共查询到20条相似文献,搜索用时 312 毫秒
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Simone Wörtge Leonid Eshkind Nina Cabezas-Wallscheid Bernard Lakaye Jinhyun Kim Rosario Heck Yasmin Abassi Mustafa Diken Rolf Sprengel Ernesto Bockamp 《BMC developmental biology》2010,10(1):95
Background
Conditional gene activation is an efficient strategy for studying gene function in genetically modified animals. Among the presently available gene switches, the tetracycline-regulated system has attracted considerable interest because of its unique potential for reversible and adjustable gene regulation. 相似文献2.
Seon-Young Kim 《BMC bioinformatics》2009,10(1):147
Background
Few overlap between independently developed gene signatures and poor inter-study applicability of gene signatures are two of major concerns raised in the development of microarray-based prognostic gene signatures. One recent study suggested that thousands of samples are needed to generate a robust prognostic gene signature. 相似文献3.
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Radim Cegan Gabriel AB Marais Hana Kubekova Nicolas Blavet Alex Widmer Boris Vyskot Jaroslav Doležel Jan Šafář Roman Hobza 《BMC plant biology》2010,10(1):180
Background
The evolution of sex chromosomes is often accompanied by gene or chromosome rearrangements. Recently, the gene AP3 was characterized in the dioecious plant species Silene latifolia. It was suggested that this gene had been transferred from an autosome to the Y chromosome. 相似文献7.
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Gene finding in novel genomes 总被引:1,自引:0,他引:1
Background
Computational gene prediction continues to be an important problem, especially for genomes with little experimental data. 相似文献9.
Markey?C?McNutt Ron?Tongbai Wenwu?Cui Irene?Collins Wendy?J?Freebern Idalia?Montano Cynthia?M?Haggerty GVR?Chandramouli Kevin?Gardner
Background
The purpose of this study is to determine whether or not there exists nonrandom grouping of cis-regulatory elements within gene promoters that can be perceived independent of gene expression data and whether or not there is any correlation between this grouping and the biological function of the gene. 相似文献10.
Background
Accurate and automatic gene finding and structural prediction is a common problem in bioinformatics, and applications need to be capable of handling non-canonical splice sites, micro-exons and partial gene structure predictions that span across several genomic clones. 相似文献11.
Barry?R?Zeeberg Joseph?Riss David?W?Kane Kimberly?J?Bussey Edward?Uchio W?Marston?Linehan J?Carl?Barrett John?N?Weinstein
Background
When processing microarray data sets, we recently noticed that some gene names were being changed inadvertently to non-gene names. 相似文献12.
Background
gene identification in genomic DNA sequences by computational methods has become an important task in bioinformatics and computational gene prediction tools are now essential components of every genome sequencing project. Prediction of splice sites is a key step of all gene structural prediction algorithms. 相似文献13.
James Mallet Margarita Beltrán Walter Neukirchen Mauricio Linares 《BMC evolutionary biology》2007,7(1):28
Background
To understand speciation and the maintenance of taxa as separate entities, we need information about natural hybridization and gene flow among species. 相似文献14.
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Background
Although most of the current disease candidate gene identification and prioritization methods depend on functional annotations, the coverage of the gene functional annotations is a limiting factor. In the current study, we describe a candidate gene prioritization method that is entirely based on protein-protein interaction network (PPIN) analyses. 相似文献16.
Background
While eukaryotes primarily evolve by duplication-divergence expansion (and reduction) of their own gene repertoire with only rare horizontal gene transfers, prokaryotes appear to evolve under both gene duplications and widespread horizontal gene transfers over long evolutionary time scales. But, the evolutionary origin of this striking difference in the importance of horizontal gene transfers remains by and large a mystery. 相似文献17.
Pei-Chang Sun Ching Tzao Ban-Hen Chen Chen-Wei Liu Cheng-Ping Yu Jong-Shiaw Jin 《Journal of biomedical science》2010,17(1):76
Background
Histone deacetylases and histone acetyl transferases covalently modify histone proteins, consequentially altering chromatin architecture and gene expression. 相似文献18.
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Background
The most fundamental task using gene expression data in clinical oncology is to classify tissue samples according to their gene expression levels. Compared with traditional pattern classifications, gene expression-based data classification is typically characterized by high dimensionality and small sample size, which make the task quite challenging. 相似文献20.
Dennis Wormuth Margarete Baier Andrea Kandlbinder Renate Scheibe Wolfram Hartung Karl-Josef Dietz 《BMC plant biology》2006,6(1):15-14