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1.
Serum and tissue levels of six trace elements and copper/zinc ratio in patients with cervical cancer and uterine myoma 总被引:2,自引:0,他引:2
Cunzhi H Jiexian J Xianwen Z Jingang G Shumin Z Lili D 《Biological trace element research》2003,94(2):113-122
The aim of this study is to investigate the relationship between trace elements and the incidence of cervical cancer. Tissue
and serum levels of six elements (Cu, Zn, Fe, Mn, Ca, and Se) and the Cu/Zn ratio in 40 cases of patients with cervical cancer,
30 cases of uterine myoma, and 50 healthy subjects were measured by atomic absorption spectrophotometry; the selenium content
was determined by atomic fluorescence spectrometry. The results showed that the tissue contents of Zn, Se, and Ca were significantly
lower and the Cu and Fe concentrations and Cu/Zn ratio were significantly higher in cervical cancer tissue than that for paired
nonlesion tissue (p<0.02 and p<0.001, respectively). The serum levels of Zn, Se, Ca, and Fe were lower and Cu and Mn levels and Cu/Zn ratio were higher
in patients with cervical cancer than in healthy subjects (p<0.01 and p<0.001, respectively) and in the uterine myoma group compared with healthy subjects (p< 0.05–0.001). There are no significant differences in the contents of six elements and the Cu/Zn ratio between uterine myoma
tissue and paired nonlesion tissue. The results showed also that the Fe level and Cu/Zn ratio were significantly higher and
the Zn and Se levels were significantly lower in cervical cancer tissue than in uterine myoma tissue (p<0.01 and p<0.001, respectively). The serum Cu level and Cu/Zn ratio were significantly higher in the cervical cancer group than the
uterine myoma group (p<0.01). Data were also analyzed using multivarate logistic regression. After adjustment for age, occupation, life habit, and
other covariates for the development of cervical cancer, the odds ratios were 22.64 (95% confidence interval [CI]: 5.64–90.88,
p=0.001) for Cu, 0.11 (95% CI: 0.034–0.373; p=0.005) for Zn, and 0.60 (95% CI: 0.36–0.99, p=0.01) for Se. Thus, the serum and tissue levels of Cu increase and the deficiency of Zn and Se may be risk factors for the
development of cervical cancer. 相似文献
2.
The aim of the present study is to evaluate the status of plasma essential trace elements selenium (Se), zinc (Zn), copper
(Cu), and iron (Fe) concentrations and their related acute-phase proteins, ceruloplasmin (Cp), ferritin, transferrin (Tf),
and albumin levels in patients with vivax malaria. Plasma Cu and Zn concentrations were determined by atomic absorption spectrometry
(AAS). Se concentrations were determined by graphite furnace AAS. Fe, Cp, Tf, and albumin levels were determined by colorimetric
methods. Plasma Se, Fe, and albumin levels were found to be significantly lower (p<0.01, p<0.001, and p<0.05, respectively) and Cu, Cp, and ferritin levels and Cu/Zn ratios were significantly higher (p<0.001, p<0.001, p<0.001, and p<0.05, respectively) in patients when compared with those of healthy subjects. Plasma, Tf, and Zn levels were not found to
be significantly different (p>0.05) in patients and controls. There were positive important correlations between Cu and Cp (r=0.908, p<0.001), Zn and albumin (r=0.633, p<0.001), and negative correlations between Fe and ferritin content (r=−0.521, p<0.05) and Fe and Tf (r=−0.616, p<0.01) in the patients group. Our findings demonstrated that plasma essential trace elements Se, Cu, and Fe change, but these
changes might be dependent on acute-phase proteins, which were regulated as a part of defense strategies of the organism,
induced by hormonelike substances. 相似文献
3.
The pathogenesis of heart disease has been associated with changes in the balance of certain trace elements. The aim of this
study was to evaluate the Zn, Fe, Cu, Cr, Ni, Pb, and Cd contents in scalp hair samples of myocardial infarction (MCI) patients
hospitalized in the cardiac ward of National Hospital in Hyderabad city (Pakistan). Scalp hair samples were collected from
193 patients (104 male, 89 female) of 3 age groups (46–60, 61–75, and 76–90 yr), for a comparative study, 200 normal, healthy
subjects (103 male, 97 female) of the same age groups residing in the same city were selected. All metals in scalp hair samples
were assessed by a flame/graphite furnace atomic absorption spectrophotometer, prior to microwave-assisted and conventional
wet acid digestion methods. Results were calculated in micrograms per gram.
The mean values of Fe and Zn of scalp hair samples of MCI patients were significantly reduced compared to the control subjects
of both genders. The mean Fe concentrations in male patients were 19.42, 12.36, and 6.98 vs 30.69, 24.42, and 16.75 for the
control patients in the three age groups (46–60, 61–75, and 76–90 yrs, respectively). The mean Zn concentration in male patients
were 169.2, 149.4, and 107.7 μg/g vs 206.1, 188.0, and 154.4 μg/g for the control group (p<0.002, 0.004, and 0.001) in all three age groups, respectively. These differences were also observed in the female study
groups. The mean values of Pb, Cd, and Ni were significantly high in patients compared to healthy subjects (mean Pb in male
patients: 11.85, 12.89, and 14.52 those of female patients were 11.88, 12.73, and 14.21 vs the male controls patients (6.08,
7.56, and 8.56) and female controls (5.99, 7.41, and 8.25) for all three age groups, respectively. The concentration of Ni
and Cd in the scalp hair samples of the heart patients of both sexes were significantly higher compared to the control; in
the case of Ni the range of significant difference for males was found to be p<0.001–0.009 and for females to be p<0.0.002–0.007 and significantly high concentration of Cd were observed in hair samples of patients than in controls in the
range for males (p<0.001–0.009) and in females (p<0.001–0.011). The Zn/Cu and Zn/Cd ratios in the scalp hair (p<0.01) of the diseased groups were significantly lower than that of the healthy groups.
Deficiency of essential trace metals and high level of toxic metals might play a role in the development of heart disease
in the subjects of this study. Toxic metals might also cause diminished absorption of essential elements. 相似文献
4.
J. I. Anetor O. A. Ajose F. N. Adeleke G. O. Olaniyan-Taylor F. A. Fasola 《Biological trace element research》2010,136(2):157-170
Iron (Fe) remains a commonly prescribed supplement in pregnancy. Its possible pathologic potential is either uncommonly considered
or ignored. We determined the antioxidant status in pregnant women with and without Fe supplements. Fifty-eight apparently
healthy pregnant women on Fe supplements were selected for the study from the antenatal clinic of the University College Hospital,
Ibadan, Nigeria. Fifty-five aged matched pregnant women who were not on Fe from various parishes of the Christ Apostolic Church,
Ibadan (non-drug using Christian sect) were randomly selected as controls. Both groups were classified according to the trimesters
of pregnancy. The gestational age in both pregnant women on Fe supplements and non-supplement pregnant women was similar.
Fruit and vegetables consumption was higher in the supplement than in the non-supplement group (57.2% vs. 37.3%). Anthropometric
indices, weight, height, and BMI, were also similar. But while the weight of the Fe supplement group decreased by nearly 3%
in the third trimester, it increased by over 10% (p < 0.00) in the non-supplement group in the same period. Serum Fe level was significantly higher in the supplement than the
non-supplement group (p < 0.001). In contrast, the levels of the antioxidants, ascorbic acid, copper (Cu), zinc (Zn), and bilirubin were all significantly
decreased (p < 0.05, p < 0.001, p < 0.05, and p < 0.05, respectively). Uric acid level though also lower in the supplement group did not reach statistical significance (p > 0.05), while vitamin E was similar in both groups. There was relative stability of all antioxidants except uric acid, which
declined from the first to the last trimester in the non-supplement group. The significantly higher Fe level in the second
trimester was sustained in the third trimester though to a lesser degree (p < 0.05) and associated with significant decreases in the following antioxidant levels in the supplement group, ascorbic acid,
bilirubin, Cu, and Zn (p < 0.02, p < 0.02, p < 0.02, and p < 0.001, respectively). Uric acid and vitamin E though lower in the supplement group were not significantly different. Remarkably,
percentage changes between the first and third trimesters revealed that serum Fe increased by over 116% in the Fe supplement
group, while it only increased by over 50% in the non-supplement group. This was associated with 23.50% decrease in ascorbate
level (p < 0.003) in the supplement group, while it decreased by only 3.70% in the non-supplement group (p > 0.05). Again vitamin E decreased by 17.22% in the supplement group, while it decreased by only 7.30% in the non-supplement
group during the period. Uric acid and bilirubin levels decreased by similar proportions during the period, while Zn decreased
by 18.55% in the supplement group and by 14.86% in the non-supplement group. In contrast Cu increased by 7.20% in the supplement
group, while it increased by only 2.96 in the non-supplement group. Additionally, all the antioxidants in the supplement group
except vitamin E, viz, ascorbic acid, bilirubin, Cu, uric acid, and Zn, were significantly inversely correlated with serum
Fe level (r − 0.299, p < 0.05, r − 0.278, p < 0.05, r − 0.383, p < 0.05, and r − 0.0369, p < 0.05). These data imply markedly depressed antioxidant status in the Fe supplement pregnant group with attendant oxidative
stress (most probably pro-oxidant Fe-induced). This is associated with molecular and cellular damage as well as a number of
pathologic and clinical correlates that underlie the exacerbation of morbidity and mortality in maternal and child populations,
particularly in the developing countries. This appears to call for serious caution and prior evaluation of antioxidant and
Fe status and during the use of Fe supplements in pregnancy for monitoring and prognostic purposes and to avert or ameliorate
oxidative stress-induced pathologies in maternal and fetal systems. 相似文献
5.
Rafał Kocyłowski Iwona Lewicka Mariusz Grzesiak Zuzanna Gaj Przemysław Oszukowski Constantin von Kaisenberg Joanna Suliburska 《Biological trace element research》2018,182(2):217-223
The mineral levels in maternal serum change during pregnancy and may be correlated with those of newborn cord blood. The aim of this study was to evaluate the concentrations of calcium (Ca), magnesium (Mg), zinc (Zn), iron (Fe), and copper (Cu) in maternal blood before and after delivery and in umbilical cord vein and artery serum. The study was carried out in 64 Caucasian pregnant women who delivered in a district hospital in Greater Poland region, aged 28.1 ± 5.4 years, with a mean gestational age of 39.2 ± 1.3 weeks. Blood samples were taken from women 2–8 h before delivery and immediately after childbirth. The umbilical cord artery and vein blood of newborns was obtained immediately after childbirth. The levels of minerals in serum were determined by flame atomic absorption spectrometry. A significant drop in the concentrations of Mg (17.71 ± 1.51 vs 17.07 ± 1.61 μg/ml; p < 0.007), Fe (1.08 ± 0.46 vs 0.82 ± 0.35 μg/ml; p < 0.0004), and Zn (0.63 ± 0.17 vs 0.46 ± 0.16; p < 0.0001) in maternal serum was found after delivery. Moreover, higher levels of Ca, Fe, and Zn and lower levels of Cu were observed in the umbilical vein (Ca: 102.80 ± 7.80 μg/ml; p < 0.0001, Fe: 1.96 ± 0.43 μg/ml; p < 0.0001, Zn: 0.65 ± 0.16 μg/ml; p < 0.0001, Cu: 0.36 ± 0.09 μg/ml; p < 0.0001) and in the umbilical artery cord blood (Ca: 98.07 ± 8.18 μg/ml; p < 0.0001, Fe: 1.63 ± 0.30 μg/ml; p < 0.0001, Zn: 0.65 ± 0.15 μg/ml; p < 0.0001, and Cu: 0.36 ± 0.10 μg/ml; p < 0.0001) compared to the maternal serum (Ca: 85.05 ± 10.76 μg/ml, Fe: 0.82 ± 0.35 μg/ml, Zn: 0.46 ± 0.16 μg/ml, and Cu: 1.90 ± 0.35 μg/ml). Fe levels in the cord artery serum negatively correlated with blood loss during delivery (R = ?0.48; p = 0.01), while the Ca concentration in the maternal serum after birth decreased with the age of the women (R = ?0.25; p = 0.03). In conclusion, it seems that the process of birth alters the mineral levels in pregnant women’s blood. Moreover, it was found that blood loss and the age of the mother are associated with mineral concentrations in the maternal serum and cord artery blood. 相似文献
6.
In recent years, a great number of studies have investigated the possible role of trace elements in the etiology and pathogenesis
of rheumatoid arthritis (RA) and osteoartritis (OA). We studied synovial fluid and plasma concentrations of selenium (Se),
zinc (Zn), copper (Cu), and iron (Fe) in patients with RA and OA and compared them with sex- and age-matched healthy subjects.
Plasma albumin levels were measured as an index of nutritional status. Plasma Se, Cu, and Zn concentrations were determined
by atomic absorption spectrophotometry and Fe concentrations were determined by the colorimetric method. Although plasma and
synovial fluid Se concentration were found to be significantly lower (p<0.05, and p<0.05, respectively), Cu concentrations were significantly higher in patients with RA than those of healthy subjects and OA
(p<0.05 and p<0.05, respectively). There were no significant differences in plasma and synovial fluid Zn concentrations and albumin levels
among three groups (p>0.05). On the other hand, synovial fluid Cu and Fe concentrations were significantly higher in patients with OA than those
of healthy subjects (p<0.05). There was a significantly positive correlation between synovial fluid Se−Cu values and Zn−Fe values in patients with
RA. Our results showed that synovial fluid and plasma trace element concentrations, excluding Zn, change in inflammatory RA,
but not in OA. These alterations in trace element concentrations in inflammatory Ra might be a result on the changes of the
immunoregulatory cytokines. 相似文献
7.
Wojciech Wasowicz Piotr Wolkanin Marek Bednarski Jolanta Gromadzinska Maria Sklodowska Krystyna Grzybowska 《Biological trace element research》1993,38(2):205-215
Selenium (Se), copper (Cu), and zinc (Zn) concentrations were determined in plasma of 64 mothers at delivery, 58 nonpregnant women, 64 neonates, and 12 infants, aged 2–12 mo. Se and Zn concentrations in mothers at delivery were significantly lower, and Cu higher than in nonpregnant women. Mean Se and Cu concentrations in newborns were statistically lower than those in mothers at delivery, and Zn and Cu concentrations in preterm infants (n=13) were significantly higher than in fullterm infants (n=51). Maternal parity had no significant influence on the distribution of plasma trace element levels. No significant differences were observed in Se and Zn levels in maternal and cord blood plasma according to birth weight, contrary to maternal Cu concentration. Significant correlations were found between maternal and cord blood Se content, and between maternal plasma Cu concentration and birth weight of neonates. 相似文献
8.
Direct analysis of human blood (mothers and newborns) by energy dispersive X-ray fluorescence 总被引:3,自引:0,他引:3
P.J. Custdio Maria Luisa Carvalho F. Nunes S. Pedroso A. Campos 《Journal of trace elements in medicine and biology》2005,19(2-3):151-158
This work is an application of energy dispersive X-ray fluorescence (EDXRF) as analytical technique for trace element determination in human tissues. Potassium (K), calcium (Ca), iron (Fe), copper (Cu), zinc (Zn), bromine (Br), rubidium (Rb) and lead (Pb) were determined directly in blood samples from 66 mothers at delivery after full-term pregnancies. The corresponding 66 cord-blood samples of the newborns were also analysed, in order to find element correlations between maternal and newborn blood at birth. The studied samples were obtained from mothers aged between 15 and 39 years old, the gestational age being between 35 and 41 weeks and the newborns' weight between 2.310 and 4.310 kg. Samples were lyophilised and analysed without any chemical treatment. Very low levels of Pb were found both in maternal and fetal cord blood samples. Cu values ranged from 3 to 13 microg g-1, both for mothers and children. A correlation between Cu and Fe concentrations in maternal and fetal cord blood was found. Zn is considered as one of the key elements in newborn health. Concentrations between 10 and 40 microg g-1 were measured. A positive correlation between Br levels in mothers and children was observed. Positive correlations for mothers were observed between Zn and Rb as well as K and Fe. The corresponding correlations in fetal cord blood samples were not observed, however positive correlations were found between Ca and K; Cu and Fe. The mean concentrations for each element were similar in maternal and in fetal cord blood, except for Cu and Zn, being higher in maternal samples. No correlations between element concentrations and pathologies of the mothers were observed. 相似文献
9.
Lech T 《Biological trace element research》2002,89(2):111-125
The lead, copper, zinc, and magnesium contents of scalp hair taken from 173 children aged 1–15 yr and young people (16–18
yr) with certain disorders of the osteomuscular articular system (osteomuscular pains of unknown origin, once described as
“growing pains”) were measured, using the flame atomic absorption spectrometry method, and then compared with those of 108
normal, healthy children. The research showed increased average levels of lead (a statistically significant p<0.05 in both the overall group of children, and in those over 11 yr old), and zinc (increased in the total group, in a statistically
significant way at p<0.10 only in adolescents over 15 yr old) and decreased levels of copper (although not significantly) in the hair of children
suffering from “rheumatic” diseases, as compared with controls. The magnesium levels for the total group of ill children were
admittedly enhanced, but in the youngest children, the levels were reduced.
The values of the Mg/Pb and Mg/Zn ratios were lower (in the youngest children, 70% decrease of the Mg/Pb ratio) and Zn/Cu
were higher in the group of children suffering from rheumatic diseases than in the healthy children. The difference of Mg/Pb
ratio between the total controls and rheumatic subjects was statistically significant at p<0.05 and the Zn/Cu at p<0.10. The Mg/Zn ratio was not statistically significant. 相似文献
10.
Many factors are known to influence trace element metabolism and one of them is dietary protein. The present study examines
the effects of casein, soybean protein, and peanut protein on the metabolism of the Zn, Cu, Fe, and Mn in growing rats. The
results showed that Zn, Fe, and Mn excretions in the feces of peanut protein-fed rats (PPERs) were similar to that of casein-fed
rats (CPFRs) (p>0.05), whereas all of the Zn, Cu, Fe, and Mn excretions in the urine of PPFRs were significantly higher than that of CPFRs
(p<0.05), but its apparent absorption rate (AAR) of Cu, Fe and its apparent retention rate (ARR) of Cu were all higher than
that of CPFRs (p<0.05). Hepatic Zn content of soybean protein-fed rats (SPFRs) was higher than that of CPFRs and PPFRs (p<0.05 respectively) and serum, renal, and femoral Cu contents of SPFRs were significantly lower; however, hepatic Cu, and
renal Mn contents were significantly higher than that of CPFRs (p<0.05, respectively); The hepatic Fe content of SPFRs was significantly higher than that of CPFRs and PPFRs (p<0.01, respectively). To sum up, compared to casein, soybean protein might be a good dietary source to make up for Zn and
Fe deficiency, and also peanut protein to make up for Cu and Fe deficiency. 相似文献
11.
Jaume Folch Arturo Ortega Maria Cabré José L. Paternáin 《Biological trace element research》1998,63(2):113-121
The monitoring of heavy metals is important if adverse effects on health are to be avoided. In humans, metallothionein (MT)
has been used as a biomonitor for the assessment of cadmium (Cd). In the present study, subjects drawn from the population
of Tarragona Province (NE Spain) were investigated. Urinary MT, zinc (Zn), and copper (Cu) concentrations, corrected for creatine
concentrations, were determined in 625 samples from healthy subjects aged between 10 and 65 yr. Mean values of MT and Cu in
females were higher than those in males, with levels of 29.5 (23.8) vs. 22.7 (24.9) μg MT/creatinine (p<0.001) and 4.8 (6.1) vs 3.4 (4.9) μg Cu/g creatinine (p<0.001). No differences between males and females were observed with respect to urinary Zn: 78.0 (66.4) vs 73.0 (85.5) μg/g
creatinine, respectively (p=0.332). Significantly higher MT, Zn, and Cu values were observed in the females aged 15–19 yr and, in the age group of 50–54
yr, only in the Zn and Cu values, when compared with those in males. Significant positive correlations of MT vs Zn and Cu
as well as correlations of Zn vs Cu levels were observed in both genders. The present findings confirm the proposed role of
MT as a biomonitor of mineral status. 相似文献
12.
Samiran Bisai Dilip Mahalanabis Kaushik Bose 《International Journal of Anthropology》2006,21(3-4):241-246
This study compared several maternal risk factors of low birth weight (LBW) between 204 normal birth weight (NBW) and 133
LBW newborns from Kolkata, India. Based on their birth weight (BW), newborns were classified as LBW (BW < 2.5 kg) and NBW
(BW ≥ 2.5 kg). Results revealed that means for maternal age (MA, p < 0.05), gestational age (GA, p < 0.01), hemoglobin (Hb) concentration (p < 0.05), and per capita daily income (PCDI, p < 0.05) were significantly higher among mothers of NBW. Correlation analyses revealed that MA (r = 0.119, p < 0.05), GA (r = 0.583, p < 0.01), PCDI (r = 0.118, p < 0.05), and Hb (r = 0.138, p < 0.05) were significantly positively correlated with BW; PCDI was also significantly positively correlated (r = 0.142, p < 0.01) with Hb. Stepwise regression analyses with BW as the dependent variable revealed that GA (t = 7.915, p < 0.001) and Hb (t = 2.057, p < 0.05) were the most important predictive variables. The effect of Hb, independent of GA, was statistically significant
(change in F = 4.231, p < 0.05). Because GA is not modifiable in pregnant women, there is a need to increase Hb levels among pregnant mothers. Most
importantly, appropriately targeted preventive strategies, including iron supplementation, need to be implemented for health
promotion. 相似文献
13.
Brucellosis is a zoonotic disease that is encountered in sheep rather frequently. In this study, 100 sheep diagnosed with
brucellosis that had aborts and 40 healthy sheep were used as materials. Analyses for Cu, Zn, Fe, Cr, Ca, Mg, and K were performed
with the atomic absorption spectrophotometric method on blood collected from vena jugularis of all the sheep and rheumatoid
factor levels were determined by the nephelometry method. Although it was found that Cu, Ca, and rheumatoid factor values
in the sera of the sheep with brucellosis were high when compared to the control group (p<0.001, p<0.05, p<0.001, respectively), their serum Zn values were low (p<0.05). No significant changes in serum Cr, Fe, K, and Mg levels were found. 相似文献
14.
Aydin E Cumurcu T Ozugurlu F Ozyurt H Sahinoglu S Mendil D Hasdemir E 《Biological trace element research》2005,108(1-3):33-41
The purpose of this study was to investigate iron (Fe), zinc (Zn), and copper (Cu) levels of aqueous humor, lens, and serum
in nondiabetics and diabetics and to determine the effects of diabetes on Fe, Zn, and Cu contents in the lens. Fe, Zn, and
Cu contents of aqueous humor, lens, and serum samples of 19 patients (9 nondiabetic patients with a mean age of 62.3±5.4 yr,
and 10 diabetic patients with a mean age of 59.5±5.9 yr) were analyzed by atomic absorption spectrometry using a prospective
study design. The lens levels of Cu in diabetic patients were significantly higher compared with nondiabetic patients (p=0.02); however; there was no difference in the other elements (Zn, Fe; p=0.28, p=0.74, respectively). The levels of Fe, Zn, and Cu in the aqueous humor and serum of diabetic patients were not found to be
statistically significant when compared to nondiabetics (p=0.46, p=0.11, p=0.18, and p=0.22, p=0.43, p=0.72, respectively). These results demonstrate that increased Cu content of the lens presumably has a greater association
with the development of lens opacification in diabetics than Zn and Fe content. 相似文献
15.
Gümüş M Yüksel H Evliyaoğlu O Kapan M Böyük A Önder A Aldemir M 《Biological trace element research》2011,143(1):386-393
Ellagic acid (EA) is a natural polyphenolic compound. Although, modulator effects of EA on copper (Cu) and zinc (Zn) levels
in some liver diseases have been reported in experimental animals, its effects in obstructive jaundice (OJ) has not been clarified.
We aimed to evaluate potential effects of EA on Cu and Zn levels in liver and serum of cholestatic rats. Forty Wistar albino
rats were equally divided into four groups. First group was used as controls. Second group received EA (60 mg−1 kg−1 day−1) for 8 days. Third was OJ group, and fourth group was OJ plus EA group. After 8 days, blood and liver samples were obtained.
Higher serum and liver Cu and lower serum and liver Zn levels were found in OJ group (p < 0.05) compared with other groups. However, these differences reached to significant levels for Cu in serum and for Zn in
lever. Higher serum copper levels were decreased, and lower liver Zn levels were increased by EA treatment in cholestatic
rats (p < 0.05). Also, higher Cu/Zn ratio in OJ group was decreased by EA treatment both in liver (p < 0.05) and in serum (p < 0.05). Significantly higher serum bilirubin, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase
values were found in OJ and OJ + EA groups compared with the control and EA groups (p < 0.05). In conclusion, result of the current study indicated that ellagic acid has modulator effects on Cu and Zn levels
in liver and serum of cholestatic rats. 相似文献
16.
The levels of, zinc, copper, Fe, Zn, Cu, Mn, Mg, K, Na, and Cl and the activity of carbonic anhydrase were determined in lambs
with pneumonia. A significant decrease of p<0.01 level in Zn concentration, in Cu level (p<0.001) and significant increases in K and Na levels (p<0.05) and of the Cu/Zn ratio (p<0.001) were observed in the study group. The carbonic anhydrase activity was decreased in the study group, but the decrease
was not statistically significant (p>0.05). Also, nonsignificant decreases of Fe, Mg, and Cl and increase of the Mn concentration were also observed in the lambs
with pneumonia (p>0.05). Our results suggest that the significant element changes reported here and the Cu/Zn ratio, but not the activity of
carbonic anhydrase, can be used as indicators of pneumococcal infection. 相似文献
17.
Ayhan Dogukan Nurhan Sahin Mehmet Tuzcu Vijaya Juturu Cemal Orhan Muhittin Onderci James Komorowski Kazim Sahin 《Biological trace element research》2009,131(2):124-132
The present study was conducted to investigate the effects of chromium histidinate (CrHis) against experimentally induced
type II diabetes and on chromium (Cr), zinc (Zn), selenium (Se), manganese (Mn), iron (Fe), and copper (Cu) in serum, liver,
and kidney of diabetic rats. The male Wistar rats (n = 60, 8 weeks old) were divided into four groups. Group I received a standard diet (12% of calories as fat); group II were
fed standard diet and received CrHis (110 mcg CrHis/kg body weight per day); group III received a high-fat diet (HFD; 40% of calories as fat) for 2 weeks and then
were injected with streptozotocin (STZ) on day 14 (STZ, 40 mg/kg i.p.; HFD/STZ); group IV were treated as group III (HFD/STZ)
but supplemented with 110 mcg CrHis/kg body weight per day. The mineral concentrations in the serum and tissue were determined
by atomic absorption spectrometry. Compared to the HFD/STZ group, CrHis significantly increased body weight and reduced blood
glucose in diabetic rats (p < 0.001). Concentrations of Cr, Zn, Se, and Mn in serum, liver, and kidney of the diabetic rats were significantly lower
than in the control rats (p < 0.0001). In contrast, higher Fe and Cu levels were found in serum and tissues from diabetic versus the non-diabetic rats
(p < 0.001). Chromium histidinate supplementation increased serum, liver, and kidney concentrations of Cr and Zn both in diabetic
and non-diabetic rats (p < 0.001). Chromium supplementation increased Mn and Se levels in diabetic rats (p < 0.001); however, it decreased Cu levels in STZ-treated group (p < 0.001). Chromium histidinate supplementation did not affect Fe levels in both groups (p > 0.05). The results of the present study conclude that supplementing Cr to the diet of diabetic rats influences serum and
tissue Cr, Zn, Se, Mn, and Cu concentrations. 相似文献
18.
The aim of the present study is to evaluate the status of plasma essential trace element selenium (Se), manganese (Mn), copper
(Cu), zinc (Zn), and iron (Fe) concentrations and the effect of these elements on oxidative status in patients with childhood
asthma. Plasma Se, Mn, Cu, and Zn concentrations were determined by atomic absorption spectrophotometry (AAS) and Fe concentrations,
malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined by the colorimetric method. The plasma MDA/TAC
ratio was calculated as an index of oxidative status. Plasma albumin levels were measured to determine nutritional status.
Plasma Fe concentrations, MDA levels and the MDA/TAC ratio were significantly higher (p<0.001, p<0.001, and p<0.01, respectively) and Se and Mn concentrations and TAC were lower (p<0.01, p<0.05, and p<0.01, respectively) in patients when compared to the healthy subjects. Plasma Zn, Cu, and albumin levels were not found to
be significantly different in patients and controls (p>0.05). There were positive relationships between plasma MDA and Fe (r=0.545, p<0.001) and TAC and Se (r=0.485, p<0.021), and a negative correlation between TAC and MDA values (r= −0.337, p<0.031) in patients with childhood asthma. However, there was no correlation between these trace elements and albumin content
in patient groups. These observations suggest that increased Fe and decreased Se concentrations in patients with childhood
asthma may be responsible for the oxidant/antioxidant imbalance. 相似文献
19.
We have previously shown that a low-copper (Cu) diet produced alterations in placental Cu transport and fetal Cu stores. Because
Cu deficiency has been associated with lipid deposition in rat dam liver, we hypothesized that a high fat intake, a prevalent
dietary habit in many populations, may worsen fetal Cu status and its closely linked iron (Fe) deposits. Pregnant rats were
fed one of four diets during the second half of gestation: NFNCu: normal fat (7%), normal Cu (6 mg/kg); HFNCu: high fat (21%),
normal Cu; NFLCu: normal fat, low Cu (0.6 mg/kg), and HFLCu: high fat, low Cu. One day before delivery, dams were anesthetized,
and maternal as well as fetal plasma and tissues were obtained. Maternal, fetal, and placental weights were indistinguishable
regardless of the group. Dam plasma Cu and placental Cu were lower in both LCu groups than in the NFNCu or the HFNCu groups.
However, fetal plasma Cu was similar in all treatment groups. Dam and fetal liver Cu stores were reduced in the LCu groups
compared to the NCu groups. This resulted in lower fetal/maternal liver Cu ratios in the NFLCu (1.79 ± 0.14,p < 0.05) and HFLCu (1.59 ± 0.21,p < 0.05) as compared to the NFNCu (4.12 ± 0.44) and the HFNCu (4.15 ± 0.27). Dam liver Fe was higher in the NFNCu than in
HFNCu group (1.10 ± 0.8 vs. 0.89 ± 0.06 μmol/g,p < 0.05); fetal liver Fe from HFNCu and NFLCu dams was lower than that from NFNCu fetuses (NFNCu: 2.42 ± 0.14; HFNCu: 1.92
± 0.15,p < 0.05; NFLCu: 1.81 ± 0.10,p < 0.01). Fetuses of the HFLCu group had a lower heart Fe than the NFNCu group (0.56 ± 0.03 vs. 44.0 ± 3.0 μg/g,p < 0.01). These data indicate that a maternal high-fat diet can potentially aggravate the effects of Cu deficiency by further
altering fetal Cu and Fe tissue stores. 相似文献
20.
Al-Saleh E Nandakumaran M Al-Harmi J Sadan T Al-Enezi H 《Biological trace element research》2006,113(2):113-123
Obesity is well known to be a contributory risk factor for several disease states, including diabetes mellitus. Further, obese
women are more prone to have babies born with congenital abnormalities. Paucity of data on maternal-fetal disposition of essential
trace elements in obese pregnancies prompted us to undertake this study. Maternal venous and umbilical arterial and venous
samples were collected from obese patients (body mass index >30) and control pregnant women (body mass index <25) at time
of spontaneous delivery or cesarean sections and concentrations of essential trace elements such as Cu, Fe, Mo, Se, and Zn
determined in various samples by atomic absorption spectrophotometry. Activities of antioxidant enzymes, superoxide dismutase,
glutathione peroxidase, and total antioxidant activity in maternal and umbilical blood were assessed using appropriate reagent
kits. Maternal-fetal disposition and exchange parameters of elements studied were assessed using established critieria. Concentrations
of Cu, Fe, Mo, Se, and Zn in the serum of control pregnant women at time of delivery averaged 2232.6, 2398.1, 10.9, 108.9,
and 661.9 μg/L, respectively, whereas in the obese group, the values of the above elements averaged 2150.3, 2446.8, 12.6,
96.8, and 838.9 μg/L, respectively. Umbilical vein/maternal vein ratios of Cu, Fe, Mo, Se, and Zn in the control group averaged
0.29, 1.93, 1.06, 0.76, and 1.12, respectively, whereas in the obese group, their fetal-maternal ratios averaged 0.32, 2.23,
1.06, 0.78, and 1.53, respectively. The Cu:Zn ratio in the maternal vein of the obese group (3.60±0.20) was significantly
lower (Student's t-test; p<0.05) than that of the controls (2.50±0.19); however, Cu:Fe ratio (1.04±0.08 vs 1.02±0.09) was not significantly different
(Student's t-test; p>0.05) in the two groups. Varying differences were noted in the case of antioxidant enzyme activities between the control
and study groups. We conclude that obesity is associated with alterations in maternal-fetal disposition of some essential
trace elements and antioxidant enzyme status and that these alterations could pose a potential health risk for the mother
as well as the fetus. 相似文献