双链杂交分子“胰岛素—类胰岛素生长因子—I”

以去Ｂ链Ｃ端八肽胰岛素和化学合成的ＩＧＦ－Ｉ的２２－２９及２２－３２为底物,用酶促半合成方法制备了杂交分子“胰岛素－类胰岛素茵子－Ｉ”,Ｉｎｓ／ＩＧＦ－Ｉ和Ｉｎｓ－ＩＧＦ－Ｉ。研究了它们的胰岛中生物活性。结果表明,猪胰岛素Ｂ链Ｃ端Ｂ２７的Ｔｈｒ被Ａｓｎ取代,Ｂ３０的Ａｌａ被Ａｌａ被Ｔｈｒ取代同时Ｂ２５－Ｂ２６及Ｂ２８－Ｂ２９氨基酸顺序颠紧及在Ｂ链Ｃ末端延长３肽都不影响胰岛素的生物活力。     

Contributions to the mathematical theory of epidemics—I

(1) A mathematical investigation has been made of the progress of an epidemic in a homogeneous population. It has been assumed that complete immunity is conferred by a single attack, and that an individual is not infective at the moment at which he receives infection. With these reservations the problem has been investigated in its most general aspects, and the following conclusions have been arrived at. (2) In general a threshold density of population is found to exist, which depends upon the infectivity, recovery and death rates peculiar to the epidemic. No epidemic can occur if the population density is below this threshold value. (3) Small increases of the infectivity rate may lead to large epidemics; also, if the population density slightly exceeds its threshold value the effect of an epidemic will be to reduce the density as far below the threshold value as initially it was above it. (4) An epidemic, in general, comes to an end, before the susceptible population has been exhausted. (5) Similar results are indicated for the case in which transmission is through an intermediate host.