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1.
Xue‐Feng Zhou Peng Zhang Hui‐Fang Pi Yong‐Hui Zhang Han‐Li Ruan Hui Wang Ji‐Zhou Wu 《化学与生物多样性》2009,6(8):1202-1207
Two new triterpenoids, 1 and 2 , were isolated from the hepatoprotective AcOEt fraction of the roots of Actinidia chinensis, together with eight known 12‐en‐28‐oic acids of oleanane or ursane type, 3 – 10 . The two new compounds were elucidated as 2α,3β‐dihydroxyurs‐12‐en‐28,30‐olide ( 1 ) and 2α,3β,24‐trihydroxyurs‐12‐en‐28,30‐olide ( 2 ), on the basis of spectroscopic (IR, NMR, and MS) analyses. The chemotaxonomic significances of some triterpenoids were also discussed. 相似文献
2.
Kuo Xu Penglong Wang Lin Wang Congmin Liu Shixun Xu Yatao Cheng Yanhui Wang Qiang Li Haimin Lei 《化学与生物多样性》2014,11(3):341-363
The extracts and phytochemicals of the genus Rubia have drawn much attention due to their potent effects; among them, naphthoquinone and cyclopeptide derivatives, with significant biological activities, have great potential to be developed to new drugs. This review updates and compiles a total of 142 quinone derivatives including anthraquinone and naphthoquinone derivatives, occuring in twelve Rubia species. These compounds were listed together with their sources, melting points, bioactivities, as well as 112 corresponding references. Furthermore, the structure? activity relationships of these quinone derivatives were discussed. 相似文献
3.
Umeo Takahama 《Physiologia plantarum》1995,93(1):61-68
Fungal laccase oxidized derivatives of hydroxycinnamic acid. The rates decreased in the order sinapic acid > ferulic acid ≥p-coumaric acid. The laccase oxidized sinapyl alcohol faster than coniferyl alcohol. The rates of oxidation of the hydroxycinnamic acid derivatives by an isoenzyme of peroxidase from horseradish decreased in the order p-coumaric acid > ferulic acid ≥ sinapic acid. The peroxidase oxidized coniferyl alcohol much faster than sinapyl alcohol. The laccase and the peroxidase predominantly oxidized (a) ferulic acid in a reaction mixture that contained p-coumaric acid and ferulic acid, (b) sinapic acid in a mixture of p-coumaric acid plus sinapic acid, and (c) sinapic acid in a mixture of ferulic acid plus sinapic acid. In a reaction mixture that contained both coniferyl and sinapyl alcohols, both fungal laccase and horseradish peroxidase predominantly oxidized sinapyl alcohol. From these results, it is concluded (1) that the p-hydroxyphenyl radical can oxidize guaiacyl and syringyl groups and produce their radicals and (2) that the guaiacyl radical can oxidize the syringyl group under formation of its radical; and that (3) in both cases the reverse reactions are very slow. 相似文献
4.
Dihydrozeatin, at 4×10–5 M, delayed the senescence of carnation flowers while tZ, at the same concentration, accelerated it. cis-Zeatin was ineffective. The DHZ derivatives as well as the Z derivatives gave responses very similar to those observed for the parent free bases. While additional experimentation with radiolabelled derivatives is clearly called for, the similarity between the responses observed for the respective derivatives and the free bases, suggests that in the carnation flower there is a great deal of metabolic interconversion.Abbreviations DHZ
dihydrozeatin
- DHZR
ribosyldihydrozeatin
- DHZOG
glucosyl-O-dihydrozeatin
- DHZ9G
glucosyl-9-dihydrozeatin
- DHZROG
glucosyl-O-ribosyldihydrozeatin
- cZ
cis-zeatin
- tZ
trans-zeatin
- ZR
ribosylzeatin
- Z9G
glucosyl-9-zeatin
- ZOG
glucosyl-O-zeatin
- ZROG
glucosyl-O-ribosylzeatin 相似文献
5.
Albert K. Beck Dieter Seebach Jennifer Leeds Katherine Thompson Heinz E. Moser 《化学与生物多样性》2015,12(2):179-193
β3‐Octaarginine chains were attached to the functional groups NH and CO2H of the antibacterial fluoroquinolones ciprofloxacin (→ 1 ) and enrofloxacin (→ 2 ), respectively, in order to find out whether the activity increases by attachment of the polycationic, cell‐penetrating peptide (CPP) moiety. For comparison, simple amides, 3 – 5 , of the two antimicrobial compounds and β3‐octaarginine amide ( βR8 ) were included in the antibacterial susceptibility tests to clarify the impact of chemical modification on the microbiological activity of either scaffold (Table). 相似文献
6.
Amira Arciniegas Ana L. Pérez‐Castorena Mariana Meléndez‐Aguirre José Guillermo Ávila Ana María García‐Bores José Luis Villaseñor Alfonso Romo de Vivar 《化学与生物多样性》2018,15(3)
The chemical study of Ageratina deltoidea afforded grandiflorenic acid ( 1 ), ent‐kaurenoic acid ( 2 ), and eight benzylbenzoates ( 3 – 10 ), two of them, 3,5‐dimethoxybenzyl 2,3,6‐trimethoxybenzoate ( 5 ) and 4‐(β‐d ‐glucopyranosyloxy)‐3‐hydroxybenzyl 2,6‐dimethoxybenzoate ( 9 ), described for the first time. In addition, the new sesquiterpene lactone deltoidin C ( 13 ), together with the known 11 and 12 , the phenolic compounds: ayanin, 2,6‐dimethoxybenzoic acid, methyl 3,4‐dihydroxycinnamate, chlorogenic acid, and 3,5‐dicaffeoylquinic acid were also isolated. The structures of these compounds were determined by spectroscopic methods and chemical reactions. The antibacterial and antifungal activities of compounds 1 – 12 were evaluated on Staphylococcus aureus, Escherichia coli, and Candida albicans. Deltoidin A ( 11 ) was the most active antibacterial agent (MIC 16.0 μg ml?1) against E. coli, and the ent‐kaurenoid derivatives ( 1 – 2 ) showed activity (MIC 31.0 μg ml?1) against S. aureus. 相似文献
7.
New Thymol Derivatives and Cytotoxic Constituents from the Root of Eupatorium cannabinum ssp. asiaticum
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Li‐Chai Chen Tzong‐Huei Lee Ping‐Jyun Sung Chih‐Wen Shu Yun‐Ping Lim Ming‐Jen Cheng Wen‐Lung Kuo Jih‐Jung Chen 《化学与生物多样性》2014,11(9):1374-1380
Two new thymol (=5‐methyl‐2‐(1‐methylethyl)phenol) derivatives, 8,10‐didehydro‐9‐(3‐methylbutanoyl)thymol 3‐O‐tiglate ( 1 ) and 9‐O‐angeloyl‐8‐methoxythymol 3‐O‐isobutyrate ( 2 ), were isolated from the root of Eupatorium cannabinum ssp. asiaticum, together with six known compounds, 3 – 8 . The structures of 1 and 2 were determined through extensive 1D/2D‐NMR and MS analyses. Among the isolates, 9‐acetoxy‐8,10‐epoxythymol 3‐O‐tiglate ( 3 ) was the most cytotoxic, with IC50 values of 0.02±0.01, 1.02±0.07, and 1.36±0.12 μg/ml, respectively, against DLD‐1, CCRF‐CEM, and HL‐60 cell lines. In addition, 10‐acetoxy‐9‐O‐angeloyl‐8‐hydroxythymol ( 4 ) and eupatobenzofuran ( 6 ) exhibited cytotoxicities, with IC50 values of 1.14±0.16 and 2.63±0.22, and 7.63±0.94 and 2.31±0.14 μg/ml, respectively, against DLD‐1 and CCRF‐CEM cell lines. 相似文献
8.
Michele Tonelli Giuseppe Paglietti Vito Boido Fabio Sparatore Fabio Marongiu Esther Marongiu Paolo La Colla Roberta Loddo 《化学与生物多样性》2008,5(11):2386-2401
Forty‐three 2‐[(benzotriazol‐1/2‐yl)methyl]benzimidazoles, bearing either linear (dialkylamino)alkyl‐ or bulkier (quinolizidin‐1‐yl)alkyl moieties at position 1, were evaluated in cell‐based assays for cytotoxicity and antiviral activity against viruses representative of two of the three genera of the Flaviviridae family, i.e. Flaviviruses (Yellow Fever Virus (YFV)) and Pestiviruses (Bovine Viral Diarrhoea Virus (BVDV)), as Hepaciviruses can hardly be used in routine cell‐based assays. Compounds were also tested against representatives of other virus families. Among ssRNA+ viruses were a retrovirus (Human Immunodeficiency Virus type 1 (HIV‐1)), two picornaviruses (Coxsackie Virus type B2 (CVB2), and Poliovirus type‐1, Sabin strain (Sb‐1)); among ssRNA? viruses were a Paramyxoviridae (Respiratory Syncytial Virus (RSV)) and a Rhabdoviridae (Vesicular Stomatitis Virus (VSV)) representative. Among double‐stranded RNA (dsRNA) viruses was a Reoviridae representative (Reo‐1). Two representatives of DNA virus families were also included: Herpes Simplex type 1, (HSV‐1; Herpesviridae) and Vaccinia Virus (VV; Poxviridae). Most compounds exhibited potent activity against RSV, with EC50 values as low as 20 nM . Moreover, some compounds, in particular when bearing a (quinolizidin‐1‐yl)alkyl residue, were also moderately active against BVDV, YFV, and CVB2. 相似文献
9.
Seza Arslan Elİf Loğoğlu Atİlla Öktemer 《Journal of enzyme inhibition and medicinal chemistry》2013,28(2):211-214
The in vitro antibacterial and antifungal activities of the compounds synthesised from some 1,2,3,5-tetrahalogeno benzenes in presence of sodium piperidide and sodium pyrrolidide (2,6-dipiperidino-1,4-dihalogenobenzenes; 2,6-dipyrrolidino-1,4-dibromobenzene; 2,4,6-tripyrrolidino chlorobenzene; and 1,3-dipyrrolidino benzene) were investigated. The in vitro antimicrobial activities were screened against the standard strains: Staphylococcus aureus ATCC 25923 and Bacillus subtilis ATCC 6633 as Gram positive, Yersinia enterocolitica ATCC 1501, Escherichia coli ATCC 11230 and Klebsiella pneumoniae as Gram negative, and Candida albicans as yeast-like fungus. Compounds (3, 5, 6, 7) inhibited the growth of all the test strains at MIC values of 32–512 μg/ml. None of the four compounds (1, 2, 4, 8) studied showed antimicrobial activity against any of the test strains within the MIC range 0.25–512 μg/ml. 相似文献
10.
Hnin Thanda Aung Alessio Porta Marco Clericuzio Yoshiaki Takaya Giovanni Vidari 《化学与生物多样性》2017,14(5)
Two new sterols 1 and 2 and five known ones 3 – 7 were isolated for the first time from the fruiting bodies of Cortinarius glaucopus. Their structures were established by 1‐ and 2D‐NMR spectra and HR‐FABS‐MS. The relative configuration of 1 was firmly determined by comparison of the observed 1H–1H couplings and NOESY correlations, with those predicted for the computed geometries of the conformers. Calculations were performed by means of DFT with the B3LYP functional at 6‐31 + G(d,p) level of theory, in CHCl3 as the solvent. The structures of the new ergosterol derivatives, called glaucoposterol A ( 1 ) and B ( 2 ), were thus established as (3S,5R,7R,10R,13R,17R,20S,22R,23R,24R)‐5,6‐epoxy‐3,7,23‐trihydroxystrophast‐8‐en‐14‐one and (22E,3S,5S,9S,10R,13R,17R,20R,24R)‐3,5‐dihydroxyergosta‐6,8(14),22‐trien‐15‐one, respectively. Moreover, the configuration of known strophasterol C ( 3 ) was determined as (3S,5R,6S,7R,10R,13R,17R,20S,22S,24R). Glaucoposterol A ( 1 ) and strophasterol C ( 3 ) represent the second finding in nature of steroids with the rare strophastane skeleton. 相似文献
11.
Gangyuan Luo Senhua Chen Jianchen Yu Jie Yuan Li Zheng Lan Liu Bin Chen Jing Li 《化学与生物多样性》2020,17(8)
One new naphthalenone, didymelol A, and three new naphthols, didymelol B–D, together with three known naphthalenones, (3S,4R)‐3,4,6‐trihydroxy‐3,4‐dihydronaphthalen‐1(2H)‐one, (4S)‐4,6‐dihydroxy‐3,4‐dihydronaphthalen‐1(2H)‐one, (4S)‐4‐hydroxy‐3,4‐dihydronaphthalen‐1(2H)‐one, were isolated from the Saussurea laniceps endophytic fungus Didymella glomerata X223. The structures of the isolates were elucidated based on extensive spectroscopic data analysis. The absolute configuration of didymelol A was established through single‐crystal X‐ray diffraction data and didymelols B–D were identified through comparisons of experimental and calculated ECD spectra. All compounds were evaluated for cytotoxic activity against human non‐small cell lung cancer A549 cells and human breast carcinoma MDA‐MB‐435 cells. 相似文献
12.
Three sulfonamide derivatives (SAD) were first synthesized from p‐hydroxybenzoic acid and sulfonamides (sulfadimidine, sulfamethoxazole and sulfachloropyridazine sodium) and were characterized by elemental analysis, 1H NMR and MS. The interaction between bovine serum albumin (BSA) and SAD was studied using UV/vis absorption spectroscopy, fluorescence spectroscopy, time‐resolved fluorescence spectroscopy and circular dichroism spectra under imitated physiological conditions. The experimental results indicated that SAD effectively quenched the intrinsic fluorescence of BSA via a static quenching process. The thermodynamic parameters showed that hydrogen bonding and van der Waal's forces were the predominant intermolecular forces between BSA and two SADs [4‐((4‐(N‐(4,6‐dimethylpyrimidin‐2‐yl)sulfamoyl)phenyl)carbamoyl)phenyl acetate and 4‐((4‐(N‐(5‐methylisoxazol‐3‐yl)sulfamoyl)phenyl)carbamoyl)phenyl acetate], but hydrophobic forces played a major role in the binding process of BSA and 4‐((4‐(N‐(6‐chloropyridazin‐3‐yl)sulfamoyl)phenyl) carbamoyl)phenyl acetate. In addition, the effect of SAD on the conformation of BSA was investigated using synchronous fluorescence spectroscopy and circular dichroism spectra. Molecular modeling results showed that SAD was situated in subdomain IIA of BSA. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
13.
T. V. Abramova J. P. Leonetti V. V. Vlassov B. Lebleu 《Russian Journal of Bioorganic Chemistry》2000,26(3):174-182
Dinucleoside phosphates that harbor phosphate groups transiently blocked (caged) byo-nitrobenzyl oro-nitroveratryl residues were synthesized. It was shown that the conditions of the UV-induced deprotection largely depend on
the nature of the protective group. The phosphotriesters obtained were resistant toward snake venom phosphodiesterase and
nucleases of the cellular extract. The synthesis of the dinucleoside phosphates containing a photolabile group preceeded the
incorporation of the modified blocks into extended oligonucleotides by the phosphoramidite method. 相似文献
14.
Several new and differently functionalized cis‐2,3‐dimethylnorbornane derivatives presenting diverse side‐chain lengths were prepared, the structures of which are related to the natural fragrance β‐santalol. In particular, exo‐ and endo‐3,8‐dihydro‐β‐santalols, with either (E) or (Z) C?C‐bond configuration on the side chain, were synthesized in seven steps and 21–24% overall yields. Several other exo‐ and endo‐norbornyl alcohols with shorter side chains were also prepared in high yields. The olfactory evaluation indicated woody, sandalwood, as well as fruity notes for some of the derivatives. 相似文献
15.
László Galgóczy Laura Kovács Krisztina Krizsán Tamás Papp Csaba Vágvölgyi 《Mycopathologia》2009,168(3):125-134
The in vitro antifungal activity of cysteine (d- and l-cysteine) and its four derivatives (l-cysteine-methyl-ester, N-acetyl-cysteine, N-isobutyryl-d-cysteine, and N-isobutyryl-l-cysteine) were investigated on 20 fungal isolates representing 16 genera (Absidia, Actinomucor, Backusella, Gilbertella, Micromucor, Mortierella, Mucor, Mycotypha, Phycomyces, Rhizomucor, Rhizopus, Saksenaea, Syncephalastrum, Thamnostylum, Umbellopsis, and Zygorynchus). The inhibitory potential of different concentrations of these compounds, ranging from 0.625 to 10 mM, were investigated
on the germination of sporangiospores as well as on hyphal extension, using broth microdilution method and agar plate test.
Treatment with cysteine and its derivatives resulted in a strong inhibition in most studied strains. At 10 mM of compounds,
complete blockage of growth was observed for some isolates. Sensitive species exhibited severe changes in colony morphology
in the presence of 10 mM l-cysteine, N-acetyl-cysteine, and N-isobutyryl-l-cysteine. Microscopic observations revealed that 10 mM N-acetyl-cysteine induced dramatic modifications in the structural organization of the hyphae. Results suggest that cysteine
and its derivatives have a therapeutic potential against fungal infections caused by Zygomycetes species. 相似文献
16.
《Journal of enzyme inhibition and medicinal chemistry》2013,28(6):786-795
AbstractThis study presents the synthesis, antiproliferative and antimicrobial evaluation of a new series of Mannich base derivatives containing 1,2,4-triazole system. New compounds were prepared by the reaction of 4,5-disubstituted 1,2,4-triazole-3-thiones with formaldehyde and various amines. The structures of the prepared compounds were confirmed by means of 1H NMR, 13C NMR and elemental analyses. Twelve compounds were evaluated for their in vitro antiproliferative activities against six chosen cancer cell lines. All synthesized compounds were screened for their in vitro antimicrobial activity by using the agar dilution technique. For 17 potentially active compounds, their antibacterial activity was confirmed on the basis of MIC (minimal inhibitory concentration) by broth microdilution method using the reference Gram-positive and Gram-negative bacterial strains. 相似文献
17.
Hyung-In Moon Ill-Min Chung Jae-Chul Jung Eunyoung Lim Yongnam Lee 《Journal of enzyme inhibition and medicinal chemistry》2013,28(2):328-336
In the present study we report the simple synthesis and antitumour activity of novel stilbene derivatives 13–22. The key synthetic strategies involved Wadsworth-Horner-Emmons condensation and coupling reactions in high yields. All compounds showed significant growth inhibition on human tumour cell lines, with the most potent compound (19) exhibiting an IC50 of 5.7 μM – 11.4 μM in vitro. 相似文献
18.
Letícia do Nascimento Andrade de Almeida Rego Kaio Cesar Chaboli Alevi Maria Tercília Vilela de Azeredo-Oliveira 《Fly》2016,10(1):47-52
The genus Zaprionus consists of approximately 60 species of drosophilids that are native to the Afrotropical region. The phylogenetic position of Zaprionus within the Drosophilidae family is still unresolved. In the present study, ultrastructural features of spermatozoa of 6 species of Zaprionus as well as the species Drosophila willistoni and Scaptodrosophila latifasciaeformis were analyzed. The ultrastructure revealed that the species have the same flagellar ultrastructure. Two mitochondrial derivatives, one larger than the other, close to the axoneme were present, primarily in D. willistoni (subgenus Sophophora). Except for Z. davidi and Z. tuberculatus, the analyzed species had paracrystalline material in both mitochondrial derivatives. Moreover, the testes showed 64 spermatozoa per bundle in all of the species. In the cluster analysis, 6 Zaprionus species were grouped closely, but there were some incongruent positions in the cladogram. The results indicated that sperm ultrastructure is an important tool for elucidating the phylogeny and taxonomy of insects. 相似文献
19.
Bioactive Steroid Derivatives and Butyrolactone Derivatives from a Gorgonian‐Derived Aspergillus sp. Fungus
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Six steroid derivatives, 1 – 6 , and five butyrolactone derivatives, 7 – 11 , were isolated from the fermentation broth of a gorgonian‐derived Aspergillus sp. fungus. Their structures were elucidated on the basis of NMR and MS spectral data. Compound 1 is a new, highly conjugated steroid. The NMR and MS data of 7 and 8 are reported for the first time, as their structures were listed in SciFinder Scholar with no associated reference. Compounds 1, 4, 5 , and 8 – 11 inhibited the larval settlement of barnacle Balanus amphitrite with EC50 values ranging from 0.63 to 18.4 μg ml?1. Butyrolactone derivatives 7 and 8 showed pronounced antibacterial activities against Staphylococcus aureus with the same MIC values as the positive control ciprofloxacin (MIC 1.56 μM for all three compounds). 相似文献
20.
Degradation ofortho-chlorophenol,para-chlorophenol, and 2,4-dichlorophenoxyacetic acid by the bacterial community of anaerobic sludge 总被引:1,自引:0,他引:1
Yu. Yu. Berestovskaya V. V. Ignatov L. N. Markina A. A. Kamenev O. E. Makarov 《Microbiology》2000,69(4):397-400
The bacterial community of anaerobic sludge could degradeo-chlorophenol,p-chlorophenol, and 2,4-dichlorophenoxyacetic acid at concentrations as high as 100 mg/l. The time needed for the degradation
of a given chlorinated phenol derivative increased 1.5- to 2-fold upon a twofold increase in its concentration (from 50 to
100 mg/l). The duration of the adaptation period depended on the compound studied and on its concentration. The degradation
of 2,4-dichlorophenoxyacetic acid proceeded via 2,4-dichlorophenol andp-chlorophenol as intermediates; the degradation ofo-chlorophenol occurred with the formation of phenol. The dynamics ofp-chlorophenol degradation and chloride ion accumulation were studied. 相似文献