共查询到20条相似文献,搜索用时 15 毫秒
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P. Dhanavanthan 《Biometrical journal. Biometrische Zeitschrift》1998,40(5):641-646
The nature and characteristics of Intervened Poisson Distribution (IPD) has been well discussed by Shanmugam (1985). In this paper, Compound Intervened Poisson Distribution (CIPD) is introduced and its properties are studied. 相似文献
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Bayesian hierarchical models usually model the risk surface on the same arbitrary geographical units for all data sources. Poisson/gamma random field models overcome this restriction as the underlying risk surface can be specified independently to the resolution of the data. Moreover, covariates may be considered as either excess or relative risk factors. We compare the performance of the Poisson/gamma random field model to the Markov random field (MRF)‐based ecologic regression model and the Bayesian Detection of Clusters and Discontinuities (BDCD) model, in both a simulation study and a real data example. We find the BDCD model to have advantages in situations dominated by abruptly changing risk while the Poisson/gamma random field model convinces by its flexibility in the estimation of random field structures and by its flexibility incorporating covariates. The MRF‐based ecologic regression model is inferior. WinBUGS code for Poisson/gamma random field models is provided. 相似文献
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A test to detect clusters of disease 总被引:2,自引:0,他引:2
WHITTEMORE ALICE S.; FRIEND NINA; BROWN BYRON W. JR; HOLLY ELIZABETH A. 《Biometrika》1987,74(3):631-635
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Sun Ping 《Biometrical journal. Biometrische Zeitschrift》1995,37(2):199-203
In the study of spatial patterns, the statistic I' = (n — 1)s2/x was commonly used. In this paper, we found that x — s2 has an approximated normal distribution with zero mean if the xi's (i = 1 to n) are independent identically distributed Poisson variables. Based on this conclusion, the hypothesis that a point pattern is completely random can be tested directly. And a method for the test of spatial patterns was proposed which can be sued as an alternative to the Chi-square based dispersion index test. 相似文献
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Summary As a major analytical method for outbreak detection, Kulldorff's space–time scan statistic (2001, Journal of the Royal Statistical Society, Series A 164, 61–72) has been implemented in many syndromic surveillance systems. Since, however, it is based on circular windows in space, it has difficulty correctly detecting actual noncircular clusters. Takahashi et al. (2008, International Journal of Health Geographics 7 , 14) proposed a flexible space–time scan statistic with the capability of detecting noncircular areas. It seems to us, however, that the detection of the most likely cluster defined in these space–time scan statistics is not the same as the detection of localized emerging disease outbreaks because the former compares the observed number of cases with the conditional expected number of cases. In this article, we propose a new space–time scan statistic which compares the observed number of cases with the unconditional expected number of cases, takes a time‐to‐time variation of Poisson mean into account, and implements an outbreak model to capture localized emerging disease outbreaks more timely and correctly. The proposed models are illustrated with data from weekly surveillance of the number of absentees in primary schools in Kitakyushu‐shi, Japan, 2006. 相似文献
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Interspecific niche differentiation has attracted much more attention than intraspecific niche differentiation. If the intraspecific competition of invasive species is greater than the interspecific competition, it should reduce the invasive abilities of invasive species. Thus, it is important to understand how invasive species avoid or reduce the intraspecific competition. Phyllostachys edulis in southern China is more competitive than many trees. After it invades a community, it can displace other trees. In the current study, we tested whether the different aged bamboo plants (aged two to eight in two-yr increments) exhibited spatial segregation (spatial niche differentiation). The study was performed in the Ecological Station of Dagang Mountain (114°30′~114°45′E, 27°30′~27°50′N), about 200 km east from Nanchang City, Jiangxi province, China. We recorded the planar coordinates of all the plants with diameter at breast height (DBH) ?3 cm. We used the conditional probability (type-specific probability) surface to show the spatial niche differentiation. We also compared the DBH of four aged groups of bamboo plants. We used the Shapiro–Wilk test to test the normality of DBHs of each age group. If DBHs did not follow the Normal distribution, we used the Weibull function to fit these data. Then we used the Kolmogorov–Smirnov test to test whether any two aged groups of DBHs came from the same population. At the end, we used the generalized additive models (GAMs) and a local regression model (LOESS) to explore whether there is a correlation between DBHs and the corresponding planar coordinates. We found that there was significant spatial segregation in four aged groups based on the statistical test. Bamboo plants may reduce their intraspecific competition by spatial niche differentiation. We found that the DBHs approximated the Weibull distribution, and there were very weak relationships between the DBHs and the spatial locations. We concluded that different aged bamboo plants exhibited spatial segregation and may reduce their intraspecific competition by spatial niche differentiation. 相似文献
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In the analysis of spatial patterns, the most extensively used index of dispersion is s2/m in which s2 and m are respectively the sample variance and sample mean of the count x in each sample unit. For statistical testing, the statistic I' = (n — 1) s2/m has been introduced since it has an approximate X distribution under the null hypothesis that individuals are distributed randomly. The main problem with the use of index I' is that the random distribution and the superdispersed distribution are not distinguished. In this paper, we have tried to induce a new statistical method for the detection of spatial pattern, based on the special characteristic of Poisson distribution that both of the m and s2 are the unbiased estimates of the parameter. 相似文献
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Paola M. V. Rancoita Morten Valberg Romano Demicheli Elia Biganzoli Clelia Di Serio 《Biometrics》2017,73(1):260-270
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Andrea J. Cook Diane R. Gold Yi Li 《Biometrical journal. Biometrische Zeitschrift》2009,51(5):801-818
Spatial cluster detection has become an important methodology in quantifying the effect of hazardous exposures. Previous methods have focused on cross‐sectional outcomes that are binary or continuous. There are virtually no spatial cluster detection methods proposed for longitudinal outcomes. This paper proposes a new spatial cluster detection method for repeated outcomes using cumulative geographic residuals. A major advantage of this method is its ability to readily incorporate information on study participants relocation, which most cluster detection statistics cannot. Application of these methods will be illustrated by the Home Allergens and Asthma prospective cohort study analyzing the relationship between environmental exposures and repeated measured outcome, occurrence of wheeze in the last 6 months, while taking into account mobile locations. 相似文献
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M. Tariqul Hasan Gary Sneddon Renjun Ma 《Biometrical journal. Biometrische Zeitschrift》2009,51(6):946-960
Analysis of longitudinal data with excessive zeros has gained increasing attention in recent years; however, current approaches to the analysis of longitudinal data with excessive zeros have primarily focused on balanced data. Dropouts are common in longitudinal studies; therefore, the analysis of the resulting unbalanced data is complicated by the missing mechanism. Our study is motivated by the analysis of longitudinal skin cancer count data presented by Greenberg, Baron, Stukel, Stevens, Mandel, Spencer, Elias, Lowe, Nierenberg, Bayrd, Vance, Freeman, Clendenning, Kwan, and the Skin Cancer Prevention Study Group[New England Journal of Medicine 323 , 789–795]. The data consist of a large number of zero responses (83% of the observations) as well as a substantial amount of dropout (about 52% of the observations). To account for both excessive zeros and dropout patterns, we propose a pattern‐mixture zero‐inflated model with compound Poisson random effects for the unbalanced longitudinal skin cancer data. We also incorporate an autoregressive of order 1 correlation structure in the model to capture longitudinal correlation of the count responses. A quasi‐likelihood approach has been developed in the estimation of our model. We illustrated the method with analysis of the longitudinal skin cancer data. 相似文献
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The cumulative damage model as outlined in previous papers is unable to reproduce latency periods, particularly after short-term exposures. A refinement being straightforward within the present frame of point process theory is proposed using displacement processes applied to the single damages. For the displacement distribution, the lognormal distribution has been suggested. As in the previous model, exact formula for the behaviour of the survival function after the onset and the cessation of an additional exposure can be derived. Qualitative examinations demonstrate that the thus extended model shows the relevant features known from reports on shortterm exposures. Fitting the model to data of follow-up studies should provide a measure for the impact of an environmental exposure and the parameters for the distribution of the related latency period. 相似文献
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Many current statistical methods for disease clustering studies are based on a hypothesis testing paradigm. These methods typically do not produce useful estimates of disease rates or cluster risks. In this paper, we develop a Bayesian procedure for drawing inferences about specific models for spatial clustering. The proposed methodology incorporates ideas from image analysis, from Bayesian model averaging, and from model selection. With our approach, we obtain estimates for disease rates and allow for greater flexibility in both the type of clusters and the number of clusters that may be considered. We illustrate the proposed procedure through simulation studies and an analysis of the well-known New York leukemia data. 相似文献
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Kwok Fai Lam Kin Yau Wong Feifei Zhou 《Biometrical journal. Biometrische Zeitschrift》2013,55(5):771-788
There is a growing interest in the analysis of survival data with a cured proportion particularly in tumor recurrences studies. Biologically, it is reasonable to assume that the recurrence time is mainly affected by the overall health condition of the patient that depends on some covariates such as age, sex, or treatment type received. We propose a semiparametric frailty‐Cox cure model to quantify the overall health condition of the patient by a covariate‐dependent frailty that has a discrete mass at zero to characterize the cured patients, and a positive continuous part to characterize the heterogeneous health conditions among the uncured patients. A multiple imputation estimation method is proposed for the right‐censored case, which is further extended to accommodate interval‐censored data. Simulation studies show that the performance of the proposed method is highly satisfactory. For illustration, the model is fitted to a set of right‐censored melanoma incidence data and a set of interval‐censored breast cosmesis data. Our analysis suggests that patients receiving treatment of radiotherapy with adjuvant chemotherapy have a significantly higher probability of breast retraction, but also a lower hazard rate of breast retraction among those patients who will eventually experience the event with similar health conditions. The interpretation is very different to those based on models without a cure component that the treatment of radiotherapy with adjuvant chemotherapy significantly increases the risk of breast retraction. 相似文献
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Currently, the spatial patterns of mitochondrial genes and how the genomic localization of (pseudo)genes originated from mitochondrial DNA remain largely unexplained. The aim of this study was to elucidate the organization of mitochondrial (pseudo)genes given their evolutionary origin. We used a keyword finding method and a bootstrapping method to estimate parameter values that represent the distribution pattern of mitochondrial genes in the nuclear genome. Almost half of mitochondrial genes showing physical clusters were located in the pericentromeric and subtelomeric regions of the chromosome. Most interestingly, the size of these clusters ranged from 0.085 to 3.2 Mb (average ± SD 1.3 ± 0.73 Mb), which coincides with the size of the evolutionary pocket, or the average size of evolutionary breakpoint regions. Our findings imply that the localization of mitochondrial genes in the human genome is determined independent of adaptation. 相似文献
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The multiple Poisson distribution, known under different names, such as generalized Poisson, compound Poisson, composed Poisson, stuttering Poisson, Poisson power series, Poisson-stopped sum distribution, etc., plays an important role in discrete distribution theory. Here we want to show its basic characteristics, the variety of its forms and specify the generalizing distributions. 相似文献
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