing-Tao Zhang 《Biotechnology letters》2011,33(1):191-197
Purpose of work
Our study provides a promising alternative of biomimetic coating which functionalizes the dental implant with adhesion peptides and may be useful for enhancing the bone remodeling around Ti implants. 相似文献13.
Background
Recent research show that polycystic ovary syndrome (PCOS) may have an association with low-grade chronic inflammation, IL-18 is considered as a strong risk marker of inflammation. 相似文献14.
Joseph Horzempa Paul E CarlsonJr Dawn M O'Dee Robert MQ Shanks Gerard J Nau 《BMC microbiology》2008,8(1):172
Background
After infecting a mammalian host, the facultative intracellular bacterium,Francisella tularensis, encounters an elevated environmental temperature. We hypothesized that this temperature change may regulate genes essential for infection. 相似文献15.
Paul-Ludwig Lott Marvin Mundry Christoph Sassenberg Stefan Lorkowski Georg Fuellen 《BMC bioinformatics》2006,7(1):231-15
Background
In the genomic age, gene trees may contain large amounts of data making them hard to read and understand. Therefore, an automated simplification is important. 相似文献16.
Yong Li Dingguo Zhang Yuqing Zhang Guoping He Fumin Zhang 《Journal of biomedical science》2010,17(1):75
Objectives
We postulated that combining high-dose simvastatin with bone marrow derived-mesenchymal stem cells (MSCs) delivery may give better prognosis in a mouse hindlimb ischemia model. 相似文献17.
Mario Varcamonti Slavica Arsenijevic Luca Martirani Daniela Fusco Gino Naclerio Maurilio De Felice 《Microbial cell factories》2006,5(1):6-6
Background
Heat and cold shock response are normally considered as independent phenomena. A small amount of evidence suggests instead that interactions may exist between them in two Lactococcus strains. 相似文献18.
Background
Fast, cheap and reliable methods are needed to identify large populations, which may be at risk in relation to environmental exposure. Polymorphisms in NAT1 (N-acetyl transferase) may be suitable markers to identify individuals at risk. 相似文献19.
Background
Cutaneous horns (cornu cutaneum) are uncommon lesions consisting of keratotic material resembling that of an animal horn. Cutaneous horn may arise from a wide range of the epidermal lesions, which may be benign, premalignant or malignant. 相似文献20.
Cleo Robinson Marinella Callow Sandra Stevenson Bruce WS Robinson Richard A Lake 《Respiratory research》2001,2(2):119-6