共查询到20条相似文献,搜索用时 328 毫秒
1.
2.
3.
4.
GATA6 regulates differentiation of distal lung epithelium 总被引:8,自引:0,他引:8
Yang H Lu MM Zhang L Whitsett JA Morrisey EE 《Development (Cambridge, England)》2002,129(9):2233-2246
5.
6.
Mesaeli N Nakamura K Zvaritch E Dickie P Dziak E Krause KH Opas M MacLennan DH Michalak M 《The Journal of cell biology》1999,144(5):857-868
7.
8.
9.
Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts 总被引:4,自引:0,他引:4
下载免费PDF全文
![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Fischer A Klattig J Kneitz B Diez H Maier M Holtmann B Englert C Gessler M 《Molecular and cellular biology》2005,25(20):8960-8970
10.
The roles of GATA-4, -5 and -6 in vertebrate heart development 总被引:15,自引:0,他引:15
11.
GATA4 is a dosage-sensitive regulator of cardiac morphogenesis 总被引:15,自引:0,他引:15
12.
GATA6 Is Required for Proliferation, Migration, Secretory Cell Maturation, and Gene Expression in the Mature Mouse Colon 总被引:1,自引:0,他引:1
Beuling E Aronson BE Tran LM Stapleton KA Ter Horst EN Vissers LA Verzi MP Krasinski SD 《Molecular and cellular biology》2012,32(17):3392-3402
Controlled renewal of the epithelium with precise cell distribution and gene expression patterns is essential for colonic function. GATA6 is expressed in the colonic epithelium, but its function in the colon is currently unknown. To define GATA6 function in the colon, we conditionally deleted Gata6 throughout the epithelium of small and large intestines of adult mice. In the colon, Gata6 deletion resulted in shorter, wider crypts, a decrease in proliferation, and a delayed crypt-to-surface epithelial migration rate. Staining techniques and electron microscopy indicated deficient maturation of goblet cells, and coimmunofluorescence demonstrated alterations in specific hormones produced by the endocrine L cells and serotonin-producing cells. Specific colonocyte genes were significantly downregulated. In LS174T, the colonic adenocarcinoma cell line, Gata6 knockdown resulted in a significant downregulation of a similar subset of goblet cell and colonocyte genes, and GATA6 was found to occupy active loci in enhancers and promoters of some of these genes, suggesting that they are direct targets of GATA6. These data demonstrate that GATA6 is necessary for proliferation, migration, lineage maturation, and gene expression in the mature colonic epithelium. 相似文献
13.
14.
GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos 总被引:2,自引:0,他引:2
The individual contributions of the three vertebrate GATA factors to endoderm formation have been unclear. Here we detail the early expression of GATA4, 5 and 6 in presumptive endoderm in Xenopus embryos and their induction of endodermal markers in presumptive ectoderm. Induction of HNF3beta by all three GATA factors was abolished when protein synthesis was inhibited, showing that these inductions are indirect. In contrast, whereas induction of Sox17alpha and HNF1beta by GATA4 and 5 was substantially reduced when protein synthesis was inhibited, induction by GATA6 was minimally affected, suggesting that GATA6 is a direct activator of these early endodermal genes. GATA4 induced GATA6 expression in the same assay and antisense morpholino oligonucleotides (MOs), designed to knock down translation of GATA6, blocked induction of Sox17alpha and HNF1beta by GATA4, suggesting that GATA4 induces these genes via GATA6 in this assay. All three GATA factors were induced by activin, although GATA4 and 6 required lower concentrations. GATA MOs inhibited Sox17alpha and HNF1beta induction by activin at low and high concentrations in the order: GATA6>GATA4>GATA5. Together with the timing of their expression and the effects of GATA MOs in vivo, these observations identify GATA6 as the predominant GATA factor in the maintenance of endodermal gene expression by TGFbeta signaling in gastrulating embryos. In addition, examination of gene expression and morphology in later embryos, revealed GATA5 and 6 as the most critical for the development of the gut and the liver. 相似文献
15.
16.
17.
18.
19.