共查询到20条相似文献,搜索用时 15 毫秒
1.
Kelly Ishida Juliany Cola Fernandes Rodrigues Marcos Dornelas Ribeiro Taíssa Vieira Machado Vila Wanderley de Souza Julio A Urbina Celso Vataru Nakamura Sonia Rozental 《BMC microbiology》2009,9(1):74
Background
Although Candida species are commensal microorganisms, they can cause many invasive fungal infections. In addition, antifungal resistance can contribute to failure of treatment. 相似文献2.
Morgenstern B Prohaska SJ Pöhler D Stadler PF 《Algorithms for molecular biology : AMB》2006,1(1):6-12
Background
Automated software tools for multiple alignment often fail to produce biologically meaningful results. In such situations, expert knowledge can help to improve the quality of alignments. 相似文献3.
4.
Jørgen R Jepsen Lise H Laursen Carl-Göran Hagert Svend Kreiner Anders I Larsen 《BMC neurology》2006,6(1):10-9
Background
In a sample of patients in clinical occupational medicine we have demonstrated that an upper limb neurological examination can reliably identify patterns of findings suggesting upper limb focal neuropathies. This further study aimed at approaching the diagnostic accuracy of the examination. 相似文献5.
Evolution of a subtilisin-like protease gene family in the grass endophytic fungus Epichlo? festucae
Michelle K Bryant Christopher L Schardl Uljana Hesse Barry Scott 《BMC evolutionary biology》2009,9(1):168
Background
Subtilisin-like proteases (SLPs) form a superfamily of enzymes that act to degrade protein substrates. In fungi, SLPs can play either a general nutritive role, or may play specific roles in cell metabolism, or as pathogenicity or virulence factors. 相似文献6.
Hugh J O'Neill Conall McCaughey Dorothy E Wyatt Frederick Mitchell Peter V Coyle 《BMC microbiology》2001,1(1):14-8
Background
Norwalk-like viruses are the most common cause of gastroenteritis outbreaks and sporadic cases of vomiting and diarrhoea. In healthy individuals infection is often mild and short-lived but in debilitated patients infection can be severe. It is essential that the virus laboratory can offer a sensitive and specific test, delivered in a timely manner. 相似文献7.
Arielle Click Chandni H Savaliya Simone Kienle Matthias Herrmann Andre Pires-daSilva 《BMC evolutionary biology》2009,9(1):75
Background
Evolution of selfing can be associated with an increase in fixation of deleterious mutations, which in certain conditions can lead to species extinction. In nematodes, a few species evolved self-fertilization independently, making them excellent model systems to study the evolutionary consequences of this type of mating system. 相似文献8.
Ronald van Eijk Paul HC Eilers Remco Natté Anne-Marie Cleton-Jansen Hans Morreau Tom van Wezel Jan Oosting 《BMC bioinformatics》2010,11(1):67
Background
Multiplex Ligation-Dependent Probe Amplification (MLPA) is an application that can be used for the detection of multiple chromosomal aberrations in a single experiment. In one reaction, up to 50 different genomic sequences can be analysed. For a reliable work-flow, tools are needed for administrative support, data management, normalisation, visualisation, reporting and interpretation. 相似文献9.
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Background
In many applications, ordinary differential equation (ODE) models are subject to uncertainty or variability in initial conditions and parameters. Both, uncertainty and variability can be quantified in terms of a probability density function on the state and parameter space. 相似文献11.
Background
Multilocus phylogenies can be used to infer the species tree of a group of closely related species. In species trees, the nodes represent the actual separation between species, thus providing essential information about their evolutionary history. In addition, multilocus phylogenies can help in analyses of species delimitation, gene flow and genetic differentiation within species. However, few adequate markers are available for such studies. 相似文献12.
13.
Background
Experimental results are commonly fitted by determining parameter values of suitable mathematical expressions. In case a relation exists between different data sets, the accuracy of the parameters obtained can be increased by incorporating this relationship in the fitting process instead of fitting the recordings separately. 相似文献14.
Deng-Ke Niu 《Biology direct》2007,2(1):11-9
Background
Accumulating evidence indicates that the nascent RNA can invade and pair with one strand of DNA, forming an R-loop structure that threatens the stability of the genome. In addition, the cost and benefit of introns are still in debate. 相似文献15.
Background
Many in vitro studies have shown that adenosine (Ado) can induce vascular endothelial growth factor (VEGF) mRNA and protein expression and stimulate endothelial proliferation. In the present study, we seek to determine whether Ado can increase circulating levels of VEGF protein in the intact human. 相似文献16.
Background
In order to take full advantage of the newly available public human genome sequence data and associated annotations, biologists require visualization tools ("genome browsers") that can accommodate the high frequency of alternative splicing in human genes and other complexities. 相似文献17.
Background
Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper we show how a supervised multivariate statistical method, Between Group Analysis (BGA), can be used to identify these residues from families of proteins with different substrate specifities using multiple sequence alignments. 相似文献18.
Background
In the post-genomic era, correct gene prediction has become one of the biggest challenges in genome annotation. Improved promoter prediction methods can be one step towards developing more reliable ab initio gene prediction methods. This work presents a novel prokaryotic promoter prediction method based on DNA stability. 相似文献19.
Aims
To test the hypothesis that Mycobacterium bovis can persist in the environment within protozoa.Methods and Results
In this study, we used a novel approach to detect internalized mycobacteria in environmental protozoa from badger latrines. Acid‐fast micro‐organisms were visualized in isolated amoebae, although we were unable to identify them to species level as no mycobacteria were grown from these samples nor was M. bovis detected by IS6110 PCR. Co‐incubation of Acanthamoeba castellanii with virulent M. bovis substantially reduced levels of bacilli, indicating that the amoebae have a negative effect on the persistence of M. bovis.Conclusions
The internalization of mycobacteria in protozoa might be a rare event under environmental conditions. The results suggest that amoebae might contribute to the inactivation of M. bovis rather than representing a potential environmental reservoir.Significance and Impact of the Study
Protozoa have been suggested to act as an environmental reservoir for M. bovis. The current study suggests that environmental amoebae play at most a minor role as potential reservoirs of M. bovis and that protozoa might inhibit persistence of M. bovis in the environment. 相似文献20.