Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

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Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation

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Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells

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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

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A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis

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Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism

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Bacterial infection reinforces host metabolic flux from arginine to spermine for NLRP3 inflammasome evasion

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Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis

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The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB

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Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer

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Specific Eco-evolutionary Contexts in the Mouse Gut Reveal Escherichia coli Metabolic Versatility

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Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome

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Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure

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Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function

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Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells

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Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

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The role of lipids in cancer progression and metastasis

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Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma

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