Dead as a dodo: the fortuitous rise to fame of an extinction icon

Today, the Dodo is the most famous species known to have been driven to extinction through human activity. However, it disappeared over a century before Cuvier demonstrated the reality of extinction, and was only one of a huge number of species that died out following early European expansion around the globe. Unlike many other now-extinct Mascarene species, the Dodo's decline and disappearance was not documented by contemporary observers. Repeated settlement changes on Mauritius during the seventeenth century led to protracted ‘cultural amnesia’ over its very existence, and it was widely regarded as mythical by European scientists into the nineteenth century. A series of scientific and socio-cultural hurdles, which all had to be overcome before a given species could be widely appreciated by the general public as an icon of human-caused extinction, are identified and assessed in order to understand how the Dodo returned from scientific death and achieved its tremendous posthumous celebrity. This review indicates that although some ecological and evolutionary factors may have given the Dodo an increased chance of becoming famous, these factors are offset by a much greater series of serendipitous events, emphasising the importance of contingence and the fundamental lack of inevitability in historical processes.

The dodo was (perverse distinction) Immortalized by his extinction     

Specialization and medical mycology in the US, Britain and Japan

This paper attempts to bring new insights to a long-standing historical debate over medical specialization by analyzing the formation of medical mycology, a somewhat marginal biomedical discipline that emerged in the mid-twentieth century around studies of fungal disease in humans. The study of fungi predates that of bacteria and viruses, but from the 1880s it became eclipsed by bacteriology. However, in the postwar period, there were moves to establish medical mycology as an independent speciality. I trace the processes that led to the launch of professional societies in the United States, Britain and Japan, three major players in medical mycology, and more broadly in biomedicine. The analysis of the three different national contexts illustrates how geographical, medico-technological, epidemiological, political and social conditions gave the specialty a distinctive character in each country; this was further complicated by the different and changing medical fields in which fungal diseases were studied and treated. The three case studies show medical specialization as a process that is not simply cumulative but responds to specific historical events and developments.     

The pneumococcus and some men who came to Yale: the Dorothy M. Horstmann Lecture.

Yale has been fortunate indeed to have had Dorothy Horstmann as a member of its faculty for all but one of the last 50 years. It has had also the wisdom to take cognizance of her value as an individual and of her contributions to biomedical science and human welfare on two occasions in recent years. Her studies of poliomyelitis, hepatitis, and rubella, executed with perceptiveness, rigor and modesty, have benefited countless numbers; and for her many achievements all are in her debt. I am beholden to her colleagues for this opportunity to pay tribute to a wise and gracious friend. In casting about for a subject befitting this occasion, the thought occurred that it might be of interest to examine the contributions of some former and present members of Yale''s faculty to the subject of a group of infections still endemic in all human societies, namely those caused by Streptococcus pneumoniae or the pneumococcus. The list is doubtless not exhaustive but includes such notables as Winternitz, Blake, Paul, Trask, Eaton, and Beeson of former days, as well as reflecting ongoing investigations today by Eugene Shapiro and his colleagues. In reviewing some of this earlier work, it will be my endeavor to place it in the context of contemporary understanding. In the interest of some semblance of order, the material will be examined in topical rather than in chronological order, dealing with bacteriologic and immunologic, pathogenetic, therapeutic, and prophylactic considerations in that sequence.     

Academic and molecular matrices: a study of the transformations of connective tissue research at the University of Manchester (1947-1996)

This paper explores the different identities adopted by connective tissue research at the University of Manchester during the second half of the 20th century. By looking at the long-term redefinition of a research programme, it sheds new light on the interactions between different and conflicting levels in the study of biomedicine, such as the local and the global, or the medical and the biological. It also addresses the gap in the literature between the first biomedical complexes after World War II and the emergence of biotechnology. Connective tissue research in Manchester emerged as a field focused on new treatments for rheumatic diseases. During the 1950s and 60s, it absorbed a number of laboratory techniques from biology, namely cell culture and electron microscopy. The transformations in scientific policy during the late 70s and the migration of Manchester researchers to the US led them to adopt recombinant DNA methods, which were borrowed from human genetics. This resulted in the emergence of cell matrix biology, a new field which had one of its reference centres in Manchester. The Manchester story shows the potential of detailed and chronologically wide local studies of patterns of work to understand the mechanisms by which new biomedical tools and institutions interact with long-standing problems and existing affiliations.     

From the Waters of the Empire to the Tanks of Paris: The Creation and Early Years of the Aquarium Tropical,Palais de la Porte Dorée

From May to November 1931, the Exposition coloniale internationale was held in Paris. Publicized as a trip around the world in a single day, it was designed to stimulate investments and general enthusiasm for the colonies. Along with exotic temporary pavilions representing the various colonies, model villages inhabited by colonial natives, and pavilions representing commercial product brands and other colonial powers, the exposition included a zoo and an aquarium featuring animals from the colonies. Installing a large aquarium had been a costly and difficult process, and construction was plagued by many delays and problems. But when the aquarium finally opened a few months into the exposition, it quickly became a favorite of the public. With the double mission to provide a living synthesis of the products of the warm waters of the French empire and give visitors a sense of the diversity, beauty, and economic resources of their colonial possessions, the aquarium functioned as a panorama that presented a striking visual metaphor for the empire. This article follows the aquarium during the exposition and in the years that followed. We explore its place in the history of aquaria in general and pay particular attention to its role in the exposition and within the French colonial context of the 1930s and onward. Here, both the scientists in charge of the site and the aquatic animals living in its tanks and terrariums provide a window into the relationship of marine biology, public education, consumerism, and colonialism at mid-twentieth century.     

Introducing the Internet.

The benefits to medical practitioners of using the Internet are growing rapidly as the Internet becomes easier to use and ever more biomedical resources become available on line. The Internet is the largest computer network in the world; it is also a virtual community, larger than many nation states, with its own rules of behaviour or "netiquette." There are several types of Internet connection and various ways of acquiring a connection. Once connected, you can obtain, free of charge, programs that allow easy use of the Internet''s resources and help on how to use these resources; you can access many of these resources through the hypertext references in the on line version of this series (go to http:@www.bmj.com/bmj/ to reach the electronic version). You can then explore the various methods for accessing, manipulating, or disseminating data on the Internet, such as electronic mail, telnet, file transfer protocol, and the world wide web. Results from a search of the world wide web for information on the rare condition of Recklinghausen''s neurofibromatosis illustrate the breadth of medical information available on the Internet.     

Evolutionary History of Contagious Bovine Pleuropneumonia Using Next Generation Sequencing of Mycoplasma mycoides Subsp. mycoides “Small Colony”

Mycoplasma mycoides subsp. mycoides “Small Colony” (MmmSC) is responsible for contagious bovine pleuropneumonia (CBPP) in bovidae, a notifiable disease to the World Organization for Animal Health (OIE). Although its origin is not documented, the disease was known in Europe in 1773. It reached nearly world-wide distribution in the 19^th century through the cattle trade and was eradicated from most continents by stamping-out policies. During the 20^th century it persisted in Africa, and it reappeared sporadically in Southern Europe. Yet, classical epidemiology studies failed to explain the re-occurrence of the disease in Europe in the 1990s. The objectives of this study were to obtain a precise phylogeny of this pathogen, reconstruct its evolutionary history, estimate the date of its emergence, and determine the origin of the most recent European outbreaks. A large-scale genomic approach based on next-generation sequencing technologies was applied to construct a robust phylogeny of this extremely monomorphic pathogen by using 20 representative strains of various geographical origins. Sixty two polymorphic genes of the MmmSC core genome were selected, representing 83601 bp in total and resulting in 139 SNPs within the 20 strains. A robust phylogeny was obtained that identified a lineage specific to European strains; African strains were scattered in various branches. Bayesian analysis allowed dating the most recent common ancestor for MmmSC around 1700. The strains circulating in Sub-Saharan Africa today, however, were shown to descend from a strain that existed around 1810. MmmSC emerged recently, about 300 years ago, and was most probably exported from Europe to other continents, including Africa, during the 19^th century. Its diversity is now greater in Africa, where CBPP is enzootic, than in Europe, where outbreaks occurred sporadically until 1999 and where CBPP may now be considered eradicated unless MmmSC remains undetected.     

Organotherapy and the emergence of reproductive endocrinology

Conclusions Early scientific investigation of the reproductive process was neither a cause nor a direct result of changing social attitudes toward sex. It was instead part of the continuing search, initiated in the 1890s, to discover internal secretions that might be isolated and prove useful in therapy. Laboratory scientists, nonetheless, were among the many groups altering understanding of human sexual physiology in the first quarter of this century. The new data they generated regarding the dependence of human sexuality and fertility on chemical substances elaborated by the ovaries and testes became part of the evidence which hastened that quite tortuous transformation called the sexual revolution.Increasingly, as social reformers demanded more information about human reproduction, scientists were asked to provide it, and scientific concerns were shaped in the process. In the 1920s, especially in the United States, studies of the physiology of reproduction began to receive financial backing from social reformers. This was because for many, contraception had become a fact of life. Expression rather than repression of sexuality was accepted as being necessary to the stability of the fundamental social unit, the family. Theoretical and practical incentives for continued study of the reproductive process could thus be joined in common effort. This convergence of goals occurred just as the gonadal hormones were being isolated. The 1920s, therefore, mark an important juncture in the congruence of interests represented by theoretical science on the one hand and expressed social needs on the other.As a result of this convergence of interests and goals, physiologists gained a new realm of influence, claiming authoritative knowledge over a subject which once had been allocated to the priest and then, by the mid-nineteenth century, transferred to the physician. Since that formative period other research scientists, such as Alfred Kinsey and, more recently, William Masters and Virginia Johnson, have explored that niche and applied the scientific method to study of behavioral and physiological aspects of the human sexual response. They have been beset by many of the same tactical issues that confronted the earliest investigators of reproductive physiology. The definition, specification, and measurement of phenomena relating to sexual and reproductive activity have been as inherently difficult as they have been taboo.⁷⁹ Traditional resistance to scientific study of the reproductive process was overcome in the early twentieth century by the expectation that this particular line of inquiry would lead to understanding and therefore medical control of the complex of disorders—physiological, psychological, and social — associated with the generative glands. Early investigators, particularly in Britain, did not wish to be social reformers. Especially in the 1910s such a stance would have threatened their credibility in a field determined to establish itself as a theoretical science. Once scientific progress was assured, as it was from about 1920, new problems opened for investigation and began to be motivated by social needs as well as by the concerns of a rapidly developing science. Especially in the United States new resources encouraged this work, allowing development of the specialized focus on gonadal hormones represented by the emerging field of reproductive endocrinology.     

Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases

Developing effective treatments for neurodegenerative diseases is one of the greatest medical challenges of the 21st century. Although many of these clinical entities have been recognized for more than a hundred years, it is only during the past twenty years that the molecular events that precipitate disease have begun to be understood. Protein aggregation is a common feature of many neurodegenerative diseases, and it is assumed that the aggregation process plays a central role in pathogenesis. In this process, one molecule (monomer) of a soluble protein interacts with other monomers of the same protein to form dimers, oligomers, and polymers. Conformation changes in three-dimensional structure of the protein, especially the formation of beta-strands, often accompany the process. Eventually, as the size of the aggregates increases, they may precipitate as insoluble amyloid fibrils, in which the structure is stabilized by the beta-strands interacting within a beta-sheet. In this review, we discuss this theme as it relates to the two most common neurodegenerative conditions-Alzheimer's and Parkinson's diseases.     

Major histocompatibility complex variation in the endangered Przewalski's horse.

The major histocompatibility complex (MHC) is a fundamental part of the vertebrate immune system, and the high variability in many MHC genes is thought to play an essential role in recognition of parasites. The Przewalski's horse is extinct in the wild and all the living individuals descend from 13 founders, most of whom were captured around the turn of the century. One of the primary genetic concerns in endangered species is whether they have ample adaptive variation to respond to novel selective factors. In examining 14 Przewalski's horses that are broadly representative of the living animals, we found six different class II DRB major histocompatibility sequences. The sequences showed extensive nonsynonymous variation, concentrated in the putative antigen-binding sites, and little synonymous variation. Individuals had from two to four sequences as determined by single-stranded conformation polymorphism (SSCP) analysis. On the basis of the SSCP data, phylogenetic analysis of the nucleotide sequences, and segregation in a family group, we conclude that four of these sequences are from one gene (although one sequence codes for a nonfunctional allele because it contains a stop codon) and two other sequences are from another gene. The position of the stop codon is at the same amino-acid position as in a closely related sequence from the domestic horse. Because other organisms have extensive variation at homologous loci, the Przewalski's horse may have quite low variation in this important adaptive region.     

Natural and human-mediated factors in the recovery and subsequent expansion of the Purple swamphen Porphyrio porphyrio L. (Rallidae) in the Iberian Peninsula

Instances of range contraction and population decline in bird species in Europe are more common than cases of recovery following decline. Here we report on the recovery and expansion processes of an endangered bird species in Europe, the purple swamphen (Porphyrio porphyrio L., Rallidae), with special reference to the Iberian Peninsula, its main distribution area in Western Europe. After a drastic decline during the first half of the 20th century, which restricted its range to a few areas in southern Spain, the Iberian population has recovered. Currently, the species occurs in a range similar to the one it had at the beginning of the 20th century, and has even colonized new areas. These processes seem to be the result of both human-mediated (effective protection of the species and suitable habitats; success of reintroduction programs as expansion focuses of birds colonizing nearby and distant regions [>300 km] wetlands) and natural factors (inter- and intra-seasonal cycles of wet and dry years). Thus, we found a significant relationship between rainfall and bird abundance and productivity, suggesting that such inter- and intra-seasonal cycles may have significant effects on demographic parameters that could be related to the expansion process. Finally the species shows remarkable adaptability, as proven by data on breeding success in recently colonized areas and the ability to breed shortly after reintroduction. We hypothesize that saturation of breeding habitats in established areas, a reasonable habitat continuity and favorable environmental conditions, and protection have facilitated the dispersion of birds.     

Template-directed photoligation of oligodeoxyribonucleotides via 4-thiothymidine.

Non-enzymatic, template-directed ligation of oligonucleotides in aqueous solution has been of great interest because of its potential synthetic and biomedical utility and implications for the origin of life. Though there are many methods for template-directed chemical ligation of oligonucleotides, there are only three reported photochemical methods. In the first report, template-directed photoligation was effected by cyclobutane dimer formation between the 5'- and 3'-terminal thymidines of two oligonucleotides with >290 nm light, which also damages DNA itself. To make the photochemistry of native DNA more selective, we have replaced the thymidine at the 5'-end of one oligonucleotide with 4-thiothymidine (s4T) and show that it photoreacts at 366 nm with a T at the 3'-endof another oligonucleotide in the presence of a complementary template. When a single mismatch is introduced opposite either the s4T or its adjoining T, the ligation efficiency drops by a factor of five or more. We also show that by linking the two ends of the oligonucleotides together, photoligation can be used to form circular DNA molecules and to 'photopadlock' circular DNA templates. Thus, s4T-mediated photo-ligation may have applications to phototriggered antisense-based or antigene-based genetic tools, diagnostic agents and drugs, especially for those situations in which chemical or enzyme-mediated ligation isundesirable or impossible, for example inside a cell.     

Computational Modeling of Single-Cell Migration: The Leading Role of Extracellular Matrix Fibers

Cell migration is vitally important in a wide variety of biological contexts ranging from embryonic development and wound healing to malignant diseases such as cancer. It is a very complex process that is controlled by intracellular signaling pathways as well as the cell’s microenvironment. Due to its importance and complexity, it has been studied for many years in the biomedical sciences, and in the last 30 years it also received an increasing amount of interest from theoretical scientists and mathematical modelers. Here we propose a force-based, individual-based modeling framework that links single-cell migration with matrix fibers and cell-matrix interactions through contact guidance and matrix remodelling. With this approach, we can highlight the effect of the cell’s environment on its migration. We investigate the influence of matrix stiffness, matrix architecture, and cell speed on migration using quantitative measures that allow us to compare the results to experiments.     

Affirmative reaction: new formations of white masculinity

Within the politics of nationalism and nation-building, the emigration of ethnic and religious minorities, whether voluntary or involuntary, appears to be a commonly occurring practice. After the collapse of the Ottoman Empire in the early twentieth century, modern Turkey still carried the legacy of a multi-ethnic, multi-religious diversity in which its Armenian, Greek and Jewish communities had official minority status based upon the 1923 Treaty of Lausanne. However, throughout the twentieth century, Turkey's non-Muslim minority populations have undergone a mass emigration experience in which thousands of their numbers have migrated to various countries around the globe. While in the 1920s the population of non-Muslims in the country was close to 3 per cent of the total, today it has dropped to less than two per thousand. This article analyses the emigration of non-Muslim people from Turkey and relates this movement to the wider context of nation-building in the country.     

On the impoverishment of scientific education

Hannah Arendt, one of the foremost political philosophers of the twentieth century, has argued that it is the responsibility of educators not to leave children in their own world but instead to bring them into the adult world so that, as adults, they can carry civilization forward to whatever challenges it will face by bringing to bear the learning of the past. In the same collection of essays, she discusses the recognition by modern science that Nature is inconceivable in terms of ordinary human conceptual categories - as she writes, ‘unthinkable in terms of pure reason’. Together, these views on scientific education lead to an educational process that transforms children into adults, with a scientific adult being one who has the ability to conceptualize scientific systems independent of ordinary physical intuition. This article begins with Arendt’s basic educational and scientific points and develops from them a critique of current scientific education in conjunction with an appeal to educate young scientists in a manner that allows them to fulfill their potential ‘on the shoulders of giants’. While the article takes a general philosophical perspective, its specifics tend to be directed at biomedical education, in particular, how such education pertains to translational science.     

Land‐use changes may explain the recent range expansion of the Black‐shouldered Kite Elanus caeruleus in southern Europe

Occasional observations of Black‐shouldered Kites Elanus caeruleus in Europe date back to the mid‐19th century, but it was only recorded as a breeding species in the early 1960s in Portugal and a few years later in neighbouring Spain. This recent colonization, possibly from Africa where the species is abundant, may be due to climate change, land‐use changes in southern Europe, or both. As a first step to understanding this range expansion process we have developed a habitat selection model using data from the current strongholds of its European distribution. Comparing the proportion of different habitat types around 46 breeding sites and 45 randomly chosen plots, we have found that the area of cultivated parklands known as dehesas in Spain is a strong predictor of the current distribution range of breeding pairs of Black‐shouldered Kites. Specifically, the percentage of dehesas with planted cereal and a low density of trees (i.e. < 7 trees/ha and thus a savannah‐like habitat) within the study plots explained 44.6% of the residual deviance in our model. The minimal adequate model classified 81.3% of breeding sites and random plots correctly. Our results suggest that Black‐shouldered Kites may have taken advantage of the gradual increase of cultivated dehesas in the second half of the 20th century to expand its range in Europe. This particular type of dehesa is structurally similar to the African savannahs where the species thrives and may offer a higher density of rodents than traditional dehesas, which primarily contain pastureland for livestock ranching.     

Science education and popularization of science in the biomedical area: its role for the future of science and of society

This paper presents the main subjects discussed in the round-table: "Educational Base for Biomedical Research", during the International Symposium on Biomedical Research in the 21st century; two main aspects will be focused: (1) the importance of popularizing science in order to stimulate comprehension of the scientific process and progress, their critical thinking, citizenship and social commitment, mainly in the biomedical area, considering the new advances of knowledge and the resulting technology; (2) the importance to stimulate genuine scientific vocation among young people, by giving them opportunity to early experience scientific environment, through the hands of well prepared master in a humanistic atmosphere.     

美国生物医药产业竞争力分析与启示

进入生物经济时代以来,以生物医药产业为代表的生物技术产业正在引领人类新一波技术产业革命。我国针对生物医药产业作出的战略部署已经取得了明显成效,但与美国等生物医药强国相比仍有较大的竞争差距。采用波特钻石模型构建了生物医药产业国际竞争力理论分析框架,以美国为例分析其生物医药产业在要素状况、企业结构和竞争、需求条件、相关及支持性产业、政府和发展机会六个方面的竞争优势,并基于此提出了我国发展生物医药产业的政策建议,从而为我国生物医药产业发展提供政策参考。     

Malaria and social health determinants: a new heuristic framework from the perspective of Latin American social medicine

Traditionally, malaria research and study have followed the positivist scientific paradigm and its biomedical conception of disease. From this perspective, diverse control actions and strategies have been designed. However, despite a century of scientific experience and the depth and thoroughness achieved in the knowledge of malaria, this has not been translated into a constant and progressive decrease of its epidemiological burden. This essay argues for the need for a change in malaria conception, reconfiguring it as a process of biological and social character, where the geno-phenotypical possibilities of the host-parasite relationship and of the diseases clinical expression are articulated with the historic and social dynamics of the spaces in which they occur. In addition, it proposes rethinking the epidemiological research of this entity on the basis of the visualization of the dynamic, heterogeneous, dialectic and complex character of biosocial organizations that constitute the reality of malaria (from the social structure to the genetic and phenotypic level of parasite individuals, vectors and humans). To achieve this, it is suggested that: 1) the Latin American perspective on the social determinants of health be adopted; 2) new analytical categories (for instance, malaria social territory) and new investigation tools (matrices of critical processes of social determination) be incorporated, and 3) the conventional epidemiological categories of infectious diseases such as the transmission and infectiousness be reinterpreted.