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1.
Barbara Reis-Santos Rodrigo Locatelli Bernardo L. Horta Eduardo Faerstein Mauro N. Sanchez Lee W. Riley Ethel Leonor Maciel 《PloS one》2013,8(4)
Background
Several studies have evaluated the relationship between diabetes mellitus (DM) and tuberculosis (TB), but the nature of this relationship is not fully understood. TB incidence may be influenced by immunosuppression from DM, but this association may be confounded by other clinical and socioeconomic factors. We aimed to assess socio-demographic and clinical differences in TB patients with and without DM.Methods
Using the Brazilian national surveillance system (SINAN), we compared 1,797 subjects with TB and DM with 29,275 subjects diagnosed with TB only in 2009. We performed multivariate analysis to identify factors associated with the presence of DM among TB patients.Results
Subjects with TB – DM were older; have initial positive sputum smear test (OR = 1.42, 95% CI 1.26–1.60), and were more likely to die from TB (OR = 1.44, 95% CI 1.03–2.01). They were less likely to have been institutionalized [in prison, shelter, orphanage, psychiatric hospital (OR = 0.74, 95% CI 0.60–0.93)]; developed extra pulmonary TB (OR = 0.62, 95% CI 0.51–0.75) and to return to TB treatment after abandonment (OR = 0.66, 95% CI 0.51–0.86).Conclusions
Prevalence of NCD continues to rise in developing countries, especially with the rise of elderly population, the prevention and treatment of infectious diseases will be urgent. DM and TB represent a critical intersection between communicable and non-communicable diseases in these countries and the effect of DM on TB incidence and outcomes provide numerous opportunities for collaboration and management of these complex diseases in the national public health programs. 相似文献2.
Parimelzaghan Anitha Vaideeswaran Sivasakthi Pandian Lavanya Susmita Bag Kalavathi Murugan Kumar Anand Anbarasu Sudha Ramaiah 《Bioinformation》2012,8(17):820-826
Metalloproteins have many different functions in cells such as enzymes; signal transduction, transport and storage proteins. About
one third of all proteins require metals to carry out their functions. In the present study we have analyzed the roles played by Arg
and Lys (cationic side chains) interactions with π (Phe, Tyr or Trp) residues and their role in the structural stability of
metalloproteins. These interactions might play an important role in the global conformational stability in metalloproteins. In spite
of its lower natural occurrence (1.76%) the number of Trp residues involved in energetically significant interactions is higher in
metalloproteins. 相似文献
3.
Summary A comparison was made of the activity of carboxydismutase (ribulose-1,5-diphosphate carboxylase) between higher plant species which possess the -carboxylation (C4-dicarboxylic acid) pathway for photosynthesis and species which lack this pathway. Contrary to earlier findings no marked difference in the level of this enzyme was found between the two groups of species. Chloroplast-containing vascular-bundle-sheath cells which seem to be present only in plants with -carboxylation apparently contain relatively high carboxydismutase activity.C.I.W.-D.P.B. Publ. No. 453. 相似文献
4.
David Harris Abdul Rashid Ghazal Miraj Muhammad Arif Muhammed Yunas 《Plant and Soil》2008,306(1-2):3-10
A series of on-station trials was implemented between 2002 and 2006 to assess the response of wheat (Triticum aestivum L.) and chickpea (Cicer arietinum) to zinc (Zn) added by soaking seeds (priming) in solutions of ZnSO4 before sowing. Wheat seed was primed for 10 h in 0.3% Zn and chickpea for 6 h in 0.05% Zn. Seed treatments increased the
seed concentration in wheat from 27 to 470 mg/kg and in chickpea from 49 to 780 mg/kg. Priming wheat seeds with 0.3% Zn significantly
increased the mean shoot dry mass, Zn concentration and Zn uptake of 15-day-old seedlings relative to non-primed controls
and seeds primed with water alone. Using 0.4% Zn further increased shoot Zn concentration but depressed shoot dry mass to
the level of the non-primed control. In seven trials, mean grain yield of wheat was significantly increased from 2.28 to 2.42 t/ha
(6%) by priming with water alone and to 2.61 t/ha (14%) by priming with 0.3% Zn. Mean grain yield of chickpea in seven trials
was increased significantly from 1.39 to 1.65 t/ha (19%) by priming seeds with 0.05% Zn. The effect of priming chickpea seeds
with water was intermediate (1.49 t/ha) and not statistically separable from the non-primed and zinc-primed treatments. Increased
grain yield due to priming in both crops was associated with increases in total biomass but there was no significant effect
of priming on harvest index. In addition to increasing yield, priming seeds with Zn also significantly increased grain zinc
concentration, by 12% in wheat (mean of three trials) and by 29% in chickpea (one trial) and the total amount of Zn taken
up by the grain (by 27% in wheat and by 130% in chickpea). Using ZnSO4 to prime seeds was very cost-effective, with net benefit-to-cost ratios of 75 for wheat and 780 for chickpea.
An erratum to this article can be found at 相似文献
5.
Chitalu C. Musonda Gavin A. Whitlock Michael J. Witty Reto Brun Marcel Kaiser 《Bioorganic & medicinal chemistry letters》2009,19(2):481-484
A dual activity, conjugated approach has been taken to form hybrid molecules of two known antimalarial drugs, chloroquine (CQ) and the non-sedating H1 antagonist astemizole. A variety of linkers were investigated to conjugate the two agents into one molecule. Compounds 5–8 possessed improved in vitro activity against a CQ-resistant strain of Plasmodium falciparum, and examples 7 and 8 were active in vivo in mouse models of malaria. 相似文献
6.
Sylvie Tordjman George M. Anderson Michel Botbol Sylvie Brailly-Tabard Fernando Perez-Diaz Rozenn Graignic Michèle Carlier Gérard Schmit Anne-Catherine Rolland Olivier Bonnot Séverine Trabado Pierre Roubertoux Guillaume Bronsard 《PloS one》2009,4(8)
Background
Reports of reduced pain sensitivity in autism have prompted opioid theories of autism and have practical care ramifications. Our objective was to examine behavioral and physiological pain responses, plasma β-endorphin levels and their relationship in a large group of individuals with autism.Methodology/Principal Findings
The study was conducted on 73 children and adolescents with autism and 115 normal individuals matched for age, sex and pubertal stage. Behavioral pain reactivity of individuals with autism was assessed in three observational situations (parents at home, two caregivers at day-care, a nurse and child psychiatrist during blood drawing), and compared to controls during venepuncture. Plasma β-endorphin concentrations were measured by radioimmunoassay. A high proportion of individuals with autism displayed absent or reduced behavioral pain reactivity at home (68.6%), at day-care (34.2%) and during venepuncture (55.6%). Despite their high rate of absent behavioral pain reactivity during venepuncture (41.3 vs. 8.7% of controls, P<0.0001), individuals with autism displayed a significantly increased heart rate in response to venepuncture (P<0.05). Moreover, this response (Δ heart rate) was significantly greater than for controls (mean±SEM; 6.4±2.5 vs. 1.3±0.8 beats/min, P<0.05). Plasma β-endorphin levels were higher in the autistic group (P<0.001) and were positively associated with autism severity (P<0.001) and heart rate before or after venepuncture (P<0.05), but not with behavioral pain reactivity.Conclusions/Significance
The greater heart rate response to venepuncture and the elevated plasma β-endorphin found in individuals with autism reflect enhanced physiological and biological stress responses that are dissociated from observable emotional and behavioral reactions. The results suggest strongly that prior reports of reduced pain sensitivity in autism are related to a different mode of pain expression rather than to an insensitivity or endogenous analgesia, and do not support opioid theories of autism. Clinical care practice and hypotheses regarding underlying mechanisms need to assume that children with autism are sensitive to pain. 相似文献7.
8.
Eric Hirsch 《The journal of the Royal Anthropological Institute》2022,28(1):204-221
Marshall Sahlins described divine king forms for a wide range of societies from Southeast Asia, Africa, and the Pacific, among others. In this article, I document a divine king form among the Fuyuge people of the Papuan highlands, revising my previous understanding of this powerful figure. At the same time, I argue there is an inextricable connection between Sahlins's theory of divine power and Marilyn Strathern's model of Melanesian gift exchange: both operate according to distinct ideas of otherness. The capacity to engage in transaction derives from cosmological sources while evidence of cosmological power is provided by the ability to engage in transactions with others in effective and powerful ways. More generally, I argue that conventional Melanesian figures of big-men, great men, and chiefs are all versions of the alterity of power in related political forms; each instantiates the mutual relations between cosmological and transactional otherness. 相似文献
9.
Y. Hattori F. Kutlar S. S. Chen T. H. J. Huisman P. Demuro M. Formato L. Manca B. Masala 《Biochemical genetics》1986,24(9-10):669-681
Fetal hemoglobin analysis and globin gene mapping have identified one type of beta(0)-thalassemia and four different gamma globin gene arrangements among newborn babies from the northern part of Sardinia. The beta(0)-thalassemia with a nonsense mutation at codon 39 was found on two chromosomes, each with a distinct pattern of polymorphic restriction sites; one had the A gamma T (A gamma 75 Ile----Thr) mutation, while the second did not. Four closely related haplotypes were identified for chromosomes with the A gamma T mutation. The gamma-thalassemia heterozygosity with the -GA gamma- hybrid gene fell into two categories. One apparently originated through crossing-over between mismatched chromosomes characterized by the most common haplotype, while the other had polymorphisms resembling those of a less frequently occurring chromosome. Chromosomes with the -G gamma-AG gamma-A gamma- triplication had polymorphic sites to be expected for this condition, being complimentary to the -GA gamma- thalassemias. Of the two additional gamma globin gene variations the -G gamma- G gamma- arrangement was associated with the chromosome with the most commonly occurring haplotype, while the chromosome with the -A gamma-A gamma- arrangement had a haplotype characteristic for that with the A gamma T mutation, which identified an -A gamma-A gamma T- arrangement. The incidental discovery of a silent beta-chain mutant, Hb Hamilton, with the Val----Ile substitution at position beta 11, in five newborns was also reported. 相似文献
10.
Welander H Bontha SV Näsström T Karlsson M Nikolajeff F Danzer K Kostka M Kalimo H Lannfelt L Ingelsson M Bergström J 《Biochemical and biophysical research communications》2011,(1):32-38
Deposition of fibrillar α-synuclein as Lewy bodies is the neuropathological hallmark of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Apart from α-synuclein, these intraneuronal inclusions contain over 250 different proteins. The actin binding protein gelsolin, has previously been suggested to be part of the Lewy body, but its potential role in α-synuclein aggregation remains unknown. Here, we studied the association between gelsolin and α-synuclein in brain tissue from PD and DLB patients as well as in a cell model for α-synuclein aggregation. Moreover, the potential effect of gelsolin on α-synuclein fibrillization was also investigated. Our data demonstrate that gelsolin co-occured with α-synuclein in Lewy bodies from affected human brain as well as with Lewy body-like inclusions in α-synuclein over expressing cells. Furthermore, in the presence of calcium chloride, gelsolin was found to enhance the aggregation rate of α-synuclein in vitro. Moreover, no apparent structural differences could be observed between fibrils formed in the presence or absence of gelsolin. Further studies on gelsolin and other Lewy body associated proteins are warranted to learn more about their potential role in the α-synuclein aggregation process. 相似文献
11.
Fang-Yu Cheng Yea-Ru Yang Chung-Jen Wang Yih-Ru Wu Shih-Jung Cheng Han-Cheng Wang Ray-Yau Wang 《PloS one》2014,9(4)
Background
Falls are a major problem for people with Parkinson’s disease (PD). Many studies indicate that more than 50% of people with PD have difficulty in turning that may lead to falls during daily activities. The aims of this study were to identify the relationship between turning performance and falls, and to determine the factors that influence turning performance.Methods
This study examined 45 patients with idiopathic PD (Hoehn and Yahr stage 1–3) using a battery of tests, including 180° turn time, balance, and muscle strength. The levels of disease severity and freezing of gait were also measured. The number of falls in the past 6 months was recorded.Results
Sixteen out of forty-five participants experienced falls in the past 6 months. A receiver operating characteristic curve showed that turn time was highly related to falls [more affected side: sensitivity = 0.81, specificity = 0.79, area under the curve (AUC) = 0.83; less affected side: sensitivity = 0.88, specificity = 0.76, AUC = 0.83]. The most important factor influencing turn time was balance ability (both sides: p = 0.000) according to the regression model. Correlations between turn time and dynamic balance were further established with reaction time, movement velocity, endpoint excursion, and maximal excursion of the LOS (limits of stability) test.Conclusion
The time needed to complete a 180° turn during the SQT (step/quick turn) test is a good index to differentiate fallers from non-fallers in persons with PD. Turn time is most influenced by balance. Furthermore, balance control, especially in an anterior or sideways direction, is important for turning performance. 相似文献12.
Harman E Karadeniz M Avci CB Zengi A Erdogan M Yalcin M Cetinkalp S Ahmet Gokhan O Gunduz C Saygili F Yilmaz C 《Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology》2012,28(10):830-833
Objective: Infertility and reproductive impairment can be compromised by abnormalities in both endocrine and immune system. TNF-α promotes apoptotic cell death in fetal membrane tissues and pro-inflammatory, proapoptotic, and procoagulant properties of TNF-α probably contribute to widely accepted abortogenic profile of this cytokine. The aim of this study was to assess the alteration in the levels of TSH, FT3, FT4, TNF-α, osteopontin in pregnant and controls. Methods: Study subjects were 28 pregnant women, 28 non-pregnant women, and 28 healthy controls. All subjects underwent venous blood drawing for levels of TNF-α, osteopontin, and also hormonal assays including the levels of anti-TPO, anti-TG antibodies, TSH, FT3, FT4. Results: Both patient and control groups are similar in terms of age. Pregnancy age in conceived patients is 23.64 ± 2.040. No statistically meaningful relation was found in correlation analysis between TNF-α and osteopontin among the groups (p = 0.963). Anti-thyroglobuline antibody and anti-microsomal antibody levels were found to be higher in patients with non-pregnant patients with Hashimoto thyroiditis than the control group (p < 0.001). No statistically meaningful relation was found in terms of TNF-α (p = 0.66) and osteopontin serum levels (p = 0.50) in patient groups with or without miscarriage history. Conclusions: In our study, no statistically meaningful relation was found in terms of TNF-α and osteopontin serum levels in patient groups with and without miscarriage history. 相似文献
13.
Recombination-Deficient Deletions in Bacteriophage λ and Their Interaction with CHI Mutations 总被引:7,自引:7,他引:0
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We have isolated a new class of deletion mutants of phage lambda that extend from the prophage attachment site, att, into the gam and cIII genes. In this respect they are similar to certain of the λpbio transducing phage, but they differ in having a low burst size and in forming minute plaques. Lytically grown stocks of the deletions contain a variable proportion of phage that produce large plaques. These have been shown to carry an additional point mutation. Similar mutations, called chi, have been described by Lam et al. (1974), who showed that they result in a hot-spot for recombination produced by the host recombination system (Rec). We show that chi mutations can occur at several sites in the lambda genome and produce a Rec-dependent increase in the burst size of the one deletion tested.—In addition to reducing burst size, the one deletion tested reduces synthesis of DNA and endolysin but increases production of serum blocking protein. A chi mutation partially restores DNA synthesis and endolysin production and reduces serum blocking protein to normal levels. Our results are consistent with the hypothesis put forward by Lam et al., that chi enhances the frequency of Rec-promoted recombination, which provides the only pathway for production of maturable DNA in a red- gam- infection. The mechanism of the differential effect on protein production is, however, unclear.—Chi mutations are found to occur in DNA other than that of λ. We show that, as has been suggested elsewhere (McMilin, Stahl and Stahl 1974), the λpbio transducing phages carry a chi mutation within the E. coli DNA substitution. A chi mutation also arose in a new substitution of unknown origin isolated in the course of this work. 相似文献
14.
Determination of copper in human tissues and body fluids may be crucial in the diagnosis of Wilson’s disease. In this study
we evaluated urinary copper excretion and urine and blood concentration in 14 patients in whom Wilson’s disease was confirmed
(group A) and in 21 subjects in whom the disease was only suspected (group B). The following values (mean ± SD) were found:
24-h urine (μg Cu/24 h), 152 ± 135 (A) and 31.8 ± 10.9 (B); urine (μg Cu/ml), 0.091 ± 0.087 (A) and 0.028 ± 0.011 (B); and
blood (μg Cu/ml), 0.62 ± 0.25 (A) and 0.72 ± 0.09 (B). By comparison, urine copper concentration in the group of apparently
healthy subjects was 0.035 ± 0.010 (n = 50), and blood copper concentration in autopsy cases of nonpoisoned people was 0.85 ± 0.19 (n = 73). 相似文献
15.
Milan Dastych Dagmar Procházková Antonin Pokorný Libor Zdražil 《Biological trace element research》2010,133(3):265-269
The purpose of this study was to determine the different levels of copper and zinc in the serum, urine, and scalp hair of
patients with Wilson’s disease receiving different, currently accepted methods of treatment to reduce the copper load (penicillamine—group
1, n = 8; zinc—group 2, n = 8; penicillamine+zinc—group 3, n = 8). Blood, urine, and hair samples were collected from the patients. All three treatments resulted in a significant decrease
of the serum copper levels. Significantly increased levels of zinc in the serum were detected in the patients in groups 2
and 3 (19.1 and 18.8 μmol/l, respectively; p < 0.05). Copper excretion in the urine significantly increased during its administration to groups 1 and 3 (11.5 and 7.94 μmol/24 h
respectively; p < 0.001) due to the effect of penicillamine. The administration of zinc as monotherapy (group 2) or in combination with penicillamine
(group 3) led to an increase of its excretion (25.3 and 22.4 μmol/24 h, respectively; p < 0.01). Only an insignificant rise of the copper content in the hair was found in all three groups of patients. The content
of zinc in the hair did not differ significantly in any of the groups in comparison with the control group. 相似文献
16.
17.
Jörgen Hellman 《Anthropological Forum》2013,23(2):178-197
Ancestors have often played an important role in the exercise of politics in Indonesia. However, from a situation in which they were highly influential and present in ritual, as well as in the everyday lives of both commoners and kings, ancestors and traditional lifestyles have been increasingly marginalised through the impact of secular politics and Islamist movements. An era of political reformation began after the fall of Indonesia's former political regime, Orde Baru. Reform meant the decentralisation of political power, and this led to a revival of local traditions. This article takes this revival of tradition as a framework to understand meetings that took place with ancestors at local pilgrimage sites on West Java. It is concluded that meetings of this kind are not simply about fulfilling personal goals, but they also show features of resistance and subversion in relation to the dominant political and religious leadership in Indonesia. 相似文献
18.
Seung Jin Kim Sami Kara Michael Hauschild 《The International Journal of Life Cycle Assessment》2017,22(8):1257-1265
Purpose
The static functional unit definition in the current LCA framework has limitations in addressing the changing product functionality and associated environmental impact of constantly evolving product technologies. As a result, it overlooks the changes in consumer behaviour of increased consumption of products in provided services as well as in growing volumes. This article aims to present a new framework in defining a dynamic functional unit of product technologies that caters for changes in consumer behaviour and growing market.Methods
A new approach to defining the functional unit is proposed that caters for changes in consumer behaviour and the use of technology from a technical performance perspective. A dynamic approach to definition of the functional unit is proposed that is based on Kano’s model of product function and satisfaction.Results and discussion
The new approach is demonstrated on a case study in which the analysis of historical data for two TV product technologies—CRT and LCD—is used to show how the total environmental impact is increasing due to the increased functionality which triggers an increase in the volume of the market. Despite the efforts of improving product life cycle design, the society is still faced with increasing environmental impact from the product type overall.Conclusions
This article presents the challenges of using a static, single functional unit definition in an industrial culture with constant evolution of products that influences usage behaviour and demonstrates the vicious circle of improving product efficiency that leads to further consumption and environmental impact. To address this problem, a new framework of dynamic functional unit definition is put forward for performing comparative LCA to manage the development of product life cycle design that helps keep the total environmental impact of the company’s product portfolio within absolute boundaries.19.
Background
In Sweden, diabetes prevalence is increasing in spite of unchanged incidence, indicating improved survival. In recent US studies mortality in diabetic subjects has decreased over three decades, but only in men. Our aim was to study mortality over time in diabetic subjects.Methods
The annual Swedish Living Conditions Survey from 1980 to 2004 has been record-linked to the Cause of Death Register in order to study trends in mortality risk for those reporting diabetes as a chronic illness. Survival and the relative mortality risk within 5 years of follow-up have been calculated for a random sample of men and women aged 40–84 years with (n = 3,589) and without diabetes (n = 85,685) for the period 1980 to 2004. Poisson regression models were used.Results
The age-adjusted mortality risk relative to non-diabetics within 5 years of follow-up for men was doubled during all periods. The relative risk for women was initially about 2.5, with a substantial drop in mortality in 1995–1999 to 1.45 although it increased to 1.90 in the last period. Using models that took into consideration the presence of heart disease, hypertension, daily smoking, and socio-economic status at the initial interview did not change the relative mortality risk. The age-adjusted 10-year observed survival rate for men with diabetes increased from 41.4% 1980–1984 to 51.5% in 1995–1999. The observed survival for women increased from 43.7% to 61.0%.Conclusion
Survival rates have improved in subjects with diabetes since the early 1980s, more so in women than in men, thereby decreasing the gap to non-diabetic women.20.