Cancer et Hérédité

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Quelques réminiscences

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Radiopharmaceutiques et réglementations

The radiopharmaceuticals are products that combine two very stringent regulatory requirements from two different authorities: as medicine from a pharmaceutical point of view (Afssaps) and as radioactive source with specific authorization (ASN). This article discusses the different regulatory constraints imposed by these authorities but suggests also that legislation is supposed to be modified in the coming years in collaboration with nuclear physicians and their Society (SFMN).     

La réaction acrosomique

The acrosome reacting capacity of spermatozoa is essential for the fertilization of the oocyte. Several methods are available for the evaluation of the acrosomal status; each method detects a step of the reaction which is a continuous process. Due to the diversity and the relative specificity of each technique, it is difficult to compare results in absolute values. The reaction is Ca++ dependent. The use of Ca++ ionophores is valuable for a dynamic study which gives a better appreciation of the capacity of spermatozoa to react to a specific stimulus. Many authors have attempted to correlate the acrosomal status to the fertilizing ability of spermatozoa. The results show a reduced induction of AR in hypofertile sperm. More studies with standard materials and methods are needed in order to confirm the diagnostic value of this test.     

Les Actinomycoses rénales

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Scintigraphie de perfusion cérébrale positionnelle : résultats physiologiques et applications cliniques

To assess the impact of standing on brain perfusion, 125 brain perfusion scans in the upright and supine position were performed, including 108 patients. Perfusion values were compared using a relative quantitative approach and a segmentation of vascular territories with the help of an atlas of brain perfusion. We found a change in the distribution of the perfusion in favor of the vertebro-basilar system in the upright position. We discuss the case of a patient whose symptoms could be explained with the help of the comparison of brain perfusion scans in the upright and supine position. Atheromatous and post-dissection stenosis and their influence on perfusion are also discussed.     

Kyste du tractus thyréoglosse dégénéré révélant un microcarcinome papillaire multifocal de la thyroïde

The malignant degeneration of thyroglossal duct cyst (TDC) is a very rare phenomenon. It occurs 1% of operated cysts where papillary carcinoma represents the most frequent pathological type. The authors report a clinical observation of a papillary carcinoma of thyroid occurring in a thyroglossal duct cyst concomitant to a multifocal micropapillary thyroid discovered in a 21-year-old woman. A total thyroidectomy was performed. A complementary treatment by radioactive iodine 131 (3,7 GBq) was undertaken. Two years later, the patient is doing well and does not present any sign of recurrence. In the light of this observation, the authors propose to report the diagnosis and therapeutic aspects of degenerated thyroglossal duct cyst.